-
1
-
-
0036469001
-
Troglitazone suppresses cell growth of KU812 cells independently of PPARγ
-
Abe, A., Kiriyama, Y., Hirano, M., Miura, T., Kamiya, H., Harashima, H., and Tokumitsu, Y. 2002. Troglitazone suppresses cell growth of KU812 cells independently of PPARγ. Eur. J. Pharmacol. 436: 7-13.
-
(2002)
Eur. J. Pharmacol.
, vol.436
, pp. 7-13
-
-
Abe, A.1
Kiriyama, Y.2
Hirano, M.3
Miura, T.4
Kamiya, H.5
Harashima, H.6
Tokumitsu, Y.7
-
2
-
-
0035369341
-
On par with PPARs
-
Akiyama, T.E., Nicol, C.J., and Gonzalez, F.J. 2001. On par with PPARs. Trends Genet. 17: 310-312.
-
(2001)
Trends Genet.
, vol.17
, pp. 310-312
-
-
Akiyama, T.E.1
Nicol, C.J.2
Gonzalez, F.J.3
-
3
-
-
0033213637
-
PPARγ is required for placental, cardiac, and adipose tissue development
-
Barak, Y., Nelson, M.C., Ong, E.S., Jones, Y.Z., Ruiz-Lozano, P., Chien, K.R., Koder, A., and Evans, R.M. 1999. PPARγ is required for placental, cardiac, and adipose tissue development. Mol. Cell 4: 585-595.
-
(1999)
Mol. Cell
, vol.4
, pp. 585-595
-
-
Barak, Y.1
Nelson, M.C.2
Ong, E.S.3
Jones, Y.Z.4
Ruiz-Lozano, P.5
Chien, K.R.6
Koder, A.7
Evans, R.M.8
-
4
-
-
0034644526
-
Linking colorectal cancer to Wnt signaling
-
Bienz, M. and Clevers, H. 2000. Linking colorectal cancer to Wnt signaling. Cell 103: 311-320.
-
(2000)
Cell
, vol.103
, pp. 311-320
-
-
Bienz, M.1
Clevers, H.2
-
5
-
-
0034740504
-
Nuclear factor-κB (NF-κB) regulates proliferation and branching in mouse mammary epithelium
-
Brantley, D.M., Chen, C.L., Muraoka, R.S., Bushdid, P.B., Bradberry, J.L., Kittrell, F., Medina, D., Matrisian, L.M., Kerr, L.D., and Yull, F.E. 2001. Nuclear factor-κB (NF-κB) regulates proliferation and branching in mouse mammary epithelium. Mol. Biol. Cell 12: 1445-1455.
-
(2001)
Mol. Biol. Cell
, vol.12
, pp. 1445-1455
-
-
Brantley, D.M.1
Chen, C.L.2
Muraoka, R.S.3
Bushdid, P.B.4
Bradberry, J.L.5
Kittrell, F.6
Medina, D.7
Matrisian, L.M.8
Kerr, L.D.9
Yull, F.E.10
-
6
-
-
0037899628
-
Use of the peroxisome proliferator-activated receptor (PPAR) γ ligand troglitazone as treatment for refractory breast cancer: A phase II study
-
Burstein, H.J., Demetri, G.D., Mueller, E., Sarraf, P., Spiegelman, B.M., and Winer, E.P. 2003. Use of the peroxisome proliferator-activated receptor (PPAR) γ ligand troglitazone as treatment for refractory breast cancer: A phase II study. Breast Cancer Res. Treat. 79: 391-397.
-
(2003)
Breast Cancer Res. Treat.
, vol.79
, pp. 391-397
-
-
Burstein, H.J.1
Demetri, G.D.2
Mueller, E.3
Sarraf, P.4
Spiegelman, B.M.5
Winer, E.P.6
-
7
-
-
0035823587
-
Peroxisome proliferator-activated receptor-γ-independent inhibition of macrophage activation by the non-thiazolidinedione agonist L-796,449. Comparison with the effects of 15-deoxy-delta(12,14)-prostaglandin J(2)
-
Castrillo, A., Mojena, M., Hortelano, S., and Bosca, L. 2001. Peroxisome proliferator-activated receptor-γ-independent inhibition of macrophage activation by the non-thiazolidinedione agonist L-796,449. Comparison with the effects of 15-deoxy-delta(12,14)-prostaglandin J(2). J. Biol. Chem. 276: 34082-34088.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 34082-34088
-
-
Castrillo, A.1
Mojena, M.2
Hortelano, S.3
Bosca, L.4
-
8
-
-
0035132330
-
PPAR-γ dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation
-
Chawla, A., Barak, Y., Nagy, L., Liao, D., Tontonoz, P., and Evans, R.M. 2001. PPAR-γ dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation. Nat. Med. 7: 48-52.
-
(2001)
Nat. Med.
, vol.7
, pp. 48-52
-
-
Chawla, A.1
Barak, Y.2
Nagy, L.3
Liao, D.4
Tontonoz, P.5
Evans, R.M.6
-
9
-
-
0034889267
-
Magnitude of peroxisome proliferator-activated receptor-γ activation is associated with important and seemingly opposite biological responses in breast cancer cells
-
Clay, C.E., Namen, A.M., Atsumi, G., Trimboli, A.J., Fonteh, A.N., High, K.P., and Chilton, F.H. 2001. Magnitude of peroxisome proliferator-activated receptor-γ activation is associated with important and seemingly opposite biological responses in breast cancer cells. J. Investig. Med. 49: 413-420.
