ATM and ATR: Networking cellular responses to DNA damage

Current Opinion in Genetics and Development

Volumn 11, Issue 1, 2001, Pages 71-77

  Shiloh, Y ^a  

^a TEL AVIV UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; ATR PROTEIN; PROTEIN KINASE; UNCLASSIFIED DRUG;

APOPTOSIS; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; CELL PROLIFERATION; CELL SURVIVAL; DNA DAMAGE; ENZYME ACTIVITY; GENE REPLICATION; GENETIC STABILITY; HUMAN; MOLECULAR WEIGHT; ONCOGENE; PRIORITY JOURNAL; PROTEIN DEGRADATION; REVIEW; SIGNAL TRANSDUCTION;

EID: 0035253615     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-437X(00)00159-3     Document Type: Review

References (72)

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4. The genetic defect in ataxia-telangiectasia
5. ATM: A mediator of multiple responses to genotoxic stress
6. ATR disruption leads to chromosomal fragmentation and early embryonic lethality
7. Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice
8. Overexpression of a kinase-inactive ATR protein cases sensitivity to DNA-damaging agents and defects in cell cycle checkpoints
9. Protein kinase mutants of human ATR increase sensitivity to UV and ionizing radiation and abrogate cell cycle checkpoint control
10. The yeast TEL1 gene patially substitutes for human ATM in suppressing hyperrecombination, radiation-induced apoptosis and telomere shortening in A-T cells
11. Signaling to p53: Breaking the posttranslational modifications code
12. DNA damage induces phosphorylation of the amino terminus of p53
13. Requirement of ATM in phosphorylation of the human p53 protein at serine 15 following DNA double-strand breaks
14. Enhanced phosphorylation of p53 by ATM in response to DNA damage
15. Activation of the ATM kinase by ionizing radiation and phosphorylation of p53
16. ATM associates with and phosphorylates p53: Mapping the region of interaction
17. Phosphorylation of p53 serine 15 increases interactions with CBP
18. Serine 15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2
19. Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage
20. Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2
21. Protein Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53
22. 1 by stabilizing p53
23. The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites
24. DNA damage-induced activation of p53 by the checkpoint kinase Chk2
25. 2-phase DNA-damage checkpoint
26. 2/M DNA damage checkpoint by inhibiting ataxiA-Telangiectasia-mutated kinase activity
27. ATM phosphorylates Chk2 in vivo and in vitro
28. GADD45 induction of a G2/M cell cycle checkpoint
29. Cooperation effects of genes controlling the G(2)M checkpoint
30. ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins
31. Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA
32. The ataxia-telangiectasia related protein ATR mediates DNA-dependent phosphorylation of p53
33. ATR is a caffeine-sensitive, DNA-activated protein kinase with a substrate specificity distinct from DNA-PK
34. A role for ATR in the DNA damage-induced phosphorylation of p53
35. 2/M DNA damage checkpoint
36. Roles of BRCA1 and its interacting proteins
37. Requirement of ATM dependent phosphorylation of Brca1 in the DNA damage response to double-strand breaks
38. Role for ATM in DNA damage-induced phosphorylation of BRCA1
39. hCds1 mediated phosphorylation of BRCA1 regulates the DNA damage response
40. Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response
41. BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures
42. BRCA1 is associated with human SWI/NSF-related complex: Linking chromatin remodeling with breast cancer
43. Sensing of ionizing radiation-induced damage by ATM through interaction with histone deacetylase
44. Molecular association between ATR and two components of the nucleosome remodeling and deacetylating complex, HDAC2 and CHD4
45. Splitting the ATM: Distinct repair and checkpoint defects in ataxiA-Telangiectasia
46. Radiation-induced assembly of Rad51 and Rad52 recombination complex requires ATM and c-Ab1
47. The controlling role of ATM in homologous recombination repair of DNA damage
48. Nijmegen breakage syndrome: Consequences of defective DNA double strand break repair
49. The Mre11 complex and ATM: Collaborating to navigate S phase
50. A mechanistic basis for Mre11-directed DNA joining at microhomologies
51. Nbs1 potentiates ATP-driven DNA unwinding and enconuclease cleavage by the Mre11/Rad50 complex
52. Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres
53. ATM phosphorylates p85/nbs1 in an S-phase checkpoint pathway
54. Functional link between ataxiA-Telangiectasia and Nijmegen breakage syndrome gene products
55. ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response
56. ATM-dependent phosphorylation of nibrin in response to radiation exposure
57. The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxiA-Telangiectasia-like disorder
58. Rearranging views on neurogenesis: Neuronal death in the absence of DNA end-joining proteins
59. Linking DNA damage and neurodegeneration
60. c-Abl: Actiation and nuclear targets
61. Interaction of c-Abl and p73α and their collaboration to induce apoptosis
62. The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage
63. p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage
64. p73: Structure and function
65. Substrate specificities and identification of putative substrates of ATM kinase family members
66. Utilization of oriented peptide libraries to identify substrate motifs selected by ATM
67. Characterization of ATM expression, localization, and associated DNA-dependent protein kinase activity
68. Purification and DNA binding properties of the ataxiA-Telangiectasia gene product ATM
69. Purification and characterization of ATM from human placenta
70. Recruitment of ATM protein to double strand DNA irradiated with ionizing radiation
71. Localization of a portion of extranuclear ATM to peroxisomes
72. ATM is a cytoplasmic protein in mouse brain required to prevent lysosomal accumulation