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Volumn 5, Issue 4, 2016, Pages

Signal transduction pathways of EMT induced by TGF-β, SHH, and WNT and their crosstalks

Author keywords

EMT; Modeling; SHH; Signaling transduction pathways; TGF ; WNT

Indexed keywords

BETA CATENIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLOPAMINE; E1A ASSOCIATED P300 PROTEIN; GLYCOGEN SYNTHASE KINASE 3BETA; MICRORNA; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN P15; PROTEIN P53; RHO FACTOR; SMAD PROTEIN; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR SNAIL; TRANSCRIPTION FACTOR TWIST; TRANSCRIPTION FACTOR ZEB1; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; VITAMIN D; WNT PROTEIN;

EID: 85114273645     PISSN: None     EISSN: 20770383     Source Type: Journal    
DOI: 10.3390/jcm5040041     Document Type: Review
Times cited : (273)

References (153)
  • 1
    • 25444443688 scopus 로고    scopus 로고
    • Modelling glandular epithelial cancers in three-dimensional cultures
    • Debnath, J.; Brugge, J.S. Modelling glandular epithelial cancers in three-dimensional cultures. Nat. Rev. Cancer 2005, 5, 675–688.
    • (2005) Nat. Rev. Cancer , vol.5 , pp. 675-688
    • Debnath, J.1    Brugge, J.S.2
  • 3
    • 0034885325 scopus 로고    scopus 로고
    • Human mesenchymal stem cells persist, demonstrate site-specific multipotential differentiation, and are present in sites of wound healing and tissue regeneration after transplantation into fetal sheep
    • Mackenzie, T.C.; Flake, A.W. Human mesenchymal stem cells persist, demonstrate site-specific multipotential differentiation, and are present in sites of wound healing and tissue regeneration after transplantation into fetal sheep. Blood Cells Mol. Dis. 2001, 27, 601–604.
    • (2001) Blood Cells Mol. Dis , vol.27 , pp. 601-604
    • Mackenzie, T.C.1    Flake, A.W.2
  • 5
    • 84874518656 scopus 로고    scopus 로고
    • Mesenchymal stem cells in transplantation and tissue regeneration
    • Hoogduijn, M.J.; Dor, F.J. Mesenchymal stem cells in transplantation and tissue regeneration. Front. Immunol. 2011, 2, 84.
    • (2011) Front. Immunol. , vol.2 , pp. 84
    • Hoogduijn, M.J.1    Dor, F.J.2
  • 7
    • 0001946304 scopus 로고
    • Organization and fine structure of epithelium and mesenchyme in the developing chick embryo
    • Hay, E.D. Organization and fine structure of epithelium and mesenchyme in the developing chick embryo. Epithel. Mesenchymal Interact. 1968, 2, 31–35.
    • (1968) Epithel. Mesenchymal Interact , vol.2 , pp. 31-35
    • Hay, E.D.1
  • 8
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and disease
    • Thiery, J.P.; Acloque, H.; Huang, R.Y.J.; Nieto, M.A. Epithelial-mesenchymal transitions in development and disease. Cell 2009, 139, 871–890.
    • (2009) Cell , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.J.3    Nieto, M.A.4
  • 9
    • 54949102409 scopus 로고    scopus 로고
    • Wnt signaling mediates self-organization and axis formation in embryoid bodies
    • Ten Berge, D.; Koole, W.; Fuerer, C.; Fish, M.; Eroglu, E.; Nusse, R. Wnt signaling mediates self-organization and axis formation in embryoid bodies. Cell Stem Cell 2008, 3, 508–518.
    • (2008) Cell Stem Cell , vol.3 , pp. 508-518
    • Ten Berge, D.1    Koole, W.2    Fuerer, C.3    Fish, M.4    Eroglu, E.5    Nusse, R.6
  • 10
    • 33750442483 scopus 로고    scopus 로고
    • Canonical wnt signaling is required for development of embryonic stem cell-derived mesoderm
    • Lindsley, R.C.; Gill, J.G.; Kyba, M.; Murphy, T.L.; Murphy, K.M. Canonical wnt signaling is required for development of embryonic stem cell-derived mesoderm. Development 2006, 133, 3787–3796.
    • (2006) Development , vol.133 , pp. 3787-3796
    • Lindsley, R.C.1    Gill, J.G.2    Kyba, M.3    Murphy, T.L.4    Murphy, K.M.5
  • 11
    • 13444263240 scopus 로고    scopus 로고
    • Fibroblast growth factor signaling during early vertebrate development
    • Bottcher, R.T.; Niehrs, C. Fibroblast growth factor signaling during early vertebrate development. Endocr. Rev. 2005, 26, 63–77.
    • (2005) Endocr. Rev , vol.26 , pp. 63-77
    • Bottcher, R.T.1    Niehrs, C.2
  • 12
    • 37049007672 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition events during human embryonic stem cell differentiation
    • Eastham, A.M.; Spencer, H.; Soncin, F.; Ritson, S.; Merry, C.L.; Stern, P.L.; Ward, C.M. Epithelial-mesenchymal transition events during human embryonic stem cell differentiation. Cancer Res. 2007, 67, 11254–11262.
    • (2007) Cancer Res. , vol.67 , pp. 11254-11262
    • Eastham, A.M.1    Spencer, H.2    Soncin, F.3    Ritson, S.4    Merry, C.L.5    Stern, P.L.6    Ward, C.M.7
  • 13
    • 26244458018 scopus 로고    scopus 로고
    • TGF-β1 induces human alveolar epithelial to mesenchymal cell transition (EMT)
    • Kasai, H.; Allen, J.T.; Mason, R.M.; Kamimura, T.; Zhang, Z. TGF-β1 induces human alveolar epithelial to mesenchymal cell transition (EMT). Respir. Res. 2005, 6, 56.
    • (2005) Respir. Res , vol.6 , pp. 56
    • Kasai, H.1    Allen, J.T.2    Mason, R.M.3    Kamimura, T.4    Zhang, Z.5
  • 14
    • 0033560169 scopus 로고    scopus 로고
    • TGF β 2 and TGF β 3 have separate and sequential activities during epithelial-mesenchymal cell transformation in the embryonic heart
    • Boyer, A.S.; Ayerinskas, I.I.; Vincent, E.B.; McKinney, L.A.; Weeks, D.L.; Runyan, R.B. TGF β 2 and TGF β 3 have separate and sequential activities during epithelial-mesenchymal cell transformation in the embryonic heart. Dev. Biol. 1999, 208, 530–545.
    • (1999) Dev. Biol , vol.208 , pp. 530-545
    • Boyer, A.S.1    Ayerinskas, I.I.2    Vincent, E.B.3    McKinney, L.A.4    Weeks, D.L.5    Runyan, R.B.6
  • 17
    • 77952052843 scopus 로고    scopus 로고
    • Epithelial to mesenchymal transition in human skin wound healing is induced by tumor necrosis factor- β through bone morphogenic protein-2
    • Yan, C.; Grimm, W.A.; Garner, W.L.; Qin, L.; Travis, T.; Tan, N.; Han, Y.-P. Epithelial to mesenchymal transition in human skin wound healing is induced by tumor necrosis factor- β through bone morphogenic protein-2. Am. J. Pathol. 2010, 176, 2247–2258.
    • (2010) Am. J. Pathol , vol.176 , pp. 2247-2258
    • Yan, C.1    Grimm, W.A.2    Garner, W.L.3    Qin, L.4    Travis, T.5    Tan, N.6    Han, Y.-P.7
  • 18
    • 47749139256 scopus 로고    scopus 로고
    • Cancer as an overhealing wound: An old hypothesis revisited
    • Schäfer, M.; Werner, S. Cancer as an overhealing wound: An old hypothesis revisited. Nat. Rev. Mol. Cell Biol. 2008, 9, 628–638.
    • (2008) Nat. Rev. Mol. Cell Biol , vol.9 , pp. 628-638
    • Schäfer, M.1    Werner, S.2
  • 19
    • 77954860342 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition in cancer: Parallels between normal development and tumor progression
    • Micalizzi, D.S.; Farabaugh, S.M.; Ford, H.L. Epithelial-mesenchymal transition in cancer: Parallels between normal development and tumor progression. J. Mammary Gland Biol. Neoplasia 2010, 15, 117–134.
    • (2010) J. Mammary Gland Biol. Neoplasia , vol.15 , pp. 117-134
    • Micalizzi, D.S.1    Farabaugh, S.M.2    Ford, H.L.3
  • 22
    • 84948429460 scopus 로고    scopus 로고
    • Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance
    • Fischer, K.R.; Durrans, A.; Lee, S.; Sheng, J.; Li, F.; Wong, S.T.C.; Choi, H.; El Rayes, T.; Ryu, S.; Troeger, J.; et al. Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance. Nature 2015, 527, 472–476.