-
(2001)
J. Investig. Med.
, vol.49
, pp. 413-420
-
-
Clay, C.E.1
Namen, A.M.2
Atsumi, G.3
Trimboli, A.J.4
Fonteh, A.N.5
High, K.P.6
Chilton, F.H.7
-
11
-
-
0034708132
-
Selective activation of NF-κ B subunits in human breast cancer: Potential roles for NF-κ B2/p52 and for Bcl-3
-
Cogswell, P.C., Guttridge, D.C., Funkhouser, W.K., and Baldwin Jr., A.S. 2000. Selective activation of NF-κ B subunits in human breast cancer: Potential roles for NF-κ B2/p52 and for Bcl-3. Oncogene 19: 1123-1131.
-
(2000)
Oncogene
, vol.19
, pp. 1123-1131
-
-
Cogswell, P.C.1
Guttridge, D.C.2
Funkhouser, W.K.3
Baldwin Jr., A.S.4
-
12
-
-
0033889189
-
Peroxisome proliferator-activated receptor α is an androgen-responsive gene in human prostate and is highly expressed in prostatic adenocarcinoma
-
Collett, G.P., Betts, A.M., Johnson, M.I., Pulimood, A.B., Cook, S., Neal, D.E., and Robson, C.N. 2000. Peroxisome proliferator-activated receptor α is an androgen-responsive gene in human prostate and is highly expressed in prostatic adenocarcinoma. Clin. Cancer Res. 6: 3241-3248.
-
(2000)
Clin. Cancer Res.
, vol.6
, pp. 3241-3248
-
-
Collett, G.P.1
Betts, A.M.2
Johnson, M.I.3
Pulimood, A.B.4
Cook, S.5
Neal, D.E.6
Robson, C.N.7
-
13
-
-
0034677853
-
Central role of PPARα in the mechanism of action of hepatocarcinogenic peroxisome proliferators
-
Corton, J.C., Lapinskas, P.J., and Gonzalez, F.J. 2000. Central role of PPARα in the mechanism of action of hepatocarcinogenic peroxisome proliferators. Mutat. Res. 448: 139-151.
-
(2000)
Mutat. Res.
, vol.448
, pp. 139-151
-
-
Corton, J.C.1
Lapinskas, P.J.2
Gonzalez, F.J.3
-
14
-
-
0037124098
-
Loss of the peroxisome proliferation-activated receptor γ (PPARγ) does not affect mammary development and propensity for tumor formation but leads to reduced fertility
-
Cui, Y., Miyoshi, K., Claudio, E., Siebenlist, U.K., Gonzalez, F.J., Flaws, J., Wagner, K.U., and Hennighausen, L. 2002. Loss of the peroxisome proliferation-activated receptor γ (PPARγ) does not affect mammary development and propensity for tumor formation but leads to reduced fertility. J. Biol. Chem. 277: 17830-17835.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 17830-17835
-
-
Cui, Y.1
Miyoshi, K.2
Claudio, E.3
Siebenlist, U.K.4
Gonzalez, F.J.5
Flaws, J.6
Wagner, K.U.7
Hennighausen, L.8
-
15
-
-
0242408156
-
A phase II trial with rosiglitazone in liposarcoma patients
-
Debrock, G., Vanhentenrijk, V., Sciot, R., Debiec-Rychter, M., Oyen, R., and Van Oosterom, A. 2003. A phase II trial with rosiglitazone in liposarcoma patients. Brit. J. of Cancer 89: 1409-1412.
-
(2003)
Brit. J. of Cancer
, vol.89
, pp. 1409-1412
-
-
Debrock, G.1
Vanhentenrijk, V.2
Sciot, R.3
Debiec-Rychter, M.4
Oyen, R.5
Van Oosterom, A.6
-
16
-
-
0033616795
-
Induction of solid tumor differentiation by the peroxisome proliferator-activated receptor-γ ligand troglitazone in patients with liposarcoma
-
Demetri, G.D., Fletcher, C.D., Mueller, E., Sarraf, P., Naujoks, R., Campbell, N., Spiegelman, B.M., and Singer, S. 1999. Induction of solid tumor differentiation by the peroxisome proliferator-activated receptor-γ ligand troglitazone in patients with liposarcoma. Proc. Natl. Acad. Sci. 96: 3951-3956.
-
(1999)
Proc. Natl. Acad. Sci.
, vol.96
, pp. 3951-3956
-
-
Demetri, G.D.1
Fletcher, C.D.2
Mueller, E.3
Sarraf, P.4
Naujoks, R.5
Campbell, N.6
Spiegelman, B.M.7
Singer, S.8
-
17
-
-
0003357507
-
-
Academic Press, San Diego, CA
-
Detrich, H.W., Westerfield, M., Zon, L.I., and American Society for Cell Biology. 1999a. The Zebrafish: Biology. Academic Press, San Diego, CA.
-
(1999)
The Zebrafish: Biology
-
-
Detrich, H.W.1
Westerfield, M.2
Zon, L.I.3
-
19
-
-
0031844535
-
The nuclear eicosanoid receptor, PPARγ, is aberrantly expressed in colonic cancers
-
DuBois, R.N., Gupta, R., Brockman, J., Reddy, B.S., Krakow, S.L., and Lazar, M.A. 1998. The nuclear eicosanoid receptor, PPARγ, is aberrantly expressed in colonic cancers. Carcinogenesis 19: 49-53.
