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Volumn 2, Issue 4, 1998, Pages 405-415

p300/MDM2 complexes participate in MDM2-mediated p53 degradation

Author keywords

[No Author keywords available]

Indexed keywords

DNA BINDING PROTEIN; E6 PROTEIN, HUMAN PAPILLOMAVIRUS TYPE 18; MDM2 PROTEIN, HUMAN; NUCLEAR PROTEIN; ONCOPROTEIN; PROTEIN MDM2; PROTEIN P53; TRANSACTIVATOR PROTEIN; TUMOR PROTEIN; UBIQUITIN;

EID: 0032185124     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(00)80140-9     Document Type: Article
Times cited : (366)

References (57)
  • 2
    • 9244234507 scopus 로고    scopus 로고
    • The SV40 large T antigen and adenovirus E1a oncoproteins interact with distinct isoforms of the transcriptional coactivator, p300
    • Avantaggiati, M.L., Carbone, M., Graessmann, A., Nakatani, Y., Howard, B., and Levine, A.S. (1996).The SV40 large T antigen and adenovirus E1a oncoproteins interact with distinct isoforms of the transcriptional coactivator, p300. EMBO J. 15, 2236-2248.
    • (1996) EMBO J. , vol.15 , pp. 2236-2248
    • Avantaggiati, M.L.1    Carbone, M.2    Graessmann, A.3    Nakatani, Y.4    Howard, B.5    Levine, A.S.6
  • 4
    • 0031058283 scopus 로고    scopus 로고
    • Antisense targeting of E6AP elevates p53 in HPV-infected cells but not in normal cells
    • Beer-Romero, P., Glass, S., and Rolfe, M. (1997). Antisense targeting of E6AP elevates p53 in HPV-infected cells but not in normal cells. Oncogene 14, 595-602.
    • (1997) Oncogene , vol.14 , pp. 595-602
    • Beer-Romero, P.1    Glass, S.2    Rolfe, M.3
  • 5
    • 0031282325 scopus 로고    scopus 로고
    • Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo
    • Bottger, A., Bottger, V., Sparks, A., Liu, W.L., Howard, S.F., and Lane, D.P. (1997). Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo. Curr. Biol. 7, 860-869.
    • (1997) Curr. Biol. , vol.7 , pp. 860-869
    • Bottger, A.1    Bottger, V.2    Sparks, A.3    Liu, W.L.4    Howard, S.F.5    Lane, D.P.6
  • 6
    • 0023392945 scopus 로고
    • High-efficiency transformation of mammalian cells by plasmid DNA
    • Chen, C., and Okayama, H. (1987). High-efficiency transformation of mammalian cells by plasmid DNA. Mol. Cell. Biol. 7, 2745-2752.
    • (1987) Mol. Cell. Biol. , vol.7 , pp. 2745-2752
    • Chen, C.1    Okayama, H.2
  • 7
    • 0027222956 scopus 로고
    • Mapping of the p53 and mdm-2 interaction domains
    • Chen, J., Marechal, V., and Levine, A.J. (1993). Mapping of the p53 and mdm-2 interaction domains. Mol. Cell. Biol. 13, 4107-4114.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 4107-4114
    • Chen, J.1    Marechal, V.2    Levine, A.J.3
  • 8
    • 0029171789 scopus 로고
    • Regulation of transcription functions of the p53 tumor suppressor by the mdm-2 oncogene
    • Chen, J., Lin, J., and Levine, A.J. (1995). Regulation of transcription functions of the p53 tumor suppressor by the mdm-2 oncogene. Mol. Med. 1, 142-152.
    • (1995) Mol. Med. , vol.1 , pp. 142-152
    • Chen, J.1    Lin, J.2    Levine, A.J.3
  • 9
    • 0029913730 scopus 로고    scopus 로고
    • Mdm-2 inhibits the G1 arrest and apoptosis functions of the p53 tumor suppressor protein
    • Chen, J., Wu, X., Lin, J., and Levine, A.J. (1996). Mdm-2 inhibits the G1 arrest and apoptosis functions of the p53 tumor suppressor protein. Mol. Cell. Biol. 16, 2445-2452.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 2445-2452
    • Chen, J.1    Wu, X.2    Lin, J.3    Levine, A.J.4
  • 10
    • 0030945245 scopus 로고    scopus 로고
    • p300 binding by E1A cosegregates with p53 induction but is dispensable for apoptosis
    • Chiou, S.K., and White, E. (1997). p300 binding by E1A cosegregates with p53 induction but is dispensable for apoptosis. J. Virol. 71, 3515-3525.
