메뉴 건너뛰기




Volumn 4, Issue 9, 1998, Pages 1053-1057

Activation of the peroxisome proliferator-activated receptor γ promotes the development of colon tumors in C57BL/6J-APC(Min)/+ mice

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDIABETIC AGENT; BETA CATENIN; CYCLOOXYGENASE 2; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; ROSIGLITAZONE; TROGLITAZONE;

EID: 0031694577     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/2036     Document Type: Article
Times cited : (580)

References (38)
  • 1
    • 0030592517 scopus 로고    scopus 로고
    • Lessons from heriditary colorectal cancer
    • Kinzler, K.W. & Vogelstein, B. Lessons from heriditary colorectal cancer. Cell 87, 159-170 (1996).
    • (1996) Cell , vol.87 , pp. 159-170
    • Kinzler, K.W.1    Vogelstein, B.2
  • 2
    • 0025998557 scopus 로고
    • Aspirin use and reduced risk of fatal colon cancer
    • Thun, M.J., Namboodiri, M.M. & Heath, C.W. Aspirin use and reduced risk of fatal colon cancer. N. Engl. J. Med. 325, 1593-1596 (1991).
    • (1991) N. Engl. J. Med. , vol.325 , pp. 1593-1596
    • Thun, M.J.1    Namboodiri, M.M.2    Heath, C.W.3
  • 3
    • 0030606299 scopus 로고    scopus 로고
    • Suppression of intestinal polyposis in APCΔ716 knockout mice by inhibition of cyclooxygenase 2 (COX-2)
    • Oshima, M. et al. Suppression of intestinal polyposis in APCΔ716 knockout mice by inhibition of cyclooxygenase 2 (COX-2). Cell 87, 803-809 (1996).
    • (1996) Cell , vol.87 , pp. 803-809
    • Oshima, M.1
  • 4
    • 0030019753 scopus 로고    scopus 로고
    • Chemoprevention of spontaneous intestinal adenoma in the ApcMin mouse model by the nonsteroidal anti-inflammatory drug piroxicam
    • Jacoby, R.F. et al. Chemoprevention of spontaneous intestinal adenoma in the ApcMin mouse model by the nonsteroidal anti-inflammatory drug piroxicam. Cancer Res. 56, 710-714 (1996).
    • (1996) Cancer Res. , vol.56 , pp. 710-714
    • Jacoby, R.F.1
  • 5
    • 0028576901 scopus 로고
    • Dietary factors and risk of colon cancer
    • Giovanucci, E. & Willet, W.C. Dietary factors and risk of colon cancer. Ann. Med. 26, 443-452 (1994).
    • (1994) Ann. Med. , vol.26 , pp. 443-452
    • Giovanucci, E.1    Willet, W.C.2
  • 6
    • 0030903037 scopus 로고    scopus 로고
    • Dietary fat influences on polyp phenotype in multiple intestinal neoplasia mice
    • Wasan, H.S., Novelli, M., Bee, J. & Bodmer, W.F. Dietary fat influences on polyp phenotype in multiple intestinal neoplasia mice. Proc. Natl. Acad. Sci. USA 94, 3308-3313 (1997).
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 3308-3313
    • Wasan, H.S.1    Novelli, M.2    Bee, J.3    Bodmer, W.F.4
  • 7
    • 0030794057 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors, orphans with ligands and functions
    • Schoonjans, K., Martin, C., Staels, B. & Auwerx, J. Peroxisome proliferator-activated receptors, orphans with ligands and functions. Curr. Opin. Lipidol. 8, 159-166 (1997).
    • (1997) Curr. Opin. Lipidol. , vol.8 , pp. 159-166
    • Schoonjans, K.1    Martin, C.2    Staels, B.3    Auwerx, J.4
  • 8
    • 0030835678 scopus 로고    scopus 로고
    • Organization, promoter analysis and expression of the human PPARγ gene
    • Fajas, L. et al. Organization, promoter analysis and expression of the human PPARγ gene. J. Biol. Chem. 272, 18779-18789 (1997).
