Wnt-3a overcomes β-amyloid toxicity in rat hippocampal neurons

Experimental Cell Research

Volumn 297, Issue 1, 2004, Pages 186-196

  Alvarez, Alejandra R ^a   Godoy, Juan A ^a   Mullendorff, Karin ^a   Olivares, Gonzalo H ^a   Bronfman, Miguel ^a   Inestrosa, Nibaldo C ^a  

^a PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

Author keywords

Alzheimer's disease; Amyloid; Apoptosis; Engrailed; GSK 3 ; Neurotoxicity; Wnt signaling

Indexed keywords

AMYLOID BETA PROTEIN; BETA CATENIN; GLYCOGEN SYNTHASE KINASE 3BETA; TAU PROTEIN; UNCLASSIFIED DRUG; WNT PROTEIN; WNT3A PROTEIN;

ALZHEIMER DISEASE; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; DEGENERATIVE DISEASE; EMBRYO; HIPPOCAMPUS; HUMAN; HUMAN CELL; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; TOXICITY;

STAPHYLOCOCCUS PHAGE 3A;

EID: 2942578107     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yexcr.2004.02.028     Document Type: Article

References (51)

1. Wodarz A., Nusse R. Mechanisms of Wnt signaling in development. Annu. Rev. Cell Dev. Biol. 14:1998;59-88
2. Barker N., Morin P.J., Clevers H. The Yin-Yang of TCF/beta-catenin signaling. Adv. Cancer Res. 77:2000;1-24
3. Peifer M., Polakis P. Wnt signaling in oncogenesis and embryogenesis - a look outside the nucleus. Science. 287:2000;1606-1609
4. Moon R.T., Bowerman B., Boutros M., Perrimon N. The promise and perils of Wnt signaling through β-Catenin. Science. 296:2002;1644-1646
5. Patapoutian A., Reichardt L.F. Roles of Wnt proteins in neural development and maintenance. Curr. Opin. Neurobiol. 10:2000;392-399
6. Lee S.M.K., Tole S., Grove E., Mc Mahon A. A local Wnt-3a signal is required for development of the mammalian hippocampus. Development. 127:2000;457-467
7. Krylova O., Herreros J., Cleverley K.E., Ehler E., Henriquez J.P., Hughes S.M., Salinas P.C. Wnt-3, expressed by motoneurons, regulates terminal arborization of neurotrophin-3-responsive spinal sensory neurons. Neuron. 12:2002;1043-1056
8. Hall A.C., Lucas F.R., Salinas P.C. Axonal remodelling and synaptic differentiation in the cerebellum is regulated by Wnt-7a signalling. Cell. 100:2000;525-535
9. Packard M., Sumin Koo E., Gorczyca M., Sharpe J., Cumberledge S., Budnik V. The Drosophila Wnt, Wingless, provides an essential signal for pre- and postsynaptic differentiation. Cell. 111:2002;319-330
10. Hardy J., Selkoe D.J. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science. 297:2002;353-356
11. Selkoe D.J. Alzheimer's disease: genes, proteins, and therapy. Physiol. Rev. 81:2001;741-766
12. De Ferrari G.V., Inestrosa N.C. Wnt signaling function in Alzheimer's disease. Brain Res. Brain Res. Rev. 33:2000;1-12
13. Mudher A., Lovestone S. Alzheimer's disease - do tauists and baptists finally shake hands? Trends Neurosci. 25:2002;22-26
14. Zhou J., Liyanage U., Medina M., Ho C., Simmons A.D., Lovett M., Kosik K.S. Presenilin 1 interaction in the brain with a novel member of the Armadillo family. NeuroReport. 8:1997;2085-2090
15. Levesque G., Yu G., Nishimura M., Zhang D.M., Levesque L., Yu H., Xu D., Liang Y., Rogaeva E., Ikeda M., Duthie M., Murgolo N., Wang L., VanderVere P., Bayne M.L., Strader C.D., Rommens J.M., Fraser P.E., St George-Hyslop P. Presenilins interact with armadillo proteins including neural-specific plakophilin-related protein and β-catenin. J. Neurochem. 72:1999;999-1008
16. Yu G., Chen F., Levesque G., Nishimura M., Zhang D.M., Levesque L., Rogaeva E., Xu D., Liang Y., Duthie M., St George-Hyslop P., Fraser P.E. The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains β-catenin. J. Biol. Chem. 273:1998;16470-16475
