Evolution of functions within the p53/p63/p73 family

Annals of the New York Academy of Sciences

Volumn 926, Issue , 2000, Pages 90-100

  De Laurenzi, Vincenzo ^a   Melino, Gerry ^a  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

Author keywords

Apoptosis; c Abl; Development; Differentiation; DNA damage; p53; p63; p73

Indexed keywords

CYCLINE; PROTEIN 14 3 3; PROTEIN BAX; PROTEIN MDM2; PROTEIN P21; PROTEIN P300; PROTEIN P53; PROTEIN P63; PROTEIN P73; PROTEIN SUBUNIT; VIRUS PROTEIN;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; CANCER; CANCER INHIBITION; CARBOXY TERMINAL SEQUENCE; CARCINOGENESIS; CELL DEATH; CELL DIFFERENTIATION; CONFERENCE PAPER; DNA DAMAGE; GENE MUTATION; HUMAN; KNOCKOUT MOUSE; PROTEIN DOMAIN; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; TRANSACTIVATION; TUMOR SUPPRESSOR GENE;

ADENOVIRIDAE;

EID: 0034517534     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2000.tb05602.x     Document Type: Conference Paper

References (63)

1. p53 mutations in human cancers
2. Somatic point mutations in the p53 gene of human tumors and cell lines: Updated compilation
3. p53: Puzzle and paradigm
4. p53, the cellular gatekeeper for growth and division
5. Apoptosis and the cell cycle: The p53 connection
6. Regulation of p53 downstream genes
7. The p53 pathway
8. Regulation of the p53 tumor suppressor protein
9. Structure and function in the p53 family
10. Structure, function and regulation of p63 and p73
11. The p53/p63/p73 family of transcription factors: Overlapping and distinct functions
12. Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers
13. p63, a p53 homolog at q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities
14. Two new p73 splice variants, gamma and delta, with different transcriptional activity
15. p73 and p63 are homotetramers capable of weak heterotypic interactions with each other but not with p53
16. p73 function is inhibited by tumor-derived p53 mutants in mammalian cells
17. Solution structure of a conserved C-terminal domain of p73 with structural homology to the SAM domain
18. Additional complexity in p73: Induction by mitogens in lymphoid cells and identification of two new splicing variants epsilon and zeta
19. New p73 variants with altered C-terminal structures have varied transcriptional activities
20. Molecular cloning and functional characterization of the upstream promoter region of the human p73 gene
21. p73 is a human p53 related protein that can induce apoptosis
22. The large T antigen of simian virus 40 binds and inactivates p53 but not p73
23. Cloning and functional analysis of human p51, which structurally and functionally resembles p53
24. Promoter specificity and stability control of the p53-related protein p73
25. MDM2 suppresses p73 function without promoting p73 degradation
26. The potential tumor suppressor p73 differentially regulates cellular p53 target genes
27. Identification and classification of p53-regulated genes
28. Induction of neuronal differentiation by p73, in a neuroblastoma cell line
29. p63 and p73 transactivate differentiation gene promoters in human keratinocytes
30. p53 family genes: Structural comparison, expression and mutation
31. Mutational analysis of the p73 gene localized at chromosome 1p36.3 in colorectal carcinomas
32. Search for mutations and examination of allelic expression imbalance of the p73 gene at 1p36.33 in human lung cancers
33. Overexpression of the wild type p73 gene in human bladder cancer
34. Overexpression of the wild type p73 gene in breast cancer tissues and cell lines
35. Alterations of p73 preferentially occur in gastric adenocarcinomas with foveolar epithelial phenotype
36. Expression level, allelic origin, and mutation analysis of the p73 gene in neuroblastoma tumors and cell lines
37. Loss of imprinting and allele switching of p73 in renal cell carcinoma
38. Expression of p73 and its relation to histopathology and prognosis in hepatocellular carcinoma
39. Expression of p73, a novel protein related to the p53 tumour suppressor p53 and apoptosis in cholangiocellular carcinoma of the liver
40. Different p73 splicing variants are expressed in distinct tumour areas of a multifocal neuroblastoma
41. p53 and apoptosis
42. Roles for p53 in growth arrest and apoptosis: Putting on the brakes after genotoxic stress
43. The complexity of p53 modulation: Emerging patterns from divergent signals
44. c-Abl: Activation and nuclear targets
45. The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage
46. Interaction of c-Abl and p73 and their collaboration to induce apoptosis
47. p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage
48. P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2
49. Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53
50. Adenovirus E4orf6 oncoprotein modulates the function of the p53-related protein, p73
51. Viral oncoproteins discriminate between p53 and the p53 homolog p73
52. Distinct regulation of p53 and p73 activity by adenovirus E1A, E1B, and E4orf6 proteins
53. p73beta, unlike p53, suppresses growth and induces apoptosis of human papillomavirus E6-expressing cancer cells
54. Regulation and activation of p53 and its family members
55. Mdm2 binds p73 alpha without targeting degradation
56. MDM2 and MDMX bind and stabilize the p53-related protein p73
57. The N-terminal domain of p73 interacts with the CH1 domain of p300/CREB binding protein and mediates transcriptional activation and apoptosis
58. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
59. Deficiency of p53 accelerates mammary tumorigenesis in Wnt-1 transgenic mice and promotes chromosomal instability
60. p63 is a p53 homologue required for limb and epidermal morphogenesis
61. p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development
62. Heterozygous germline mutations in the p53 homolog p63 are the cause of eec syndrome
63. p73-deficient mice have neurological, pherormonal and inflammatory defects but lack spontaneous tumours