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Volumn 223, Issue 2, 2011, Pages 163-177

Jekyll and Hyde: The role of the microenvironment on the progression of cancer

Author keywords

angiogenesis; extracellular matrix; hypoxia; inflammation; microenvironment; tumour associated macrophages

Indexed keywords

APRIL PROTEIN; CHEMOKINE RECEPTOR CXCR4; CONNECTIVE TISSUE GROWTH FACTOR; EPIDERMAL GROWTH FACTOR; FIBRONECTIN; GAMMA INTERFERON; HYPOXIA INDUCIBLE FACTOR 1ALPHA; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MATRIX METALLOPROTEINASE; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROTEIN LYSINE 6 OXIDASE; SCATTER FACTOR; STROMAL CELL DERIVED FACTOR 1; TENASCIN; TRANSFORMING GROWTH FACTOR BETA; UVOMORULIN; VASCULOTROPIN;

EID: 78649997911     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.2803     Document Type: Review
Times cited : (148)

References (197)
  • 1
    • 0035901090 scopus 로고    scopus 로고
    • Inflammation and cancer: Back to Virchow?
    • Balkwill F, Mantovani A,. Inflammation and cancer: back to Virchow? Lancet 2001; 357: 539-545.
    • (2001) Lancet , vol.357 , pp. 539-545
    • Balkwill, F.1    Mantovani, A.2
  • 2
    • 50549121134 scopus 로고
    • The distribution of secondary growths in cancer of the breast
    • Paget S,. The distribution of secondary growths in cancer of the breast. Lancet 1889; 133: 571-573.
    • (1889) Lancet , vol.133 , pp. 571-573
    • Paget, S.1
  • 3
    • 0020456385 scopus 로고
    • How does the extracellular matrix direct gene expression?
    • Bissell MJ, Hall HG, Parry G,. How does the extracellular matrix direct gene expression? J Theor Biol 1982; 99: 31-68.
    • (1982) J Theor Biol , vol.99 , pp. 31-68
    • Bissell, M.J.1    Hall, H.G.2    Parry, G.3
  • 5
    • 18844428327 scopus 로고    scopus 로고
    • Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion
    • Orimo A, Gupta PB, Sgroi DC, et al., Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell 2005; 121: 335-348.
    • (2005) Cell , vol.121 , pp. 335-348
    • Orimo, A.1    Gupta, P.B.2    Sgroi, D.C.3
  • 6
    • 25444506333 scopus 로고    scopus 로고
    • Stromal expression of connective tissue growth factor promotes angiogenesis and prostate cancer tumorigenesis
    • Yang F, Tuxhorn JA, Ressler SJ, et al., Stromal expression of connective tissue growth factor promotes angiogenesis and prostate cancer tumorigenesis. Cancer Res 2005; 65: 8887-8895.
    • (2005) Cancer Res , vol.65 , pp. 8887-8895
    • Yang, F.1    Tuxhorn, J.A.2    Ressler, S.J.3
  • 7
    • 0029808645 scopus 로고    scopus 로고
    • A novel transforming growth factor-β response element controls the expression of the connective tissue growth factor gene
    • Grotendorst GR, Okochi H, Hayashi N,. A novel transforming growth factor-β response element controls the expression of the connective tissue growth factor gene. Cell Growth Differ 1996; 7: 469-480.
    • (1996) Cell Growth Differ , vol.7 , pp. 469-480
    • Grotendorst, G.R.1    Okochi, H.2    Hayashi, N.3
  • 8
    • 0031024116 scopus 로고    scopus 로고
    • Expression of connective tissue growth factor mRNA in the fibrous stroma of mammary tumors
    • Frazier KS, Grotendorst GR,. Expression of connective tissue growth factor mRNA in the fibrous stroma of mammary tumors. Int J Biochem Cell Biol 1997; 29: 153-161.
    • (1997) Int J Biochem Cell Biol , vol.29 , pp. 153-161
    • Frazier, K.S.1    Grotendorst, G.R.2
  • 9
    • 0036548760 scopus 로고    scopus 로고
    • Connective tissue growth factor gene expression alters tumor progression in esophageal cancer
    • Koliopanos A, Friess H, di Mola FF, et al., Connective tissue growth factor gene expression alters tumor progression in esophageal cancer. World J Surg 2002; 26: 420-427.
    • (2002) World J Surg , vol.26 , pp. 420-427
    • Koliopanos, A.1    Friess, H.2    Di Mola, F.F.3
  • 10
    • 0033611584 scopus 로고    scopus 로고
    • Expression and differential regulation of connective tissue growth factor in pancreatic cancer cells
    • Wenger C, Ellenrieder V, Alber B, et al., Expression and differential regulation of connective tissue growth factor in pancreatic cancer cells. Oncogene 1999; 18: 1073-1080.
    • (1999) Oncogene , vol.18 , pp. 1073-1080
    • Wenger, C.1    Ellenrieder, V.2    Alber, B.3
  • 11
    • 0033215242 scopus 로고    scopus 로고
    • Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium
    • Olumi AF, Grossfeld GD, Hayward SW, et al., Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium. Cancer Res 1999; 59: 5002-5011.
    • (1999) Cancer Res , vol.59 , pp. 5002-5011
    • Olumi, A.F.1    Grossfeld, G.D.2    Hayward, S.W.3
  • 12
    • 0842288323 scopus 로고    scopus 로고
    • TGFβ signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia
    • Bhowmick NA, Chytil A, Plieth D, et al., TGFβ signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia. Science 2004; 303: 848-851.
    • (2004) Science , vol.303 , pp. 848-851
    • Bhowmick, N.A.1    Chytil, A.2    Plieth, D.3
  • 13
    • 76349096670 scopus 로고    scopus 로고
    • Cancer-associated fibroblasts are activated in incipient neoplasia to orchestrate tumor-promoting inflammation in an NF-κB-dependent manner
    • Erez N, Truitt M, Olson P, et al., Cancer-associated fibroblasts are activated in incipient neoplasia to orchestrate tumor-promoting inflammation in an NF-κB-dependent manner. Cancer Cell 2010; 17: 135-147.
    • (2010) Cancer Cell , vol.17 , pp. 135-147
    • Erez, N.1    Truitt, M.2    Olson, P.3
  • 14
    • 0031848068 scopus 로고    scopus 로고
    • Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4
    • Korinek V, Barker N, Moerer P, et al., Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4. Nat Genet 1998; 19: 379-383.
    • (1998) Nat Genet , vol.19 , pp. 379-383
    • Korinek, V.1    Barker, N.2    Moerer, P.3
  • 15
    • 18644373146 scopus 로고    scopus 로고
    • The β-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells
    • van de Wetering M, Sancho E, Verweij C, et al., The β-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. Cell 2002; 111: 241-250.
    • (2002) Cell , vol.111 , pp. 241-250
    • Van De Wetering, M.1    Sancho, E.2    Verweij, C.3
  • 16
    • 77951975325 scopus 로고    scopus 로고
    • Wnt activity defines colon cancer stem cells and is regulated by the microenvironment
    • Vermeulen L, De Sousa EMF, van der Heijden M, et al., Wnt activity defines colon cancer stem cells and is regulated by the microenvironment. Nat Cell Biol 2010; 12: 468-476.
    • (2010) Nat Cell Biol , vol.12 , pp. 468-476
    • Vermeulen, L.1    De Sousa, E.M.F.2    Van Der Heijden, M.3
  • 17
    • 32944466121 scopus 로고    scopus 로고
    • Bone marrow-derived stromal cells express lineage-related messenger RNA species
    • Direkze NC, Jeffery R, Hodivala-Dilke K, et al., Bone marrow-derived stromal cells express lineage-related messenger RNA species. Cancer Res 2006; 66: 1265-1269.
    • (2006) Cancer Res , vol.66 , pp. 1265-1269
    • Direkze, N.C.1    Jeffery, R.2    Hodivala-Dilke, K.3
  • 18
    • 34948884579 scopus 로고    scopus 로고
    • Stromal induction of breast cancer: Inflammation and invasion
    • Radisky ES, Radisky DC,. Stromal induction of breast cancer: inflammation and invasion. Rev Endocr Metab Disord 2007; 8: 279-287.
    • (2007) Rev Endocr Metab Disord , vol.8 , pp. 279-287
    • Radisky, E.S.1    Radisky, D.C.2
  • 19
    • 34248564820 scopus 로고    scopus 로고
    • Genomic instability within tumor stroma and clinicopathological characteristics of sporadic primary invasive breast carcinoma
    • Fukino K, Shen L, Patocs A, et al., Genomic instability within tumor stroma and clinicopathological characteristics of sporadic primary invasive breast carcinoma. J Am Med Assoc 2007; 297: 2103-2111.