    • (1997) J. Biol. Chem. , vol.272 , pp. 18779-18789
    • Fajas, L.1
  • 10
    • 0028641559 scopus 로고
    • Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor
    • Tontonoz, P., Hu, E. & Spiegelman, B.M. Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor. Cell 79, 1147-1156 (1994).
    • (1994) Cell , vol.79 , pp. 1147-1156
    • Tontonoz, P.1    Hu, E.2    Spiegelman, B.M.3
  • 11
    • 0029016829 scopus 로고
    • An antidiabetic thiazolidinedione is a high affinity ligand for Peroxisome Proliferator-Activated Receptor γ (PPARγ)
    • Lehmann, J.M. et al. An antidiabetic thiazolidinedione is a high affinity ligand for Peroxisome Proliferator-Activated Receptor γ (PPARγ). J. Biol. Chem. 270, 12953-12956 (1995).
    • (1995) J. Biol. Chem. , vol.270 , pp. 12953-12956
    • Lehmann, J.M.1
  • 12
    • 0028972025 scopus 로고
    • 15-Deoxy-Δ12,14 prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ
    • Forman, B.M. et al. 15-Deoxy-Δ12,14 prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ. Cell 83, 803-812 (1995).
    • (1995) Cell , vol.83 , pp. 803-812
    • Forman, B.M.1
  • 13
    • 0028972026 scopus 로고
    • A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation
    • Kliewer, S.A. et al. A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation. Cell 83, 813-819 (1995).
    • (1995) Cell , vol.83 , pp. 813-819
    • Kliewer, S.A.1
  • 14
    • 0026562404 scopus 로고
    • Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene
    • Su, L.K. et al. Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene. Science 256, 668-670 (1992).
    • (1992) Science , vol.256 , pp. 668-670
    • Su, L.K.1
  • 15
    • 0025899162 scopus 로고
    • Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients
    • Nishisho, I. et al. Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients. Science 253, 665-669 (1991).
    • (1991) Science , vol.253 , pp. 665-669
    • Nishisho, I.1
  • 16
    • 0025938038 scopus 로고
    • Identification and characterization of the familial adenomatous polyposis coli gene
    • Groden, J. et al. Identification and characterization of the familial adenomatous polyposis coli gene. Cell 66, 589-600 (1991).
    • (1991) Cell , vol.66 , pp. 589-600
    • Groden, J.1
  • 17
    • 0027763498 scopus 로고
    • Molecular diagnosis of familial adenomatous polyposis
    • Powell, S.M. et al. Molecular diagnosis of familial adenomatous polyposis. N. Engl. J. Med. 329, 1982-1987 (1993).
    • (1993) N. Engl. J. Med. , vol.329 , pp. 1982-1987
    • Powell, S.M.1
  • 18
    • 0026894053 scopus 로고
    • Somatic mutations of the APC gene in colorectal tumors: Mutation cluster region in the APC gene
    • Miyoshi, Y. et al. Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene. Hum. Mol. Genet. 1, 229-233 (1992).
    • (1992) Hum. Mol. Genet. , vol.1 , pp. 229-233
    • Miyoshi, Y.1
  • 19
    • 0030612740 scopus 로고    scopus 로고
    • PPARγ induces cell cycle withdrawal: Inhibition of E2F/DP DNA-binding activity via down-regulation of PP2A
    • Altiok, S., Xu, M. & Spiegelman, B. PPARγ induces cell cycle withdrawal: inhibition of E2F/DP DNA-binding activity via down-regulation of PP2A. Genes Dev. 11, 1987-1998 (1997).
    • (1997) Genes Dev. , vol.11 , pp. 1987-1998
    • Altiok, S.1    Xu, M.2    Spiegelman, B.3
  • 20
    • 0030831977 scopus 로고    scopus 로고
    • Peroxisome proliferator activated receptor γ, CCAAT/enhancer binding protein α, and cell cycle status regulate the commitment to adipocyte differentiation
    • Shao, D. & Lazar, M.A. Peroxisome proliferator activated receptor γ, CCAAT/enhancer binding protein α, and cell cycle status regulate the commitment to adipocyte differentiation. J. Biol. Chem. 272, 21473-21478 (1997).