-
(1998)
Carcinogenesis
, vol.19
, pp. 49-53
-
-
DuBois, R.N.1
Gupta, R.2
Brockman, J.3
Reddy, B.S.4
Krakow, S.L.5
Lazar, M.A.6
-
20
-
-
0032555196
-
Ligands for peroxisome proliferator-activated receptor γ and retinoic acid receptor inhibit growth and induce apoptosis of human breast cancer cells in vitro and in BNX mice
-
Elstner, E., Muller, C., Koshizuka, K., Williamson, E.A., Park, D., Asou, H., Shintaku, P., Said, J.W., Heber, D., and Koeffler, H.P. 1998. Ligands for peroxisome proliferator-activated receptor γ and retinoic acid receptor inhibit growth and induce apoptosis of human breast cancer cells in vitro and in BNX mice. Proc. Natl. Acad. Sci. 95: 8806-8811.
-
(1998)
Proc. Natl. Acad. Sci.
, vol.95
, pp. 8806-8811
-
-
Elstner, E.1
Muller, C.2
Koshizuka, K.3
Williamson, E.A.4
Park, D.5
Asou, H.6
Shintaku, P.7
Said, J.W.8
Heber, D.9
Koeffler, H.P.10
-
21
-
-
0031887693
-
Prognostic significance of cathepsins B and L in primary human breast cancer
-
Foekens, J.A., Kos, J., Peters, H.A., Krasovec, M., Look, M.P., Cimerman, N., Meijer-van Gelder, M.E., Henzen-Logmans, S.C., van Putten, W.L., and Klijn, J.G. 1998. Prognostic significance of cathepsins B and L in primary human breast cancer. J. Clin. Oncol. 16: 1013-1021.
-
(1998)
J. Clin. Oncol.
, vol.16
, pp. 1013-1021
-
-
Foekens, J.A.1
Kos, J.2
Peters, H.A.3
Krasovec, M.4
Look, M.P.5
Cimerman, N.6
Meijer-Van Gelder, M.E.7
Henzen-Logmans, S.C.8
Van Putten, W.L.9
Klijn, J.G.10
-
22
-
-
0032583608
-
Expression of peroxisome proliferator activated receptor mRNA in normal and tumorigenic rodent mammary glands
-
Gimble, J.M., Pighetti, G.M., Lerner, M.R., Wu, X., Lightfoot, S.A., Brackett, D.J., Darcy, K., and Hollingsworth, A.B. 1998. Expression of peroxisome proliferator activated receptor mRNA in normal and tumorigenic rodent mammary glands. Biochem. Biophys. Res. Commun. 253: 813-817.
-
(1998)
Biochem. Biophys. Res. Commun.
, vol.253
, pp. 813-817
-
-
Gimble, J.M.1
Pighetti, G.M.2
Lerner, M.R.3
Wu, X.4
Lightfoot, S.A.5
Brackett, D.J.6
Darcy, K.7
Hollingsworth, A.B.8
-
23
-
-
0037109043
-
APC-dependent suppression of colon carcinogenesis by PPARγ
-
Girnun, G.D., Smith, W.M., Drori, S., Sarraf, P., Mueller, E., Eng, C., Nambiar, P., Rosenberg, D.W., Bronson, R.T., Edelmann, W., et al. 2002. APC-dependent suppression of colon carcinogenesis by PPARγ. Proc. Natl. Acad. Sci. 99: 13771-13776.
-
(2002)
Proc. Natl. Acad. Sci.
, vol.99
, pp. 13771-13776
-
-
Girnun, G.D.1
Smith, W.M.2
Drori, S.3
Sarraf, P.4
Mueller, E.5
Eng, C.6
Nambiar, P.7
Rosenberg, D.W.8
Bronson, R.T.9
Edelmann, W.10
-
24
-
-
0033615004
-
Association between src-kinases and the polyoma virus oncogene middle T-antigen requires PP2A and a specific sequence motif
-
Glover, H.R., Brewster, C.E., and Dilworth, S.M. 1999. Association between src-kinases and the polyoma virus oncogene middle T-antigen requires PP2A and a specific sequence motif. Oncogene 18: 4364-4370.
-
(1999)
Oncogene
, vol.18
, pp. 4364-4370
-
-
Glover, H.R.1
Brewster, C.E.2
Dilworth, S.M.3
-
25
-
-
0034700110
-
Prostacyclin-mediated activation of peroxisome proliferator-activated receptor δ in colorectal cancer
-
Gupta, R.A., Tan, J., Krause, W.F., Geraci, M.W., Willson, T.M., Dey, S.K., and DuBois, R.N. 2000. Prostacyclin-mediated activation of peroxisome proliferator-activated receptor δ in colorectal cancer. Proc. Natl. Acad. Sci. 97: 13275-13280.
-
(2000)
Proc. Natl. Acad. Sci.
, vol.97
, pp. 13275-13280
-
-
Gupta, R.A.1
Tan, J.2
Krause, W.F.3
Geraci, M.W.4
Willson, T.M.5
Dey, S.K.6
DuBois, R.N.7
-
26
-
-
0026587657
-
Induction of mammary tumors by expression of polyomavirus middle T oncogene: A transgenic mouse model for metastatic disease
-
Guy, C.T., Cardiff, R.D., and Muller, W.J. 1992. Induction of mammary tumors by expression of polyomavirus middle T oncogene: A transgenic mouse model for metastatic disease. Mol. Cell. Biol. 12: 954-961.
-
(1992)
Mol. Cell. Biol.
, vol.12
, pp. 954-961
-
-
Guy, C.T.1
Cardiff, R.D.2
Muller, W.J.3
-
27
-
-
0034614637
-
The hallmarks of cancer
-
Hanahan, D. and Weinberg, R.A. 2000. The hallmarks of cancer. Cell 100: 57-70.