    • (2007) J Am Med Assoc , vol.297 , pp. 2103-2111
    • Fukino, K.1    Shen, L.2    Patocs, A.3
  • 20
    • 0035445625 scopus 로고    scopus 로고
    • Genetic model of multi-step breast carcinogenesis involving the epithelium and stroma: Clues to tumour-microenvironment interactions
    • Kurose K, Hoshaw-Woodard S, Adeyinka A, et al., Genetic model of multi-step breast carcinogenesis involving the epithelium and stroma: clues to tumour-microenvironment interactions. Hum Mol Genet 2001; 10: 1907-1913.
    • (2001) Hum Mol Genet , vol.10 , pp. 1907-1913
    • Kurose, K.1    Hoshaw-Woodard, S.2    Adeyinka, A.3
  • 21
    • 42549109044 scopus 로고    scopus 로고
    • Macro-environment of breast carcinoma: Frequent genetic alterations in the normal appearing skins of patients with breast cancer
    • Moinfar F, Beham A, Friedrich G, et al., Macro-environment of breast carcinoma: frequent genetic alterations in the normal appearing skins of patients with breast cancer. Mod Pathol 2008; 21: 639-646.
    • (2008) Mod Pathol , vol.21 , pp. 639-646
    • Moinfar, F.1    Beham, A.2    Friedrich, G.3
  • 22
    • 37349101054 scopus 로고    scopus 로고
    • Breast-cancer stromal cells with TP53 mutations and nodal metastases
    • Patocs A, Zhang L, Xu Y, et al., Breast-cancer stromal cells with TP53 mutations and nodal metastases. N Engl J Med 2007; 357: 2543-2551.
    • (2007) N Engl J Med , vol.357 , pp. 2543-2551
    • Patocs, A.1    Zhang, L.2    Xu, Y.3
  • 23
    • 42049091225 scopus 로고    scopus 로고
    • Breast-cancer stromal cells with TP53 mutations
    • author reply, 1636.
    • Campbell IG, Qiu W, Polyak K, et al., Breast-cancer stromal cells with TP53 mutations. N Engl J Med 2008; 358: 1634-1635; author reply, 1636.
    • (2008) N Engl J Med , vol.358 , pp. 1634-1635
    • Campbell, I.G.1    Qiu, W.2    Polyak, K.3
  • 24
    • 42549152045 scopus 로고    scopus 로고
    • No evidence of clonal somatic genetic alterations in cancer-associated fibroblasts from human breast and ovarian carcinomas
    • Qiu W, Hu M, Sridhar A, et al., No evidence of clonal somatic genetic alterations in cancer-associated fibroblasts from human breast and ovarian carcinomas. Nat Genet 2008; 40: 650-655.
    • (2008) Nat Genet , vol.40 , pp. 650-655
    • Qiu, W.1    Hu, M.2    Sridhar, A.3
  • 25
    • 0025150148 scopus 로고
    • Altered methylation of versican proteoglycan gene in human colon carcinoma
    • Adany R, Iozzo RV,. Altered methylation of versican proteoglycan gene in human colon carcinoma. Biochem Biophys Res Commun 1990; 171: 1402-1413.
    • (1990) Biochem Biophys Res Commun , vol.171 , pp. 1402-1413
    • Adany, R.1    Iozzo, R.V.2
  • 26
    • 23044499067 scopus 로고    scopus 로고
    • Distinct epigenetic changes in the stromal cells of breast cancers
    • Hu M, Yao J, Cai L, et al., Distinct epigenetic changes in the stromal cells of breast cancers. Nat Genet 2005; 37: 899-905.
    • (2005) Nat Genet , vol.37 , pp. 899-905
    • Hu, M.1    Yao, J.2    Cai, L.3
  • 27
    • 0035328461 scopus 로고    scopus 로고
    • Evidence of DNA repair/processing defects in cultured skin fibroblasts from breast cancer patients
    • Hannan MA, Siddiqui Y, Rostom A, et al., Evidence of DNA repair/processing defects in cultured skin fibroblasts from breast cancer patients. Cancer Res 2001; 61: 3627-3631.
    • (2001) Cancer Res , vol.61 , pp. 3627-3631
    • Hannan, M.A.1    Siddiqui, Y.2    Rostom, A.3
  • 28
    • 0035720007 scopus 로고    scopus 로고
    • Phenotypic and genetic alterations in mammary stroma: Implications for tumour progression
    • Schor SL, Schor AM,. Phenotypic and genetic alterations in mammary stroma: implications for tumour progression. Breast Cancer Res 2001; 3: 373-379.
    • (2001) Breast Cancer Res , vol.3 , pp. 373-379
    • Schor, S.L.1    Schor, A.M.2
  • 29
    • 0033742833 scopus 로고    scopus 로고
    • Polymorphism in matrix metalloproteinase gene promoters: Implication in regulation of gene expression and susceptibility of various diseases
    • Ye S,. Polymorphism in matrix metalloproteinase gene promoters: implication in regulation of gene expression and susceptibility of various diseases. Matrix Biol 2000; 19: 623-629.
    • (2000) Matrix Biol , vol.19 , pp. 623-629
    • Ye, S.1
  • 30
    • 0037058723 scopus 로고    scopus 로고
    • Association of functional polymorphisms of matrix metalloproteinase (MMP)-1 and MMP-3 genes with colorectal cancer
    • Hinoda Y, Okayama N, Takano N, et al., Association of functional polymorphisms of matrix metalloproteinase (MMP)-1 and MMP-3 genes with colorectal cancer. Int J Cancer 2002; 102: 526-529.
    • (2002) Int J Cancer , vol.102 , pp. 526-529
    • Hinoda, Y.1    Okayama, N.2    Takano, N.3
  • 31
    • 36549041840 scopus 로고    scopus 로고
    • Intrinsic genetic characteristics determine tumor-modifying capacity of fibroblasts: Matrix metalloproteinase-3 5A/5A genotype enhances breast cancer cell invasion
    • Holliday DL, Hughes S, Shaw JA, et al., Intrinsic genetic characteristics determine tumor-modifying capacity of fibroblasts: matrix metalloproteinase-3 5A/5A genotype enhances breast cancer cell invasion. Breast Cancer Res 2007; 9: R67.
    • (2007) Breast Cancer Res , vol.9
    • Holliday, D.L.1    Hughes, S.2    Shaw, J.A.3
  • 32
    • 32944479186 scopus 로고    scopus 로고
    • Germ line polymorphism in metastatic progression
    • Hunter KW, Crawford NP,. Germ line polymorphism in metastatic progression. Cancer Res 2006; 66: 1251-1254.
    • (2006) Cancer Res , vol.66 , pp. 1251-1254
    • Hunter, K.W.1    Crawford, N.P.2
  • 33
    • 23744515305 scopus 로고    scopus 로고
    • Modeling dynamic reciprocity: Engineering three-dimensional culture models of breast architecture, function, and neoplastic transformation
    • Nelson CM, Bissell MJ,. Modeling dynamic reciprocity: engineering three-dimensional culture models of breast architecture, function, and neoplastic transformation. Semin Cancer Biol 2005; 15: 342-352.
    • (2005) Semin Cancer Biol , vol.15 , pp. 342-352
    • Nelson, C.M.1    Bissell, M.J.2
  • 34
    • 0033731472 scopus 로고    scopus 로고
    • Tenascin-C in development and disease: Gene regulation and cell function
    • Jones PL, Jones FS,. Tenascin-C in development and disease: gene regulation and cell function. Matrix Biol 2000; 19: 581-596.
    • (2000) Matrix Biol , vol.19 , pp. 581-596
    • Jones, P.L.1    Jones, F.S.2
  • 35
    • 67649415956 scopus 로고    scopus 로고
    • Role of fibrillar Tenascin-C in metastatic pancreatic cancer
    • Chen J, Chen Z, Chen M, et al., Role of fibrillar Tenascin-C in metastatic pancreatic cancer. Int J Oncol 2009; 34: 1029-1036.
    • (2009) Int J Oncol , vol.34 , pp. 1029-1036
    • Chen, J.1    Chen, Z.2    Chen, M.3
  • 36
    • 3242664404 scopus 로고    scopus 로고
    • MRNA expression and protein distribution of the unspliced tenascin-C isoform in prostatic adenocarcinoma
    • Katenkamp K, Berndt A, Hindermann W, et al., mRNA expression and protein distribution of the unspliced tenascin-C isoform in prostatic adenocarcinoma. J Pathol 2004; 203: 771-779.
    • (2004) J Pathol , vol.203 , pp. 771-779
    • Katenkamp, K.1    Berndt, A.2    Hindermann, W.3
  • 37
    • 0032932980 scopus 로고    scopus 로고
    • Identification of a glioblastoma-associated tenascin-C isoform by a high affinity recombinant antibody
    • Carnemolla B, Castellani P, Ponassi M, et al., Identification of a glioblastoma-associated tenascin-C isoform by a high affinity recombinant antibody. Am J Pathol 1999; 154: 1345-1352.
