How p53 binds DNA as a tetramer

EMBO Journal

Volumn 17, Issue 12, 1998, Pages 3342-3350

  McLure, Kevin G ^a   Lee, Patrick W K ^a  

^a Health Sciences Centre Calgary   (Canada)

Author keywords

Dimer dimer interaction; p53 tumor suppressor protein DNA binding; Tetramer

Indexed keywords

DIMER; DNA; DNA BINDING PROTEIN; PROTEIN P53; TETRAMER;

ARTICLE; BINDING AFFINITY; BINDING SITE; CONSENSUS SEQUENCE; DNA SEQUENCE; PRIORITY JOURNAL; PROTEIN DNA BINDING;

DNA; DNA-BINDING PROTEINS; GENES, TUMOR SUPPRESSOR; HUMANS; POLYMERS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0032526426     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/17.12.3342     Document Type: Article

References (24)

1. Arrowsmith, C.H. and Morin, P. (1996) New insights into p53 function from structural studies. Oncogene, 12, 1379-1385.
2. Balagurumoorthy, P. et al. (1995) Four p53 DNA-binding domain peptides bind natural p53-response elements and bend the DNA. Proc. Natl Acad. Sci. USA, 92, 8591-8595.
3. Cho, Y., Gorina, S., Jeffrey, P.D. and Pavletich, N.P. (1994) Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations. Science, 265, 346-355.
4. Chodosh, L.A. (1991) DNA-protein interactions. In Ausubel, F.M., Brent, R., Kingston, R.E., Moore, D.D., Seidman, J.G., Smith, J.A. and Struhl, K. (eds), Current Protocols in Molecular Biology. Green Publishing Associates/Wiley-Interscience, New York, pp. 12.2.3-12.2.7.
5. Clore, G.M. et al. (1994) High-resolution structure of the oligomenzation domain of p53 by multidimensional NMR. Science, 265, 386-391.
6. Clore, G.M. et al. (1995a) Interhelical angles in the solution structure of the oligomerization domain of p53: correction. Science, 267, 1515-1516.
7. Clore, G.M. et al. (1995b) Refined solution structure of the oligomerization domain of the tumour suppressor p53. Nature Struct. Biol., 2, 321-333.
8. El-Deiry, W.S., Kern, S.E., Pietenpol, J.A., Kinzler, K.W. and Vogelstein, B. (1992) Definition of a consensus binding site for p53. Nature Genet., 1, 45-49.
9. Friend, S. (1994) p53: a glimpse at the puppet behind the shadow play. Science, 265, 334-335.
10. Funk, W.D., Pak, D.T., Karas, R.H., Wright, W.E. and Shay, J.W. (1992) A transcriptionally active DNA-binding site for human p53 protein complexes. Mol. Cell. Biol., 12, 2866-2871.
11. Halazonetis, T.D. and Kandil, A.N. (1993) Conformational shifts propagate from the oligomerization domain of p53 to its tetrameric DNA binding domain and restore DNA binding to select p53 mutants. EMBO J., 12, 5057-5064.
12. Hollstein, M. Shomer, B., Greenblatt, M. Soussi, T., Hovig, E., Montesano, R. and Harris, C.C. (1996) Somatic point mutations in the p53 gene of human tumors and cell lines: updated compilation. Nucleic Acids Res., 24, 141-146.
13. Jeffrey, P.D., Gorina, S. and Pavletich, N.P. (1995) Crystal structure of the tetramerization domain of the p53 tumor suppressor at 1.7 angstroms. Science, 267, 1498-1502.
14. Kern, S.E., Kinzler, K.W., Bruskin, A., Jarosz, D., Friedman, P., Prives, C. and Vogelstein, B. (1991) Identification of p53 as a sequence-specific DNA-binding protein. Science, 252, 1708-1711.
15. Ko, L.J. and Prives, C. (1996) p53: puzzle and paradigm. Genes Dev., 10, 1054-1072.
16. Larson, R.E. and Hostetler, R.P. (1989) Calculus. Part one (3rd edn). D.C. Heath and Company, Toronto, Canada, pp. 342-345.
17. Lee, W., Harvey, T.S., Yin, Y., Yau, P. Litchfield, D. and Arrowsmith, C.H. (1994) Solution structure of the tetrameric minimum transforming domain of p53. Nature Struct. Biol., 1, 877-890.
18. Levine, A.J. (1997) p53, the cellular gatekeeper for growth and division. Cell, 88, 323-331.
19. Pavletich, N.P., Chambers, K.A. and Pabo, C.O. (1993) The DNA-binding domain of p53 contains the four conserved regions and the major mutation hot spots. Genes Dev., 7, 2556-2564.
20. Pennisi, E. (1996) Filling in the blanks in the p53 protein structure. Science, 274, 921-922.
21. Soussi, T. and May, P (1996) Structural aspects of the p53 protein in relation to gene evolution: a second look. J. Mol. Biol., 260, 623-637.
22. Wang, Y., Reed, M., Wang, P., Stenger, J.E., Mayr, G., Anderson, M.E., Schwedes, J.F. and Tegtmeyer, P. (1993) p53 domains: identification and characterization of two autonomous DNA-binding regions. Genes Dev., 7, 2576-2586.
23. Wang, Y., Schwedes, J.F., Parks, D., Mann, K. and Tegtmeyer, P. (1995) Interaction of p53 with its consensus DNA-binding site. Mol. Cell. Biol., 15, 2157-2165.
24. Waterman, J.L.F., Shenk, J.L. and Halazonetis, T.D. (1995) The dihedral symmetry of the p53 tetramerization domain mandates a conformational switch upon DNA binding. EMBO J., 14, 512-519.