    • (1997) J. Virol. , vol.71 , pp. 3515-3525
    • Chiou, S.K.1    White, E.2
  • 11
    • 0026660339 scopus 로고
    • Properties of p53 mutations detected in primary and secondary cervical cancers suggest mechanisms of metastasis and involvement of environmental carcinogens
    • Crook, T., and Vousden, K.H. (1992). Properties of p53 mutations detected in primary and secondary cervical cancers suggest mechanisms of metastasis and involvement of environmental carcinogens. EMBO J. 11, 3935-3940.
    • (1992) EMBO J. , vol.11 , pp. 3935-3940
    • Crook, T.1    Vousden, K.H.2
  • 12
    • 0028296414 scopus 로고
    • Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor
    • Eckner, R., Ewen, M.E., Newsome, D., Gerdes, M., DeCaprio, J.A., Lawrence, J.B., and Livingston, D.M. (1994). Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor. Genes Dev. 8, 869-884.
    • (1994) Genes Dev. , vol.8 , pp. 869-884
    • Eckner, R.1    Ewen, M.E.2    Newsome, D.3    Gerdes, M.4    DeCaprio, J.A.5    Lawrence, J.B.6    Livingston, D.M.7
  • 14
    • 0030797585 scopus 로고    scopus 로고
    • Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain
    • Gu, W., and Roeder, R.G. (1997). Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. Cell 90, 595-606.
    • (1997) Cell , vol.90 , pp. 595-606
    • Gu, W.1    Roeder, R.G.2
  • 15
    • 0030996361 scopus 로고    scopus 로고
    • Synergistic activation of transcription by CBP and p53
    • Gu, W., Shi, X.L., and Roeder, R.G. (1997). Synergistic activation of transcription by CBP and p53. Nature 387, 819-823.
    • (1997) Nature , vol.387 , pp. 819-823
    • Gu, W.1    Shi, X.L.2    Roeder, R.G.3
  • 16
    • 0030905284 scopus 로고    scopus 로고
    • Mdm2 promotes the rapid degradation of p53
    • Haupt, Y., Maya, R., Kazaz, A., and Oren, M. (1997). Mdm2 promotes the rapid degradation of p53. Nature 387, 296-299.
    • (1997) Nature , vol.387 , pp. 296-299
    • Haupt, Y.1    Maya, R.2    Kazaz, A.3    Oren, M.4
  • 17
    • 0030724422 scopus 로고    scopus 로고
    • Roles of ubiquitin-mediated proteolysis in cell cycle control
    • Hershko, A. (1997). Roles of ubiquitin-mediated proteolysis in cell cycle control. Curr. Opin. Cell Biol. 9, 788-799.
    • (1997) Curr. Opin. Cell Biol. , vol.9 , pp. 788-799
    • Hershko, A.1
  • 18
    • 0031583962 scopus 로고    scopus 로고
    • Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53
    • Honda, R., Tanaka, H., and Yasuda, H. (1997). Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53. FEBS Lett. 420, 25-27.
    • (1997) FEBS Lett. , vol.420 , pp. 25-27
    • Honda, R.1    Tanaka, H.2    Yasuda, H.3
  • 20
    • 0027396829 scopus 로고
    • Cloning and expression of the cDNA for E6-AP, a protein that mediates the interaction of the human papillomavirus E6 oncoprotein with p53
    • Huibregtse, J.M., Scheffner, M., and Howley, P.M. (1993). Cloning and expression of the cDNA for E6-AP, a protein that mediates the interaction of the human papillomavirus E6 oncoprotein with p53. Mol. Cell. Biol. 13, 775-784.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 775-784
    • Huibregtse, J.M.1    Scheffner, M.2    Howley, P.M.3
  • 22
    • 0029972806 scopus 로고    scopus 로고
    • p53: Puzzle and paradigm
    • Ko, L.J., and Prives, C. (1996). p53: puzzle and paradigm. Genes Dev. 10, 1054-1072.
    • (1996) Genes Dev. , vol.10 , pp. 1054-1072
    • Ko, L.J.1    Prives, C.2
  • 24
    • 0030965946 scopus 로고    scopus 로고
    • Regulation of p53 stability by Mdm2
    • Kubbutat, M.H.G., Jones, S.N., and Vousden, K.H. (1997). Regulation of p53 stability by Mdm2. Nature 387, 299-303.
    • (1997) Nature , vol.387 , pp. 299-303
    • Kubbutat, M.H.G.1    Jones, S.N.2    Vousden, K.H.3
  • 25
    • 0028199891 scopus 로고
    • Inhibition of p53 DNA binding by human papillomavirus E6 proteins
    • Lechner, M.S., and Laimins, L.A. (1994). Inhibition of p53 DNA binding by human papillomavirus E6 proteins. J. Virol. 68, 4262-4273.
