Metalloenzyme-like activity of Alzheimer's disease β-amyloid: Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H2O2

Journal of Biological Chemistry

Volumn 277, Issue 43, 2002, Pages 40302-40308

  Opazo, Carlos ^a   Huang, Xudong ^b   Cherny, Robert A ^c   Moir, Robert D ^d   Roher, Alex E ^b   White, Anthony R ^c   Cappai, Roberto ^b   Masters, Colin L ^b   Tanzi, Rudolph E ^c   Inestrosa, Nibaldo C ^c   Bush, Ashley I ^a,b  

^a PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d SUN HEALTH RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; DISEASES; ENZYMES; SUBSTRATES; TOXICITY;

PATHOGENESIS;

BIOCHEMISTRY;

AMYLOID BETA PROTEIN; ASCORBIC ACID; CHELATING AGENT; CHOLESTEROL; COPPER COMPLEX; COPPER ION; COPPER ZINC SUPEROXIDE DISMUTASE; DOPAMINE; HYDROGEN PEROXIDE; LEVODOPA; METALLOPROTEINASE; REDUCING AGENT; ZINC ION;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN CELL; CATALYSIS; CELL VIABILITY; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVITY; ENZYME SUBSTRATE; MOUSE; NERVE CELL CULTURE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; CATALYSIS; CELLS, CULTURED; CHOLESTEROL; COPPER; DOPAMINE; HUMANS; HYDROGEN PEROXIDE; METALLOPROTEINS; MICE; NEURONS; PEPTIDE FRAGMENTS;

ANIMALIA;

EID: 0037174856     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M206428200     Document Type: Article

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