    • (1999) Am J Pathol , vol.154 , pp. 1345-1352
    • Carnemolla, B.1    Castellani, P.2    Ponassi, M.3
  • 38
    • 0036606644 scopus 로고    scopus 로고
    • Changes in tenascin-C isoform expression in invasive and preinvasive breast disease
    • Adams M, Jones JL, Walker RA, et al., Changes in tenascin-C isoform expression in invasive and preinvasive breast disease. Cancer Res 2002; 62: 3289-3297.
    • (2002) Cancer Res , vol.62 , pp. 3289-3297
    • Adams, M.1    Jones, J.L.2    Walker, R.A.3
  • 39
    • 0032944478 scopus 로고    scopus 로고
    • Regulation and function of the extracellular matrix protein tenascin-C in ovarian cancer cell lines
    • Wilson KE, Bartlett JM, Miller EP, et al., Regulation and function of the extracellular matrix protein tenascin-C in ovarian cancer cell lines. Br J Cancer 1999; 80: 685-692.
    • (1999) Br J Cancer , vol.80 , pp. 685-692
    • Wilson, K.E.1    Bartlett, J.M.2    Miller, E.P.3
  • 40
    • 68349100337 scopus 로고    scopus 로고
    • Tumour-associated tenascin-C isoforms promote breast cancer cell invasion and growth by matrix metalloproteinase-dependent and independent mechanisms
    • Hancox RA, Allen MD, Holliday DL, et al., Tumour-associated tenascin-C isoforms promote breast cancer cell invasion and growth by matrix metalloproteinase-dependent and independent mechanisms. Breast Cancer Res 2009; 11: R24.
    • (2009) Breast Cancer Res , vol.11
    • Hancox, R.A.1    Allen, M.D.2    Holliday, D.L.3
  • 41
    • 0032961299 scopus 로고    scopus 로고
    • Neurite outgrowth promotion by the alternatively spliced region of tenascin-C is influenced by cell-type specific binding
    • Meiners S, Powell EM, Geller HM,. Neurite outgrowth promotion by the alternatively spliced region of tenascin-C is influenced by cell-type specific binding. Matrix Biol 1999; 18: 75-87.
    • (1999) Matrix Biol , vol.18 , pp. 75-87
    • Meiners, S.1    Powell, E.M.2    Geller, H.M.3
  • 42
    • 33846253207 scopus 로고    scopus 로고
    • Tenascin-C stimulates glioma cell invasion through matrix metalloproteinase-12
    • Sarkar S, Nuttall RK, Liu S, et al., Tenascin-C stimulates glioma cell invasion through matrix metalloproteinase-12. Cancer Res 2006; 66: 11771-11780.
    • (2006) Cancer Res , vol.66 , pp. 11771-11780
    • Sarkar, S.1    Nuttall, R.K.2    Liu, S.3
  • 43
    • 50249176028 scopus 로고    scopus 로고
    • New insights into form and function of fibronectin splice variants
    • White ES, Baralle FE, Muro AF,. New insights into form and function of fibronectin splice variants. J Pathol 2008; 216: 1-14.
    • (2008) J Pathol , vol.216 , pp. 1-14
    • White, E.S.1    Baralle, F.E.2    Muro, A.F.3
  • 44
    • 0027315769 scopus 로고
    • Coordinate oncodevelopmental modulation of alternative splicing of fibronectin pre-messenger RNA at ED-A, ED-B, and CS1 regions in human liver tumors
    • Oyama F, Hirohashi S, Sakamoto M, et al., Coordinate oncodevelopmental modulation of alternative splicing of fibronectin pre-messenger RNA at ED-A, ED-B, and CS1 regions in human liver tumors. Cancer Res 1993; 53: 2005-2011.
    • (1993) Cancer Res , vol.53 , pp. 2005-2011
    • Oyama, F.1    Hirohashi, S.2    Sakamoto, M.3
  • 45
    • 0031828004 scopus 로고    scopus 로고
    • The fibronectin domain ED-A is crucial for myofibroblastic phenotype induction by transforming growth factor-β1
    • Serini G, Bochaton-Piallat ML, Ropraz P, et al., The fibronectin domain ED-A is crucial for myofibroblastic phenotype induction by transforming growth factor-β1. J Cell Biol 1998; 142: 873-881.
    • (1998) J Cell Biol , vol.142 , pp. 873-881
    • Serini, G.1    Bochaton-Piallat, M.L.2    Ropraz, P.3
  • 46
    • 0028131531 scopus 로고
    • Distribution of oncofetal fibronectin isoforms in normal, hyperplastic and neoplastic human breast tissues
    • Kaczmarek J, Castellani P, Nicolo G, et al., Distribution of oncofetal fibronectin isoforms in normal, hyperplastic and neoplastic human breast tissues. Int J Cancer 1994; 59: 11-16.
    • (1994) Int J Cancer , vol.59 , pp. 11-16
    • Kaczmarek, J.1    Castellani, P.2    Nicolo, G.3
  • 47
    • 0036841992 scopus 로고    scopus 로고
    • Differentiation between high- and low-grade astrocytoma using a human recombinant antibody to the extra domain-B of fibronectin
    • Castellani P, Borsi L, Carnemolla B, et al., Differentiation between high- and low-grade astrocytoma using a human recombinant antibody to the extra domain-B of fibronectin. Am J Pathol 2002; 161: 1695-1700.
    • (2002) Am J Pathol , vol.161 , pp. 1695-1700
    • Castellani, P.1    Borsi, L.2    Carnemolla, B.3
  • 48
    • 33644518982 scopus 로고    scopus 로고
    • Fibronectin as target for tumor therapy
    • Kaspar M, Zardi L, Neri D,. Fibronectin as target for tumor therapy. Int J Cancer 2006; 118: 1331-1339.
    • (2006) Int J Cancer , vol.118 , pp. 1331-1339
    • Kaspar, M.1    Zardi, L.2    Neri, D.3
  • 49
    • 24944547482 scopus 로고    scopus 로고
    • Tensional homeostasis and the malignant phenotype
    • Paszek MJ, Zahir N, Johnson KR, et al., Tensional homeostasis and the malignant phenotype. Cancer Cell 2005; 8: 241-254.
    • (2005) Cancer Cell , vol.8 , pp. 241-254
    • Paszek, M.J.1    Zahir, N.2    Johnson, K.R.3
  • 50
    • 33747152561 scopus 로고    scopus 로고
    • Matrix elasticity directs stem cell lineage specification
    • Engler AJ, Sen S, Sweeney HL, et al., Matrix elasticity directs stem cell lineage specification. Cell 2006; 126: 677-689.
    • (2006) Cell , vol.126 , pp. 677-689
    • Engler, A.J.1    Sen, S.2    Sweeney, H.L.3
  • 51
    • 0037371153 scopus 로고    scopus 로고
    • Lysyl oxidase: Properties, specificity, and biological roles inside and outside of the cell
    • Kagan HM, Li W,. Lysyl oxidase: properties, specificity, and biological roles inside and outside of the cell. J Cell Biochem 2003; 88: 660-672.
    • (2003) J Cell Biochem , vol.88 , pp. 660-672
    • Kagan, H.M.1    Li, W.2
  • 52
    • 70450222098 scopus 로고    scopus 로고
    • Matrix crosslinking forces tumor progression by enhancing integrin signaling
    • Levental KR, Yu H, Kass L, et al., Matrix crosslinking forces tumor progression by enhancing integrin signaling. Cell 2009; 139: 891-906.
    • (2009) Cell , vol.139 , pp. 891-906
    • Levental, K.R.1    Yu, H.2    Kass, L.3
  • 53
    • 43149112727 scopus 로고    scopus 로고
    • Mammographic density. Potential mechanisms of breast cancer risk associated with mammographic density: Hypotheses based on epidemiological evidence
    • Martin LJ, Boyd NF,. Mammographic density. Potential mechanisms of breast cancer risk associated with mammographic density: hypotheses based on epidemiological evidence. Breast Cancer Res 2008; 10: 201.
    • (2008) Breast Cancer Res , vol.10 , pp. 201
    • Martin, L.J.1    Boyd, N.F.2
  • 54
    • 0036512208 scopus 로고    scopus 로고
    • New functions for the matrix metalloproteinases in cancer progression
    • Egeblad M, Werb Z,. New functions for the matrix metalloproteinases in cancer progression. Nat Rev Cancer 2002; 2: 161-174.
    • (2002) Nat Rev Cancer , vol.2 , pp. 161-174
    • Egeblad, M.1    Werb, Z.2
  • 55
    • 0037192458 scopus 로고    scopus 로고
    • Matrix metalloproteinase inhibitors and cancer: Trials and tribulations
    • Coussens LM, Fingleton B, Matrisian LM,. Matrix metalloproteinase inhibitors and cancer: trials and tribulations. Science 2002; 295: 2387-2392.