    • (1994) J. Virol. , vol.68 , pp. 4262-4273
    • Lechner, M.S.1    Laimins, L.A.2
  • 26
    • 0030941458 scopus 로고    scopus 로고
    • p53, the cellular gatekeeper for growth and division
    • Levine, A.J. (1997). p53, the cellular gatekeeper for growth and division. Cell 88, 323-331.
    • (1997) Cell , vol.88 , pp. 323-331
    • Levine, A.J.1
  • 28
    • 0031060151 scopus 로고    scopus 로고
    • p300 family members associate with the carboxyl terminus of simian virus 40 large tumor antigen
    • Lill, N.L., Tevethia, M.J., Eckner, R., Livingston, D.M., and Modjtahedi, N. (1997b). p300 family members associate with the carboxyl terminus of simian virus 40 large tumor antigen. J. Virol. 71, 129-137.
    • (1997) J. Virol. , vol.71 , pp. 129-137
    • Lill, N.L.1    Tevethia, M.J.2    Eckner, R.3    Livingston, D.M.4    Modjtahedi, N.5
  • 29
    • 0028303752 scopus 로고
    • Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein
    • Lin, J., Chen, J., Elenbaas, B., and Levine, A.J. (1994). Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein. Genes Dev. 8, 1235-1246.
    • (1994) Genes Dev. , vol.8 , pp. 1235-1246
    • Lin, J.1    Chen, J.2    Elenbaas, B.3    Levine, A.J.4
  • 30
    • 0027262606 scopus 로고
    • Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis
    • Lowe, S.W., and Ruley, H.E. (1993). Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis. Genes Dev. 7, 535-545.
    • (1993) Genes Dev. , vol.7 , pp. 535-545
    • Lowe, S.W.1    Ruley, H.E.2
  • 31
    • 0031015044 scopus 로고    scopus 로고
    • Ubiquitination of p53 and p21 is differentially affected by ionizing and UV radiation
    • Maki, C.G., and Howley, P.M. (1997). Ubiquitination of p53 and p21 is differentially affected by ionizing and UV radiation. Mol. Cell. Biol. 17, 355-363.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 355-363
    • Maki, C.G.1    Howley, P.M.2
  • 32
    • 0029952441 scopus 로고    scopus 로고
    • In vivo ubiquitination and proteasome-mediated degradation of p53
    • Maki, C.G., Huibregtse, J.M., and Howley, P.M. (1996). In vivo ubiquitination and proteasome-mediated degradation of p53. Cancer Res. 56, 2649-2654.
    • (1996) Cancer Res. , vol.56 , pp. 2649-2654
    • Maki, C.G.1    Huibregtse, J.M.2    Howley, P.M.3
  • 33
    • 0028821580 scopus 로고
    • The domain of p53 required for binding HPV 16 E6 is separable from the degradation domain
    • Mansur, C.P., Marcus, B., Dalal, S., and Androphy, E.J. (1995). The domain of p53 required for binding HPV 16 E6 is separable from the degradation domain. Oncogene 10, 457-465.
    • (1995) Oncogene , vol.10 , pp. 457-465
    • Mansur, C.P.1    Marcus, B.2    Dalal, S.3    Androphy, E.J.4
  • 34
    • 0029984820 scopus 로고    scopus 로고
    • Analysis of the proportion of p53 bound to mdm-2 in cells with defined growth characteristics
    • Momand, J., and Zambetti, G.P. (1996). Analysis of the proportion of p53 bound to mdm-2 in cells with defined growth characteristics. Oncogene 12, 2279-2289.
    • (1996) Oncogene , vol.12 , pp. 2279-2289
    • Momand, J.1    Zambetti, G.P.2
  • 35
    • 0026649648 scopus 로고
    • The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
    • Momand, J., Zambetti, G.P., Olson, D.C., George, D., and Levine, A.J. (1992). The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell 69, 1237-1245.
    • (1992) Cell , vol.69 , pp. 1237-1245
    • Momand, J.1    Zambetti, G.P.2    Olson, D.C.3    George, D.4    Levine, A.J.5
  • 37
    • 0030606239 scopus 로고    scopus 로고
    • The transcriptional coactivators p300 and CBP are histone acetyltransferases
    • Ogryzko, V.V., Schiltz, R.L., Russanova, V., Howard, B.H., and Nakatani, Y. (1996). The transcriptional coactivators p300 and CBP are histone acetyltransferases. Cell 87, 953-959.
