메뉴 건너뛰기




Volumn 405, Issue 6785, 2000, Pages 421-424

Roles of PPARS in health and disease

Author keywords

[No Author keywords available]

Indexed keywords

FIBRIC ACID DERIVATIVE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; THIAZOLE DERIVATIVE;

EID: 0034713444     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35013000     Document Type: Article
Times cited : (1729)

References (30)
  • 1
    • 0033305213 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors: Nuclear control of metabolism
    • Desvergene, B. & Wahli, W. Peroxisome proliferator-activated receptors: nuclear control of metabolism. Endocr. Rev. 20, 649-688 (1999).
    • (1999) Endocr. Rev. , vol.20 , pp. 649-688
    • Desvergene, B.1    Wahli, W.2
  • 2
    • 0033524415 scopus 로고    scopus 로고
    • Ligand selectivity of peroxisome proliferator activated receptor alpha
    • Lin, Q., Ruuska, S. E., Shaw, N. S., Dong, D. & Noy, N. Ligand selectivity of peroxisome proliferator activated receptor alpha. Biochemistry 38, 185-190 (1999).
    • (1999) Biochemistry , vol.38 , pp. 185-190
    • Lin, Q.1    Ruuska, S.E.2    Shaw, N.S.3    Dong, D.4    Noy, N.5
  • 3
    • 0033613869 scopus 로고    scopus 로고
    • Phytanic acid activates the peroxisome proliferator-activated receptor alpha (PPARalpha) in sterol carrier protein 2-/sterol carrier protein x-deficient mite
    • Ellinghaus, P., Wolfrum, C., Assmann, G., Spencer, F. & Seedorf, U. Phytanic acid activates the peroxisome proliferator-activated receptor alpha (PPARalpha) in sterol carrier protein 2-/sterol carrier protein x-deficient mite. J. Biol. Chem. 274, 2766-2772 (1999).
    • (1999) J. Biol. Chem. , vol.274 , pp. 2766-2772
    • Ellinghaus, P.1    Wolfrum, C.2    Assmann, G.3    Spencer, F.4    Seedorf, U.5
  • 5
    • 0033213631 scopus 로고    scopus 로고
    • PPAR is required for the differentiation of adipose tissue in vivo and in vitro
    • Rosen, E. D. et al. PPAR is required for the differentiation of adipose tissue in vivo and in vitro. Mol. Cell 4, 611-617 (1999).
    • (1999) Mol. Cell , vol.4 , pp. 611-617
    • Rosen, E.D.1
  • 6
    • 0033544955 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor beta regulates acyl-CoA synthetase 2 in reaggregated rat brain cell cultures
    • Basu-Modak, S. et al. Peroxisome proliferator-activated receptor beta regulates acyl-CoA synthetase 2 in reaggregated rat brain cell cultures. J. Biol. Chem. 274, 35881-35888 (1999).
    • (1999) J. Biol. Chem. , vol.274 , pp. 35881-35888
    • Basu-Modak, S.1
  • 7
    • 0033564698 scopus 로고    scopus 로고
    • Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPARδ
    • Lim, H. et al. Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPARδ. Genes Dev. 13, 1561-1574 (1999).
    • (1999) Genes Dev. , vol.13 , pp. 1561-1574
    • Lim, H.1
  • 8
    • 0032933626 scopus 로고    scopus 로고
    • ADD1/SREBP-1c is required in the activation of hepatic lipogenic gene expression by glucose
    • Foretz, M. et al. ADD1/SREBP-1c is required in the activation of hepatic lipogenic gene expression by glucose. Mol. Cell. Biol. 19, 3760-3768 (1999).
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 3760-3768
    • Foretz, M.1
  • 9
    • 0033607176 scopus 로고    scopus 로고
    • Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic, expression of glucokinase and lipogenesis-related genes
    • Foretz, M., Guichard, C., Ferre, P. & Foufelle, F. Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic, expression of glucokinase and lipogenesis-related genes. Proc. Natl Acad. Sci. USA 96, 12737-12742 (1999).
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 12737-12742
    • Foretz, M.1    Guichard, C.2    Ferre, P.3    Foufelle, F.4
  • 10
    • 0032994523 scopus 로고    scopus 로고
    • Insulin acutely regulates the expression of the peroxisome proliferator-activated receptor-gamma in human adipocytes
    • Rieusset, J. et al. Insulin acutely regulates the expression of the peroxisome proliferator-activated receptor-gamma in human adipocytes. Diabetes 48, 699-705 (1999).
    • (1999) Diabetes , vol.48 , pp. 699-705
    • Rieusset, J.1
  • 11
    • 0032793068 scopus 로고    scopus 로고
    • Regulation of peroxisome proliferator-activated receptor gamma expression by adipocyte differentiation and determination factor 1/sterol regulatory element binding protein 1: Implications for adipocyte differentiation and metabolism