    • (2002) Science , vol.295 , pp. 2387-2392
    • Coussens, L.M.1    Fingleton, B.2    Matrisian, L.M.3
  • 56
    • 42349115927 scopus 로고    scopus 로고
    • Matrix metalloproteinase-8 functions as a metastasis suppressor through modulation of tumor cell adhesion and invasion
    • Gutierrez-Fernandez A, Fueyo A, Folgueras AR, et al., Matrix metalloproteinase-8 functions as a metastasis suppressor through modulation of tumor cell adhesion and invasion. Cancer Res 2008; 68: 2755-2763.
    • (2008) Cancer Res , vol.68 , pp. 2755-2763
    • Gutierrez-Fernandez, A.1    Fueyo, A.2    Folgueras, A.R.3
  • 57
    • 33745700206 scopus 로고    scopus 로고
    • Macrophage elastase (matrix metalloproteinase-12) suppresses growth of lung metastases
    • Houghton AM, Grisolano JL, Baumann ML, et al., Macrophage elastase (matrix metalloproteinase-12) suppresses growth of lung metastases. Cancer Res 2006; 66: 6149-6155.
    • (2006) Cancer Res , vol.66 , pp. 6149-6155
    • Houghton, A.M.1    Grisolano, J.L.2    Baumann, M.L.3
  • 58
    • 0034691828 scopus 로고    scopus 로고
    • The human myoepithelial cell displays a multifaceted anti-angiogenic phenotype
    • Nguyen M, Lee MC, Wang JL, et al., The human myoepithelial cell displays a multifaceted anti-angiogenic phenotype. Oncogene 2000; 19: 3449-3459.
    • (2000) Oncogene , vol.19 , pp. 3449-3459
    • Nguyen, M.1    Lee, M.C.2    Wang, J.L.3
  • 60
    • 1342269681 scopus 로고    scopus 로고
    • Primary breast myoepithelial cells exert an invasion-suppressor effect on breast cancer cells via paracrine down-regulation of MMP expression in fibroblasts and tumour cells
    • Jones JL, Shaw JA, Pringle JH, et al., Primary breast myoepithelial cells exert an invasion-suppressor effect on breast cancer cells via paracrine down-regulation of MMP expression in fibroblasts and tumour cells. J Pathol 2003; 201: 562-572.
    • (2003) J Pathol , vol.201 , pp. 562-572
    • Jones, J.L.1    Shaw, J.A.2    Pringle, J.H.3
  • 61
    • 0030665289 scopus 로고    scopus 로고
    • The human myoepithelial cell is a natural tumor suppressor
    • Sternlicht MD, Kedeshian P, Shao ZM, et al., The human myoepithelial cell is a natural tumor suppressor. Clin Cancer Res 1997; 3: 1949-1958.
    • (1997) Clin Cancer Res , vol.3 , pp. 1949-1958
    • Sternlicht, M.D.1    Kedeshian, P.2    Shao, Z.M.3
  • 62
    • 0028806271 scopus 로고
    • Expression of hemidesmosomes and component proteins is lost by invasive breast cancer cells
    • Bergstraesser LM, Srinivasan G, Jones JC, et al., Expression of hemidesmosomes and component proteins is lost by invasive breast cancer cells. Am J Pathol 1995; 147: 1823-1839.
    • (1995) Am J Pathol , vol.147 , pp. 1823-1839
    • Bergstraesser, L.M.1    Srinivasan, G.2    Jones, J.C.3
  • 64
    • 0036088478 scopus 로고    scopus 로고
    • Mechanisms of normal and tumor-derived angiogenesis
    • Papetti M, Herman IM,. Mechanisms of normal and tumor-derived angiogenesis. Am J Physiol Cell Physiol 2002; 282: C947-970.
    • (2002) Am J Physiol Cell Physiol , vol.282
    • Papetti, M.1    Herman, I.M.2
  • 65
    • 0034979159 scopus 로고    scopus 로고
    • Vascular endothelial growth factor and vascular adjustments to perturbations in oxygen homeostasis
    • Dor Y, Porat R, Keshet E,. Vascular endothelial growth factor and vascular adjustments to perturbations in oxygen homeostasis. Am J Physiol Cell Physiol 2001; 280: C1367-1374.
    • (2001) Am J Physiol Cell Physiol , vol.280
    • Dor, Y.1    Porat, R.2    Keshet, E.3
  • 66
    • 0033571682 scopus 로고    scopus 로고
    • Overexpression of hypoxia-inducible factor 1α in common human cancers and their metastases
    • Zhong H, De Marzo AM, Laughner E, et al., Overexpression of hypoxia-inducible factor 1α in common human cancers and their metastases. Cancer Res 1999; 59: 5830-5835.
    • (1999) Cancer Res , vol.59 , pp. 5830-5835
    • Zhong, H.1    De Marzo, A.M.2    Laughner, E.3
  • 67
    • 0030742027 scopus 로고    scopus 로고
    • Tumor hypoxia adversely affects the prognosis of carcinoma of the head and neck
    • Brizel DM, Sibley GS, Prosnitz LR, et al., Tumor hypoxia adversely affects the prognosis of carcinoma of the head and neck. Int J Radiat Oncol Biol Phys 1997; 38: 285-289.
    • (1997) Int J Radiat Oncol Biol Phys , vol.38 , pp. 285-289
    • Brizel, D.M.1    Sibley, G.S.2    Prosnitz, L.R.3
  • 68
    • 0031688165 scopus 로고    scopus 로고
    • Tumour hypoxia and vascular density as predictors of metastasis in squamous cell carcinoma of the uterine cervix
    • Sundfor K, Lyng H, Rofstad EK,. Tumour hypoxia and vascular density as predictors of metastasis in squamous cell carcinoma of the uterine cervix. Br J Cancer 1998; 78: 822-827. (Pubitemid 28418321)
    • (1998) British Journal of Cancer , vol.78 , Issue.6 , pp. 822-827
    • Sundfor, K.1    Lyng, H.2    Rofstad, E.K.3
  • 69
    • 77954564670 scopus 로고    scopus 로고
    • Hypoxia and metabolic phenotypes during breast carcinogenesis: Expression of HIF-1α, GLUT1, and CAIX
    • Chen CL, Chu JS, Su WC, et al., Hypoxia and metabolic phenotypes during breast carcinogenesis: expression of HIF-1α, GLUT1, and CAIX. Virchows Arch 2010; 457: 53-61.
    • (2010) Virchows Arch , vol.457 , pp. 53-61
    • Chen, C.L.1    Chu, J.S.2    Su, W.C.3
  • 70
    • 0032581277 scopus 로고    scopus 로고
    • Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
    • Carmeliet P, Dor Y, Herbert JM, et al., Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature 1998; 394: 485-490.
    • (1998) Nature , vol.394 , pp. 485-490
    • Carmeliet, P.1    Dor, Y.2    Herbert, J.M.3
  • 71
    • 0035399174 scopus 로고    scopus 로고
    • Oxygen-mediated regulation of gelatinase and tissue inhibitor of metalloproteinases-1 expression by invasive cells
    • Canning MT, Postovit LM, Clarke SH, et al., Oxygen-mediated regulation of gelatinase and tissue inhibitor of metalloproteinases-1 expression by invasive cells. Exp Cell Res 2001; 267: 88-94.
    • (2001) Exp Cell Res , vol.267 , pp. 88-94
    • Canning, M.T.1    Postovit, L.M.2    Clarke, S.H.3
  • 72
    • 33645748171 scopus 로고    scopus 로고
    • Regulation of E-cadherin expression by VHL and hypoxia-inducible factor
    • Esteban MA, Tran MG, Harten SK, et al., Regulation of E-cadherin expression by VHL and hypoxia-inducible factor. Cancer Res 2006; 66: 3567-3575.
    • (2006) Cancer Res , vol.66 , pp. 3567-3575
    • Esteban, M.A.1    Tran, M.G.2    Harten, S.K.3
  • 73
    • 33644614520 scopus 로고    scopus 로고
    • HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
    • Kim JW, Tchernyshyov I, Semenza GL, et al., HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. Cell Metab 2006; 3: 177-185.
    • (2006) Cell Metab , vol.3 , pp. 177-185
    • Kim, J.W.1    Tchernyshyov, I.2    Semenza, G.L.3
  • 74
    • 32244443542 scopus 로고    scopus 로고
    • Alterations in DNA repair gene expression under hypoxia: Elucidating the mechanisms of hypoxia-induced genetic instability
    • Bindra RS, Schaffer PJ, Meng A, et al., Alterations in DNA repair gene expression under hypoxia: elucidating the mechanisms of hypoxia-induced genetic instability. Ann NY Acad Sci 2005; 1059: 184-195.
    • (2005) Ann NY Acad Sci , vol.1059 , pp. 184-195
    • Bindra, R.S.1    Schaffer, P.J.2    Meng, A.3
  • 75
    • 0035881307 scopus 로고    scopus 로고
    • Hypoxia and acidosis independently up-regulate vascular endothelial growth factor transcription in brain tumors in vivo
    • Fukumura D, Xu L, Chen Y, et al., Hypoxia and acidosis independently up-regulate vascular endothelial growth factor transcription in brain tumors in vivo. Cancer Res 2001; 61: 6020-6024.