    • (2015) Nature , vol.527 , pp. 472-476
    • Fischer, K.R.1    Durrans, A.2    Lee, S.3    Sheng, J.4    Li, F.5    Wong, S.T.C.6    Choi, H.7    El Rayes, T.8    Ryu, S.9    Troeger, J.10
  • 23
    • 84948407218 scopus 로고    scopus 로고
    • Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer
    • Zheng, X.; Carstens, J.L.; Kim, J.; Scheible, M.; Kaye, J.; Sugimoto, H.; Wu, C.-C.; LeBleu, V.S.; Kalluri, R. Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer. Nature 2015, 527, 525–530.
    • (2015) Nature , vol.527 , pp. 525-530
    • Zheng, X.1    Carstens, J.L.2    Kim, J.3    Scheible, M.4    Kaye, J.5    Sugimoto, H.6    Wu, C.-C.7    Lebleu, V.S.8    Kalluri, R.9
  • 26
    • 80052712201 scopus 로고    scopus 로고
    • The ins and outs of the epithelial to mesenchymal transition in health and disease
    • Nieto, M.A. The ins and outs of the epithelial to mesenchymal transition in health and disease. Annu. Rev. Cell Dev. Biol. 2011, 27, 347–376.
    • (2011) Annu. Rev. Cell Dev. Biol , vol.27 , pp. 347-376
    • Nieto, M.A.1
  • 27
    • 84894593599 scopus 로고    scopus 로고
    • Molecular mechanisms of epithelial-mesenchymal transition
    • Lamouille, S.; Xu, J.; Derynck, R. Molecular mechanisms of epithelial-mesenchymal transition. Nat. Rev. Mol. Cell Biol. 2014, 15, 178–196.
    • (2014) Nat. Rev. Mol. Cell Biol , vol.15 , pp. 178-196
    • Lamouille, S.1    Xu, J.2    Derynck, R.3
  • 28
    • 10444261212 scopus 로고    scopus 로고
    • Development of TGF- β signalling inhibitors for cancer therapy
    • Yingling, J.M.; Blanchard, K.L.; Sawyer, J.S. Development of TGF- β signalling inhibitors for cancer therapy. Nat. Rev. Drug Discov. 2004, 3, 1011–1022.
    • (2004) Nat. Rev. Drug Discov , vol.3 , pp. 1011-1022
    • Yingling, J.M.1    Blanchard, K.L.2    Sawyer, J.S.3
  • 30
    • 69249221254 scopus 로고    scopus 로고
    • Interleukin-6 induces an epithelial-mesenchymal transition phenotype in human breast cancer cells
    • Sullivan, N.; Sasser, A.; Axel, A.E.; Vesuna, F.; Raman, V.; Ramirez, N.; Oberyszyn, T.; Hall, B. Interleukin-6 induces an epithelial-mesenchymal transition phenotype in human breast cancer cells. Oncogene 2009, 28, 2940–2947.
    • (2009) Oncogene , vol.28 , pp. 2940-2947
    • Sullivan, N.1    Sasser, A.2    Axel, A.E.3    Vesuna, F.4    Raman, V.5    Ramirez, N.6    Oberyszyn, T.7    Hall, B.8
  • 31
    • 78649997911 scopus 로고    scopus 로고
    • Jekyll and hyde: The role of the microenvironment on the progression of cancer
    • Allen, M.; Louise Jones, J. Jekyll and hyde: The role of the microenvironment on the progression of cancer. J. Pathol. 2011, 223, 163–177.
    • (2011) J. Pathol , vol.223 , pp. 163-177
    • Allen, M.1    Louise Jones, J.2
  • 33
    • 84859822323 scopus 로고    scopus 로고
    • Emt and oxidative stress: A bidirectional interplay affecting tumor malignancy
    • Giannoni, E.; Parri, M.; Chiarugi, P. Emt and oxidative stress: A bidirectional interplay affecting tumor malignancy. Antioxid. Redox Signal. 2012, 16, 1248–1263.
    • (2012) Antioxid. Redox Signal , vol.16 , pp. 1248-1263
    • Giannoni, E.1    Parri, M.2    Chiarugi, P.3
  • 35
    • 58249119433 scopus 로고    scopus 로고
    • Blocking of p53-SNAIL binding, promoted by oncogenic K-Ras, recovers p53 expression and function
    • Lee, S.-H.; Lee, S.-J.; Jung, Y.S.; Xu, Y.; Kang, H.S.; Ha, N.-C.; Park, B.-J. Blocking of p53-SNAIL binding, promoted by oncogenic K-Ras, recovers p53 expression and function. Neoplasia 2009, 11, 22–31.
    • (2009) Neoplasia , vol.11 , pp. 22-31
    • Lee, S.-H.1    Lee, S.-J.2    Jung, Y.S.3    Xu, Y.4    Kang, H.S.5    Ha, N.-C.6    Park, B.-J.7
  • 36
    • 61749097816 scopus 로고    scopus 로고
    • TGF- β superfamily signaling in embryonic development and homeostasis
    • Wu, M.Y.; Hill, C.S. TGF- β superfamily signaling in embryonic development and homeostasis. Dev. Cell 2009, 16, 329–343.
    • (2009) Dev. Cell , vol.16 , pp. 329-343
    • Wu, M.Y.1    Hill, C.S.2
  • 37
    • 84862770484 scopus 로고    scopus 로고
    • Dynamics of TGF- β /SMAD signaling
    • Zi, Z.; Chapnick, D.A.; Liu, X. Dynamics of TGF- β /SMAD signaling. FEBS Lett. 2012, 586, 1921–1928.
    • (2012) FEBS Lett , vol.586 , pp. 1921-1928
    • Zi, Z.1    Chapnick, D.A.2    Liu, X.3
  • 38
    • 0034574298 scopus 로고    scopus 로고
    • How cells read TGF- β signals
    • Massagué, J. How cells read TGF- β signals. Nat. Rev. Mol. Cell Biol. 2000, 1, 169–178.
    • (2000) Nat. Rev. Mol. Cell Biol , vol.1 , pp. 169-178
    • Massagué, J.1
  • 39
    • 0031438047 scopus 로고    scopus 로고
    • TGF- β signalling from cell membrane to nucleus through SMAD proteins
    • Heldin, C.-H.; Miyazono, K.; Ten Dijke, P. TGF- β signalling from cell membrane to nucleus through SMAD proteins. Nature 1997, 390, 465–471.
    • (1997) Nature , vol.390 , pp. 465-471
    • Heldin, C.-H.1    Miyazono, K.2    Ten Dijke, P.3
  • 40
    • 0035827668 scopus 로고    scopus 로고
    • Formation of a stable heterodimer between SMAD2 and SMAD4
    • Wu, J.-W.; Fairman, R.; Penry, J.; Shi, Y. Formation of a stable heterodimer between SMAD2 and SMAD4. J. Biol. Chem. 2001, 276, 20688–20694.
    • (2001) J. Biol. Chem. , vol.276 , pp. 20688-20694
    • Wu, J.-W.1    Fairman, R.2    Penry, J.3    Shi, Y.4
  • 43
  • 44
    • 57749114754 scopus 로고    scopus 로고
    • HMGA2 and Smads co-regulate SNAIL1 expression during induction of epithelial-to-mesenchymal transition
    • Thuault, S.; Tan, E.-J.; Peinado, H.; Cano, A.; Heldin, C.-H.; Moustakas, A. HMGA2 and Smads co-regulate SNAIL1 expression during induction of epithelial-to-mesenchymal transition. J. Biol. Chem. 2008, 283, 33437–33446.
    • (2008) J. Biol. Chem , vol.283 , pp. 33437-33446
    • Thuault, S.1    Tan, E.-J.2    Peinado, H.3    Cano, A.4    Heldin, C.-H.5    Moustakas, A.6
  • 45
    • 68249092353 scopus 로고    scopus 로고
    • Leopold, P.L.; et al. A SNAIL1-SMAD3/4 transcriptional repressor complex promotes TGF- β mediated epithelial-mesenchymal transition. Nat
    • Vincent, T.; Neve, E.P.A.; Johnson, J.R.; Kukalev, A.; Rojo, F.; Albanell, J.; Pietras, K.; Virtanen, I.; Philipson, L.; Leopold, P.L.; et al. A SNAIL1-SMAD3/4 transcriptional repressor complex promotes TGF- β mediated epithelial-mesenchymal transition. Nat. Cell Biol. 2009, 11, 943–950.
    • (2009) Cell Biol , vol.11 , pp. 943-950
    • Vincent, T.1    Neve, E.P.A.2    Johnson, J.R.3    Kukalev, A.4    Rojo, F.5    Albanell, J.6    Pietras, K.7    Virtanen, I.8    Philipson, L.9
  • 46
    • 78649755556 scopus 로고    scopus 로고
    • IKK β controls canonical TGF β –SMAD signaling to regulate genes expressing SNAIL and SLUG during EMT in Panc1 cells
    • Brandl, M.; Seidler, B.; Haller, F.; Adamski, J.; Schmid, R.M.; Saur, D.; Schneider, G. IKK β controls canonical TGF β –SMAD signaling to regulate genes expressing SNAIL and SLUG during EMT in Panc1 cells. J. Cell Sci. 2010, 123, 4231–4239.