-
(2000)
Cell
, vol.100
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
28
-
-
0034035376
-
Long-term follow-up confirms prognostic impact of PAI-1 and cathepsin D and L in primary breast cancer
-
Harbeck, N., Alt, U., Berger, U., Kates, R., Kruger, A., Thomssen, C., Janicke, F., Graeff, H., and Schmitt, M. 2000. Long-term follow-up confirms prognostic impact of PAI-1 and cathepsin D and L in primary breast cancer. Int. J. Biol. Markers 15: 79-83.
-
(2000)
Int. J. Biol. Markers
, vol.15
, pp. 79-83
-
-
Harbeck, N.1
Alt, U.2
Berger, U.3
Kates, R.4
Kruger, A.5
Thomssen, C.6
Janicke, F.7
Graeff, H.8
Schmitt, M.9
-
29
-
-
0033615352
-
PPARd is an APC-regulated target of nonsteroidal anti-inflammatory drugs
-
He, T.C., Chan, T.A., Vogelstein, B., and Kinzler, K.W. 1999. PPARd is an APC-regulated target of nonsteroidal anti-inflammatory drugs. Cell 99: 335-345.
-
(1999)
Cell
, vol.99
, pp. 335-345
-
-
He, T.C.1
Chan, T.A.2
Vogelstein, B.3
Kinzler, K.W.4
-
30
-
-
0035394518
-
Mutational analysis of the peroxisome proliferator-activated receptor γ gene in human malignancies
-
Ikezoe, T., Miller, C.W., Kawano, S., Heaney, A., Williamson, E.A., Hisatake, J., Green, E., Hofmann, W., Taguchi, H., and Koeffler, H.P. 2001. Mutational analysis of the peroxisome proliferator-activated receptor γ gene in human malignancies. Cancer Res. 61: 5307-5310.
-
(2001)
Cancer Res.
, vol.61
, pp. 5307-5310
-
-
Ikezoe, T.1
Miller, C.W.2
Kawano, S.3
Heaney, A.4
Williamson, E.A.5
Hisatake, J.6
Green, E.7
Hofmann, W.8
Taguchi, H.9
Koeffler, H.P.10
-
31
-
-
0034779322
-
Correlation of expression of cyclooxygenase-2, vascular endothelial growth factor, and peroxisome proliferator-activated receptor δ with head and neck squamous cell carcinoma
-
Jaeckel, E.C., Raja, S., Tan, J., Das, S.K., Dey, S.K., Girod, D.A., Tsue, T.T., and Sanford, T.R. 2001. Correlation of expression of cyclooxygenase-2, vascular endothelial growth factor, and peroxisome proliferator-activated receptor δ with head and neck squamous cell carcinoma. Arch. Otolaryngol. Head Neck Surg. 127: 1253-1259.
-
(2001)
Arch. Otolaryngol. Head Neck Surg.
, vol.127
, pp. 1253-1259
-
-
Jaeckel, E.C.1
Raja, S.2
Tan, J.3
Das, S.K.4
Dey, S.K.5
Girod, D.A.6
Tsue, T.T.7
Sanford, T.R.8
-
32
-
-
0029074677
-
Zebrafish wnt8 and wnt8b share a common activity but are involved in distinct developmental pathways
-
Kelly, G.M., Greenstein, P., Erezyilmaz, D.F., and Moon, R.T. 1995. Zebrafish wnt8 and wnt8b share a common activity but are involved in distinct developmental pathways. Development 121: 1787-1799.
-
(1995)
Development
, vol.121
, pp. 1787-1799
-
-
Kelly, G.M.1
Greenstein, P.2
Erezyilmaz, D.F.3
Moon, R.T.4
-
33
-
-
0030592517
-
Lessons from hereditary colorectal cancer
-
Kinzler, K.W. and Vogelstein, B. 1996. Lessons from hereditary colorectal cancer. Cell 87: 159-170.
-
(1996)
Cell
, vol.87
, pp. 159-170
-
-
Kinzler, K.W.1
Vogelstein, B.2
-
34
-
-
0035522894
-
Two genetic hits (more or less) to cancer
-
Knudson, A.G. 2001. Two genetic hits (more or less) to cancer. Nat. Rev. Cancer 1: 157-162.
-
(2001)
Nat. Rev. Cancer
, vol.1
, pp. 157-162
-
-
Knudson, A.G.1
-
35
-
-
0032145363
-
Ligand for peroxisome proliferator-activated receptor γ (troglitazone) has potent antitumor effect against human prostate cancer both in vitro and in vivo
-
Kubota, T., Koshizuka, K., Williamson, E.A., Asou, H., Said, J.W., Holden, S., Miyoshi, I., and Koeffler, H.P. 1998. Ligand for peroxisome proliferator-activated receptor γ (troglitazone) has potent antitumor effect against human prostate cancer both in vitro and in vivo. Cancer Res. 58: 3344-3352.
-
(1998)
Cancer Res.
, vol.58
, pp. 3344-3352
-
-
Kubota, T.1
Koshizuka, K.2
Williamson, E.A.3
Asou, H.4
Said, J.W.5
Holden, S.6
Miyoshi, I.7
Koeffler, H.P.8
-
36
-
-
0031694577
-
Activation of the peroxisome proliferator-activated receptor γ promotes the development of colon tumors in C57BL/6J-APCMin/+ mice
-
Lefebvre, A.M., Chen, L, Desreumaux, P., Najib, J., Fruchart, J.C., Geboes, K., Briggs, M., Heyman, R., and Auwerx, J. 1998. Activation of the peroxisome proliferator-activated receptor γ promotes the development of colon tumors in C57BL/6J-APCMin/+ mice. Nat. Med. 4: 1053-1057.
