메뉴 건너뛰기




Volumn 28, Issue 33, 2009, Pages 2940-2947

Interleukin-6 induces an epithelial-mesenchymal transition phenotype in human breast cancer cells

Author keywords

Breast cancer; Epithelial mesenchymal transition; Interleukin 6; Metastasis; Tumor microenvironment

Indexed keywords

ESTROGEN RECEPTOR ALPHA; INTERLEUKIN 6; NERVE CELL ADHESION MOLECULE; STAT3 PROTEIN; TRANSCRIPTION FACTOR SNAIL; TRANSCRIPTION FACTOR TWIST; UVOMORULIN; VIMENTIN;

EID: 69249221254     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2009.180     Document Type: Article
Times cited : (610)

References (36)
  • 1
    • 0037591513 scopus 로고    scopus 로고
    • Prognostic value of serum levels of interleukin 6 and of serum and plasma levels of vascular endothelial growth factor in hormonerefractory metastatic breast cancer patients
    • Bachelot T, Ray-Coquard I, Menetrier-Caux C, Rastkha M, Duc A, Blay JY. (2003). Prognostic value of serum levels of interleukin 6 and of serum and plasma levels of vascular endothelial growth factor in hormonerefractory metastatic breast cancer patients. Br J Cancer 88: 1721-1726.
    • (2003) Br J Cancer , vol.88 , pp. 1721-1726
    • Bachelot, T.1    Ray-Coquard, I.2    Menetrier-Caux, C.3    Rastkha, M.4    Duc, A.5    Blay, J.Y.6
  • 2
    • 4243156987 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription 3 (STAT3) activation in prostate cancer: Direct STAT3 inhibition induces apoptosis in prostate cancer lines
    • Barton BE, Karras JG, Murphy TF, Barton A, Huang HF. (2004). Signal transducer and activator of transcription 3 (STAT3) activation in prostate cancer: direct STAT3 inhibition induces apoptosis in prostate cancer lines. Mol Cancer Ther 3: 11-20.
    • (2004) Mol Cancer Ther , vol.3 , pp. 11-20
    • Barton, B.E.1    Karras, J.G.2    Murphy, T.F.3    Barton, A.4    Huang, H.F.5
  • 3
    • 0037444373 scopus 로고    scopus 로고
    • Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice
    • Blaskovich MA, Sun J, Cantor A, Turkson J, Jove R, Sebti SM. (2003). Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice. Cancer Res 63: 1270-1279.
    • (2003) Cancer Res , vol.63 , pp. 1270-1279
    • Blaskovich, M.A.1    Sun, J.2    Cantor, A.3    Turkson, J.4    Jove, R.5    Sebti, S.M.6
  • 5
    • 47249161129 scopus 로고    scopus 로고
    • Twist is transcriptionally induced by activation of STAT3 and mediates STAT3 oncogenic function
    • Cheng GZ, Zhang WZ, Sun M, Wang Q, Coppola D, Mansour M et al. (2008). Twist is transcriptionally induced by activation of STAT3 and mediates STAT3 oncogenic function. J Biol Chem 283: 14665-14673.
    • (2008) J Biol Chem , vol.283 , pp. 14665-14673
    • Cheng, G.Z.1    Zhang, W.Z.2    Sun, M.3    Wang, Q.4    Coppola, D.5    Mansour, M.6
  • 6
    • 0035893768 scopus 로고    scopus 로고
    • Autocrine production of interleukin 6 causes multidrug resistance in breast cancer cells
    • Conze D, Weiss L, Regen PS, Bhushan A, Weaver D, Johnson P et al. (2001). Autocrine production of interleukin 6 causes multidrug resistance in breast cancer cells. Cancer Res 61: 8851-8858.
    • (2001) Cancer Res , vol.61 , pp. 8851-8858
    • Conze, D.1    Weiss, L.2    Regen, P.S.3    Bhushan, A.4    Weaver, D.5    Johnson, P.6
  • 7
    • 0026072872 scopus 로고
    • Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: Experience from a large study with long-term follow-up
    • Elston CW, Ellis IO. (1991). Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up. Histopathology 19: 403-410.
    • (1991) Histopathology , vol.19 , pp. 403-410
    • Elston, C.W.1    Ellis, I.O.2
  • 8
    • 31544458469 scopus 로고    scopus 로고