    • (2010) J. Cell Sci , vol.123 , pp. 4231-4239
    • Brandl, M.1    Seidler, B.2    Haller, F.3    Adamski, J.4    Schmid, R.M.5    Saur, D.6    Schneider, G.7
  • 47
    • 34347255755 scopus 로고    scopus 로고
    • Transforming growth factor- β 1 represses E-cadherin production via slug expression in lens epithelial cells
    • Choi, J.; Park, S.Y.; Joo, C.-K. Transforming growth factor- β 1 represses E-cadherin production via slug expression in lens epithelial cells. Investig. Ophthalmol. Vis. Sci. 2007, 48, 2708–2718.
    • (2007) Investig. Ophthalmol. Vis. Sci , vol.48 , pp. 2708-2718
    • Choi, J.1    Park, S.Y.2    Joo, C.-K.3
  • 49
    • 59449090107 scopus 로고    scopus 로고
    • TGF- β -induced epithelial to mesenchymal transition
    • Xu, J.; Lamouille, S.; Derynck, R. TGF- β -induced epithelial to mesenchymal transition. Cell Res. 2009, 19, 156–172.
    • (2009) Cell Res , vol.19 , pp. 156-172
    • Xu, J.1    Lamouille, S.2    Derynck, R.3
  • 50
    • 0142104985 scopus 로고    scopus 로고
    • Smad-dependent and SMAD-independent pathways in TGF- β family signalling
    • Derynck, R.; Zhang, Y.E. Smad-dependent and SMAD-independent pathways in TGF- β family signalling. Nature 2003, 425, 577–584.
    • (2003) Nature , vol.425 , pp. 577-584
    • Derynck, R.1    Zhang, Y.E.2
  • 51
    • 84155176716 scopus 로고    scopus 로고
    • A study of Smad4, Smad6 and Smad7 in surgically resected samples of pancreatic ductal adenocarcinoma and their correlation with clinicopathological parameters and patient survival
    • Singh, P.; Srinivasan, R.; Wig, J.D.; Radotra, B.D. A study of Smad4, Smad6 and Smad7 in surgically resected samples of pancreatic ductal adenocarcinoma and their correlation with clinicopathological parameters and patient survival. BMC Res. Notes 2011, 4, 560.
    • (2011) BMC Res. Notes , vol.4 , pp. 560
    • Singh, P.1    Srinivasan, R.2    Wig, J.D.3    Radotra, B.D.4
  • 52
    • 56649106486 scopus 로고    scopus 로고
    • Smad7 is inactivated through a direct physical interaction with the lim protein Hic-5/ARA55
    • Wang, H.; Song, K.; Krebs, T.L.; Yang, J.; Danielpour, D. Smad7 is inactivated through a direct physical interaction with the lim protein Hic-5/ARA55. Oncogene 2008, 27, 6791–6805.
    • (2008) Oncogene , vol.27 , pp. 6791-6805
    • Wang, H.1    Song, K.2    Krebs, T.L.3    Yang, J.4    Danielpour, D.5
  • 53
    • 0034785348 scopus 로고    scopus 로고
    • TGF- β signaling in tumor suppression and cancer progression
    • Derynck, R.; Akhurst, R.J.; Balmain, A. TGF- β signaling in tumor suppression and cancer progression. Nat. Genet. 2001, 29, 117–129.
    • (2001) Nat. Genet , vol.29 , pp. 117-129
    • Derynck, R.1    Akhurst, R.J.2    Balmain, A.3
  • 54
    • 12544257249 scopus 로고    scopus 로고
    • Role of Rho/ROCK and p38 MAP kinase pathways in transforming growth factor- β -mediated SMAD-dependent growth inhibition of human breast carcinoma cells in vivo
    • Kamaraju, A.K.; Roberts, A.B. Role of Rho/ROCK and p38 MAP kinase pathways in transforming growth factor- β -mediated SMAD-dependent growth inhibition of human breast carcinoma cells in vivo. J. Biol. Chem. 2005, 280, 1024–1036.
    • (2005) J. Biol. Chem. , vol.280 , pp. 1024-1036
    • Kamaraju, A.K.1    Roberts, A.B.2
  • 55
    • 0037411141 scopus 로고    scopus 로고
    • Involvement of SMAD proteins in TGF- β and activin A-induced apoptosis and growth inhibition of liver cells
    • Kanamaru, C.; Yasuda, H.; Fujita, T. Involvement of SMAD proteins in TGF- β and activin A-induced apoptosis and growth inhibition of liver cells. Hepatol. Res. 2002, 23, 211–219.
    • (2002) Hepatol. Res , vol.23 , pp. 211-219
    • Kanamaru, C.1    Yasuda, H.2    Fujita, T.3
  • 56
    • 0030886204 scopus 로고    scopus 로고
    • Transforming growth factor β -induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cells
    • Liu, X.; Sun, Y.; Constantinescu, S.N.; Karam, E.; Weinberg, R.A.; Lodish, H.F. Transforming growth factor β -induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cells. Proc. Natl. Acad. Sci. USA 1997, 94, 10669–10674.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 10669-10674
    • Liu, X.1    Sun, Y.2    Constantinescu, S.N.3    Karam, E.4    Weinberg, R.A.5    Lodish, H.F.6
  • 58
    • 79957580066 scopus 로고    scopus 로고
    • Differential roles of Smad2 and Smad3 in the regulation of TGF- β 1-mediated growth inhibition and cell migration in pancreatic ductal adenocarcinoma cells
    • Ungefroren, H.; Groth, S.; Sebens, S.; Lehnert, H.; Gieseler, F.; Fändrich, F. Differential roles of Smad2 and Smad3 in the regulation of TGF- β 1-mediated growth inhibition and cell migration in pancreatic ductal adenocarcinoma cells: Control by Rac1. Mol. Cancer 2011, 10, 67.
    • (2011) Control by Rac1. Mol. Cancer , vol.10 , pp. 67
    • Ungefroren, H.1    Groth, S.2    Sebens, S.3    Lehnert, H.4    Gieseler, F.5    Fändrich, F.6
  • 59
    • 0033606964 scopus 로고    scopus 로고
    • Smad2 and Smad4 gene mutations in hepatocellular carcinoma
    • Yakicier, M.; Irmak, M.; Romano, A.; Kew, M.; Ozturk, M. Smad2 and Smad4 gene mutations in hepatocellular carcinoma. Oncogene 1999, 18, 4879–4883.
    • (1999) Oncogene , vol.18 , pp. 4879-4883
    • Yakicier, M.1    Irmak, M.2    Romano, A.3    Kew, M.4    Ozturk, M.5
  • 61
    • 0037757793 scopus 로고    scopus 로고
    • Role of Smad4 (DPC4) inactivation in human cancer. Biochem. Biophys. Res
    • Miyaki, M.; Kuroki, T. Role of Smad4 (DPC4) inactivation in human cancer. Biochem. Biophys. Res. Commun. 2003, 306, 799–804.
    • (2003) Commun , vol.306 , pp. 799-804
    • Miyaki, M.1    Kuroki, T.2
  • 62
    • 84923071597 scopus 로고    scopus 로고
    • Ellagic acid induces cell cycle arrest and apoptosis through TGF- β /Smad3 signaling pathway in human breast cancer MCF-7 cells
    • Chen, H.-S.; Bai, M.-H.; Zhang, T.; Li, G.-D.; Liu, M. Ellagic acid induces cell cycle arrest and apoptosis through TGF- β /Smad3 signaling pathway in human breast cancer MCF-7 cells. Int. J. Oncol. 2015, 46, 1730–1738.
    • (2015) Int. J. Oncol , vol.46 , pp. 1730-1738
    • Chen, H.-S.1    Bai, M.-H.2    Zhang, T.3    Li, G.-D.4    Liu, M.5
  • 63
    • 84865059388 scopus 로고    scopus 로고
    • TGF- β induces serous borderline ovarian tumor cell invasion by activating EMTEMT but triggers apoptosis in low-grade serous ovarian carcinoma cells
    • Cheng, J.-C.; Auersperg, N.; Leung, P.C. TGF- β induces serous borderline ovarian tumor cell invasion by activating EMTEMT but triggers apoptosis in low-grade serous ovarian carcinoma cells. PLoS ONE 2012, 7, e42436.
    • (2012) Plos ONE , vol.7
    • Cheng, J.-C.1    Auersperg, N.2    Leung, P.C.3
  • 64
    • 84866742560 scopus 로고    scopus 로고
    • TGF β signalling in context
    • Massagué, J. TGF β signalling in context. Nat. Rev. Mol. Cell Biol. 2012, 13, 616–630.