-
(1998)
Nat. Med.
, vol.4
, pp. 1053-1057
-
-
Lefebvre, A.M.1
Chen, L.2
Desreumaux, P.3
Najib, J.4
Fruchart, J.C.5
Geboes, K.6
Briggs, M.7
Heyman, R.8
Auwerx, J.9
-
37
-
-
0036866649
-
Lack of association of the codon 12 polymorphism of the peroxisome proliferator-activated receptor γ gene with breast cancer and body mass
-
Memisoglu, A., Hankinson, S.E., Manson, J.E., Colditz, G.A., and Hunter, D.J. 2002. Lack of association of the codon 12 polymorphism of the peroxisome proliferator-activated receptor γ gene with breast cancer and body mass. Pharmacogenetics 12: 597-603.
-
(2002)
Pharmacogenetics
, vol.12
, pp. 597-603
-
-
Memisoglu, A.1
Hankinson, S.E.2
Manson, J.E.3
Colditz, G.A.4
Hunter, D.J.5
-
38
-
-
0035139016
-
The role of PPAR-γ in macrophage differentiation and cholesterol uptake
-
Moore, K.J., Rosen, E.D., Fitzgerald, M.L., Randow, F., Andersson, L.P., Altshuler, D., Milstone, D.S., Mortensen, R.M., Spiegelman, B.M., and Freeman, M.W. 2001. The role of PPAR-γ in macrophage differentiation and cholesterol uptake. Nat. Med. 7: 41-47.
-
(2001)
Nat. Med.
, vol.7
, pp. 41-47
-
-
Moore, K.J.1
Rosen, E.D.2
Fitzgerald, M.L.3
Randow, F.4
Andersson, L.P.5
Altshuler, D.6
Milstone, D.S.7
Mortensen, R.M.8
Spiegelman, B.M.9
Freeman, M.W.10
-
39
-
-
0031993322
-
Terminal differentiation of human breast cancer through PPAR γ
-
Mueller, E., Sarraf, P., Tontonoz, P., Evans, R.M., Martin, K.J., Zhang, M., Fletcher, C., Singer, S., and Spiegelman, B.M. 1998. Terminal differentiation of human breast cancer through PPAR γ. Mol. Cell 1: 465-470.
-
(1998)
Mol. Cell
, vol.1
, pp. 465-470
-
-
Mueller, E.1
Sarraf, P.2
Tontonoz, P.3
Evans, R.M.4
Martin, K.J.5
Zhang, M.6
Fletcher, C.7
Singer, S.8
Spiegelman, B.M.9
-
40
-
-
0343855442
-
Effects of ligand activation of peroxisome proliferator-activated receptor γ in human prostate cancer
-
Mueller, E., Smith, M., Sarraf, P., Kroll, T., Aiyer, A., Kaufman, D.S., Oh, W., Demetri, G., Figg, W.D., Zhou, X.P., et al. 2000. Effects of ligand activation of peroxisome proliferator-activated receptor γ in human prostate cancer. Proc. Natl. Acad. Sci. 97: 10990-10995.
-
(2000)
Proc. Natl. Acad. Sci.
, vol.97
, pp. 10990-10995
-
-
Mueller, E.1
Smith, M.2
Sarraf, P.3
Kroll, T.4
Aiyer, A.5
Kaufman, D.S.6
Oh, W.7
Demetri, G.8
Figg, W.D.9
Zhou, X.P.10
-
41
-
-
0020216124
-
Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome
-
Nusse, R. and Varmus, H.E. 1982. Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome. Cell 31: 99-109.
-
(1982)
Cell
, vol.31
, pp. 99-109
-
-
Nusse, R.1
Varmus, H.E.2
-
42
-
-
0034943192
-
Peroxisome proliferator-activated receptor-γ expression in human malignant and normal brain, breast and prostate-derived cells
-
Nwankwo, J.O. and Robbins, M.E. 2001. Peroxisome proliferator-activated receptor-γ expression in human malignant and normal brain, breast and prostate-derived cells. Prostaglandins Leukot. Essent. Fatty Acids 64: 241-245.
-
(2001)
Prostaglandins Leukot. Essent. Fatty Acids
, vol.64
, pp. 241-245
-
-
Nwankwo, J.O.1
Robbins, M.E.2
-
43
-
-
0031846665
-
Antisense wnt-5a mimics wnt-1-mediated C57MG mammary epithelial transformation
-
Olson, D.J., and Gibo, D.M. 1998. Antisense wnt-5a mimics wnt-1-mediated C57MG mammary epithelial transformation. Exp. Cell Res. 241: 134-141.
-
(1998)
Exp. Cell Res.
, vol.241
, pp. 134-141
-
-
Olson, D.J.1
Gibo, D.M.2
-
44
-
-
0035881317
-
Anticancer effects of thiazolidinediones are independent of peroxisome proliferator-activated receptor γ and mediated by inhibition of translation initiation
-
Palakurthi, S.S., Aktas, H., Grubissich, L.M., Mortensen, R.M., and Halperin, J.A. 2001. Anticancer effects of thiazolidinediones are independent of peroxisome proliferator-activated receptor γ and mediated by inhibition of translation initiation. Cancer Res. 61: 6213-6218.