    • Persistent activation of stat3 signaling induces survivin gene expression and confers resistance to apoptosis in human breast cancer cells
    • Gritsko T, Williams A, Turkson J, Kaneko S, Bowman T, Huang M et al. (2006). Persistent activation of stat3 signaling induces survivin gene expression and confers resistance to apoptosis in human breast cancer cells. Clin Cancer Res 12: 11-19.
    • (2006) Clin Cancer Res , vol.12 , pp. 11-19
    • Gritsko, T.1    Williams, A.2    Turkson, J.3    Kaneko, S.4    Bowman, T.5    Huang, M.6
  • 9
    • 0033852789 scopus 로고    scopus 로고
    • Individual characterisation of the metastatic capacity of human breast carcinoma
    • Heimann R, Hellman S. (2000). Individual characterisation of the metastatic capacity of human breast carcinoma. Eur J Cancer 36: 1631-1639.
    • (2000) Eur J Cancer , vol.36 , pp. 1631-1639
    • Heimann, R.1    Hellman, S.2
  • 10
    • 0033937509 scopus 로고    scopus 로고
    • Reduction in serum IL-6 after vacination of breast cancer patients with tumourassociated antigens is related to estrogen receptor status
    • Jiang XP, Yang DC, Elliott RL, Head JF. (2000). Reduction in serum IL-6 after vacination of breast cancer patients with tumourassociated antigens is related to estrogen receptor status. Cytokine 12: 458-465.
    • (2000) Cytokine , vol.12 , pp. 458-465
    • Jiang, X.P.1    Yang, D.C.2    Elliott, R.L.3    Head, J.F.4
  • 11
    • 34948896045 scopus 로고    scopus 로고
    • Mesenchymal stem cells within tumour stroma promote breast cancer metastasis
    • Karnoub AE, Dash AB, Vo AP, Sullivan A, Brooks MW, Bell GW et al (2007). Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature 449: 557-563.
    • (2007) Nature , vol.449 , pp. 557-563
    • Karnoub, A.E.1    Dash, A.B.2    Vo, A.P.3    Sullivan, A.4    Brooks, M.W.5    Bell, G.W.6
  • 12
    • 33748117796 scopus 로고    scopus 로고
    • Interleukin-6: Discovery of a pleiotropic cytokine
    • Kishimoto T. (2006). Interleukin-6: discovery of a pleiotropic cytokine. Arthritis Res Ther 8: S2.
    • (2006) Arthritis Res Ther , vol.8
    • Kishimoto, T.1
  • 13
    • 1642342156 scopus 로고    scopus 로고
    • Concentration of interleukin-6 (IL-6), interleukin-8 (IL-8) and interleukin-10 (IL-10) in blood serum of breast cancer patients
    • Kozlowski L, Zakrzewska I, Tokajuk P, Wojtukiewicz MZ. (2003). Concentration of interleukin-6 (IL-6), interleukin-8 (IL-8) and interleukin-10 (IL-10) in blood serum of breast cancer patients. Rocz Akad Med Bialymst 48: 82-84.
    • (2003) Rocz Akad Med Bialymst , vol.48 , pp. 82-84
    • Kozlowski, L.1    Zakrzewska, I.2    Tokajuk, P.3    Wojtukiewicz, M.Z.4
  • 14
    • 69249228665 scopus 로고    scopus 로고
    • Lebret SC, Newgreen DF, Thompson EW, Ackland ML. (2007). Induction of epithelial to mesenchymal transition in PMC42-LA human breast carcinoma cells by carcinoma-associated fibroblast secreted factors. Breast Cancer Res 9: R19. Lin Q, Lai R, Chirieac LR, Li C, Thomazy VA, Grammatikakis I et al. (2005). Constitutive activation of JAK3/STAT3 in colon carcinoma tumors and cell lines: inhibition of JAK3/STAT3 signaling induces apoptosis and cell cycle arrest of colon carcinoma cells. Am J Pathol 167: 969-980.
    • Lebret SC, Newgreen DF, Thompson EW, Ackland ML. (2007). Induction of epithelial to mesenchymal transition in PMC42-LA human breast carcinoma cells by carcinoma-associated fibroblast secreted factors. Breast Cancer Res 9: R19. Lin Q, Lai R, Chirieac LR, Li C, Thomazy VA, Grammatikakis I et al. (2005). Constitutive activation of JAK3/STAT3 in colon carcinoma tumors and cell lines: inhibition of JAK3/STAT3 signaling induces apoptosis and cell cycle arrest of colon carcinoma cells. Am J Pathol 167: 969-980.