    • (2012) Nat. Rev. Mol. Cell Biol , vol.13 , pp. 616-630
    • Massagué, J.1
  • 65
    • 1842839881 scopus 로고    scopus 로고
    • Activin induces hepatocyte cell growth arrest through induction of the cyclin-dependent kinase Inhibitor p15 INK4b and Sp1
    • Ho, J.; de Guise, C.; Kim, C.; Lemay, S.; Wang, X.-F.; Lebrun, J.-J. Activin induces hepatocyte cell growth arrest through induction of the cyclin-dependent kinase Inhibitor p15 INK4b and Sp1. Cell. Signal. 2004, 16, 693–701.
    • (2004) Cell. Signal , vol.16 , pp. 693-701
    • Ho, J.1    De Guise, C.2    Kim, C.3    Lemay, S.4    Wang, X.-F.5    Lebrun, J.-J.6
  • 66
    • 27344461063 scopus 로고    scopus 로고
    • Cooperation of H2O2-mediated ERK activation with Smad pathway in TGF- β 1 induction of p21 WAF1/Cip1
    • Kim, Y.K.; Bae, G.-U.; Kang, J.K.; Park, J.W.; Lee, E.K.; Lee, H.Y.; Choi, W.S.; Lee, H.W.; Han, J.-W. Cooperation of H2O2-mediated ERK activation with Smad pathway in TGF- β 1 induction of p21 WAF1/Cip1. Cell. Signal. 2006, 18, 236–243.
    • (2006) Cell. Signal , vol.18 , pp. 236-243
    • Kim, Y.K.1    Bae, G.-U.2    Kang, J.K.3    Park, J.W.4    Lee, E.K.5    Lee, H.Y.6    Choi, W.S.7    Lee, H.W.8    Han, J.-W.9
  • 67
    • 0038682002 scopus 로고    scopus 로고
    • Mechanisms of TGF- β signaling from cell membrane to the nucleus
    • Shi, Y.; Massagué, J. Mechanisms of TGF- β signaling from cell membrane to the nucleus. Cell 2003, 113, 685–700.
    • (2003) Cell , vol.113 , pp. 685-700
    • Shi, Y.1    Massagué, J.2
  • 68
    • 77954167982 scopus 로고    scopus 로고
    • Transcriptional crosstalk between TGF β and stem cell pathways in tumor cell invasion: Role of EMT promoting SMAD complexes
    • Fuxe, J.; Vincent, T.; Garcia de Herreros, A. Transcriptional crosstalk between TGF β and stem cell pathways in tumor cell invasion: Role of EMT promoting SMAD complexes. Cell Cycle 2010, 9, 2363–2374.
    • (2010) Cell Cycle , vol.9 , pp. 2363-2374
    • Fuxe, J.1    Vincent, T.2    Garcia De Herreros, A.3
  • 69
    • 84862994787 scopus 로고    scopus 로고
    • Transforming growth factor- β 1 induces epithelial-to-mesenchymal transition in human lung cancer cells via PI3K/Akt and MEK/Erk1/2 signaling pathways
    • Chen, X.-F.; Zhang, H.-J.; Wang, H.-B.; Zhu, J.; Zhou, W.-Y.; Zhang, H.; Zhao, M.-C.; Su, J.-M.; Gao, W.; Zhang, L. Transforming growth factor- β 1 induces epithelial-to-mesenchymal transition in human lung cancer cells via PI3K/Akt and MEK/Erk1/2 signaling pathways. Mol. Biol. Rep. 2012, 39, 3549–3556.
    • (2012) Mol. Biol. Rep , vol.39 , pp. 3549-3556
    • Chen, X.-F.1    Zhang, H.-J.2    Wang, H.-B.3    Zhu, J.4    Zhou, W.-Y.5    Zhang, H.6    Zhao, M.-C.7    Su, J.-M.8    Gao, W.9    Zhang, L.10
  • 70
    • 58149213801 scopus 로고    scopus 로고
    • Non-SMAD pathways in TGF- β signaling
    • Zhang, Y.E. Non-SMAD pathways in TGF- β signaling. Cell Res. 2009, 19, 128–139.
    • (2009) Cell Res , vol.19 , pp. 128-139
    • Zhang, Y.E.1
  • 71
    • 0034711307 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinasefunction is required for transforming growth factor β -mediated epithelial to mesenchymal transition and cell migration
    • Bakin, A.V.; Tomlinson, A.K.; Bhowmick, N.A.; Moses, H.L.; Arteaga, C.L. Phosphatidylinositol 3-kinase function is required for transforming growth factor β -mediated epithelial to mesenchymal transition and cell migration. J. Biol. Chem. 2000, 275, 36803–36810.
    • (2000) J. Biol. Chem , vol.275 , pp. 36803-36810
    • Bakin, A.V.1    Tomlinson, A.K.2    Bhowmick, N.A.3    Moses, H.L.4    Arteaga, C.L.5
  • 72
    • 34547587877 scopus 로고    scopus 로고
    • Cell size and invasion in TGF- β -induced epithelial to mesenchymal transition is regulated by activation of the mtor pathway
    • Lamouille, S.; Derynck, R. Cell size and invasion in TGF- β -induced epithelial to mesenchymal transition is regulated by activation of the mtor pathway. J. Cell Biol. 2007, 178, 437–451.
    • (2007) J. Cell Biol , vol.178 , pp. 437-451
    • Lamouille, S.1    Derynck, R.2
  • 73
    • 0035196587 scopus 로고    scopus 로고
    • Transforming growth factor β enhances epithelial cell survival via Akt-dependent regulation of fkhrl1
    • Shin, I.; Bakin, A.V.; Rodeck, U.; Brunet, A.; Arteaga, C.L. Transforming growth factor β enhances epithelial cell survival via Akt-dependent regulation of fkhrl1. Mol. Biol. Cell 2001, 12, 3328–3339.
    • (2001) Mol. Biol. Cell , vol.12 , pp. 3328-3339
    • Shin, I.1    Bakin, A.V.2    Rodeck, U.3    Brunet, A.4    Arteaga, C.L.5
  • 74
    • 30444434212 scopus 로고    scopus 로고
    • Novel roles of Akt and mTOR in suppressing TGF- β /Alk5-mediated Smad3 activation
    • Song, K.; Wang, H.; Krebs, T.L.; Danielpour, D. Novel roles of Akt and mTOR in suppressing TGF- β /Alk5-mediated Smad3 activation. EMBO J. 2006, 25, 58–69.
    • (2006) EMBO J , vol.25 , pp. 58-69
    • Song, K.1    Wang, H.2    Krebs, T.L.3    Danielpour, D.4
  • 77
    • 0034680863 scopus 로고    scopus 로고
    • Critical role of SMADs and AP-1 complex in transforming growth factor- β -dependent apoptosis
    • Yamamura, Y.; Hua, X.; Bergelson, S.; Lodish, H.F. Critical role of SMADs and AP-1 complex in transforming growth factor- β -dependent apoptosis. J. Biol. Chem. 2000, 275, 36295–36302.
    • (2000) J. Biol. Chem. , vol.275 , pp. 36295-36302
    • Yamamura, Y.1    Hua, X.2    Bergelson, S.3    Lodish, H.F.4
  • 78
    • 0029073142 scopus 로고
    • Transforming growth factor β induces the cyclin-dependent kinase Inhibitor p21 through a p53-independent mechanism
    • Datto, M.B.; Li, Y.; Panus, J.F.; Howe, D.J.; Xiong, Y.; Wang, X.-F. Transforming growth factor β induces the cyclin-dependent kinase Inhibitor p21 through a p53-independent mechanism. Proc. Natl. Acad. Sci. USA 1995, 92, 5545–5549.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 5545-5549
    • Datto, M.B.1    Li, Y.2    Panus, J.F.3    Howe, D.J.4    Xiong, Y.5    Wang, X.-F.6
  • 79
    • 67549086678 scopus 로고    scopus 로고
    • Transforming growth factor- β in breast cancer: Too much, too late
    • Barcellos-Hoff, M.H.; Akhurst, R.J. Transforming growth factor- β in breast cancer: Too much, too late. Breast Cancer Res. 2009, 11, 202.
    • (2009) Breast Cancer Res , vol.11 , pp. 202
    • Barcellos-Hoff, M.H.1    Akhurst, R.J.2
  • 80
    • 30644467227 scopus 로고    scopus 로고
    • Inhibition of TGF β signaling in cancer therapy
    • Arteaga, C.L. Inhibition of TGF β signaling in cancer therapy. Curr. Opin. Genet. Dev. 2006, 16, 30–37.
    • (2006) Curr. Opin. Genet. Dev , vol.16 , pp. 30-37
    • Arteaga, C.L.1
  • 81
    • 70350738483 scopus 로고    scopus 로고
    • Synergistic enhancement of CD8+ T cell-mediated tumor vaccine efficacy by an anti–transforming growth factor- β monoclonal antibody
    • Terabe, M.; Ambrosino, E.; Takaku, S.; O’Konek, J.J.; Venzon, D.; Lonning, S.; McPherson, J.M.; Berzofsky, J.A. Synergistic enhancement of CD8+ T cell-mediated tumor vaccine efficacy by an anti–transforming growth factor- β monoclonal antibody. Clin. Cancer Res. 2009, 15, 6560–6569.