    • Fajas, L. et al. Regulation of peroxisome proliferator-activated receptor gamma expression by adipocyte differentiation and determination factor 1/sterol regulatory element binding protein 1: implications for adipocyte differentiation and metabolism. Mol. Cell. Biol. 19, 5495-5503 (1999).
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 5495-5503
    • Fajas, L.1
  • 12
    • 0033580938 scopus 로고    scopus 로고
    • Novel form of lipolysis induced by leptin
    • Wang, M. Y., Lee, Y. & Unger, R. H. Novel form of lipolysis induced by leptin. J. Biol. Chem. 274, 17541-17544 (1999).
    • (1999) J. Biol. Chem. , vol.274 , pp. 17541-17544
    • Wang, M.Y.1    Lee, Y.2    Unger, R.H.3
  • 13
    • 0033212964 scopus 로고    scopus 로고
    • PPAR mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance
    • Kubota, N. et al. PPAR mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance. Mol. Cell 4, 597-609 (1999).
    • (1999) Mol. Cell , vol.4 , pp. 597-609
    • Kubota, N.1
  • 14
    • 0032699670 scopus 로고    scopus 로고
    • Peroxisome proliferator activated receptor alpha mediates the adaptive response to fasting
    • Kersten, S. et al. Peroxisome proliferator activated receptor alpha mediates the adaptive response to fasting. J. Clin. Invest. 103, 1489-1498 (1999).
    • (1999) J. Clin. Invest. , vol.103 , pp. 1489-1498
    • Kersten, S.1
  • 15
    • 0033594980 scopus 로고    scopus 로고
    • A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: The PARalpha-null mouse as a model of fatty acid oxidation disorders
    • Leone, T. C., Weinheimer, C. J. & Kelly, D. P. A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: the PARalpha-null mouse as a model of fatty acid oxidation disorders. Proc. Natl Acad. Sci. USA 96, 7473-7478 (1999).
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 7473-7478
    • Leone, T.C.1    Weinheimer, C.J.2    Kelly, D.P.3
  • 16
    • 0033047376 scopus 로고    scopus 로고
    • Troglitazone, an antidiabetic agent, inhibits cholesterol biosynthesis through a mechanism independent of peroxisome proliferator-activated receptor-gamma
    • Wang, M., Wise, S. C., Leff, T. & Su, T. Z. Troglitazone, an antidiabetic agent, inhibits cholesterol biosynthesis through a mechanism independent of peroxisome proliferator-activated receptor-gamma. Diabetes 48, 254-260 (1999).
    • (1999) Diabetes , vol.48 , pp. 254-260
    • Wang, M.1    Wise, S.C.2    Leff, T.3    Su, T.Z.4
  • 17
    • 0033134791 scopus 로고    scopus 로고
    • Fibrates suppress fibrinogen gene expression in rodents via activation of the peroxisome proliferator-activated receptor-alpha
    • Kockx, M. F. et al. Fibrates suppress fibrinogen gene expression in rodents via activation of the peroxisome proliferator-activated receptor-alpha. Blood 93, 2991-2998 (1999).
    • (1999) Blood , vol.93 , pp. 2991-2998
    • Kockx, M.F.1
  • 18
    • 0033551769 scopus 로고    scopus 로고
    • Chemical probes that differentially modulate peroxisome proliferator-activated receptor alpha and BLTR, nuclear and cell surface receptors for leukotriene B(4)
    • Devchand, P. R. et al. Chemical probes that differentially modulate peroxisome proliferator-activated receptor alpha and BLTR, nuclear and cell surface receptors for leukotriene B(4). J. Biol. Chem. 274, 23341-23348 (1999).
    • (1999) J. Biol. Chem. , vol.274 , pp. 23341-23348
    • Devchand, P.R.1
  • 19
    • 0033527569 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor alpha negatively regulates the vascular inflammatory gene response by negative cross-talk with transcription factors NH-kappaB and AP-1
    • Delerive, P. et al. Peroxisome proliferator-activated receptor alpha negatively regulates the vascular inflammatory gene response by negative cross-talk with transcription factors NH-kappaB and AP-1. J. Biol. Chem. 274, 32048-32054 (1999).
    • (1999) J. Biol. Chem. , vol.274 , pp. 32048-32054
    • Delerive, P.1
  • 20
    • 0033007231 scopus 로고    scopus 로고
    • Effect of peroxisome proliferator-activated receptor alpha activators on tumor necrosis factor expression in mice during endotoxemia
    • Hill, M. R. et al. Effect of peroxisome proliferator-activated receptor alpha activators on tumor necrosis factor expression in mice during endotoxemia Infect. Immun. 67, 3488-3493 (1999).
    • (1999) Infect. Immun. , vol.67 , pp. 3488-3493
    • Hill, M.R.1
  • 21
    • 0032737858 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor (PPARgamma) as a regulator of monocyte/macrophage function