    • (2001) Cancer Res , vol.61 , pp. 6020-6024
    • Fukumura, D.1    Xu, L.2    Chen, Y.3
  • 76
    • 0033693293 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF) modulation by targeting hypoxia-inducible factor-1α→ hypoxia response element → VEGF cascade differentially regulates vascular response and growth rate in tumors
    • Tsuzuki Y, Fukumura D, Oosthuyse B, et al., Vascular endothelial growth factor (VEGF) modulation by targeting hypoxia-inducible factor-1α→ hypoxia response element → VEGF cascade differentially regulates vascular response and growth rate in tumors. Cancer Res 2000; 60: 6248-6252.
    • (2000) Cancer Res , vol.60 , pp. 6248-6252
    • Tsuzuki, Y.1    Fukumura, D.2    Oosthuyse, B.3
  • 77
    • 0030576517 scopus 로고    scopus 로고
    • Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
    • Hanahan D, Folkman J,. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 1996; 86: 353-364.
    • (1996) Cell , vol.86 , pp. 353-364
    • Hanahan, D.1    Folkman, J.2
  • 78
    • 68049105076 scopus 로고    scopus 로고
    • Role of hypoxia in the hallmarks of human cancer
    • Ruan K, Song G, Ouyang G,. Role of hypoxia in the hallmarks of human cancer. J Cell Biochem 2009; 107: 1053-1062.
    • (2009) J Cell Biochem , vol.107 , pp. 1053-1062
    • Ruan, K.1    Song, G.2    Ouyang, G.3
  • 79
    • 0026485002 scopus 로고
    • Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
    • Shweiki D, Itin A, Soffer D, et al., Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 1992; 359: 843-845.
    • (1992) Nature , vol.359 , pp. 843-845
    • Shweiki, D.1    Itin, A.2    Soffer, D.3
  • 80
    • 0033924882 scopus 로고    scopus 로고
    • Opposing effects of hypoxia on expression of the angiogenic inhibitor thrombospondin 1 and the angiogenic inducer vascular endothelial growth factor
    • Laderoute KR, Alarcon RM, Brody MD, et al., Opposing effects of hypoxia on expression of the angiogenic inhibitor thrombospondin 1 and the angiogenic inducer vascular endothelial growth factor. Clin Cancer Res 2000; 6: 2941-2950.
    • (2000) Clin Cancer Res , vol.6 , pp. 2941-2950
    • Laderoute, K.R.1    Alarcon, R.M.2    Brody, M.D.3
  • 81
    • 70549112270 scopus 로고    scopus 로고
    • The angiogenic switch in carcinogenesis
    • Baeriswyl V, Christofori G,. The angiogenic switch in carcinogenesis. Semin Cancer Biol 2009; 19: 329-337.
    • (2009) Semin Cancer Biol , vol.19 , pp. 329-337
    • Baeriswyl, V.1    Christofori, G.2
  • 82
    • 0037967272 scopus 로고    scopus 로고
    • Tumorigenesis and the angiogenic switch
    • Bergers G, Benjamin LE,. Tumorigenesis and the angiogenic switch. Nat Rev Cancer 2003; 3: 401-410.
    • (2003) Nat Rev Cancer , vol.3 , pp. 401-410
    • Bergers, G.1    Benjamin, L.E.2
  • 83
    • 70450176108 scopus 로고    scopus 로고
    • Targeting vascular endothelial growth factor in renal cell carcinoma
    • Patel NS, Muneer A, Blick C, et al., Targeting vascular endothelial growth factor in renal cell carcinoma. Tumour Biol 2009; 30: 292-299.
    • (2009) Tumour Biol , vol.30 , pp. 292-299
    • Patel, N.S.1    Muneer, A.2    Blick, C.3
  • 84
    • 33646365644 scopus 로고    scopus 로고
    • Lysyl oxidase is essential for hypoxia-induced metastasis
    • Erler JT, Bennewith KL, Nicolau M, et al., Lysyl oxidase is essential for hypoxia-induced metastasis. Nature 2006; 440: 1222-1226.
    • (2006) Nature , vol.440 , pp. 1222-1226
    • Erler, J.T.1    Bennewith, K.L.2    Nicolau, M.3
  • 85
    • 0037478437 scopus 로고    scopus 로고
    • Hypoxia promotes invasive growth by transcriptional activation of the met proto-oncogene
    • Pennacchietti S, Michieli P, Galluzzo M, et al., Hypoxia promotes invasive growth by transcriptional activation of the met proto-oncogene. Cancer Cell 2003; 3: 347-361.
    • (2003) Cancer Cell , vol.3 , pp. 347-361
    • Pennacchietti, S.1    Michieli, P.2    Galluzzo, M.3
  • 86
    • 35448976966 scopus 로고    scopus 로고
    • Role of Wnt/β-catenin signaling pathway in epithelial-mesenchymal transition of human prostate cancer induced by hypoxia-inducible factor-1α
    • Jiang YG, Luo Y, He DL, et al., Role of Wnt/β-catenin signaling pathway in epithelial-mesenchymal transition of human prostate cancer induced by hypoxia-inducible factor-1α. Int J Urol 2007; 14: 1034-1039.
    • (2007) Int J Urol , vol.14 , pp. 1034-1039
    • Jiang, Y.G.1    Luo, Y.2    He, D.L.3
  • 87
    • 0037050723 scopus 로고    scopus 로고
    • Somatic mutations of the lysyl oxidase gene on chromosome 5q23.1 in colorectal tumors
    • Csiszar K, Fong SF, Ujfalusi A, et al., Somatic mutations of the lysyl oxidase gene on chromosome 5q23.1 in colorectal tumors. Int J Cancer 2002; 97: 636-642.
    • (2002) Int J Cancer , vol.97 , pp. 636-642
    • Csiszar, K.1    Fong, S.F.2    Ujfalusi, A.3
  • 88
    • 4644256597 scopus 로고    scopus 로고
    • Lysyl oxidase is a tumor suppressor gene inactivated by methylation and loss of heterozygosity in human gastric cancers
    • Kaneda A, Wakazono K, Tsukamoto T, et al., Lysyl oxidase is a tumor suppressor gene inactivated by methylation and loss of heterozygosity in human gastric cancers. Cancer Res 2004; 64: 6410-6415.
    • (2004) Cancer Res , vol.64 , pp. 6410-6415
    • Kaneda, A.1    Wakazono, K.2    Tsukamoto, T.3
  • 89
    • 0141988559 scopus 로고    scopus 로고
    • Molecular mechanisms of tumor invasion and metastasis: An integrated view
    • Cairns RA, Khokha R, Hill RP,. Molecular mechanisms of tumor invasion and metastasis: an integrated view. Curr Mol Med 2003; 3: 659-671.
    • (2003) Curr Mol Med , vol.3 , pp. 659-671
    • Cairns, R.A.1    Khokha, R.2    Hill, R.P.3
  • 90
    • 20144386127 scopus 로고    scopus 로고
    • Robustness, scalability, and integration of a wound-response gene expression signature in predicting breast cancer survival
    • Chang HY, Nuyten DS, Sneddon JB, et al., Robustness, scalability, and integration of a wound-response gene expression signature in predicting breast cancer survival. Proc Natl Acad Sci USA 2005; 102: 3738-3743.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 3738-3743
    • Chang, H.Y.1    Nuyten, D.S.2    Sneddon, J.B.3
  • 91
    • 5644282650 scopus 로고    scopus 로고
    • Identification of hypoxia-regulated proteins in head and neck cancer by proteomic and tissue array profiling
    • Chen Y, Shi G, Xia W, et al., Identification of hypoxia-regulated proteins in head and neck cancer by proteomic and tissue array profiling. Cancer Res 2004; 64: 7302-7310.
    • (2004) Cancer Res , vol.64 , pp. 7302-7310
    • Chen, Y.1    Shi, G.2    Xia, W.3
  • 92
    • 29244436384 scopus 로고    scopus 로고
    • Lysyl oxidase regulates breast cancer cell migration and adhesion through a hydrogen peroxide-mediated mechanism
    • Payne SL, Fogelgren B, Hess AR, et al., Lysyl oxidase regulates breast cancer cell migration and adhesion through a hydrogen peroxide-mediated mechanism. Cancer Res 2005; 65: 11429-11436.
    • (2005) Cancer Res , vol.65 , pp. 11429-11436
    • Payne, S.L.1    Fogelgren, B.2    Hess, A.R.3
  • 93
    • 70350728931 scopus 로고    scopus 로고
    • Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation
    • Solinas G, Germano G, Mantovani A, et al., Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation. J Leukoc Biol 2009; 86: 1065-1073.
    • (2009) J Leukoc Biol , vol.86 , pp. 1065-1073
    • Solinas, G.1    Germano, G.2    Mantovani, A.3
  • 94
    • 67650151005 scopus 로고    scopus 로고
    • Cancer-related inflammation, the seventh hallmark of cancer: Links to genetic instability
    • Colotta F, Allavena P, Sica A, et al., Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability. Carcinogenesis 2009; 30: 1073-1081.