-
(2001)
Cancer Res.
, vol.61
, pp. 6213-6218
-
-
Palakurthi, S.S.1
Aktas, H.2
Grubissich, L.M.3
Mortensen, R.M.4
Halperin, J.A.5
-
45
-
-
0025103372
-
Polyoma small and middle T antigens and SV40 small t antigenform stable complexes with protein phosphatase 2A
-
Pallas, D.C., Shahrik, L.K., Martin, B.L., Jaspers, S., Miller, T.B., Brautigan, D.L., and Roberts, T.M. 1990. Polyoma small and middle T antigens and SV40 small t antigenform stable complexes with protein phosphatase 2A. Cell 60: 167-176.
-
(1990)
Cell
, vol.60
, pp. 167-176
-
-
Pallas, D.C.1
Shahrik, L.K.2
Martin, B.L.3
Jaspers, S.4
Miller, T.B.5
Brautigan, D.L.6
Roberts, T.M.7
-
46
-
-
0037470401
-
Pro12Ala polymorphism in the peroxisome proliferator-activated receptor-γ (PPAR-γ) gene and risk of prostate cancer among men in a large cancer prevention study
-
Paltoo, D., Woodson, K., Taylor, P., Albanes, D., Virtamo, J., and Tangrea, J. 2003. Pro12Ala polymorphism in the peroxisome proliferator-activated receptor-γ (PPAR-γ) gene and risk of prostate cancer among men in a large cancer prevention study. Cancer Lett. 191: 67-74.
-
(2003)
Cancer Lett.
, vol.191
, pp. 67-74
-
-
Paltoo, D.1
Woodson, K.2
Taylor, P.3
Albanes, D.4
Virtamo, J.5
Tangrea, J.6
-
47
-
-
0035956850
-
Genetic disruption of PPARδ decreases the tumorigenicity of human colon cancer cells
-
Park, B.H., Vogelstein, B., and Kinzler, K.W. 2001. Genetic disruption of PPARδ decreases the tumorigenicity of human colon cancer cells. Proc. Natl. Acad. Sci. 98: 2598-2603.
-
(2001)
Proc. Natl. Acad. Sci.
, vol.98
, pp. 2598-2603
-
-
Park, B.H.1
Vogelstein, B.2
Kinzler, K.W.3
-
48
-
-
0029010734
-
Mammary tumor suppression by transforming growth factor β 1 transgene expression
-
Pierce Jr., D.F., Gorska, A.E., Chytil, A., Meise, K.S., Page, D.L., Coffey Jr., R.J., and Moses, H.L. 1995. Mammary tumor suppression by transforming growth factor β 1 transgene expression. Proc. Natl. Acad. Sci. 92: 4254-4258.
-
(1995)
Proc. Natl. Acad. Sci.
, vol.92
, pp. 4254-4258
-
-
Pierce Jr., D.F.1
Gorska, A.E.2
Chytil, A.3
Meise, K.S.4
Page, D.L.5
Coffey Jr., R.J.6
Moses, H.L.7
-
49
-
-
0035002199
-
Therapeutic treatment of DMBA-induced mammary tumors with PPAR ligands
-
Pighetti, G.M., Novosad, W., Nicholson, C., Hitt, D.C., Hansens, C., Hollingsworth, A.B., Lerner, M.L., Brackett, D., Lightfoot, S.A., and Gimble, J.M. 2001. Therapeutic treatment of DMBA-induced mammary tumors with PPAR ligands. Anticancer Res. 21: 825-829.
-
(2001)
Anticancer Res.
, vol.21
, pp. 825-829
-
-
Pighetti, G.M.1
Novosad, W.2
Nicholson, C.3
Hitt, D.C.4
Hansens, C.5
Hollingsworth, A.B.6
Lerner, M.L.7
Brackett, D.8
Lightfoot, S.A.9
Gimble, J.M.10
-
50
-
-
12444337488
-
The novel synthetic triterpenoid, CDDO-imidazole, inhibits inflammatory response and tumor growth in vivo
-
Place, A.E., Suh, N., Williams, C.R., Risingsong, R., Honda, T., Honda, Y., Gribble, G.W., Leesnitzer, L.M., Stimmel, J.B., Willson, T.M., et al. 2003. The novel synthetic triterpenoid, CDDO-imidazole, inhibits inflammatory response and tumor growth in vivo. Clin. Cancer Res. 9: 2798-2806.
-
(2003)
Clin. Cancer Res.
, vol.9
, pp. 2798-2806
-
-
Place, A.E.1
Suh, N.2
Williams, C.R.3
Risingsong, R.4
Honda, T.5
Honda, Y.6
Gribble, G.W.7
Leesnitzer, L.M.8
Stimmel, J.B.9
Willson, T.M.10
-
51
-
-
0033895709
-
Wnt signaling and cancer
-
Polakis, P. 2000. Wnt signaling and cancer. Genes & Dev. 14: 1837-1851.
-
(2000)
Genes & Dev.
, vol.14
, pp. 1837-1851
-
-
Polakis, P.1
-
52
-
-
0034680788
-
A positive role for the PP2A catalytic subunit in Wnt signal transduction
-
Ratcliffe, M.J., Itoh, K., and Sokol, S.Y. 2000. A positive role for the PP2A catalytic subunit in Wnt signal transduction. J. Biol. Chem. 275: 35680-35683.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 35680-35683
-
-
Ratcliffe, M.J.1
Itoh, K.2
Sokol, S.Y.3
-
53
-
-
0033596124
-
Aberrant rel/nfkb genes and activity in human cancer
-
Rayet, B. and Gelinas, C. 1999. Aberrant rel/nfkb genes and activity in human cancer. Oncogene 18: 6938-6947.
