Regulation of p53 by Hypoxia: Dissociation of transcriptional repression and apoptosis from p53-dependent transactivation

Molecular and Cellular Biology

Volumn 21, Issue 4, 2001, Pages 1297-1310

  Koumenis, C ^a   Alarcon, R ^a   Hammond, E ^a   Sutphin, P ^a   Hoffman, W ^a   Murphy, M ^a   Derr, J ^a   Taya, Y ^a   Lowe, S W ^a   Kastan, M ^a   Giaccia, A ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE DEACETYLASE; MESSENGER RNA; PROTEIN; PROTEIN P300; PROTEIN P53;

APOPTOSIS; ARTICLE; CELL CYCLE; CELL TRANSFORMATION; DNA DAMAGE; GENE INDUCTION; GENE REPRESSION; GENETIC TRANSCRIPTION; GENOTOXICITY; HUMAN; HUMAN CELL; HYPOXIA; IONIZING RADIATION; PRIORITY JOURNAL; PROTEIN INTERACTION; REPRESSOR GENE; TRANSACTIVATION;

ACETYLATION; APOPTOSIS; BINDING SITES; CELL HYPOXIA; CELL LINE; CELL NUCLEUS; CELL TRANSFORMATION, NEOPLASTIC; DNA DAMAGE; GENES, P53; HISTONE DEACETYLASES; HUMANS; MODELS, BIOLOGICAL; NUCLEAR PROTEINS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2; RNA, MESSENGER; SIGNAL TRANSDUCTION; TRANS-ACTIVATION (GENETICS); TUMOR SUPPRESSOR PROTEIN P53;

EID: 0035140981     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.21.4.1297-1310.2001     Document Type: Article

References (55)

1. Down-regulation of the stathmin/Op18 and FKBP25 genes following p53 induction
2. Hypoxia induces p53 accumulation through MDM2 down-regulation and inhibition of E6-mediated degradation
3. Stress signals utilize multiple pathways to stabilize p53
4. Recruitment of p300/CBP in p53-dependent signal pathways
5. Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1
6. The unique physiology of solid tumors: Opportunities (and problems) for cancer therapy
7. p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes
8. Activation of the ATM kinase by ionizing radiation and phosphorylation of p53
9. p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells
10. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
11. WAF1, a potential mediator of p53 tumor suppression
12. The comet assay: A comprehensive review
13. Functional interaction between p53, the TATA-binding protein (TBP), and TBP-associated factors in vivo
14. The complexity of p53 modulation: Emerging patterns from divergent signals
15. 1-phase checkpoint by low-oxygen conditions is independent of p53 status
16. Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumors
17. Mutations in the p53 tumor suppressor gene: Clues to cancer etiology and molecular pathogenesis
18. Synergistic activation of transcription by CBP and p53
19. A role for histone deacetylase activity in HDAC1-mediated transcriptional repression
20. Mdm2 promotes the rapid degradation of p53
21. Induction of apoptosis in HeLa cells by trans-activation-deficient p53
22. Intratumoral pO2 predicts survival in advanced cancer of the uterine cervix
23. A mammalian cell-cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia
24. Selective induction of cyclin-dependent kinase inhibitors and their roles in cell cycle arrest caused by trichostatin A, an inhibitor of histone deacetylase
25. Regulation of p53 stability by Mdm2
26. p53, the cellular gatekeeper for growth and division
27. Binding and modulation of p53 by p300/CBP coactivators
28. Ubiquitination of p53 and p21 is differentially affected by ionizing and UV radiation
29. Multisite phosphorylation and the integration of stress signals at p53
30. p53 activates the CD95 (APO-1/Fas) gene in response to DNA damage by anticancer drugs
31. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
32. The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
33. Negative feedback regulation of wild-type p53 biosynthesis
34. Hypoxia induces c-fos transcription via a mitogen-activated protein kinase-dependent pathway
35. Wild-type p53 negatively regulates the expression of a microtubule-associated protein
36. Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a
37. A model for p53-induced apoptosis
38. Signaling to p53: Breaking the MDM2-p53 circuit
39. Inhibition of presenilin 1 expression is promoted by p53 and p21WAF-1 and results in apoptosis and tumor suppression
40. Characterization of structural p53 mutants which show selective defects in apoptosis but not cell cycle arrest
41. Modulation of p53-mediated transcriptional repression and apoptosis by the adenovirus E1B 19K protein
42. DNA damage activates p53 through a phosphorylation-acetylation cascade
43. The polyproline region of p53 is required to activate apoptosis but not growth arrest
44. DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2
45. DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization
46. DNA damage induces phosphorylation of the amino terminus of p53
47. Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition
48. Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2
49. Mutations in serines 15 and 20 of human p53 impair its apoptotic activity
50. The requirement for the p53 proline-rich functional domain for mediation of apoptosis is correlated with specific PIG3 gene transactivation and with transcriptional repression
51. Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21/waf1/cip1
52. The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathway
53. Transcriptional activation plays a role in the induction of apoptosis by transiently transfected wild-type p53
54. Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostain A
55. Identification of a novel p53 functional domain that is necessary for mediating apoptosis