Characterization of copper interactions with Alzheimer amyloid β peptides: Identification of an attomolar-affinity copper binding site on amyloid β1-42

Journal of Neurochemistry

Volumn 75, Issue 3, 2000, Pages 1219-1233

  Atwood, Craig S ^a,b   Scarpa, Richard C ^a,b   Huang, Xudong ^a,b   Moir, Robert D ^a,b   Jones, Walton D ^a,b   Fairlie, David P ^a,b   Tanzi, Rudolph E ^a,b   Bush, Ashley I ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Affinity; Alzheimer's disease; Binding affinity method; Chelators; Copper; Human amyloid peptide; Stoichiometry

Indexed keywords

AMYLOID BETA PROTEIN; COPPER;

ALZHEIMER DISEASE; ARTICLE; BINDING AFFINITY; COMPETITIVE INHIBITION; CONTAMINATION; LIGAND BINDING; NERVE DEGENERATION; NONHUMAN; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; RECEPTOR AFFINITY; SCATCHARD PLOT; SENILE PLAQUE; STOICHIOMETRY;

AMYLOID BETA-PROTEIN; ANIMALS; BINDING SITES; CHELATING AGENTS; COPPER; DOGS; HUMANS; KINETICS; PEPTIDE FRAGMENTS; REGRESSION ANALYSIS; SERUM ALBUMIN; ZINC;

EID: 0033844944     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2000.0751219.x     Document Type: Article

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