    • (2009) Carcinogenesis , vol.30 , pp. 1073-1081
    • Colotta, F.1    Allavena, P.2    Sica, A.3
  • 95
    • 39649098678 scopus 로고    scopus 로고
    • Tumour immunity: Effector response to tumour and role of the microenvironment
    • Mantovani A, Romero P, Palucka AK, et al., Tumour immunity: effector response to tumour and role of the microenvironment. Lancet 2008; 371: 771-783.
    • (2008) Lancet , vol.371 , pp. 771-783
    • Mantovani, A.1    Romero, P.2    Palucka, A.K.3
  • 96
    • 0035911221 scopus 로고    scopus 로고
    • Colony-stimulating factor 1 promotes progression of mammary tumors to malignancy
    • Lin EY, Nguyen AV, Russell RG, et al., Colony-stimulating factor 1 promotes progression of mammary tumors to malignancy. J Exp Med 2001; 193: 727-740.
    • (2001) J Exp Med , vol.193 , pp. 727-740
    • Lin, E.Y.1    Nguyen, A.V.2    Russell, R.G.3
  • 97
    • 68749109536 scopus 로고    scopus 로고
    • A distinct macrophage population mediates metastatic breast cancer cell extravasation, establishment and growth
    • Qian B, Deng Y, Im JH, et al., A distinct macrophage population mediates metastatic breast cancer cell extravasation, establishment and growth. PLoS One 2009; 4: e6562.
    • (2009) PLoS One , vol.4
    • Qian, B.1    Deng, Y.2    Im, J.H.3
  • 98
    • 76249106734 scopus 로고    scopus 로고
    • Gene expression analysis of macrophages that facilitate tumor invasion supports a role for Wnt-signaling in mediating their activity in primary mammary tumors
    • Ojalvo LS, Whittaker CA, Condeelis JS, et al., Gene expression analysis of macrophages that facilitate tumor invasion supports a role for Wnt-signaling in mediating their activity in primary mammary tumors. J Immunol 2010; 184: 702-712.
    • (2010) J Immunol , vol.184 , pp. 702-712
    • Ojalvo, L.S.1    Whittaker, C.A.2    Condeelis, J.S.3
  • 99
    • 77955443639 scopus 로고    scopus 로고
    • Osteopontin-positive infiltrating tumor-associated macrophages in bulky ampullary cancer predict survival
    • Hsu HP, Shan YS, Lai MD, et al., Osteopontin-positive infiltrating tumor-associated macrophages in bulky ampullary cancer predict survival. Cancer Biol Ther 2010; 10.
    • (2010) Cancer Biol Ther , vol.10
    • Hsu, H.P.1    Shan, Y.S.2    Lai, M.D.3
  • 100
    • 0033780453 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor by macrophages is up-regulated in poorly vascularized areas of breast carcinomas
    • Lewis JS, Landers RJ, Underwood JC, et al., Expression of vascular endothelial growth factor by macrophages is up-regulated in poorly vascularized areas of breast carcinomas. J Pathol 2000; 192: 150-158.
    • (2000) J Pathol , vol.192 , pp. 150-158
    • Lewis, J.S.1    Landers, R.J.2    Underwood, J.C.3
  • 101
    • 0027246256 scopus 로고
    • Secretion of epidermal growth factor by macrophages associated with breast carcinoma
    • O'Sullivan C, Lewis CE, Harris AL, et al., Secretion of epidermal growth factor by macrophages associated with breast carcinoma. Lancet 1993; 342: 148-149.
    • (1993) Lancet , vol.342 , pp. 148-149
    • O'Sullivan, C.1    Lewis, C.E.2    Harris, A.L.3
  • 102
    • 31544441610 scopus 로고    scopus 로고
    • Distinct role of macrophages in different tumor microenvironments
    • Lewis CE, Pollard JW,. Distinct role of macrophages in different tumor microenvironments. Cancer Res 2006; 66: 605-612.
    • (2006) Cancer Res , vol.66 , pp. 605-612
    • Lewis, C.E.1    Pollard, J.W.2
  • 103
    • 33845524204 scopus 로고    scopus 로고
    • Role of tumor-associated macrophages in tumor progression and invasion
    • Mantovani A, Schioppa T, Porta C, et al., Role of tumor-associated macrophages in tumor progression and invasion. Cancer Metast Rev 2006; 25: 315-322.
    • (2006) Cancer Metast Rev , vol.25 , pp. 315-322
    • Mantovani, A.1    Schioppa, T.2    Porta, C.3
  • 104
    • 0034650833 scopus 로고    scopus 로고
    • Autocrine production of IL-10 mediates defective IL-12 production and NF-κB activation in tumor-associated macrophages
    • Sica A, Saccani A, Bottazzi B, et al., Autocrine production of IL-10 mediates defective IL-12 production and NF-κB activation in tumor-associated macrophages. J Immunol 2000; 164: 762-767.
    • (2000) J Immunol , vol.164 , pp. 762-767
    • Sica, A.1    Saccani, A.2    Bottazzi, B.3
  • 105
    • 0037265240 scopus 로고    scopus 로고
    • Alternative activation of macrophages
    • Gordon S,. Alternative activation of macrophages. Nat Rev Immunol 2003; 3: 23-35.
    • (2003) Nat Rev Immunol , vol.3 , pp. 23-35
    • Gordon, S.1
  • 106
    • 56749174940 scopus 로고    scopus 로고
    • Exploring the full spectrum of macrophage activation
    • Mosser DM, Edwards JP,. Exploring the full spectrum of macrophage activation. Nat Rev Immunol 2008; 8: 958-969.
    • (2008) Nat Rev Immunol , vol.8 , pp. 958-969
    • Mosser, D.M.1    Edwards, J.P.2
  • 107
    • 0033067163 scopus 로고    scopus 로고
    • Necrosis correlates with high vascular density and focal macrophage infiltration in invasive carcinoma of the breast
    • Leek RD, Landers RJ, Harris AL, et al., Necrosis correlates with high vascular density and focal macrophage infiltration in invasive carcinoma of the breast. Br J Cancer 1999; 79: 991-995.
    • (1999) Br J Cancer , vol.79 , pp. 991-995
    • Leek, R.D.1    Landers, R.J.2    Harris, A.L.3
  • 108
    • 0029816609 scopus 로고    scopus 로고
    • Association of macrophage infiltration with angiogenesis and prognosis in invasive breast carcinoma
    • Leek RD, Lewis CE, Whitehouse R, et al., Association of macrophage infiltration with angiogenesis and prognosis in invasive breast carcinoma. Cancer Res 1996; 56: 4625-4629.
    • (1996) Cancer Res , vol.56 , pp. 4625-4629
    • Leek, R.D.1    Lewis, C.E.2    Whitehouse, R.3
  • 109
    • 4944244259 scopus 로고    scopus 로고
    • Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues
    • Murdoch C, Giannoudis A, Lewis CE,. Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues. Blood 2004; 104: 2224-2234.
    • (2004) Blood , vol.104 , pp. 2224-2234
    • Murdoch, C.1    Giannoudis, A.2    Lewis, C.E.3
  • 110
    • 34548545297 scopus 로고    scopus 로고
    • Inflammation and breast cancer. Microenvironmental factors regulating macrophage function in breast tumours: Hypoxia and angiopoietin-2
    • Lewis CE, Hughes R,. Inflammation and breast cancer. Microenvironmental factors regulating macrophage function in breast tumours: hypoxia and angiopoietin-2. Breast Cancer Res 2007; 9: 209.
    • (2007) Breast Cancer Res , vol.9 , pp. 209
    • Lewis, C.E.1    Hughes, R.2
  • 111
    • 0033040133 scopus 로고    scopus 로고
    • Hypoxia inhibits macrophage migration
    • Turner L, Scotton C, Negus R, et al., Hypoxia inhibits macrophage migration. Eur J Immunol 1999; 29: 2280-2287.
    • (1999) Eur J Immunol , vol.29 , pp. 2280-2287
    • Turner, L.1    Scotton, C.2    Negus, R.3
  • 112
    • 0141425768 scopus 로고    scopus 로고
    • Hypoxia-induced gene expression in human macrophages: Implications for ischemic tissues and hypoxia-regulated gene therapy
    • Burke B, Giannoudis A, Corke KP, et al., Hypoxia-induced gene expression in human macrophages: implications for ischemic tissues and hypoxia-regulated gene therapy. Am J Pathol 2003; 163: 1233-1243.
    • (2003) Am J Pathol , vol.163 , pp. 1233-1243
    • Burke, B.1    Giannoudis, A.2    Corke, K.P.3
  • 113
    • 0036007293 scopus 로고    scopus 로고
    • Expression of HIF-1α by human macrophages: Implications for the use of macrophages in hypoxia-regulated cancer gene therapy
    • Burke B, Tang N, Corke KP, et al., Expression of HIF-1α by human macrophages: implications for the use of macrophages in hypoxia-regulated cancer gene therapy. J Pathol 2002; 196: 204-212.
