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Volumn 9, Issue 2, 1999, Pages 76-84

Sonic hedgehog signaling by the patched-smoothened receptor complex

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA; ERINACEIDAE; INSECTA; VERTEBRATA;

EID: 0009603803     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(99)80018-9     Document Type: Article
Times cited : (274)

References (52)
  • 1
    • 0019133661 scopus 로고
    • Mutations affecting segment number and polarity in Drosophila
    • Nusslein-Volhard C, Wieschaus E: Mutations affecting segment number and polarity in Drosophila. Nature 1980, 287:795-801.
    • (1980) Nature , vol.287 , pp. 795-801
    • Nusslein-Volhard, C.1    Wieschaus, E.2
  • 3
    • 0027756145 scopus 로고
    • Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity
    • Echelard Y, Epstein DJ, St-Jacques B, Shen L, Mohler J, McMahon JA, et al.: Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell 1993, 75:1417-1430.
    • (1993) Cell , vol.75 , pp. 1417-1430
    • Echelard, Y.1    Epstein, D.J.2    St-Jacques, B.3    Shen, L.4    Mohler, J.5    McMahon, J.A.6
  • 4
    • 0027749249 scopus 로고
    • A functionally conserved homolog of the Drosophila segment polarity gene hh is expressed in tissues with polarizing activity in zebrafish embryos
    • Krauss S, Concordet JP, Ingham PW: A functionally conserved homolog of the Drosophila segment polarity gene hh is expressed in tissues with polarizing activity in zebrafish embryos. Cell 1993, 75:1431-1444.
    • (1993) Cell , vol.75 , pp. 1431-1444
    • Krauss, S.1    Concordet, J.P.2    Ingham, P.W.3
  • 6
    • 0030667761 scopus 로고    scopus 로고
    • Differentiation of the vertebrate neural tube
    • Bronner-Fraser M, Fraser SE: Differentiation of the vertebrate neural tube. Curr Opin Cell Biol 1997, 9:885-891.
    • (1997) Curr Opin Cell Biol , vol.9 , pp. 885-891
    • Bronner-Fraser, M.1    Fraser, S.E.2
  • 7
    • 0029319713 scopus 로고
    • Somite differentiation. Sonic signals somites
    • Bumcrot DA, McMahon AP: Somite differentiation. Sonic signals somites. Curr Biol 1995, 5:612-614.
    • (1995) Curr Biol , vol.5 , pp. 612-614
    • Bumcrot, D.A.1    McMahon, A.P.2
  • 8
    • 0027760995 scopus 로고
    • Sonic hedgehog mediates the polarizing activity of the ZPA
    • Riddle RD, Johnson RL, Laufer E, Tabin C: Sonic hedgehog mediates the polarizing activity of the ZPA. Cell 1993, 75:1401-1416.
    • (1993) Cell , vol.75 , pp. 1401-1416
    • Riddle, R.D.1    Johnson, R.L.2    Laufer, E.3    Tabin, C.4
  • 9
    • 0028875032 scopus 로고
    • Sonic hedgehog is an endodermal signal inducing Bmp-4 and Hox genes during induction and regionalization of the chick hindgut
    • Roberts DJ, Johnson RL, Burke AC, Nelson CE, Morgan BA, Tabin C: Sonic hedgehog is an endodermal signal inducing Bmp-4 and Hox genes during induction and regionalization of the chick hindgut. Development 1995, 121:3163-3174.
    • (1995) Development , vol.121 , pp. 3163-3174
    • Roberts, D.J.1    Johnson, R.L.2    Burke, A.C.3    Nelson, C.E.4    Morgan, B.A.5    Tabin, C.6
  • 10
    • 0029784223 scopus 로고    scopus 로고
    • Smoothened encodes a receptor-like serpentine protein required for hedgehog signalling
    • van den Heuvel M, Ingham PW: Smoothened encodes a receptor-like serpentine protein required for hedgehog signalling. Nature 1996, 382:547-551.
    • (1996) Nature , vol.382 , pp. 547-551
    • Van Den Heuvel, M.1    Ingham, P.W.2
  • 11
    • 0030602796 scopus 로고    scopus 로고
    • The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal
    • Alcedo J, Ayzenzon M, Von Ohlen T, Noll M, Hooper JE: The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal. Cell 1996, 86:221-232.