    • (1996) Cell , vol.87 , pp. 953-959
    • Ogryzko, V.V.1    Schiltz, R.L.2    Russanova, V.3    Howard, B.H.4    Nakatani, Y.5
  • 39
    • 0026440995 scopus 로고
    • Native mRNA editing complexes from Trypanosoma brucei mitochondria
    • Pollard, V.W., Harris, M.E., and Hajduk, S.L. (1992). Native mRNA editing complexes from Trypanosoma brucei mitochondria. EMBO J. 11, 4429-4438.
    • (1992) EMBO J. , vol.11 , pp. 4429-4438
    • Pollard, V.W.1    Harris, M.E.2    Hajduk, S.L.3
  • 41
    • 0030982889 scopus 로고    scopus 로고
    • Accumulation of p53 induced by the adenovirus E1A protein requires regions involved in the stimulation of DNA synthesis
    • Querido, E., Teodora, J.G., and Branton, P.E. (1997). Accumulation of p53 induced by the adenovirus E1A protein requires regions involved in the stimulation of DNA synthesis. J. Virol. 71, 3526-3533.
    • (1997) J. Virol. , vol.71 , pp. 3526-3533
    • Querido, E.1    Teodora, J.G.2    Branton, P.E.3
  • 42
    • 11944262588 scopus 로고
    • Regulation of the level of the oncoprotein p53 in non-transformed and transformed cells
    • Reihsaus, E., Kohler, M., Kraiss, S., Oren, M., and Montenarh, M. (1990). Regulation of the level of the oncoprotein p53 in non-transformed and transformed cells. Oncogene 5, 137-145.
    • (1990) Oncogene , vol.5 , pp. 137-145
    • Reihsaus, E.1    Kohler, M.2    Kraiss, S.3    Oren, M.4    Montenarh, M.5
  • 43
    • 0032518917 scopus 로고    scopus 로고
    • Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein
    • Roth, J., Dobbelstein, M., Freedman, D.A., Shenk, T., and Levine, A.J. (1998). Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein. EMBO J. 17, 554-564.
    • (1998) EMBO J. , vol.17 , pp. 554-564
    • Roth, J.1    Dobbelstein, M.2    Freedman, D.A.3    Shenk, T.4    Levine, A.J.5
  • 44
    • 0029147196 scopus 로고
    • Lack of correlation between p53 level and sensitivity to DNA-damaging agents in keratinocytes carrying adenovirus E1A mutants
    • Sanchez-Prieto, R., Lleonart, M., and Ramon y Cajal, S. (1995). Lack of correlation between p53 level and sensitivity to DNA-damaging agents in keratinocytes carrying adenovirus E1A mutants. Oncogene 11, 675-682.
    • (1995) Oncogene , vol.11 , pp. 675-682
    • Sanchez-Prieto, R.1    Lleonart, M.2    Ramon Y Cajal, S.3
  • 45
    • 0020079972 scopus 로고
    • Adenovirus E1b-58kd tumor antigen and SV40 large tumor antigen are physically associated with the same 54 kd cellular protein in transformed cells
    • Sarnow, P., Ho, Y.S., Williams, J., and Levine, A.J. (1982). Adenovirus E1b-58kd tumor antigen and SV40 large tumor antigen are physically associated with the same 54 kd cellular protein in transformed cells. Cell 28, 387-394.
    • (1982) Cell , vol.28 , pp. 387-394
    • Sarnow, P.1    Ho, Y.S.2    Williams, J.3    Levine, A.J.4
  • 46
    • 0025639158 scopus 로고
    • The E6 oncoprotein encoded by human papillo-mavirus types 16 and 18 promotes the degradation of p53
    • Scheffner, M., Werness, B.A., Huibregtse, J.M., Levine, A.J., and Howley, P.M. (1990). The E6 oncoprotein encoded by human papillo-mavirus types 16 and 18 promotes the degradation of p53. Cell 63, 1129-1136.
    • (1990) Cell , vol.63 , pp. 1129-1136
    • Scheffner, M.1    Werness, B.A.2    Huibregtse, J.M.3    Levine, A.J.4    Howley, P.M.5
  • 47
    • 0027358723 scopus 로고
    • The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53
    • Scheffner, M., Huibregtse, J.M., Vierstra, R.D., and Howley, P.M. (1993). The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53. Cell 75, 495-505.