    • Ricote, M., Huang, J. T., Welch, J. S. & Glass, C. K. The peroxisome proliferator-activated receptor (PPARgamma) as a regulator of monocyte/macrophage function. J. Leukoc. Biol. 66, 733-739 (1999).
    • (1999) J. Leukoc. Biol. , vol.66 , pp. 733-739
    • Ricote, M.1    Huang, J.T.2    Welch, J.S.3    Glass, C.K.4
  • 22
    • 0034650330 scopus 로고    scopus 로고
    • Activation of peroxisome proliferator-activated receptor gamma does not inhibit IL-6 or TNF-α responses of macrophages to lipopolysaccharide in vitro and in vivo
    • Thieringer, R. et al. Activation of peroxisome proliferator-activated receptor gamma does not inhibit IL-6 or TNF-α responses of macrophages to lipopolysaccharide in vitro and in vivo. J. Immunol. 164, 1046-1054 (2000).
    • (2000) J. Immunol. , vol.164 , pp. 1046-1054
    • Thieringer, R.1
  • 23
    • 0033616795 scopus 로고    scopus 로고
    • Induction of solid tumor differentiation by the peroxisome proliferator-activated receptor-gamma ligand troglitazone in patients with liposarcoma
    • Demetri, G. D. et al. Induction of solid tumor differentiation by the peroxisome proliferator-activated receptor-gamma ligand troglitazone in patients with liposarcoma. Proc. Natl Acad. Sci. USA 96, 3951-3956 (1999).
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 3951-3956
    • Demetri, G.D.1
  • 24
    • 0033571433 scopus 로고    scopus 로고
    • A new ligand for the peroxisome proliferator-activated receptor-gamma (PPAR-gamma), GW7845, inhibits rat mammary carcinogenesis
    • Suh, N. et al. A new ligand for the peroxisome proliferator-activated receptor-gamma (PPAR-gamma), GW7845, inhibits rat mammary carcinogenesis. Cancer Res. 59, 5671-5673 (1999).
    • (1999) Cancer Res. , vol.59 , pp. 5671-5673
    • Suh, N.1
  • 25
    • 0033615352 scopus 로고    scopus 로고
    • PPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs
    • He, T. C., Chan, T. A., Vogelstein, B. & Kinzler, K. W. PPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs. Cell 99, 335-345 (1999).
    • (1999) Cell , vol.99 , pp. 335-345
    • He, T.C.1    Chan, T.A.2    Vogelstein, B.3    Kinzler, K.W.4
  • 26
    • 0033213637 scopus 로고    scopus 로고
    • PPAR gamma is required for placental, cardiac, and adipose tissue development
    • Barak, Y. et al. PPAR gamma is required for placental, cardiac, and adipose tissue development. Mol. Cell 4, 585-595 (1999).
    • (1999) Mol. Cell , vol.4 , pp. 585-595
    • Barak, Y.1
  • 27
    • 0033304551 scopus 로고    scopus 로고
    • Two polymorphisms in the peroxisome proliferator-activated receptor-gamma gene are associated with severe overweight among obese women
    • Valve, R. et al. Two polymorphisms in the peroxisome proliferator-activated receptor-gamma gene are associated with severe overweight among obese women. J. Clin. Endocrinol. Metab. 84, 3708-3712 (1999).
    • (1999) J. Clin. Endocrinol. Metab. , vol.84 , pp. 3708-3712
    • Valve, R.1
  • 28
    • 0032781890 scopus 로고    scopus 로고
    • Homozygosity of the pro12Ala variant of the peroxisome proliferation-activated receptor-gamma2 (PPAR-gamma2): Divergent modulating effects on body mass index in obese and lean Caucasian men
    • Ek, J. et al. Homozygosity of the Pro12Ala variant of the peroxisome proliferation-activated receptor-gamma2 (PPAR-gamma2): divergent modulating effects on body mass index in obese and lean Caucasian men. Diabetologia 42, 892-895 (1999).
    • (1999) Diabetologia , vol.42 , pp. 892-895
    • Ek, J.1
  • 29
    • 0033060302 scopus 로고    scopus 로고
    • Pro12Ala substitution in the peroxisome proliferator-activated receptor-gamma2 is not associated with type 2 diabetes
    • Mancini, F. P. et al Pro12Ala substitution in the peroxisome proliferator-activated receptor-gamma2 is not associated with type 2 diabetes. Diabetes 48, 1466-1468 (1999).
    • (1999) Diabetes , vol.48 , pp. 1466-1468
    • Mancini, F.P.1
  • 30
    • 0033599038 scopus 로고    scopus 로고
    • Dominant negative mutations in human PPARgamma associated with severe insulin resistance, diabetes mellitus and hypertension
    • Barroso, I. et al. Dominant negative mutations in human PPARgamma associated with severe insulin resistance, diabetes mellitus and hypertension. Nature 402, 880-883 (1999).
    • (1999) Nature , vol.402 , pp. 880-883
    • Barroso, I.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.