    • (1996) Cell , vol.86 , pp. 221-232
    • Alcedo, J.1    Ayzenzon, M.2    Von Ohlen, T.3    Noll, M.4    Hooper, J.E.5
  • 12
    • 0011102935 scopus 로고    scopus 로고
    • The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog
    • Stone DM, Hynes M, Armanini M, Swanson TA, Gu Q, Johnson RL, et al.: The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog. Nature 1996, 384:129-134.
    • (1996) Nature , vol.384 , pp. 129-134
    • Stone, D.M.1    Hynes, M.2    Armanini, M.3    Swanson, T.A.4    Gu, Q.5    Johnson, R.L.6
  • 13
    • 0024468746 scopus 로고
    • The Drosophila patched gene encodes a putative membrane protein required for segmental patterning
    • Hooper JE, Scott MP: The Drosophila patched gene encodes a putative membrane protein required for segmental patterning. Cell 1989, 59:751-765.
    • (1989) Cell , vol.59 , pp. 751-765
    • Hooper, J.E.1    Scott, M.P.2
  • 14
    • 0024440611 scopus 로고
    • A protein with several possible membrane-spanning domains encoded by the Drosophila segment polarity gene patched
    • Nakano Y, Guerrero I, Hidalgo A, Taylor A, Whittle JR, Ingham PW: A protein with several possible membrane-spanning domains encoded by the Drosophila segment polarity gene patched. Nature 1989, 341:508-513.
    • (1989) Nature , vol.341 , pp. 508-513
    • Nakano, Y.1    Guerrero, I.2    Hidalgo, A.3    Taylor, A.4    Whittle, J.R.5    Ingham, P.W.6
  • 15
    • 0025815911 scopus 로고
    • Role of the Drosophila patched gene in positional signalling
    • Ingham PW, Taylor AM, Nakano Y: Role of the Drosophila patched gene in positional signalling. Nature 1991, 353:184-187.
    • (1991) Nature , vol.353 , pp. 184-187
    • Ingham, P.W.1    Taylor, A.M.2    Nakano, Y.3
  • 16
    • 0028329349 scopus 로고
    • Compartment boundaries and the control of Drosophila limb pattern by hedgehog protein
    • Basler K, Struhl G: Compartment boundaries and the control of Drosophila limb pattern by hedgehog protein. Nature 1994, 368:208-214.
    • (1994) Nature , vol.368 , pp. 208-214
    • Basler, K.1    Struhl, G.2
  • 17
    • 0028032065 scopus 로고
    • The Drosophila segment polarity gene patched interacts with decapentaplegic in wing development
    • Capdevila J, Estrada MP, Sanchez-Herrero E, Guerrero I: The Drosophila segment polarity gene patched interacts with decapentaplegic in wing development. EMBO J 1994, 13:71-82.
    • (1994) EMBO J , vol.13 , pp. 71-82
    • Capdevila, J.1    Estrada, M.P.2    Sanchez-Herrero, E.3    Guerrero, I.4
  • 18
  • 19
  • 20
    • 15844386165 scopus 로고    scopus 로고
    • Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome
    • Hahn H, Wicking C, Zaphiropoulous PG, Gailani MR, Shanley S, Chidambaram A, et al.: Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome. Cell 1996, 85:841-851.
    • (1996) Cell , vol.85 , pp. 841-851
    • Hahn, H.1    Wicking, C.2    Zaphiropoulous, P.G.3    Gailani, M.R.4    Shanley, S.5    Chidambaram, A.6
  • 22
    • 0031913524 scopus 로고    scopus 로고
    • Activating smoothened mutations in sporadic basal-cell carcinoma
    • Xie J, Murone M, Luoh SM, Ryan A, Gu Q, Zhang C, et al.: Activating smoothened mutations in sporadic basal-cell carcinoma. Nature 1998, 391:90-92.
    • (1998) Nature , vol.391 , pp. 90-92
    • Xie, J.1    Murone, M.2    Luoh, S.M.3    Ryan, A.4    Gu, Q.5    Zhang, C.6
  • 24
    • 0023930186 scopus 로고
    • The GLI gene is a member of the Kruppel family of zinc finger proteins
    • Kinzler KW, Ruppert JM, Bigner SH, Vogelstein B: The GLI gene is a member of the Kruppel family of zinc finger proteins. Nature 1988, 332:371-374.