    • (1993) Cell , vol.75 , pp. 495-505
    • Scheffner, M.1    Huibregtse, J.M.2    Vierstra, R.D.3    Howley, P.M.4
  • 48
    • 0030880936 scopus 로고    scopus 로고
    • CREB-binding protein and p300/CBP-associated factor are transcriptional coactivators of the p53 tumor suppressor protein
    • Scolnick, D.M., Chehab, N.H., Stavridi, E.S., Lien, M.C., Caruso, L., Moran, E., Berger, S.L., and Halazonetis, T.D. (1997). CREB-binding protein and p300/CBP-associated factor are transcriptional coactivators of the p53 tumor suppressor protein. Cancer Res. 57, 3693-3696.
    • (1997) Cancer Res. , vol.57 , pp. 3693-3696
    • Scolnick, D.M.1    Chehab, N.H.2    Stavridi, E.S.3    Lien, M.C.4    Caruso, L.5    Moran, E.6    Berger, S.L.7    Halazonetis, T.D.8
  • 49
    • 0030892906 scopus 로고    scopus 로고
    • Inhibition of p53-mediated transactivation and cell cycle arrest by E1A through its p300/CBP-interacting region
    • Somasundaram, K., and El-Deiry, W.S. (1997). Inhibition of p53-mediated transactivation and cell cycle arrest by E1A through its p300/CBP-interacting region. Oncogene 14, 1047-1057.
    • (1997) Oncogene , vol.14 , pp. 1047-1057
    • Somasundaram, K.1    El-Deiry, W.S.2
  • 51
    • 0032513114 scopus 로고    scopus 로고
    • The role of E6AP in the regulation of p53 protein levels in human papillomavirus (HPV)-positive and HPV-negative cells
    • Talis, A.L., Huibregtse, J.M., and Howley, P.M. (1998). The role of E6AP in the regulation of p53 protein levels in human papillomavirus (HPV)-positive and HPV-negative cells. J. Biol. Chem. 273, 6439-6445.
    • (1998) J. Biol. Chem. , vol.273 , pp. 6439-6445
    • Talis, A.L.1    Huibregtse, J.M.2    Howley, P.M.3
  • 52
    • 0032127947 scopus 로고    scopus 로고
    • Suppression of the p300-dependent mdm2 negative-feed back loop induces the p53 apoptotic function
    • Thomas, A., and White, E. (1998). Suppression of the p300-dependent mdm2 negative-feed back loop induces the p53 apoptotic function. Genes Dev. 12, 1975-1985.
    • (1998) Genes Dev. , vol.12 , pp. 1975-1985
    • Thomas, A.1    White, E.2
  • 53
    • 0027244853 scopus 로고
    • The p53-mdm2 autoregulatory feedback loop
    • Wu, X., Bayle, J.H., Olson, D., and Levine, A.J. (1993). The p53-mdm2 autoregulatory feedback loop. Genes Dev. 7, 1126-1132.
    • (1993) Genes Dev. , vol.7 , pp. 1126-1132
    • Wu, X.1    Bayle, J.H.2    Olson, D.3    Levine, A.J.4
  • 54
    • 0029665857 scopus 로고    scopus 로고
    • A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A
    • Yang, X., Ogryzko, V.V., Nishikawa, J., Howard, B.H., and Nakatani, Y. (1996). A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A. Nature 382, 319-324.
    • (1996) Nature , vol.382 , pp. 319-324
    • Yang, X.1    Ogryzko, V.V.2    Nishikawa, J.3    Howard, B.H.4    Nakatani, Y.5
  • 55
    • 0029773871 scopus 로고    scopus 로고
    • The nuclear hormone receptor coactivator SRC-1 is a specific target of p300
    • Yao, T.P., Ku, G., Zhou, N., Scully, R., and Livingston, D.M. (1996). The nuclear hormone receptor coactivator SRC-1 is a specific target of p300. Proc. Natl. Acad. Sci. USA 93, 10626-10631.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 10626-10631
    • Yao, T.P.1    Ku, G.2    Zhou, N.3    Scully, R.4    Livingston, D.M.5
  • 56
    • 0027298576 scopus 로고
    • Induction of cellular p53 activity by DNA-damaging agents and growth arrest
    • Zhan, Q., Carrier, F., and Fornace, A.J. (1993). Induction of cellular p53 activity by DNA-damaging agents and growth arrest. Mol. Cell. Biol. 13, 4242-4250.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 4242-4250
    • Zhan, Q.1    Carrier, F.2    Fornace, A.J.3
  • 57
    • 0032549711 scopus 로고    scopus 로고
    • ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
    • Zhang, Y., Xiong, Y., and Yarbrough, W.G. (1998). ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways. Cell 92, 725-734.
    • (1998) Cell , vol.92 , pp. 725-734
    • Zhang, Y.1    Xiong, Y.2    Yarbrough, W.G.3


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