17. Takashima A., Murayama M., Murayama O., Kohno T., Honda T., Yasutake K., Nihonmatsu N., Mercken M., Yamaguchi H., Sugihara S., Wolozin B. Presenilin 1 associates with glycogen synthase kinase-3β and its substrate tau. Proc. Natl. Acad. Sci. U. S. A. 95:1998;9637-9641
18. Zhang Z., Hartmann H., Do V.M., Abramowski D., Sturchler-Pierrat C., Staufenbiel M., Sommer B., van de Wetering M., Clevers H., Saftig P., De Strooper B., He X., Yankner B.A. Destabilization of β-catenin by mutations in presenilin-1 potentiates neuronal apoptosis. Nature. 395:1998;698-702
19. Inestrosa N.C., Alvarez A., Godoy J., Reyes A.E., De Ferrari G.V. Acetylcholinesterase-amyloid-β-peptide interaction and Wnt signaling involvement in Aβ neurotoxicity. Acta Neurol. Scand., Suppl. 176:2000;53-59
20. Inestrosa N.C., De Ferrari G.V., Garrido J.L., Alvarez A., Olivares G.H., Barría M.I., Bronfman M., Chacón M. Wnt signaling involvement in β-amyloid-dependent neurodegeneration. Neurochem. Int. 41:2002;341-344
21. Alvarez G., Muñoz-Montano J.R., Satrustegui J., Avila J., Bogonez E., Diaz-Nido J. Lithium protects cultured neurons against β-amyloid- induced neurodegeneration. FEBS Lett. 453:1999;260-264
22. De Ferrari G.V., Chacón M.A., Barría M.I., Garrido J.L., Godoy J.A., Olivares G., Reyes A., Alvarez A., Bronfman M., Inestrosa N.C. Activation of Wnt signaling rescue neurodegeneration and behavioral impairments induced by β-amyloid fibrils. Mol. Psychiatry. 8:2003;195-208
23. Cáceres A., Banker G., Steward O., Binder L., Payne M. MAP2 is localized to the dendrites of hippocampal neurons which develop in culture. Brain Res. 315:1984;314-318
24. Kishida M., Koyama S., Kishida S., Matsubara K., Nakashima S., Higano K., Takada R., Takada S., Kikuchi A. Axin prevents Wnt-3a-induced accumulation of β-catenin. Oncogene. 18:1999;979-985
25. Alvarez A., Alarcón R., Opazo C., Campos E., Muñoz F., Dajas F., Gentry M.K., Doctor B.P., De Mello F., Inestrosa N.C. Stable complexes involving acetylcholinesterase and amyloid-β peptide change the biochemical properties of the enzyme and increase the neurotoxicity of Alzheimer's fibrils. J. Neurosci. 18:1998;3213-3223
26. Garrido J.L., Godoy J., Alvarez A., Bronfman M., Inestrosa N.C. Protein kinase C inhibits amyloid-β-peptide neurotoxicity by acting on members of the Wnt pathway. FASEB J. 16:2002;1982-1984
27. Doornbos R.P., Theelen M., van der Hoeven P.C.J., van Blitterswijk W.J., Verkleij A.J., van Bergen E.N., Henegouwen P.M.P. Protein kinase Cζ is a negative regulator of protein kinase C conventional isoenzymes. Eur. J. Biochem. 266:1999;855-864
28. Grimes C.A., Jope R.S. The multifaceted roles of glycogen synthase kinase 3β in cellular signalling. Prog. Neurobiol. 65:2001;391-426
29. Klein P.S., Melton D.A. A molecular mechanism for the effect of lithium on development. Proc. Natl. Acad. Sci. U. S. A. 93:1996;8455-8459
30. Frame S., Cohen P. GSK-3 takes centre stage more than 20 years after its discovery. Biochem. J. 359:2001;1-16
31. Takashima A., Noguchi K., Sato K., Hoshino T., Imahori K. Tau protein kinase I is essential for amyloid β-protein-induced neurotoxicity. Proc. Natl. Acad. Sci. U. S. A. 90:1993;7789-7793
32. Goedert M., Jakes R., Crowther R.A., Cohen P., Vanmechelen E., Vandermeeren M., Cras P. Epitope mapping of monoclonal antibodies to the paired helical filaments of Alzheimer's disease: identification of phosphorylation sites in tau protein. Biochem. J. 301:1994;871-877