    • (1988) Nature , vol.332 , pp. 371-374
    • Kinzler, K.W.1    Ruppert, J.M.2    Bigner, S.H.3    Vogelstein, B.4
  • 25
    • 0029896212 scopus 로고    scopus 로고
    • Sending and receiving the hedgehog signal: Control by the Drosophila Gli protein cubitus interruptus
    • Dominguez M, Brunner M, Hafen E, Basler K: Sending and receiving the hedgehog signal: Control by the Drosophila Gli protein cubitus interruptus. Science 1996, 272:1621-1625.
    • (1996) Science , vol.272 , pp. 1621-1625
    • Dominguez, M.1    Brunner, M.2    Hafen, E.3    Basler, K.4
  • 26
    • 0029858774 scopus 로고    scopus 로고
    • Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins
    • Alexandre C, Jacinto A, Ingham PW: Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins. Genes Dev 1996, 10:2003-2013.
    • (1996) Genes Dev , vol.10 , pp. 2003-2013
    • Alexandre, C.1    Jacinto, A.2    Ingham, P.W.3
  • 27
    • 0030795109 scopus 로고    scopus 로고
    • Control of cell pattern in the neural tube by the zinc finger transcription factor and oncogene Gli-1
    • Hynes M, Stone DM, Dowd M, Pitts-Meek S, Goddard A, Gurney A, et al.: Control of cell pattern in the neural tube by the zinc finger transcription factor and oncogene Gli-1. Neuron 1997, 19:15-26.
    • (1997) Neuron , vol.19 , pp. 15-26
    • Hynes, M.1    Stone, D.M.2    Dowd, M.3    Pitts-Meek, S.4    Goddard, A.5    Gurney, A.6
  • 28
    • 0030975697 scopus 로고    scopus 로고
    • Hedgehog signaling regulates transcription through cubitus interruptus, a sequence-specific DNA binding protein
    • Von Ohlen T, Lessing D, Nusse R, Hooper JE: Hedgehog signaling regulates transcription through cubitus interruptus, a sequence-specific DNA binding protein. Proc Natl Acad Sci USA 1997, 94:2404-2409.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 2404-2409
    • Von Ohlen, T.1    Lessing, D.2    Nusse, R.3    Hooper, J.E.4
  • 29
    • 0031820135 scopus 로고    scopus 로고
    • Combinatorial Gli gene function in floor plate and neuronal inductions by Sonic hedgehog
    • Altaba AR: Combinatorial Gli gene function in floor plate and neuronal inductions by Sonic hedgehog. Development 1998, 125:2203-2212.
    • (1998) Development , vol.125 , pp. 2203-2212
    • Altaba, A.R.1
  • 30
    • 0030805592 scopus 로고    scopus 로고
    • Gli1 is a target of Sonic hedgehog that induces ventral neural tube development
    • Lee J, Platt KA, Censullo P, Ruiz i Altaba A: Gli1 is a target of Sonic hedgehog that induces ventral neural tube development. Development 1997, 124:2537-2552.
    • (1997) Development , vol.124 , pp. 2537-2552
    • Lee, J.1    Platt, K.A.2    Censullo, P.3    Ruiz i Altaba, A.4
  • 31
    • 0030601955 scopus 로고    scopus 로고
    • Sonic hedgehog differentially regulates expression of GLI and GLI3 during limb development
    • Marigo V, Johnson RL, Vortkamp A, Tabin CJ: Sonic hedgehog differentially regulates expression of GLI and GLI3 during limb development. Dev Biol 1996, 180:273-283.
    • (1996) Dev Biol , vol.180 , pp. 273-283
    • Marigo, V.1    Johnson, R.L.2    Vortkamp, A.3    Tabin, C.J.4
  • 32
    • 0030844141 scopus 로고    scopus 로고
    • Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours
    • Dahmane N, Lee J, Robins P, Heller P, Ruiz i Altaba A: Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours. Nature 1997, 389:876-881.
    • (1997) Nature , vol.389 , pp. 876-881
    • Dahmane, N.1    Lee, J.2    Robins, P.3    Heller, P.4    Ruiz i Altaba, A.5
  • 33
    • 0032126734 scopus 로고    scopus 로고
    • Transducing Hedgehog: The story so far
    • Ingham PW: Transducing Hedgehog: The story so far. EMBO J 1998, 17:3505-3511.