    • (2009) Clin. Cancer Res , vol.15 , pp. 6560-6569
    • Terabe, M.1    Ambrosino, E.2    Takaku, S.3    O’Konek, J.J.4    Venzon, D.5    Lonning, S.6    McPherson, J.M.7    Berzofsky, J.A.8
  • 82
    • 56849115306 scopus 로고    scopus 로고
    • Phase I/II study of GC1008: A human anti-transforming growth factor- β (TGF β) monoclonal antibody (MAb) in patients with advanced malignant melanoma (MM) or renal cell carcinoma (RCC)
    • Morris, J.; Shapiro, G.; Tan, A.; Lawrence, D.; Olencki, T.; Dezube, B.; Hsu, F.; Reiss, M.; Berzofsky, J. Phase I/II study of GC1008: A human anti-transforming growth factor- β (TGF β) monoclonal antibody (MAb) in patients with advanced malignant melanoma (MM) or renal cell carcinoma (RCC). J. Clin. Oncol. 2008, 26, 9028.
    • (2008) J. Clin. Oncol , vol.26 , pp. 9028
    • Morris, J.1    Shapiro, G.2    Tan, A.3    Lawrence, D.4    Olencki, T.5    Dezube, B.6    Hsu, F.7    Reiss, M.8    Berzofsky, J.9
  • 83
    • 84897566294 scopus 로고    scopus 로고
    • Phase I study of GC1008 (Fresolimumab): A human anti-transforming growth factor- β (TGF- β) monoclonal antibody in patients with advanced malignant melanoma or renal cell carcinoma
    • Morris, J.C.; Tan, A.R.; Olencki, T.E.; Shapiro, G.I.; Dezube, B.J.; Reiss, M.; Hsu, F.J.; Berzofsky, J.A.; Lawrence, D.P. Phase I study of GC1008 (fresolimumab): A human anti-transforming growth factor- β (TGF- β) monoclonal antibody in patients with advanced malignant melanoma or renal cell carcinoma. PLoS ONE 2014, 9, e90353.
    • (2014) Plos ONE , vol.9
    • Morris, J.C.1    Tan, A.R.2    Olencki, T.E.3    Shapiro, G.I.4    Dezube, B.J.5    Reiss, M.6    Hsu, F.J.7    Berzofsky, J.A.8    Lawrence, D.P.9
  • 86
    • 78649402748 scopus 로고    scopus 로고
    • Transforming growth factor β signaling inhibitor, SB-431542, induces maturation of dendritic cells and enhances anti-tumor activity
    • Tanaka, H.; Shinto, O.; Yashiro, M.; Yamazoe, S.; Iwauchi, T.; Muguruma, K.; Kubo, N.; Ohira, M.; Hirakawa, K. Transforming growth factor β signaling inhibitor, SB-431542, induces maturation of dendritic cells and enhances anti-tumor activity. Oncol. Rep. 2010, 24, 1637–1643.
    • (2010) Oncol. Rep , vol.24 , pp. 1637-1643
    • Tanaka, H.1    Shinto, O.2    Yashiro, M.3    Yamazoe, S.4    Iwauchi, T.5    Muguruma, K.6    Kubo, N.7    Ohira, M.8    Hirakawa, K.9
  • 87
    • 78649987710 scopus 로고    scopus 로고
    • Transforming growth factor- β -induced epithelial-mesenchymal transition facilitates epidermal growth factor-dependent breast cancer progression
    • Wendt, M.K.; Smith, J.A.; Schiemann, W.P. Transforming growth factor- β -induced epithelial-mesenchymal transition facilitates epidermal growth factor-dependent breast cancer progression. Oncogene 2010, 29, 6485–6498.
    • (2010) Oncogene , vol.29 , pp. 6485-6498
    • Wendt, M.K.1    Smith, J.A.2    Schiemann, W.P.3
  • 88
    • 42249099019 scopus 로고    scopus 로고
    • LY2109761, a novel transforming growth factor β receptor type i and type ii dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis
    • Melisi, D.; Ishiyama, S.; Sclabas, G.M.; Fleming, J.B.; Xia, Q.; Tortora, G.; Abbruzzese, J.L.; Chiao, P.J. LY2109761, a novel transforming growth factor β receptor type i and type ii dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis. Mol. Cancer Ther. 2008, 7, 829–840.
    • (2008) Mol. Cancer Ther , vol.7 , pp. 829-840
    • Melisi, D.1    Ishiyama, S.2    Sclabas, G.M.3    Fleming, J.B.4    Xia, Q.5    Tortora, G.6    Abbruzzese, J.L.7    Chiao, P.J.8
  • 89
    • 76749102053 scopus 로고    scopus 로고
    • Anti-transforming growth factor β receptor II antibody has therapeutic efficacy against primary tumor growth and metastasis through multieffects on cancer, stroma, and immune cells
    • Zhong, Z.; Carroll, K.D.; Policarpio, D.; Osborn, C.; Gregory, M.; Bassi, R.; Jimenez, X.; Prewett, M.; Liebisch, G.; Persaud, K. Anti-transforming growth factor β receptor II antibody has therapeutic efficacy against primary tumor growth and metastasis through multieffects on cancer, stroma, and immune cells. Clin. Cancer Res. 2010, 16, 1191–1205.
    • (2010) Clin. Cancer Res , vol.16 , pp. 1191-1205
    • Zhong, Z.1    Carroll, K.D.2    Policarpio, D.3    Osborn, C.4    Gregory, M.5    Bassi, R.6    Jimenez, X.7    Prewett, M.8    Liebisch, G.9    Persaud, K.10
  • 90
    • 33748305561 scopus 로고    scopus 로고
    • Inhibition of transforming growth factor- β 1-induced signaling and epithelial-to-mesenchymal transition by the Smad-binding peptide aptamer Trx-SARA
    • Zhao, B.M.; Hoffmann, F.M. Inhibition of transforming growth factor- β 1-induced signaling and epithelial-to-mesenchymal transition by the Smad-binding peptide aptamer Trx-SARA. Mol. Biol. Cell 2006, 17, 3819–3831.
    • (2006) Mol. Biol. Cell , vol.17 , pp. 3819-3831
    • Zhao, B.M.1    Hoffmann, F.M.2
  • 91
    • 81155126047 scopus 로고    scopus 로고
    • Sonic hedgehog pathway promotes metastasis and lymphangiogenesis via activation of Akt, EMT, and MMP-9 pathway in gastric cancer
    • Yoo, Y.A.; Kang, M.H.; Lee, H.J.; Kim, B.-H.; Park, J.K.; Kim, H.K.; Kim, J.S.; Oh, S.C. Sonic hedgehog pathway promotes metastasis and lymphangiogenesis via activation of Akt, EMT, and MMP-9 pathway in gastric cancer. Cancer Res. 2011, 71, 7061–7070.
    • (2011) Cancer Res , vol.71 , pp. 7061-7070
    • Yoo, Y.A.1    Kang, M.H.2    Lee, H.J.3    Kim, B.-H.4    Park, J.K.5    Kim, H.K.6    Kim, J.S.7    Oh, S.C.8
  • 92
    • 84865022723 scopus 로고    scopus 로고
    • Genome-wide screening reveals an EMT molecular network mediated by Sonic hedgehog-Gli1 signaling in pancreatic cancer cells
    • Xu, X.; Zhou, Y.; Xie, C.; Wei, S.; Gan, H.; He, S.; Wang, F.; Xu, L.; Lu, J.; Dai, W. Genome-wide screening reveals an EMT molecular network mediated by Sonic hedgehog-Gli1 signaling in pancreatic cancer cells. PLoS ONE 2012, 7, e43119.
    • (2012) Plos ONE , vol.7
    • Xu, X.1    Zhou, Y.2    Xie, C.3    Wei, S.4    Gan, H.5    He, S.6    Wang, F.7    Xu, L.8    Lu, J.9    Dai, W.10
  • 93
  • 94
    • 1842853184 scopus 로고    scopus 로고
    • Palmitoylation is required for the production of a soluble multimeric hedgehog protein complex and long-range signaling in vertebrates
    • Chen, M.-H.; Li, Y.-J.; Kawakami, T.; Xu, S.-M.; Chuang, P.-T. Palmitoylation is required for the production of a soluble multimeric hedgehog protein complex and long-range signaling in vertebrates. Genes Dev. 2004, 18, 641–659.
    • (2004) Genes Dev , vol.18 , pp. 641-659
    • Chen, M.-H.1    Li, Y.-J.2    Kawakami, T.3    Xu, S.-M.4    Chuang, P.-T.5
  • 95
    • 57049089995 scopus 로고    scopus 로고
    • Hedgehog signaling in development and cancer
    • Jiang, J.; Hui, C.-C. Hedgehog signaling in development and cancer. Dev. Cell 2008, 15, 801–812.