-
(1999)
Oncogene
, vol.18
, pp. 6938-6947
-
-
Rayet, B.1
Gelinas, C.2
-
54
-
-
0034694786
-
Characterization of peroxisome proliferator-activated receptor α in normal rat mammary gland and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced mammary gland tumors from rats fed high and low fat diets
-
Roberts-Thomson, S.J. and Snyderwine, E.G. 2000. Characterization of peroxisome proliferator-activated receptor α in normal rat mammary gland and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced mammary gland tumors from rats fed high and low fat diets. Toxicol. Lett. 118: 79-86.
-
(2000)
Toxicol. Lett.
, vol.118
, pp. 79-86
-
-
Roberts-Thomson, S.J.1
Snyderwine, E.G.2
-
55
-
-
0035851187
-
PPARγ: A nuclear regulator of metabolism, differentiation, and cell growth
-
Rosen, E.D. and Spiegelman, B.M. 2001. PPARγ: A nuclear regulator of metabolism, differentiation, and cell growth. J. Biol. Chem. 276: 37731-37734.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 37731-37734
-
-
Rosen, E.D.1
Spiegelman, B.M.2
-
56
-
-
0037972688
-
Genetic profiling defines the xenobiotic gene network controlled by the nuclear receptor Pregnane X Receptor
-
Rosenfeld, J.M., Vargas, R., Xie, W., and Evans, R.M. 2003. Genetic profiling defines the xenobiotic gene network controlled by the nuclear receptor Pregnane X Receptor. Mol. Endocr. 17: 1268-1282.
-
(2003)
Mol. Endocr.
, vol.17
, pp. 1268-1282
-
-
Rosenfeld, J.M.1
Vargas, R.2
Xie, W.3
Evans, R.M.4
-
57
-
-
0031667938
-
Activators of the nuclear receptor PPARγ enhance colon polyp formation
-
Saez, E., Tontonoz, P., Nelson, M.C., Alvarez, J.G., Ming, U.T., Baird, S.M., Thomazy, V.A., and Evans, R.M. 1998. Activators of the nuclear receptor PPARγ enhance colon polyp formation. Nat. Med. 4: 1058-1061.
-
(1998)
Nat. Med.
, vol.4
, pp. 1058-1061
-
-
Saez, E.1
Tontonoz, P.2
Nelson, M.C.3
Alvarez, J.G.4
Ming, U.T.5
Baird, S.M.6
Thomazy, V.A.7
Evans, R.M.8
-
58
-
-
0031671246
-
Differentiation and reversal of malignant changes in colon cancer through PPARγ
-
Sarraf, P., Mueller, E., Jones, D., King, F.J., DeAngelo, D.J., Partridge, J.B., Holden, S.A., Chen, L.B., Singer, S., Fletcher, C., et al. 1998. Differentiation and reversal of malignant changes in colon cancer through PPARγ. Nat. Med. 4: 1046-1052.
-
(1998)
Nat. Med.
, vol.4
, pp. 1046-1052
-
-
Sarraf, P.1
Mueller, E.2
Jones, D.3
King, F.J.4
DeAngelo, D.J.5
Partridge, J.B.6
Holden, S.A.7
Chen, L.B.8
Singer, S.9
Fletcher, C.10
-
59
-
-
0033152206
-
Loss-of-function mutations in PPAR γ associated with human colon cancer
-
Sarraf, P., Mueller, E., Smith, W.M., Wright, H.M., Kum, J.B., Aaltonen, L.A., de la Chapelle, A., Spiegelman, B.M., and Eng, C. 1999. Loss-of-function mutations in PPAR γ associated with human colon cancer. Mol. Cell 3: 799-804.
-
(1999)
Mol. Cell
, vol.3
, pp. 799-804
-
-
Sarraf, P.1
Mueller, E.2
Smith, W.M.3
Wright, H.M.4
Kum, J.B.5
Aaltonen, L.A.6
De La Chapelle, A.7
Spiegelman, B.M.8
Eng, C.9
-
60
-
-
0028326046
-
Expression of zebrafish goosecoid and no tail gene products in wild-type and mutant no tail embryos
-
Schulte-Merker, S., Hammerschmidt, M., Beuchle, D., Cho, K.W., De Robertis, E.M., and Nusslein-Volhard, C. 1994a. Expression of zebrafish goosecoid and no tail gene products in wild-type and mutant no tail embryos. Development 120: 843-852.
-
(1994)
Development
, vol.120
, pp. 843-852
-
-
Schulte-Merker, S.1
Hammerschmidt, M.2
Beuchle, D.3
Cho, K.W.4
De Robertis, E.M.5
Nusslein-Volhard, C.6
-
61
-
-
0028344796
-
No tail (ntl) is the zebrafish homologue of the mouse T (Brachyury) gene
-
Schulte-Merker, S., van Eeden, F.J., Halpern, M.E., Kimmel, C.B., and Nusslein-Volhard, C. 1994b. no tail (ntl) is the zebrafish homologue of the mouse T (Brachyury) gene. Development 120: 1009-1015.