    • (1998) EMBO J , vol.17 , pp. 3505-3511
    • Ingham, P.W.1
  • 34
    • 0031042224 scopus 로고    scopus 로고
    • Fibroblasts expressing Sonic hedgehog induce osteoblast differentiation and ectopic bone formation
    • Kinto N, Iwamoto M, Enomoto-Iwamoto M, Noji S, OhucHi H, Yoshioka H, et al.: Fibroblasts expressing Sonic hedgehog induce osteoblast differentiation and ectopic bone formation. FEBS Lett 1997, 404:319-323.
    • (1997) FEBS Lett , vol.404 , pp. 319-323
    • Kinto, N.1    Iwamoto, M.2    Enomoto-Iwamoto, M.3    Noji, S.4    Ohuchi, H.5    Yoshioka, H.6
  • 35
    • 0030891148 scopus 로고    scopus 로고
    • A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro
    • Sasaki H, Hui C, Nakafuku M, Kondoh H: A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro. Development 1997, 124:1313-1322.
    • (1997) Development , vol.124 , pp. 1313-1322
    • Sasaki, H.1    Hui, C.2    Nakafuku, M.3    Kondoh, H.4
  • 36
    • 0028361809 scopus 로고
    • Chimeric muscarinic cholinergic:beta-adrenergic receptors that are functionally promiscuous among G proteins
    • Wong SK, Ross EM: Chimeric muscarinic cholinergic:beta-adrenergic receptors that are functionally promiscuous among G proteins. J Biol Chem 1994, 269:18968-18976.
    • (1994) J Biol Chem , vol.269 , pp. 18968-18976
    • Wong, S.K.1    Ross, E.M.2
  • 37
    • 0025072659 scopus 로고
    • Cell patterning in the Drosophila segment: Spatial regulation of the segment polarity gene patched
    • Hidalgo A, Ingham P: Cell patterning in the Drosophila segment: Spatial regulation of the segment polarity gene patched. Development 1990, 110:291-301.
    • (1990) Development , vol.110 , pp. 291-301
    • Hidalgo, A.1    Ingham, P.2
  • 38
    • 0030027059 scopus 로고    scopus 로고
    • Conservation of the hedgehog/patched signaling pathway from flies to mice: Induction of a mouse patched gene by Hedgehog
    • Goodrich LV, Johnson RL, Milenkovic L, McMahon JA, Scott MP: Conservation of the hedgehog/patched signaling pathway from flies to mice: Induction of a mouse patched gene by Hedgehog. Genes Dev 1996, 10:301-312.
    • (1996) Genes Dev , vol.10 , pp. 301-312
    • Goodrich, L.V.1    Johnson, R.L.2    Milenkovic, L.3    McMahon, J.A.4    Scott, M.P.5
  • 39
    • 0030297553 scopus 로고    scopus 로고
    • Dual roles for patched in sequestering and transducing Hedgehog
    • Chen Y, Struhl G: Dual roles for patched in sequestering and transducing Hedgehog. Cell 1996, 87:553-563.
    • (1996) Cell , vol.87 , pp. 553-563
    • Chen, Y.1    Struhl, G.2
  • 41
    • 0031456672 scopus 로고    scopus 로고
    • Interaction of Wnt and a frizzled homologue triggers G-protein-linked phosphatidylinositol signalling
    • Slusarski DC, Corces VG, Moon RT: Interaction of Wnt and a frizzled homologue triggers G-protein-linked phosphatidylinositol signalling. Nature 1997, 390:410-413.
    • (1997) Nature , vol.390 , pp. 410-413
    • Slusarski, D.C.1    Corces, V.G.2    Moon, R.T.3
  • 43
    • 0028911915 scopus 로고
    • cAMP-dependent protein kinase and hedgehog act antagonistically in regulating decapentaplegic transcription in Drosophila imaginal discs
    • Pan D, Rubin GM: cAMP-dependent protein kinase and hedgehog act antagonistically in regulating decapentaplegic transcription in Drosophila imaginal discs. Cell 1995, 80:543-552.
