Muscarinic m1 receptor agonists increase the secretion of the amyloid precursor protein ectodomain

Life Sciences

Volumn 60, Issue 13-14, 1997, Pages 985-991

  Müller, Dorothea M ^a   Mendla, Klaus ^b   Farber, Steven A ^c   Nitsch, Roger M ^a  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^b BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

^c GEOPHYSICAL LABORATORY   (United States)

Author keywords

Alzheimer's disease; amyloid; m1 receptor; secretase; talsaclidine

Indexed keywords

ALPHA SECRETASE; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; ATROPINE; BIBN 99; CARBACHOL; MUSCARINIC M1 RECEPTOR AGONIST; MUSCARINIC M2 RECEPTOR ANTAGONIST; PHYSOSTIGMINE; SECRETASE; TALSACLIDINE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL TISSUE; ASTROCYTOMA CELL; BRAIN; BRAIN SLICE; CELL LINE; CONCENTRATION RESPONSE; CONFERENCE PAPER; CONTROLLED STUDY; CORPUS STRIATUM; DRUG ANTAGONISM; GENETIC TRANSFECTION; HIPPOCAMPUS; HUMAN; HUMAN CELL; MALE; NONHUMAN; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN SECRETION; RAT;

AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; DIBENZAZEPINES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOPEPTIDASES; HUMANS; MALE; MUSCARINIC AGONISTS; PYRIDINES; RATS; RATS, INBRED LEW; RECEPTOR, MUSCARINIC M1; RECEPTORS, MUSCARINIC; TUMOR CELLS, CULTURED;

EID: 0343811715     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0024-3205(97)00038-6     Document Type: Conference Paper

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