    • (2008) Dev. Cell , vol.15 , pp. 801-812
    • Jiang, J.1    Hui, C.-C.2
  • 96
    • 79551600015 scopus 로고    scopus 로고
    • Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways
    • Takebe, N.; Harris, P.J.; Warren, R.Q.; Ivy, S.P. Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways. Nat.Rev. Clin. Oncol. 2011, 8, 97–106.
    • (2011) Nat.Rev. Clin. Oncol , vol.8 , pp. 97-106
    • Takebe, N.1    Harris, P.J.2    Warren, R.Q.3    Ivy, S.P.4
  • 98
    • 31644442906 scopus 로고    scopus 로고
    • Signaling from Smo to Ci/Gli: Conservation and divergence of hedgehog pathways from Drosophila to vertebrates
    • Huangfu, D.; Anderson, K.V. Signaling from Smo to Ci/Gli: Conservation and divergence of hedgehog pathways from Drosophila to vertebrates. Development 2006, 133, 3–14.
    • (2006) Development , vol.133 , pp. 3-14
    • Huangfu, D.1    Anderson, K.V.2
  • 99
    • 0009603803 scopus 로고    scopus 로고
    • Sonic hedgehog signaling by the patched-smoothened receptor complex
    • Murone, M.; Rosenthal, A.; de Sauvage, F.J. Sonic hedgehog signaling by the patched-smoothened receptor complex. Curr. Biol. 1999, 9, 76–84.
    • (1999) Curr. Biol , vol.9 , pp. 76-84
    • Murone, M.1    Rosenthal, A.2    De Sauvage, F.J.3
  • 100
    • 26444577884 scopus 로고    scopus 로고
    • A previously unidentified amino-terminal domain regulates transcriptional activity of wild-type and disease-associated human GLI2
    • Roessler, E.; Ermilov, A.N.; Grange, D.K.; Wang, A.; Grachtchouk, M.; Dlugosz, A.A.; Muenke, M. A previously unidentified amino-terminal domain regulates transcriptional activity of wild-type and disease-associated human GLI2. Hum. Mol. Genet. 2005, 14, 2181–2188.
    • (2005) Hum. Mol. Genet. , vol.14 , pp. 2181-2188
    • Roessler, E.1    Ermilov, A.N.2    Grange, D.K.3    Wang, A.4    Grachtchouk, M.5    Dlugosz, A.A.6    Muenke, M.7
  • 101
    • 0032848136 scopus 로고    scopus 로고
    • Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: Implication of Gli2 and Gli3 as primary mediators of Shh signaling
    • Sasaki, H.; Nishizaki, Y.; Hui, C.-C.; Nakafuku, M.; Kondoh, H. Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: Implication of Gli2 and Gli3 as primary mediators of Shh signaling. Development 1999, 126, 3915–3924.
    • (1999) Development , vol.126 , pp. 3915-3924
    • Sasaki, H.1    Nishizaki, Y.2    Hui, C.-C.3    Nakafuku, M.4    Kondoh, H.5
  • 102
    • 51949085076 scopus 로고    scopus 로고
    • Hedgehog: Functions and mechanisms
    • Varjosalo, M.; Taipale, J. Hedgehog: Functions and mechanisms. Genes Dev. 2008, 22, 2454–2472.
    • (2008) Genes Dev , vol.22 , pp. 2454-2472
    • Varjosalo, M.1    Taipale, J.2
  • 104
    • 84887512714 scopus 로고    scopus 로고
    • Unraveling the therapeutic potential of the hedgehog pathway in cancer
    • Amakye, D.; Jagani, Z.; Dorsch, M. Unraveling the therapeutic potential of the hedgehog pathway in cancer. Nat. Med. 2013, 19, 1410–1422.
    • (2013) Nat. Med , vol.19 , pp. 1410-1422
    • Amakye, D.1    Jagani, Z.2    Dorsch, M.3
  • 105
    • 70350534843 scopus 로고    scopus 로고
    • Hedgehog target genes: Mechanisms of carcinogenesis induced by aberrant hedgehog signaling activation
    • Katoh, Y.; Katoh, M. Hedgehog target genes: Mechanisms of carcinogenesis induced by aberrant hedgehog signaling activation. Curr. Mol. Med. 2009, 9, 873–886.
    • (2009) Curr. Mol. Med , vol.9 , pp. 873-886
    • Katoh, Y.1    Katoh, M.2
  • 107
    • 77955428416 scopus 로고    scopus 로고
    • NANOG regulates glioma stem cells and is essential in vivo acting in a cross-functional network with Gli1 and p53
    • Zbinden, M.; Duquet, A.; Lorente-Trigos, A.; Ngwabyt, S.N.; Borges, I.; i Altaba, A.R. NANOG regulates glioma stem cells and is essential in vivo acting in a cross-functional network with Gli1 and p53. EMBO J. 2010, 29, 2659–2674.
    • (2010) EMBO J , vol.29 , pp. 2659-2674
    • Zbinden, M.1    Duquet, A.2    Lorente-Trigos, A.3    Ngwabyt, S.N.4    Borges, I.5    I Altaba, A.R.6
  • 108
    • 31544480393 scopus 로고    scopus 로고
    • Snail induction is an early response to Gli1 that determines the efficiency of epithelial transformation
    • Li, X.; Deng, W.; Nail, C.D.; Bailey, S.K.; Kraus, M.H.; Ruppert, J.M.; Lobo-Ruppert, S.M. Snail induction is an early response to Gli1 that determines the efficiency of epithelial transformation. Oncogene 2006, 25, 609–621.
    • (2006) Oncogene , vol.25 , pp. 609-621
    • Li, X.1    Deng, W.2    Nail, C.D.3    Bailey, S.K.4    Kraus, M.H.5    Ruppert, J.M.6    Lobo-Ruppert, S.M.7
  • 109
    • 34247491334 scopus 로고    scopus 로고
    • Gli1 acts through Snail and E-cadherin to promote nuclear signaling by β -catenin
    • Li, X.; Deng, W.; Lobo-Ruppert, S.M.; Ruppert, J.M. Gli1 acts through Snail and E-cadherin to promote nuclear signaling by β -catenin. Oncogene 2007, 26, 4489–4498.
    • (2007) Oncogene , vol.26 , pp. 4489-4498
    • Li, X.1    Deng, W.2    Lobo-Ruppert, S.M.3    Ruppert, J.M.4
  • 111
    • 34547120220 scopus 로고    scopus 로고
    • Induction of sonic hedgehog mediators by transforming growth factor- β: Smad3-dependent activation of Gli2 and Gli1 expression in vitro and in vivo
    • Dennler, S.; André, J.; Alexaki, I.; Li, A.; Magnaldo, T.; Ten Dijke, P.; Wang, X.-J.; Verrecchia, F.; Mauviel, A. Induction of sonic hedgehog mediators by transforming growth factor- β: Smad3-dependent activation of Gli2 and Gli1 expression in vitro and in vivo. Cancer Res. 2007, 67, 6981–6986.
    • (2007) Cancer Res. , vol.67 , pp. 6981-6986
    • Dennler, S.1    André, J.2    Alexaki, I.3    Li, A.4    Magnaldo, T.5    Ten Dijke, P.6    Wang, X.-J.7    Verrecchia, F.8    Mauviel, A.9
  • 112
    • 70450257573 scopus 로고    scopus 로고
    • Cloning of the human GLI2 promoter transcriptional activation by transforming growth factor- β via Smad3/ β -catenin cooperation
    • Dennler, S.; André, J.; Verrecchia, F.; Mauviel, A. Cloning of the human GLI2 promoter transcriptional activation by transforming growth factor- β via Smad3/ β -catenin cooperation. J. Biol. Chem. 2009, 284, 31523–31531.
    • (2009) J. Biol. Chem , vol.284 , pp. 31523-31531
    • Dennler, S.1    André, J.2    Verrecchia, F.3    Mauviel, A.4
  • 114
    • 75749139262 scopus 로고    scopus 로고
    • Activation of the hedgehog-signaling pathway in human cancer and the clinical implications
    • Yang, L.; Xie, G.; Fan, Q.; Xie, J. Activation of the hedgehog-signaling pathway in human cancer and the clinical implications. Oncogene 2010, 29, 469–481.
    • (2010) Oncogene , vol.29 , pp. 469-481
    • Yang, L.1    Xie, G.2    Fan, Q.3    Xie, J.4
  • 115
    • 84922394715 scopus 로고    scopus 로고
    • Expression and clinical significance of Shh/Gli-1 in papillary thyroid carcinoma
    • Bian, X.-H.; Sun, H.; Xue, H.; Zhang, G.; Zhang, C.-H.; Liu, X.-L.; Su, J.; Li, S.-J. Expression and clinical significance of Shh/Gli-1 in papillary thyroid carcinoma. Tumor Biol. 2014, 35, 10523–10528.