    • (1995) Cell , vol.80 , pp. 543-552
    • Pan, D.1    Rubin, G.M.2
  • 44
    • 0028897883 scopus 로고
    • Function of protein kinase A in hedgehog signal transduction and Drosophila imaginal disc development
    • Li W, Ohlmeyer JT, Lane ME, Kalderon D: Function of protein kinase A in hedgehog signal transduction and Drosophila imaginal disc development. Cell 1995, 80:553-562.
    • (1995) Cell , vol.80 , pp. 553-562
    • Li, W.1    Ohlmeyer, J.T.2    Lane, M.E.3    Kalderon, D.4
  • 45
    • 0029879687 scopus 로고    scopus 로고
    • Protein kinase A is a common negative regulator of Hedgehog signaling in the vertebrate embryo
    • Hammerschmidt M, Bitgood MJ, McMahon AP: Protein kinase A is a common negative regulator of Hedgehog signaling in the vertebrate embryo. Genes Dev 1996, 10:647-658.
    • (1996) Genes Dev , vol.10 , pp. 647-658
    • Hammerschmidt, M.1    Bitgood, M.J.2    McMahon, A.P.3
  • 46
    • 0032478107 scopus 로고    scopus 로고
    • Protein kinase A directly regulates the activity and proteolysis of cubitus interruptus
    • Chen Y, Gallaher N, Goodman RH, Smolik SM: Protein kinase A directly regulates the activity and proteolysis of cubitus interruptus. Proc Natl Acad Sci USA 1998, 95:2349-2354.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 2349-2354
    • Chen, Y.1    Gallaher, N.2    Goodman, R.H.3    Smolik, S.M.4
  • 48
    • 0030901264 scopus 로고    scopus 로고
    • Drosophila CBP is a co-activator of cubitus interruptus in hedgehog signalling
    • Akimaru H, Chen Y, Dai P, Hou DX, Nonaka M, Smolik SM, et al.: Drosophila CBP is a co-activator of cubitus interruptus in hedgehog signalling. Nature 1997, 386:735-738.
    • (1997) Nature , vol.386 , pp. 735-738
    • Akimaru, H.1    Chen, Y.2    Dai, P.3    Hou, D.X.4    Nonaka, M.5    Smolik, S.M.6
  • 49
    • 0030984470 scopus 로고    scopus 로고
    • Dual pathways for induction of wingless expression by protein kinase A and Hedgehog in Drosophila embryos
    • Ohlmeyer JT, Kalderon D: Dual pathways for induction of wingless expression by protein kinase A and Hedgehog in Drosophila embryos. Genes Dev 1997, 11:2250-2258.
    • (1997) Genes Dev , vol.11 , pp. 2250-2258
    • Ohlmeyer, J.T.1    Kalderon, D.2
  • 50
    • 0030809962 scopus 로고    scopus 로고
    • Turning off the signal: Mechanisms that attenuate signaling by G protein-coupled receptors
    • Grady EF, Bohm SK, Bunnett NW: Turning off the signal: Mechanisms that attenuate signaling by G protein-coupled receptors. Am J Physiol 1997, 273:G586-601.
    • (1997) Am J Physiol , vol.273
    • Grady, E.F.1    Bohm, S.K.2    Bunnett, N.W.3
  • 51
    • 0022749655 scopus 로고
    • Neutralization of the AIDS retrovirus by antibodies to a recombinant envelope glycoprotein
    • Lasky LA, Groopman JE, Fennie CW, Benz PM, Capon DJ, Dowbenko DJ, et al.: Neutralization of the AIDS retrovirus by antibodies to a recombinant envelope glycoprotein. Science 1986, 233:209-212.
    • (1986) Science , vol.233 , pp. 209-212
    • Lasky, L.A.1    Groopman, J.E.2    Fennie, C.W.3    Benz, P.M.4    Capon, D.J.5    Dowbenko, D.J.6
  • 52
    • 0031044566 scopus 로고    scopus 로고
    • Cloning and characterization of a human leptin receptor using a biologically active leptin immunoadhesin
    • Luoh SM, Di Marco F, Levin N, Armanini M, Xie MH, Nelson C, et al.: Cloning and characterization of a human leptin receptor using a biologically active leptin immunoadhesin. J Mol Endocrinol 1997, 18:77-85.
    • (1997) J Mol Endocrinol , vol.18 , pp. 77-85
    • Luoh, S.M.1    Di Marco, F.2    Levin, N.3    Armanini, M.4    Xie, M.H.5    Nelson, C.6


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