    • (2002) J Pathol , vol.196 , pp. 204-212
    • Burke, B.1    Tang, N.2    Corke, K.P.3
  • 114
    • 34249979533 scopus 로고    scopus 로고
    • Identification of proangiogenic TIE2-expressing monocytes (TEMs) in human peripheral blood and cancer
    • Venneri MA, De Palma M, Ponzoni M, et al., Identification of proangiogenic TIE2-expressing monocytes (TEMs) in human peripheral blood and cancer. Blood 2007; 109: 5276-5285.
    • (2007) Blood , vol.109 , pp. 5276-5285
    • Venneri, M.A.1    De Palma, M.2    Ponzoni, M.3
  • 115
    • 33746932442 scopus 로고    scopus 로고
    • Angiopoietin 2 expression in invasive ductal carcinoma of the breast: Its relationship to the VEGF expression and microvessel density
    • Tsutsui S, Inoue H, Yasuda K, et al., Angiopoietin 2 expression in invasive ductal carcinoma of the breast: its relationship to the VEGF expression and microvessel density. Breast Cancer Res Treat 2006; 98: 261-266.
    • (2006) Breast Cancer Res Treat , vol.98 , pp. 261-266
    • Tsutsui, S.1    Inoue, H.2    Yasuda, K.3
  • 116
    • 34249791475 scopus 로고    scopus 로고
    • Expression of Tie-2 by human monocytes and their responses to angiopoietin-2
    • Murdoch C, Tazzyman S, Webster S, et al., Expression of Tie-2 by human monocytes and their responses to angiopoietin-2. J Immunol 2007; 178: 7405-7411.
    • (2007) J Immunol , vol.178 , pp. 7405-7411
    • Murdoch, C.1    Tazzyman, S.2    Webster, S.3
  • 117
    • 0015172562 scopus 로고
    • Infectious immunological tolerance
    • Gershon RK, Kondo K,. Infectious immunological tolerance. Immunology 1971; 21: 903-914.
    • (1971) Immunology , vol.21 , pp. 903-914
    • Gershon, R.K.1    Kondo, K.2
  • 118
    • 0018906201 scopus 로고
    • T-cell-mediated suppression of anti-tumor immunity. An explanation for progressive growth of an immunogenic tumor
    • Berendt MJ, North RJ,. T-cell-mediated suppression of anti-tumor immunity. An explanation for progressive growth of an immunogenic tumor. J Exp Med 1980; 151: 69-80.
    • (1980) J Exp Med , vol.151 , pp. 69-80
    • Berendt, M.J.1    North, R.J.2
  • 119
    • 0025114859 scopus 로고
    • Autologous melanoma-induced activation of regulatory T cells that suppress cytotoxic response
    • Chakraborty NG, Twardzik DR, Sivanandham M, et al., Autologous melanoma-induced activation of regulatory T cells that suppress cytotoxic response. J Immunol 1990; 145: 2359-2364.
    • (1990) J Immunol , vol.145 , pp. 2359-2364
    • Chakraborty, N.G.1    Twardzik, D.R.2    Sivanandham, M.3
  • 120
    • 0036839149 scopus 로고    scopus 로고
    • Tumor-induced L -selectin high suppressor T cells mediate potent effector T cell blockade and cause failure of otherwise curative adoptive immunotherapy
    • Peng L, Kjaergaard J, Plautz GE, et al., Tumor-induced L -selectin high suppressor T cells mediate potent effector T cell blockade and cause failure of otherwise curative adoptive immunotherapy. J Immunol 2002; 169: 4811-4821.
    • (2002) J Immunol , vol.169 , pp. 4811-4821
    • Peng, L.1    Kjaergaard, J.2    Plautz, G.E.3
  • 121
    • 15444377017 scopus 로고    scopus 로고
    • + cells unmasks tumor immunogenicity leading to the rejection of late-stage tumors
    • + cells unmasks tumor immunogenicity leading to the rejection of late-stage tumors. J Exp Med 2005; 201: 779-791.
    • (2005) J Exp Med , vol.201 , pp. 779-791
    • Yu, P.1    Lee, Y.2    Liu, W.3
  • 123
    • 38949202980 scopus 로고    scopus 로고
    • Extracellular matrix signature identifies breast cancer subgroups with different clinical outcome
    • Bergamaschi A, Tagliabue E, Sorlie T, et al., Extracellular matrix signature identifies breast cancer subgroups with different clinical outcome. J Pathol 2008; 214: 357-367.
    • (2008) J Pathol , vol.214 , pp. 357-367
    • Bergamaschi, A.1    Tagliabue, E.2    Sorlie, T.3
  • 125
    • 54949090320 scopus 로고    scopus 로고
    • A mouse stromal response to tumor invasion predicts prostate and breast cancer patient survival
    • Bacac M, Provero P, Mayran N, et al., A mouse stromal response to tumor invasion predicts prostate and breast cancer patient survival. PLoS One 2006; 1: e32.
    • (2006) PLoS One , vol.1
    • Bacac, M.1    Provero, P.2    Mayran, N.3
  • 126
    • 74049104125 scopus 로고    scopus 로고
    • APRIL is a novel clinical chemo-resistance biomarker in colorectal adenocarcinoma identified by gene expression profiling
    • Petty RD, Samuel LM, Murray GI, et al., APRIL is a novel clinical chemo-resistance biomarker in colorectal adenocarcinoma identified by gene expression profiling. BMC Cancer 2009; 9: 434.
    • (2009) BMC Cancer , vol.9 , pp. 434
    • Petty, R.D.1    Samuel, L.M.2    Murray, G.I.3
  • 127
    • 58149334773 scopus 로고    scopus 로고
    • A stroma-related gene signature predicts resistance to neoadjuvant chemotherapy in breast cancer
    • Farmer P, Bonnefoi H, Anderle P, et al., A stroma-related gene signature predicts resistance to neoadjuvant chemotherapy in breast cancer. Nat Med 2009; 15: 68-74.
    • (2009) Nat Med , vol.15 , pp. 68-74
    • Farmer, P.1    Bonnefoi, H.2    Anderle, P.3
  • 128
    • 0033105537 scopus 로고    scopus 로고
    • Cell adhesion mediated drug resistance (CAM-DR): Role of integrins and resistance to apoptosis in human myeloma cell lines
    • Damiano JS, Cress AE, Hazlehurst LA, et al., Cell adhesion mediated drug resistance (CAM-DR): role of integrins and resistance to apoptosis in human myeloma cell lines. Blood 1999; 93: 1658-1667.
    • (1999) Blood , vol.93 , pp. 1658-1667
    • Damiano, J.S.1    Cress, A.E.2    Hazlehurst, L.A.3
  • 129
    • 0035885933 scopus 로고    scopus 로고
    • Reduction in drug-induced DNA double-strand breaks associated with β1 integrin-mediated adhesion correlates with drug resistance in U937 cells
    • Hazlehurst LA, Valkov N, Wisner L, et al., Reduction in drug-induced DNA double-strand breaks associated with β1 integrin-mediated adhesion correlates with drug resistance in U937 cells. Blood 2001; 98: 1897-1903.
    • (2001) Blood , vol.98 , pp. 1897-1903
    • Hazlehurst, L.A.1    Valkov, N.2    Wisner, L.3
  • 130
    • 0036726312 scopus 로고    scopus 로고
    • β4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium
    • Weaver VM, Lelievre S, Lakins JN, et al., β4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium. Cancer Cell 2002; 2: 205-216.
    • (2002) Cancer Cell , vol.2 , pp. 205-216
    • Weaver, V.M.1    Lelievre, S.2    Lakins, J.N.3
  • 131
    • 0036780251 scopus 로고    scopus 로고
    • Clinical translation of angiogenesis inhibitors
    • Kerbel R, Folkman J,. Clinical translation of angiogenesis inhibitors. Nat Rev Cancer 2002; 2: 727-739.
    • (2002) Nat Rev Cancer , vol.2 , pp. 727-739
    • Kerbel, R.1    Folkman, J.2
  • 132
    • 47949089077 scopus 로고    scopus 로고
    • VEGF-targeted therapy: Mechanisms of anti-tumour activity
    • Ellis LM, Hicklin DJ,. VEGF-targeted therapy: mechanisms of anti-tumour activity. Nat Rev Cancer 2008; 8: 579-591.
    • (2008) Nat Rev Cancer , vol.8 , pp. 579-591
    • Ellis, L.M.1    Hicklin, D.J.2
  • 133
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
    • Hurwitz H, Fehrenbacher L, Novotny W, et al., Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 2004; 350: 2335-2342.
    • (2004) N Engl J Med , vol.350 , pp. 2335-2342
    • Hurwitz, H.1    Fehrenbacher, L.2    Novotny, W.3
  • 134
    • 33845490014 scopus 로고    scopus 로고
    • Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer
    • Sandler A, Gray R, Perry MC, et al., Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med 2006; 355: 2542-2550.