    • (1997) J. Biol. Chem. , vol.272 , pp. 21473-21478
    • Shao, D.1    Lazar, M.A.2
  • 21
    • 12644265334 scopus 로고    scopus 로고
    • Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator-activated receptor gamma and the retinoid X receptor
    • Tontonoz, P. et al. Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator-activated receptor gamma and the retinoid X receptor. Proc. Natl. Acad. Sci. USA 94, 237-241 (1997).
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 237-241
    • Tontonoz, P.1
  • 22
    • 0030933277 scopus 로고    scopus 로고
    • Oncoprotein networks
    • Hunter, T. Oncoprotein networks. Cell 88, 333-346 (1997).
    • (1997) Cell , vol.88 , pp. 333-346
    • Hunter, T.1
  • 23
    • 0031888098 scopus 로고    scopus 로고
    • β-catenin: A key mediator of Wnt signalling
    • Willert, K. & Nusse, R. β-catenin: a key mediator of Wnt signalling. Curr. Opin. Genet. Develop. 8, 95-102 (1998).
    • (1998) Curr. Opin. Genet. Develop. , vol.8 , pp. 95-102
    • Willert, K.1    Nusse, R.2
  • 24
    • 0030894288 scopus 로고    scopus 로고
    • Prostaglandin H synthethases, nonsteroidal anti-inflammatory drugs, and colon cancer
    • Levy, G.D. Prostaglandin H synthethases, nonsteroidal anti-inflammatory drugs, and colon cancer. FASEB Journal 11, 234-247 (1997).
    • (1997) FASEB Journal , vol.11 , pp. 234-247
    • Levy, G.D.1
  • 25
    • 0028803728 scopus 로고
    • Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2
    • Tsuji, M. & DuBois, R.N. Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2. Cell 83, 493-501 (1995).
    • (1995) Cell , vol.83 , pp. 493-501
    • Tsuji, M.1    DuBois, R.N.2
  • 26
    • 0027363063 scopus 로고
    • Genetic identification of Mom-1 a major modifier locus affecting Min-induced intestinal neoplasia in the mouse
    • Dietrich, W.F. et al. Genetic identification of Mom-1 a major modifier locus affecting Min-induced intestinal neoplasia in the mouse. Cell 75, 631-639 (1993).
    • (1993) Cell , vol.75 , pp. 631-639
    • Dietrich, W.F.1
  • 27
    • 0028998255 scopus 로고
    • Min-induced intestinal neoplasia
    • Min-induced intestinal neoplasia. Cell 81, 957-966 (1995).
    • (1995) Cell , vol.81 , pp. 957-966
    • MacPhee, M.1
  • 28
    • 0030797904 scopus 로고    scopus 로고
    • Secretory phospholipase PLa2g2a confers resistance to intestinal tumorigenesis
    • Cormier, R.T. et al. Secretory phospholipase PLa2g2a confers resistance to intestinal tumorigenesis. Nature Genet. 17, 88-91 (1997).
    • (1997) Nature Genet. , vol.17 , pp. 88-91
    • Cormier, R.T.1
  • 29
    • 0029974533 scopus 로고    scopus 로고
    • Inhibition of colon cancer precursors in the rat by sulindac sulphone is not dependent on inhibition of prostaglandin synthesis
    • Charalambous, D. & O'Brien, P.E. Inhibition of colon cancer precursors in the rat by sulindac sulphone is not dependent on inhibition of prostaglandin synthesis. J. Gastroenterol. Hepatol. 11, 307-310 (1996).
    • (1996) J. Gastroenterol. Hepatol. , vol.11 , pp. 307-310
    • Charalambous, D.1    O'Brien, P.E.2
  • 30
    • 0030747817 scopus 로고    scopus 로고
    • Sulindac sulfone inhibits azoxymethane-induced colon carcinogenesis in rats without reducing prostaglandin levels
    • Piazza, G.A. et al. Sulindac sulfone inhibits azoxymethane-induced colon carcinogenesis in rats without reducing prostaglandin levels. Cancer Res. 57, 2909-2915 (1997).