    • (2014) Tumor Biol , vol.35 , pp. 10523-10528
    • Bian, X.-H.1    Sun, H.2    Xue, H.3    Zhang, G.4    Zhang, C.-H.5    Liu, X.-L.6    Su, J.7    Li, S.-J.8
  • 118
    • 84877156129 scopus 로고    scopus 로고
    • Gli1 mediates lung cancer cell proliferation and sonic hedgehog-dependent mesenchymal cell activation
    • Bermudez, O.; Hennen, E.; Koch, I.; Lindner, M.; Eickelberg, O. Gli1 mediates lung cancer cell proliferation and sonic hedgehog-dependent mesenchymal cell activation. PLoS ONE 2013, 8, e63226.
    • (2013) Plos ONE , vol.8
    • Bermudez, O.1    Hennen, E.2    Koch, I.3    Lindner, M.4    Eickelberg, O.5
  • 119
    • 0036559186 scopus 로고    scopus 로고
    • Gli and hedgehog in cancer: Tumours, embryos and stem cells
    • Ruiz i Altaba, A.; Sánchez, P.; Dahmane, N. Gli and hedgehog in cancer: Tumours, embryos and stem cells. Nat. Rev. Cancer 2002, 2, 361–372.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 361-372
    • Ruiz I Altaba, A.1    Sánchez, P.2    Dahmane, N.3
  • 122
    • 84870366661 scopus 로고    scopus 로고
    • A phase II, randomized, placebo-controlled study of vismodegib as maintenance therapy in patients with ovarian cancer in second or third complete remission
    • Kaye, S.B.; Fehrenbacher, L.; Holloway, R.; Amit, A.; Karlan, B.; Slomovitz, B.; Sabbatini, P.; Fu, L.; Yauch, R.L.; Chang, I. A phase II, randomized, placebo-controlled study of vismodegib as maintenance therapy in patients with ovarian cancer in second or third complete remission. Clin. Cancer Res. 2012, 18, 6509–6518.
    • (2012) Clin. Cancer Res , vol.18 , pp. 6509-6518
    • Kaye, S.B.1    Fehrenbacher, L.2    Holloway, R.3    Amit, A.4    Karlan, B.5    Slomovitz, B.6    Sabbatini, P.7    Fu, L.8    Yauch, R.L.9    Chang, I.10
  • 123
    • 80555145216 scopus 로고    scopus 로고
    • Hedgehog signaling antagonist GDC-0449 (Vismodegib) inhibits pancreatic cancer stem cell characteristics: Molecular mechanisms
    • Singh, B.N.; Fu, J.; Srivastava, R.K.; Shankar, S. Hedgehog signaling antagonist GDC-0449 (vismodegib) inhibits pancreatic cancer stem cell characteristics: Molecular mechanisms. PLoS ONE 2011, 6, e27306.
    • (2011) Plos ONE , vol.6
    • Singh, B.N.1    Fu, J.2    Srivastava, R.K.3    Shankar, S.4
  • 124
    • 34249867843 scopus 로고    scopus 로고
    • Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists
    • Lauth, M.; Bergström, Å.; Shimokawa, T.; Toftgård, R. Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists. Proc. Natl. Acad. Sci. USA 2007, 104, 8455–8460.
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 8455-8460
    • Lauth, M.1    Bergström, Å.2    Shimokawa, T.3    Toftgård, R.4
  • 125
    • 0034053069 scopus 로고    scopus 로고
    • Wnt signaling in oncogenesis and embryogenesis—A look outside the nucleus
    • Peifer, M.; Polakis, P. Wnt signaling in oncogenesis and embryogenesis—A look outside the nucleus. Science 2000, 287, 1606–1609.
    • (2000) Science , vol.287 , pp. 1606-1609
    • Peifer, M.1    Polakis, P.2
  • 126
    • 25144488085 scopus 로고    scopus 로고
    • Wnt, hedgehog, and SNAIL: Sister pathways that control by GSK-3 β and β -Trcp in the regulation of metastasis
    • Zhou, B.P.; Hung, M.-C. Wnt, hedgehog, and SNAIL: Sister pathways that control by GSK-3 β and β -Trcp in the regulation of metastasis. Cell Cycle 2005, 4, 772–776.
    • (2005) Cell Cycle , vol.4 , pp. 772-776
    • Zhou, B.P.1    Hung, M.-C.2
  • 127
    • 33847740988 scopus 로고    scopus 로고
    • Wnt/ β -catenin signaling in cancer stemness and malignant behavior
    • Fodde, R.; Brabletz, T. Wnt/ β -catenin signaling in cancer stemness and malignant behavior. Curr. Opin. Cell Biol. 2007, 19, 150–158.
    • (2007) Curr. Opin. Cell Biol , vol.19 , pp. 150-158
    • Fodde, R.1    Brabletz, T.2
  • 128
    • 0033518310 scopus 로고    scopus 로고
    • Cross-regulation of β -catenin-LEF/TCF and retinoid signaling pathways
    • Easwaran, V.; Pishvaian, M.; Byers, S. Cross-regulation of β -catenin-LEF/TCF and retinoid signaling pathways. Curr. Biol. 1999, 9, 1415–1419.
    • (1999) Curr. Biol , vol.9 , pp. 1415-1419
    • Easwaran, V.1    Pishvaian, M.2    Byers, S.3
  • 129
    • 50649103964 scopus 로고    scopus 로고
    • Snail promotes Wnt target gene expression and interacts with β -catenin
    • Stemmer, V.; De Craene, B.; Berx, G.; Behrens, J. Snail promotes Wnt target gene expression and interacts with β -catenin. Oncogene 2008, 27, 5075–5080.
    • (2008) Oncogene , vol.27 , pp. 5075-5080
    • Stemmer, V.1    De Craene, B.2    Berx, G.3    Behrens, J.4
  • 130
    • 0032891720 scopus 로고    scopus 로고
    • E-cadherin binding prevents β -catenin nuclear localization and β -catenin/LEF-1-mediated transactivation
    • Orsulic, S.; Huber, O.; Aberle, H.; Arnold, S.; Kemler, R. E-cadherin binding prevents β -catenin nuclear localization and β -catenin/LEF-1-mediated transactivation. J. Cell Sci. 1999, 112, 1237–1245.
    • (1999) J. Cell Sci , vol.112 , pp. 1237-1245
    • Orsulic, S.1    Huber, O.2    Aberle, H.3    Arnold, S.4    Kemler, R.5
  • 132
    • 68249135293 scopus 로고    scopus 로고
    • Inhibition of p70S6K2 down-regulates Hedgehog/GLI pathway in non-small cell lung cancer cell lines
    • Mizuarai, S.; Kawagishi, A.; Kotani, H. Inhibition of p70S6K2 down-regulates Hedgehog/GLI pathway in non-small cell lung cancer cell lines. Mol. Cancer 2009, 8, 44.
    • (2009) Mol. Cancer , vol.8 , pp. 44
    • Mizuarai, S.1    Kawagishi, A.2    Kotani, H.3
  • 133
    • 33845721880 scopus 로고    scopus 로고
    • GSK3 β positively regulates Hedgehog signaling through Sufu in mammalian cells
    • Takenaka, K.; Kise, Y.; Miki, H. GSK3 β positively regulates Hedgehog signaling through Sufu in mammalian cells. Biochem. Biophys. Res. Commun. 2007, 353, 501–508.
    • (2007) Biochem. Biophys. Res. Commun , vol.353 , pp. 501-508
    • Takenaka, K.1    Kise, Y.2    Miki, H.3
  • 136
    • 38149054804 scopus 로고    scopus 로고
    • Axin and GSK3- β control Smad3 protein stability and modulate TGF- β signaling
    • Guo, X.; Ramirez, A.; Waddell, D.S.; Li, Z.; Liu, X.; Wang, X.-F. Axin and GSK3- β control Smad3 protein stability and modulate TGF- β signaling. Genes Dev. 2008, 22, 106–120.
    • (2008) Genes Dev , vol.22 , pp. 106-120
    • Guo, X.1    Ramirez, A.2    Waddell, D.S.3    Li, Z.4    Liu, X.5    Wang, X.-F.6
  • 137
    • 77953715690 scopus 로고    scopus 로고
    • Targeting wnt signaling: Can we safely eradicate cancer stem cells? Clin
    • Takahashi-Yanaga, F.; Kahn, M. Targeting wnt signaling: Can we safely eradicate cancer stem cells? Clin. Cancer Res. 2010, 16, 3153–3162.
    • (2010) Cancer Res , vol.16 , pp. 3153-3162
    • Takahashi-Yanaga, F.1    Kahn, M.2
  • 138
    • 84903767326 scopus 로고    scopus 로고
    • Can we safely target the Wnt pathway?
    • Kahn, M. Can we safely target the Wnt pathway? Nat. Rev. Drug Discov. 2014, 13, 513–532.