33. Lucas J.J., Hernandez F., Gomez-Ramos P., Moran M.A., Hen R., Avila J. Decreased nuclear β-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3β conditional transgenic mice. EMBO J. 20:2001;27-39
34. Ferreira A., Lu Q., Orecchio L., Kosik K.S. Selective phosphorylation of adult tau isoforms in mature hippocampal neurons exposed to fibrillar Aβ Mol. Cell. Neurosci. 9:1997;220.M-234.M
35. Hong M., Chen D.C., Klein P.S., Lee V.M. Lithium reduces tau phosphorylation by inhibition of glycogen synthase kinase-3. J. Biol. Chem. 272:1997;25326S-25332S
36. Lovestone S., Davis D.R., Webster M.T., Kaech S., Brion J.P., Matus A., Anderton B.H. Lithium reduces tau phosphorylation: effects in living cells and in neurons at therapeutic concentrations. Biol. Psychiatry. 45:1999;995-1003
37. Hetman M., Cavanaugh J.E., Kimelman D., Xia Z. Role of glycogen synthase kinase-3β in neuronal apoptosis induced by trophic withdrawal. J. Neurosci. 20:2000;2567-2574
38. Cross D.A., Culbert A.A., Chalmers K.A., Facci L., Skaper S.D., Reith A.D. Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurons from death. J. Neurochem. 77:2001;94-102
39. Busciglio J., Lorenzo A., Yeh J., Yankner B.A. β-amyloid fibrils induce tau phosphorylation and loss of microtubule binding. Neuron. 14:1995;879-888
40. Lorenzo A., Yankner B.A. β-amyloid neurotoxicity requires fibril formation and is inhibited by Congo red. Proc. Natl. Acad. Sci. U. S. A. 91:1994;12243-12247
41. Mattson M.P. Apoptosis in neurodegenerative disorders. Nat. Rev. Mol. Cell Biol. 1:2000;120-129
42. Pap M., Cooper G.M. Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-kinase/Akt cell survival pathway. J. Biol. Chem. 273:1998;19929-19932
43. Chen S., Guttridge D.C., You Z., Zhang Z., Fribley A., Mayo M.W., Kitajewski J., Wang C.Y. Wnt-1 signaling inhibits apoptosis by activating β-catenin/Tcell factor-mediated transcription. J. Cell Biol. 152:2001;87-96
44. Danielian P.S., McMahon A.P. Engrailed-1 as a target of the Wnt-1 signalling pathway in vertebrate midbrain development. Nature. 383:1996;332-334
45. Kuemerle B., Zanjani H., Joyner A., Herrup K. Pattern deformities and cell loss in Engrailed-2 mutant mice suggest two separate patterning events during cerebellar development. J. Neurosci. 17:1997;7881-7889
46. Takashima A., Honda T., Yasutake K., Michel G., Murayama O., Murayama M., Ishiguro K., Yamaguchi H. Activation of tau protein kinase I/glycogen synthase kinase-3β by amyloid β-peptide (25-35) enhances phosphorylation of tau in hippocampal neurons. Neurosci. Res. 32:1998;317-323
47. Kurt M.A., Davies D.C., Kidd M., Duff K., Howlett D.R. Hyperphosphorylated tau and paired helical filament-like structures in the brains of mice carrying mutant amyloid precursor protein and mutant presenilin-1 transgenes. Neurobiol. Dis. 14:2003;89-97
48. Oddo S., Caccamo A., Shepherd J.D., Murphy M.P., Golde T.E., Kayed R., Metherate R., Mattson M.P., Akbari Y., LaFerla F.M. Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Aβ and synaptic dysfunction. Neuron. 39:2003;409-421
49. Stein T.D., Johnson J.A. Lack of neurodegeneration in transgenic mice overexpressing mutant amyloid precursor protein is associated with increased levels of transthyretin and the activation of cell survival pathways. J. Neurosci. 22:2002;7380-7388
50. Pei J.J., Braak E., Braak H., Grundke-Iqbal I., Iqbal K., Winblad B., Cowburn R.F. Distribution of active glycogen synthase kinase 3β (GSK-3β) in brains staged for Alzheimer disease neurofibrillary changes. J. Neuropathol. Exp. Neurol. 58:1999;1010-1019
51. Miller J.R. The Wnts. Genome Biol. 3:2003;3001.1-3001.15