Mdm2 Mutant defective in binding p300 promotes ubiquitination but not degradation of p53. Evidence for the role of p300 in integrating ubiquitination and proteolysis

Journal of Biological Chemistry

Volumn 276, Issue 32, 2001, Pages 29695-29701

  Zhu, Qianzheng ^a   Yao, Jihong ^a   Wani, Gulzar ^a   Wani, Manzoor A ^a   Wani, Altaf A ^a,b,c  

^a OHIO STATE UNIVERSITY   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c 103 Wiseman Hall   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL ACTIVATION; DEGRADATION; GENETIC ENGINEERING; MUTAGENESIS; PROTEINS; TUMORS;

MUTANTS; PROTEOLYSIS;

BIOCHEMISTRY;

MUTANT PROTEIN; ONCOPROTEIN; PROTEIN MDM2; PROTEIN P300; PROTEIN P53; UBIQUITIN; VIRUS PROTEIN; E1A PROTEIN; MDM2 PROTEIN, HUMAN; NUCLEAR PROTEIN; TRANSACTIVATOR PROTEIN;

ADENOVIRUS; ANIMAL CELL; ARTICLE; DELETION MUTANT; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN METABOLISM; PROTEIN MODIFICATION; PROTEIN PROTEIN INTERACTION; UBIQUITINATION; BIOLOGICAL MODEL; CELL CULTURE; FIBROBLAST; GENE DELETION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; GENETICS; HUMAN; IMMUNOBLOTTING; METABOLISM; MUTATION; PROTEIN BINDING; REPORTER GENE; TRANSACTIVATION; WESTERN BLOTTING;

ADENOVIRIDAE; ANIMALIA;

ADENOVIRUS E1A PROTEINS; BLOTTING, WESTERN; CELLS, CULTURED; FIBROBLASTS; GENE DELETION; GENES, REPORTER; HUMANS; IMMUNOBLOTTING; MODELS, BIOLOGICAL; MUTATION; NUCLEAR PROTEINS; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC; TRANSFECTION; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITINS;

EID: 0035839451     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M102634200     Document Type: Article

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