Transforming growth factor β enhances epithelial cell survival via Akt-dependent regulation of FKHRL1

Molecular Biology of the Cell

Volumn 12, Issue 11, 2001, Pages 3328-3339

  Shin, I ^a   Bakin, A V ^a   Rodeck, U ^a   Brunet, A ^a   Arteaga, C L ^a  

^a VANDERBILT INGRAM CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL SURVIVAL; EPITHELIUM CELL; GENE INDUCTION; KERATINOCYTE; MESENCHYME CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; REPORTER GENE; TRANSCRIPTION REGULATION;

ANIMALIA;

EID: 0035196587     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.12.11.3328     Document Type: Article

References (50)

1. Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates, and activates protein kinase B alpha
2. Evidence for a role of Rho-like GTPases, and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) in transforming growth factor β-mediated signaling
3. Phosphatidylinositol 3-kinase function is required for transforming growth factor β-mediated epithelial to mesenchymal transition, and cell migration
4. Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1
5. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
6. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
7. Protein kinase SGK mediates survival signals by phosphorylating the Forkhead transcription factor FKHRL1 (FOXO3a)
8. KIP1 independent of MAPK activity
9. Regulation of cell death protease caspase-9 by phosphorylation
10. Transforming growth factor β1 rescues serum deprivation-induced apoptosis via the mitogen-activated protein kinase (MAPK) pathway in macrophages
11. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
12. Cellular survival: A play in three Akts
13. Regulation of the forkhead transcription factor FKHR, but not the PAX3-FKHR fusion protein, by the serine/threonine kinase Akt
14. Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt
15. KIP1
16. Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHRL1
17. Regulation of neuronal survival by the serine-threonine protein kinase Akt
18. Transforming growth factor β1 inhibits Fas ligand expression and subsequent activation-induced cell death in T cells via downregulation of c-Myc
19. Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR, and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence
20. Altered transforming growth factor β signaling in epithelial cells when ras activation is blocked
21. Transforming growth factor-β1 suppresses serum deprivation-induced death of A549 cells through differential effects on c-Jun, and JNK activities
22. TGF-β inhibits lipopolysaccharide-stimulated activity of c-Jun N-terminal kinase in mouse macrophages
23. L expression through a MEK-dependent pathway
24. Suppression of c-Myc-induced apoptosis by Ras signaling through PI(3)K, and PKB
25. Forkhead transcription factors: New insights into protein kinase B (c-akt) signaling
26. Direct control of the Forkhead transcription factor AFX by protein kinase B
27. Partnership between DPC4, and SMAD proteins in TGFβ signaling pathways
28. Withdrawal of survival factors results in activation of the JNK pathway in neuronal cells leading to Fas ligand induction, and cell death
29. TGF-β1 and cyclic AMP promote apoptosis in resting human B lymphocytes
30. TGFβ signal transduction
31. Controlling TGF-β signaling
32. Transcriptional control by the TGFβ/Smad signaling system
33. Differential roles of JNK and Smad2 signaling pathways in the inhibition of c-Myc-induced cell death by TGFβ
34. Invasion and metastasis of a mammary tumor involves TGFβ signaling
35. TGF-β induced transdifferentiation of mammary epithelial cells to mesenchymal cells: Involvement of type I receptors
36. Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a Wortmannin-sensitive pathway
37. TGFβ signaling is necessary for carcinoma cell invasiveness and metastasis
38. The Forkhead transcription factor DAF-16 transduces insulin-like metabolic, and longevity signals in C. elegans
39. TGF-β type I receptor/ALK-5, and Smad proteins mediate epithelial to mesenchymal transdifferentiation in NMuMG breast epithelial cells
40. Transforming growth factor β is essential for spindle cell conversion of mouse skin carcinoma in vivo: Implications for tumor invasion
41. Transforming growth factor-β1 inhibits nucleosomal fragmentation in human keratinocytes following loss of adhesion
42. Transforming growth factor β and tumor necrosis factor alpha inhibit both apoptosis and proliferation of activated rat hepatic stellate cells
43. Apoptosis induced by transforming growth factor-β in fetal hepatocyte primary cultures: Involvement of reactive oxygen intermediates
44. Progression of the myeloid differentiation program is dominant to transforming growth factor β1-induced apoptosis in M1 myeloid leukemic cells
45. Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B
46. Dual role of phosphatidylinositol-3,4,5-triphosphate in the activation of protein kinase B
47. Regulation of nuclear translocation of forkhead transcription factor AFX by protein kinase B
48. Negative regulation of the forkhead transcription factor FKHR by Akt
49. A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)
50. TGFβ signaling blockade inhibits PTHrP secretion by breast cancer cells, and bone metastases development