-
(1994)
Development
, vol.120
, pp. 1009-1015
-
-
Schulte-Merker, S.1
Van Eeden, F.J.2
Halpern, M.E.3
Kimmel, C.B.4
Nusslein-Volhard, C.5
-
62
-
-
0032525340
-
C/EBPβ, but not C/EBPα, is essential for ductal morphogenesis, lobuloalveolar proliferation, and functional differentiation in the mouse mammary gland
-
Seagroves, T.N., Krnacik, S., Raught, B., Gay, J., Burgess-Beusse, B., Darlington, G.J., and Rosen, J.M. 1998. C/EBPβ, but not C/EBPα, is essential for ductal morphogenesis, lobuloalveolar proliferation, and functional differentiation in the mouse mammary gland. Genes & Dev. 12: 1917-1928.
-
(1998)
Genes & Dev.
, vol.12
, pp. 1917-1928
-
-
Seagroves, T.N.1
Krnacik, S.2
Raught, B.3
Gay, J.4
Burgess-Beusse, B.5
Darlington, G.J.6
Rosen, J.M.7
-
63
-
-
0031595812
-
PPARγ and colorectal carcinoma: Conflicts in a nuclear family
-
Seed, B. 1998. PPARγ and colorectal carcinoma: Conflicts in a nuclear family. Nat. Med. 4: 1004-1005.
-
(1998)
Nat. Med.
, vol.4
, pp. 1004-1005
-
-
Seed, B.1
-
64
-
-
0034847431
-
Prospects for prevention and treatment of cancer with selective PPARγ modulators (SPARMs)
-
Sporn, M.B., Suh, N., and Mangelsdorf, D.J. 2001. Prospects for prevention and treatment of cancer with selective PPARγ modulators (SPARMs). Trends Mol. Med. 7: 395-400.
-
(2001)
Trends Mol. Med.
, vol.7
, pp. 395-400
-
-
Sporn, M.B.1
Suh, N.2
Mangelsdorf, D.J.3
-
65
-
-
0033571433
-
A new ligand for the peroxisome proliferator-activated receptor-γ (PPAR-γ), GW7845, inhibits rat mammary carcinogenesis
-
Suh, N., Wang, Y., Williams, C.R., Risingsong, R., Gilmer, T., Willson, T.M., and Sporn, M.B. 1999. A new ligand for the peroxisome proliferator-activated receptor-γ (PPAR-γ), GW7845, inhibits rat mammary carcinogenesis. Cancer Res. 59: 5671-5673.
-
(1999)
Cancer Res.
, vol.59
, pp. 5671-5673
-
-
Suh, N.1
Wang, Y.2
Williams, C.R.3
Risingsong, R.4
Gilmer, T.5
Willson, T.M.6
Sporn, M.B.7
-
66
-
-
0035902140
-
The Hedgehog and Wnt signalling pathways in cancer
-
Taipale, J. and Beachy, P.A. 2001. The Hedgehog and Wnt signalling pathways in cancer. Nature 411: 349-354.
-
(2001)
Nature
, vol.411
, pp. 349-354
-
-
Taipale, J.1
Beachy, P.A.2
-
67
-
-
12644265334
-
Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator-activated receptor γ and the retinoid X receptor
-
Tontonoz, P., Singer, S., Forman, B.M., Sarraf, P., Fletcher, J.A., Fletcher, C.D., Brun, R.P., Mueller, E., Altiok, S., Oppenheim, H., et al. 1997. Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator-activated receptor γ and the retinoid X receptor. Proc. Natl. Acad. Sci. 94: 237-241.
-
(1997)
Proc. Natl. Acad. Sci.
, vol.94
, pp. 237-241
-
-
Tontonoz, P.1
Singer, S.2
Forman, B.M.3
Sarraf, P.4
Fletcher, J.A.5
Fletcher, C.D.6
Brun, R.P.7
Mueller, E.8
Altiok, S.9
Oppenheim, H.10
-
68
-
-
0036189407
-
PPARadigms and PPARadoxes. Expanding roles for PPARγ in the control of lipid metabolism
-
Walczak, R. and Tontonoz, P. 2002. PPARadigms and PPARadoxes. Expanding roles for PPARγ in the control of lipid metabolism. J. Lipid Res. 43: 177-186.
-
(2002)
J. Lipid Res.
, vol.43
, pp. 177-186
-
-
Walczak, R.1
Tontonoz, P.2
-
69
-
-
0030903037
-
Dietary fat influences on polyp phenotype in multiple intestinal neoplasia mice
-
Wasan, H.S., Novelli, M., Bee, J., and Bodmer, W.F. 1997. Dietary fat influences on polyp phenotype in multiple intestinal neoplasia mice. Proc. Natl. Acad. Sci. 94: 3308-3313.
-
(1997)
Proc. Natl. Acad. Sci.
, vol.94
, pp. 3308-3313
-
-
Wasan, H.S.1
Novelli, M.2
Bee, J.3
Bodmer, W.F.4
-
70
-
-
0033998334
-
The PPARs: From orphan receptors to drug discovery
-
Willson, T.M., Brown, P.J., Sternbach, D.D., and Henke, B.R. 2000. The PPARs: From orphan receptors to drug discovery. J. Med. Chem. 43: 527-550.
-
(2000)
J. Med. Chem.
, vol.43
, pp. 527-550
-
-
Willson, T.M.1
Brown, P.J.2
Sternbach, D.D.3
Henke, B.R.4
-
71
-
-
0035856920
-
Global and societal implications of the diabetes epidemic
-
Zimmet, P., Alberti, K.G., and Shaw, J. 2001. Global and societal implications of the diabetes epidemic. Nature 414: 782-787.
-
(2001)
Nature
, vol.414
, pp. 782-787
-
-
Zimmet, P.1
Alberti, K.G.2
Shaw, J.3
|