    • (1997) Cancer Res. , vol.57 , pp. 2909-2915
    • Piazza, G.A.1
  • 31
    • 0030758925 scopus 로고    scopus 로고
    • Sulindac causes rapid regression of preexisting tumors in Min/+ mice independent of prostaglandin synthesis
    • Chiu, C.H., McEntee, M.F. & Whelan, J. Sulindac causes rapid regression of preexisting tumors in Min/+ mice independent of prostaglandin synthesis. Cancer Res. 57, 4267-4273 (1997).
    • (1997) Cancer Res. , vol.57 , pp. 4267-4273
    • Chiu, C.H.1    McEntee, M.F.2    Whelan, J.3
  • 32
    • 0028126050 scopus 로고
    • Effects of short chain fatty acids on gut morphology and function
    • Scheppach, W. Effects of short chain fatty acids on gut morphology and function. Gut 35, S35-S38 (1994).
    • (1994) Gut , vol.35
    • Scheppach, W.1
  • 33
    • 0031408419 scopus 로고    scopus 로고
    • Butyrate can act as a stimulator growth or inducer of apoptosis in human colonic epithelial cell lines depending on the presence of alternative energy sources
    • Singh, B., Halestrap, A.P. & Paraskeva, C. Butyrate can act as a stimulator growth or inducer of apoptosis in human colonic epithelial cell lines depending on the presence of alternative energy sources. Carcinogenesis 18, 1265-1270 (1997).
    • (1997) Carcinogenesis , vol.18 , pp. 1265-1270
    • Singh, B.1    Halestrap, A.P.2    Paraskeva, C.3
  • 34
    • 0028920328 scopus 로고
    • Substrate balances across colonic carcinomas in humans
    • Holm, E. et al. Substrate balances across colonic carcinomas in humans. Cancer Res. 55, 1373-1378 (1995).
    • (1995) Cancer Res. , vol.55 , pp. 1373-1378
    • Holm, E.1
  • 35
    • 0031886864 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor γ is a negative regulator of macrophage activation
    • Ricote, M., Li, A.C., Willson, T.M., Kelly, C.J. & Glass, C.K. The peroxisome proliferator-activated receptor γ is a negative regulator of macrophage activation. Nature 391, 79-82 (1998).
    • (1998) Nature , vol.391 , pp. 79-82
    • Ricote, M.1    Li, A.C.2    Willson, T.M.3    Kelly, C.J.4    Glass, C.K.5
  • 36
    • 0031888958 scopus 로고    scopus 로고
    • PPARγ agonists inhibit production of monocyte inflammatory cytokines
    • Jiang, C., Ting, A.T. & Seed, B. PPARγ agonists inhibit production of monocyte inflammatory cytokines. Nature 391, 82-86 (1998).
    • (1998) Nature , vol.391 , pp. 82-86
    • Jiang, C.1    Ting, A.T.2    Seed, B.3
  • 37
    • 0031667938 scopus 로고    scopus 로고
    • Activators of the nuclear receptor PPARγ enhance colon polyp formation
    • Saez, E. et al. Activators of the nuclear receptor PPARγ enhance colon polyp formation. Nature Med. 4, XXX-XXX (1998).
    • (1998) Nature Med. , vol.4
    • Saez, E.1
  • 38
    • 0028817459 scopus 로고
    • Fibrates down-regulate apolipoprotein C-III expression independent of induction of peroxisomal Acyl Co-enzyme A Oxidase
    • Staels, B. et al. Fibrates down-regulate apolipoprotein C-III expression independent of induction of peroxisomal Acyl Co-enzyme A Oxidase. J. Clin. Invest. 95, 705-712 (1995).
    • (1995) J. Clin. Invest. , vol.95 , pp. 705-712
    • Staels, B.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.