  • 15
    • 47549090432 scopus 로고    scopus 로고
    • TGFbeta in cancer
    • Mironchik Y, Winnard Jr PT, Vesuna F, Kato Y, Wildes F, Pathak
    • Massague J. (2008). TGFbeta in cancer. Cell 134: 215-230. Mironchik Y, Winnard Jr PT, Vesuna F, Kato Y, Wildes F, Pathak
    • (2008) Cell , vol.134 , pp. 215-230
    • Massague, J.1
  • 16
    • 28344444026 scopus 로고    scopus 로고
    • AP et al. (2005). Twist overexpression induces in vivo angiogenesis and correlates with chromosomal instability in breast cancer. Cancer Res 65: 10801-10809.
    • AP et al. (2005). Twist overexpression induces in vivo angiogenesis and correlates with chromosomal instability in breast cancer. Cancer Res 65: 10801-10809.
  • 18
    • 40649109728 scopus 로고    scopus 로고
    • The wolf in sheep's clothing: The role of interleukin-6 in immunity, inflammation and cancer
    • Naugler WE, Karin M. (2008). The wolf in sheep's clothing: the role of interleukin-6 in immunity, inflammation and cancer. Trends Mol Med 14: 109-119.
    • (2008) Trends Mol Med , vol.14 , pp. 109-119
    • Naugler, W.E.1    Karin, M.2
  • 20
    • 0027530351 scopus 로고
    • Expression of E-cadherin cell adhesion molecules in human breast cancer tissues and its relationship to metastasis
    • Oka H, Shiozaki H, Kobayashi K, Inoue M, Tahara H, Kobayashi T et al. (1993). Expression of E-cadherin cell adhesion molecules in human breast cancer tissues and its relationship to metastasis. Cancer Res 53: 1696-1701.
    • (1993) Cancer Res , vol.53 , pp. 1696-1701
    • Oka, H.1    Shiozaki, H.2    Kobayashi, K.3    Inoue, M.4    Tahara, H.5    Kobayashi, T.6
  • 22
    • 0037132407 scopus 로고    scopus 로고
    • Expression of S100A4, E-cadherin, alpha- and beta-catenin in breast cancer biopsies
    • Pedersen KB, Nesland JM, Fodstad O, Maelandsmo GM. (2002). Expression of S100A4, E-cadherin, alpha- and beta-catenin in breast cancer biopsies. Br J Cancer 87: 1281-1286.
    • (2002) Br J Cancer , vol.87 , pp. 1281-1286
    • Pedersen, K.B.1    Nesland, J.M.2    Fodstad, O.3    Maelandsmo, G.M.4
  • 23
    • 0037455841 scopus 로고    scopus 로고
    • Circulating interleukin-6 predicts survival in patients with metastatic breast cancer
    • Salgado R, Junius S, Benoy I, Van Dam P, Vermeulen P, Van Marck E et al. (2003). Circulating interleukin-6 predicts survival in patients with metastatic breast cancer. Int J Cancer 103: 642-646.
    • (2003) Int J Cancer , vol.103 , pp. 642-646
    • Salgado, R.1    Junius, S.2    Benoy, I.3    Van Dam, P.4    Vermeulen, P.5    Van Marck, E.6
  • 24
    • 36849039660 scopus 로고    scopus 로고
    • IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland
    • Sansone P, Storci G, Tavolari S, Guarnieri T, Giovannini C, Taffurelli M et al. (2007). IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland. J Clin Invest 117: 3988-4002.
    • (2007) J Clin Invest , vol.117 , pp. 3988-4002
    • Sansone, P.1    Storci, G.2    Tavolari, S.3    Guarnieri, T.4    Giovannini, C.5    Taffurelli, M.6
  • 26
    • 34547451080 scopus 로고    scopus 로고
    • Human bone marrow stromal cells enhance breast cancer cell growth rates in a cell line-dependent manner when evaluated in 3D tumor environments
    • Sasser AK, Mundy BL, Smith KM, Studebaker AW, Axel AE, Haidet AM et al. (2007a). Human bone marrow stromal cells enhance breast cancer cell growth rates in a cell line-dependent manner when evaluated in 3D tumor environments. Cancer Lett 254: 255-264.
    • (2007) Cancer Lett , vol.254 , pp. 255-264
    • Sasser, A.K.1    Mundy, B.L.2    Smith, K.M.3    Studebaker, A.W.4    Axel, A.E.5    Haidet, A.M.6