    • (2014) Nat. Rev. Drug Discov , vol.13 , pp. 513-532
    • Kahn, M.1
  • 139
    • 84927623385 scopus 로고    scopus 로고
    • Molecular pathways: Aspirin and Wnt signaling—A molecularly targeted approach to cancer prevention and treatment
    • Gala, M.K.; Chan, A.T. Molecular pathways: Aspirin and Wnt signaling—A molecularly targeted approach to cancer prevention and treatment. Clin. Cancer Res. 2015, 21, 1543–1548.
    • (2015) Clin. Cancer Res , vol.21 , pp. 1543-1548
    • Gala, M.K.1    Chan, A.T.2
  • 140
    • 68949155116 scopus 로고    scopus 로고
    • EMT 2.0: Shaping epithelia through collective migration
    • Revenu, C.; Gilmour, D. EMT 2.0: Shaping epithelia through collective migration. Curr. Opin. Genet. Dev. 2009, 19, 338–342.
    • (2009) Curr. Opin. Genet. Dev , vol.19 , pp. 338-342
    • Revenu, C.1    Gilmour, D.2
  • 141
    • 84887456252 scopus 로고    scopus 로고
    • The epigenetics of epithelial-mesenchymal plasticity in cancer
    • Tam, W.L.; Weinberg, R.A. The epigenetics of epithelial-mesenchymal plasticity in cancer. Nat. Med. 2013, 19, 1438–1449.
    • (2013) Nat. Med , vol.19 , pp. 1438-1449
    • Tam, W.L.1    Weinberg, R.A.2
  • 142
    • 84883025658 scopus 로고    scopus 로고
    • Coupled reversible and irreversible bistable switches underlying TGF β -induced epithelial to mesenchymal transition
    • Tian, X.-J.; Zhang, H.; Xing, J. Coupled reversible and irreversible bistable switches underlying TGF β -induced epithelial to mesenchymal transition. Biophys. J. 2013, 105, 1079–1089.
    • (2013) Biophys. J , vol.105 , pp. 1079-1089
    • Tian, X.-J.1    Zhang, H.2    Xing, J.3
  • 143
    • 84055184850 scopus 로고    scopus 로고
    • MiR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions
    • Siemens, H.; Jackstadt, R.; Hünten, S.; Kaller, M.; Menssen, A.; Götz, U.; Hermeking, H. miR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions. Cell Cycle 2011, 10, 4256–4271.
    • (2011) Cell Cycle , vol.10 , pp. 4256-4271
    • Siemens, H.1    Jackstadt, R.2    Hünten, S.3    Kaller, M.4    Menssen, A.5    Götz, U.6    Hermeking, H.7
  • 144
    • 84907877191 scopus 로고    scopus 로고
    • TGF- β -induced epithelial-to-mesenchymal transition proceeds through stepwise activation of multiple feedback loops
    • Zhang, J.; Tian, X.-J.; Zhang, H.; Teng, Y.; Li, R.; Bai, F.; Elankumaran, S.; Xing, J. TGF- β -induced epithelial-to-mesenchymal transition proceeds through stepwise activation of multiple feedback loops. Sci. Signal. 2014, 7, ra91.
    • (2014) Sci. Signal , vol.7
    • Zhang, J.1    Tian, X.-J.2    Zhang, H.3    Teng, Y.4    Li, R.5    Bai, F.6    Elankumaran, S.7    Xing, J.8
  • 145
    • 84949256096 scopus 로고    scopus 로고
    • An Ovol2-Zeb1 mutual inhibitory circuit governs bidirectional and multi-step transition between epithelial and mesenchymal states
    • Hong, T.; Watanabe, K.; Ta, C.H.; Villarreal-Ponce, A.; Nie, Q.; Dai, X. An Ovol2-Zeb1 mutual inhibitory circuit governs bidirectional and multi-step transition between epithelial and mesenchymal states. PLoS Comput. Biol. 2015, 11, e1004569.
    • (2015) Plos Comput. Biol , vol.11
    • Hong, T.1    Watanabe, K.2    Ta, C.H.3    Villarreal-Ponce, A.4    Nie, Q.5    Dai, X.6
  • 146
    • 84889570568 scopus 로고    scopus 로고
    • An EMT spectrum defines an anoikis-resistant and spheroidogenic intermediate mesenchymal state that is sensitive to E-cadherin restoration by a src-kinase Inhibitor, saracatinib (AZD0530)
    • Huang, R.Y.; Wong, M.; Tan, T.; Kuay, K.; Ng, A.; Chung, V.; Chu, Y.; Matsumura, N.; Lai, H.; Lee, Y. An EMT spectrum defines an anoikis-resistant and spheroidogenic intermediate mesenchymal state that is sensitive to E-cadherin restoration by a src-kinase Inhibitor, saracatinib (AZD0530). Cell Death Dis. 2013, 4, e915.
    • (2013) Cell Death Dis , vol.4
    • Huang, R.Y.1    Wong, M.2    Tan, T.3    Kuay, K.4    Ng, A.5    Chung, V.6    Chu, Y.7    Matsumura, N.8    Lai, H.9    Lee, Y.10
  • 147
    • 84909606320 scopus 로고    scopus 로고
    • Network modeling of TGF- β signaling in hepatocellular carcinoma epithelial-to-mesenchymal transition reveals joint sonic hedgehog and wnt pathway activation
    • Steinway, S.N.; Zañudo, J.G.; Ding, W.; Rountree, C.B.; Feith, D.J.; Loughran, T.P.; Albert, R. Network modeling of TGF- β signaling in hepatocellular carcinoma epithelial-to-mesenchymal transition reveals joint sonic hedgehog and wnt pathway activation. Cancer Res. 2014, 74, 5963–5977.
    • (2014) Cancer Res , vol.74 , pp. 5963-5977
    • Steinway, S.N.1    Zañudo, J.G.2    Ding, W.3    Rountree, C.B.4    Feith, D.J.5    Loughran, T.P.6    Albert, R.7
  • 148
    • 84968726686 scopus 로고    scopus 로고
    • Combinatorial interventions inhibit TGF- β -driven epithelial-to-mesenchymal transition and support hybrid cellular phenotypes
    • Steinway, S.N.; Zañudo, J.G.T.; Michel, P.J.; Feith, D.J.; Loughran, T.P.; Albert, R. Combinatorial interventions inhibit TGF- β -driven epithelial-to-mesenchymal transition and support hybrid cellular phenotypes. NPJ Syst. Biol. Appl. 2015, 1, 15014.
    • (2015) NPJ Syst. Biol. Appl , vol.1 , pp. 15014
    • Steinway, S.N.1    Zañudo, J.G.T.2    Michel, P.J.3    Feith, D.J.4    Loughran, T.P.5    Albert, R.6
  • 149
  • 150
    • 84885669414 scopus 로고    scopus 로고
    • The dynamics of signaling as a pharmacological target
    • Behar, M.; Barken, D.; Werner, S.L.; Hoffmann, A. The dynamics of signaling as a pharmacological target. Cell 2013, 155, 448–461.
    • (2013) Cell , vol.155 , pp. 448-461
    • Behar, M.1    Barken, D.2    Werner, S.L.3    Hoffmann, A.4
  • 151
    • 84860851412 scopus 로고    scopus 로고
    • Sequential application of anticancer drugs enhances cell death by rewiring apoptotic signaling networks
    • Lee, M.J.; Albert, S.Y.; Gardino, A.K.; Heijink, A.M.; Sorger, P.K.; MacBeath, G.; Yaffe, M.B. Sequential application of anticancer drugs enhances cell death by rewiring apoptotic signaling networks. Cell 2012, 149, 780–794.
    • (2012) Cell , vol.149 , pp. 780-794
    • Lee, M.J.1    Albert, S.Y.2    Gardino, A.K.3    Heijink, A.M.4    Sorger, P.K.5    Macbeath, G.6    Yaffe, M.B.7
  • 152
    • 74049122828 scopus 로고    scopus 로고
    • Cancer systems biology: A network modeling perspective
    • Kreeger, P.K.; Lauffenburger, D.A. Cancer systems biology: A network modeling perspective. Carcinogenesis 2010, 31, 2–8.
    • (2010) Carcinogenesis , vol.31 , pp. 2-8
    • Kreeger, P.K.1    Lauffenburger, D.A.2
  • 153
    • 84939812727 scopus 로고    scopus 로고
    • Inhibition of peroxidase activity of cytochrome c: De novo compound discovery and validation
    • Bakan, A.; Kapralov, A.A.; Bayir, H.; Hu, F.; Kagan, V.E.; Bahar, I. Inhibition of peroxidase activity of cytochrome c: De novo compound discovery and validation. Mol. Pharmacol. 2015, 88, 421–427.
    • (2015) Mol. Pharmacol. , vol.88 , pp. 421-427
    • Bakan, A.1    Kapralov, A.A.2    Bayir, H.3    Hu, F.4    Kagan, V.E.5    Bahar, I.6


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