  • 28
    • 0033011611 scopus 로고    scopus 로고
    • The regulation of aromatase activity in breast fibroblasts: The role of interleukin-6 and prostaglandin E2
    • Singh A, Purohit A, Ghilchik MW, Reed MJ. (1999). The regulation of aromatase activity in breast fibroblasts: the role of interleukin-6 and prostaglandin E2. Endocr Relat Cancer 6: 139-147.
    • (1999) Endocr Relat Cancer , vol.6 , pp. 139-147
    • Singh, A.1    Purohit, A.2    Ghilchik, M.W.3    Reed, M.J.4
  • 29
    • 55349104462 scopus 로고    scopus 로고
    • Fibroblasts isolated from common sites of breast cancer metastasis enhance cancer cell growth rates and invasiveness in an interleukin-6-dependent manner
    • Studebaker AW, Storci G, Werbeck JL, Sansone P, Sasser AK, Tavolari S et al. (2008). Fibroblasts isolated from common sites of breast cancer metastasis enhance cancer cell growth rates and invasiveness in an interleukin-6-dependent manner. Cancer Res 68: 9087-9095.
    • (2008) Cancer Res , vol.68 , pp. 9087-9095
    • Studebaker, A.W.1    Storci, G.2    Werbeck, J.L.3    Sansone, P.4    Sasser, A.K.5    Tavolari, S.6
  • 30
    • 0036595629 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in tumour progression
    • Thiery JP. (2002). Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2: 442-454.
    • (2002) Nat Rev Cancer , vol.2 , pp. 442-454
    • Thiery, J.P.1
  • 31
    • 33244463813 scopus 로고    scopus 로고
    • Complex networks orchestrate epithelial-mesenchymal transitions
    • Thiery JP, Sleeman JP. (2006). Complex networks orchestrate epithelial-mesenchymal transitions. Nat Rev Mol Cell Biol 7: 131-142.
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 131-142
    • Thiery, J.P.1    Sleeman, J.P.2
  • 33
    • 0027303256 scopus 로고
    • Structure-function analysis of interleukin-6 utilizing human/murine chimeric molecules. Involvement of two separate domains in receptor binding
    • van Dam M, Mullberg J, Schooltink H, Stoyan T, Brakenhoff JP, Graeve L et al. (1993). Structure-function analysis of interleukin-6 utilizing human/murine chimeric molecules. Involvement of two separate domains in receptor binding. J Biol Chem 268: 15285- 15290.
    • (1993) J Biol Chem , vol.268 , pp. 15285-15290
    • van Dam, M.1    Mullberg, J.2    Schooltink, H.3    Stoyan, T.4    Brakenhoff, J.P.5    Graeve, L.6
  • 34
    • 33748168727 scopus 로고    scopus 로고
    • ILEI: A cytokine essential for EMT, tumor formation, and late events in metastasis in epithelial cells
    • Waerner T, Alacakaptan M, Tamir I, Oberauer R, Gal A, Brabletz T et al. (2006). ILEI: a cytokine essential for EMT, tumor formation, and late events in metastasis in epithelial cells. Cancer Cell 10: 227-239.
    • (2006) Cancer Cell , vol.10 , pp. 227-239
    • Waerner, T.1    Alacakaptan, M.2    Tamir, I.3    Oberauer, R.4    Gal, A.5    Brabletz, T.6
  • 35
    • 44449144396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition: At the crossroads of development and tumor metastasis
    • Yang J, Weinberg RA. (2008). Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. Dev Cell 14: 818-829.
    • (2008) Dev Cell , vol.14 , pp. 818-829
    • Yang, J.1    Weinberg, R.A.2
  • 36
    • 0033036097 scopus 로고    scopus 로고
    • Serum interleukin-6 levels correlate to tumor progression and prognosis in metastatic breast carcinoma
    • Zhang GJ, Adachi I. (1999). Serum interleukin-6 levels correlate to tumor progression and prognosis in metastatic breast carcinoma. Anticancer Res 19: 1427-1432.
    • (1999) Anticancer Res , vol.19 , pp. 1427-1432
    • Zhang, G.J.1    Adachi, I.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.