    • (2006) N Engl J Med , vol.355 , pp. 2542-2550
    • Sandler, A.1    Gray, R.2    Perry, M.C.3
  • 135
    • 37549040613 scopus 로고    scopus 로고
    • Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer
    • Miller K, Wang M, Gralow J, et al., Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer. N Engl J Med 2007; 357: 2666-2676.
    • (2007) N Engl J Med , vol.357 , pp. 2666-2676
    • Miller, K.1    Wang, M.2    Gralow, J.3
  • 136
    • 0033866240 scopus 로고    scopus 로고
    • In vivo therapy of malignant melanoma by means of antagonists of αv integrins
    • Mitjans F, Meyer T, Fittschen C, et al., In vivo therapy of malignant melanoma by means of antagonists of αv integrins. Int J Cancer 2000; 87: 716-723.
    • (2000) Int J Cancer , vol.87 , pp. 716-723
    • Mitjans, F.1    Meyer, T.2    Fittschen, C.3
  • 137
    • 0037017835 scopus 로고    scopus 로고
    • Inhibition of the αv integrins with a cyclic RGD peptide impairs angiogenesis, growth and metastasis of solid tumours in vivo
    • Buerkle MA, Pahernik SA, Sutter A, et al., Inhibition of the αv integrins with a cyclic RGD peptide impairs angiogenesis, growth and metastasis of solid tumours in vivo. Br J Cancer 2002; 86: 788-795.
    • (2002) Br J Cancer , vol.86 , pp. 788-795
    • Buerkle, M.A.1    Pahernik, S.A.2    Sutter, A.3
  • 138
    • 0035149747 scopus 로고    scopus 로고
    • Preferential susceptibility of brain tumors to the antiangiogenic effects of an αv integrin antagonist
    • MacDonald TJ, Taga T, Shimada H, et al., Preferential susceptibility of brain tumors to the antiangiogenic effects of an αv integrin antagonist. Neurosurgery 2001; 48: 151-157.
    • (2001) Neurosurgery , vol.48 , pp. 151-157
    • MacDonald, T.J.1    Taga, T.2    Shimada, H.3
  • 140
    • 0242488947 scopus 로고    scopus 로고
    • Integrins in angiogenesis: Multitalented molecules in a balancing act
    • Hodivala-Dilke KM, Reynolds AR, Reynolds LE,. Integrins in angiogenesis: multitalented molecules in a balancing act. Cell Tissue Res 2003; 314: 131-144.
    • (2003) Cell Tissue Res , vol.314 , pp. 131-144
    • Hodivala-Dilke, K.M.1    Reynolds, A.R.2    Reynolds, L.E.3
  • 141
    • 34249087162 scopus 로고    scopus 로고
    • Phase i and correlative biology study of cilengitide in patients with recurrent malignant glioma
    • Nabors LB, Mikkelsen T, Rosenfeld SS, et al., Phase I and correlative biology study of cilengitide in patients with recurrent malignant glioma. J Clin Oncol 2007; 25: 1651-1657.
    • (2007) J Clin Oncol , vol.25 , pp. 1651-1657
    • Nabors, L.B.1    Mikkelsen, T.2    Rosenfeld, S.S.3
  • 142
    • 0034045074 scopus 로고    scopus 로고
    • Human malignant glioma therapy using anti-αvβ3 integrin agents
    • Chatterjee S, Matsumura A, Schradermeier J, et al., Human malignant glioma therapy using anti-αvβ3 integrin agents. J Neurooncol 2000; 46: 135-144.
    • (2000) J Neurooncol , vol.46 , pp. 135-144
    • Chatterjee, S.1    Matsumura, A.2    Schradermeier, J.3
  • 143
    • 0037051697 scopus 로고    scopus 로고
    • αv-Integrin antagonist EMD 121974 induces apoptosis in brain tumor cells growing on vitronectin and tenascin
    • Taga T, Suzuki A, Gonzalez-Gomez I, et al., αv-Integrin antagonist EMD 121974 induces apoptosis in brain tumor cells growing on vitronectin and tenascin. Int J Cancer 2002; 98: 690-697.
    • (2002) Int J Cancer , vol.98 , pp. 690-697
    • Taga, T.1    Suzuki, A.2    Gonzalez-Gomez, I.3
  • 144
    • 0347155579 scopus 로고    scopus 로고
    • Phase i and pharmacokinetic study of continuous twice weekly intravenous administration of Cilengitide (EMD 121974), a novel inhibitor of the integrins αvβ3 and αvβ5 in patients with advanced solid tumours
    • Eskens FA, Dumez H, Hoekstra R, et al., Phase I and pharmacokinetic study of continuous twice weekly intravenous administration of Cilengitide (EMD 121974), a novel inhibitor of the integrins αvβ3 and αvβ5 in patients with advanced solid tumours. Eur J Cancer 2003; 39: 917-926.
    • (2003) Eur J Cancer , vol.39 , pp. 917-926
    • Eskens, F.A.1    Dumez, H.2    Hoekstra, R.3
  • 145
    • 33846604223 scopus 로고    scopus 로고
    • A randomized multi-center phase II trial of the angiogenesis inhibitor Cilengitide (EMD 121974) and gemcitabine compared with gemcitabine alone in advanced unresectable pancreatic cancer
    • Friess H, Langrehr JM, Oettle H, et al., A randomized multi-center phase II trial of the angiogenesis inhibitor Cilengitide (EMD 121974) and gemcitabine compared with gemcitabine alone in advanced unresectable pancreatic cancer. BMC Cancer 2006; 6: 285.
    • (2006) BMC Cancer , vol.6 , pp. 285
    • Friess, H.1    Langrehr, J.M.2    Oettle, H.3
  • 146
    • 34548175694 scopus 로고    scopus 로고
    • Assessment of the biological and pharmacological effects of the αvβ3 and αvβ5 integrin receptor antagonist, cilengitide (EMD 121974), in patients with advanced solid tumors
    • Hariharan S, Gustafson D, Holden S, et al., Assessment of the biological and pharmacological effects of the αvβ3 and αvβ5 integrin receptor antagonist, cilengitide (EMD 121974), in patients with advanced solid tumors. Ann Oncol 2007; 18: 1400-1407.
    • (2007) Ann Oncol , vol.18 , pp. 1400-1407
    • Hariharan, S.1    Gustafson, D.2    Holden, S.3
  • 147
    • 64149106522 scopus 로고    scopus 로고
    • Stimulation of tumor growth and angiogenesis by low concentrations of RGD-mimetic integrin inhibitors
    • Reynolds AR, Hart IR, Watson AR, et al., Stimulation of tumor growth and angiogenesis by low concentrations of RGD-mimetic integrin inhibitors. Nat Med 2009; 15: 392-400.
    • (2009) Nat Med , vol.15 , pp. 392-400
    • Reynolds, A.R.1    Hart, I.R.2    Watson, A.R.3
  • 148
    • 0036498790 scopus 로고    scopus 로고
    • Phase II trial of murine (131)I-labeled antitenascin monoclonal antibody 81C6 administered into surgically created resection cavities of patients with newly diagnosed malignant gliomas
    • Reardon DA, Akabani G, Coleman RE, et al., Phase II trial of murine (131)I-labeled antitenascin monoclonal antibody 81C6 administered into surgically created resection cavities of patients with newly diagnosed malignant gliomas. J Clin Oncol 2002; 20: 1389-1397.
    • (2002) J Clin Oncol , vol.20 , pp. 1389-1397
    • Reardon, D.A.1    Akabani, G.2    Coleman, R.E.3
  • 149
    • 33748762207 scopus 로고    scopus 로고
    • Human monoclonal antibodies to domain C of tenascin-C selectively target solid tumors in vivo
    • Silacci M, Brack SS, Spath N, et al., Human monoclonal antibodies to domain C of tenascin-C selectively target solid tumors in vivo. Protein Eng Des Sel 2006; 19: 471-478.
    • (2006) Protein Eng des Sel , vol.19 , pp. 471-478
    • Silacci, M.1    Brack, S.S.2    Spath, N.3
  • 150
    • 0037314650 scopus 로고    scopus 로고
    • Immunoscintigraphic detection of the ED-B domain of fibronectin, a marker of angiogenesis, in patients with cancer
    • Santimaria M, Moscatelli G, Viale GL, et al., Immunoscintigraphic detection of the ED-B domain of fibronectin, a marker of angiogenesis, in patients with cancer. Clin Cancer Res 2003; 9: 571-579.
    • (2003) Clin Cancer Res , vol.9 , pp. 571-579
    • Santimaria, M.1    Moscatelli, G.2    Viale, G.L.3
  • 151
    • 0031026481 scopus 로고    scopus 로고
    • Tumor infarction in mice by antibody-directed targeting of tissue factor to tumor vasculature
    • Huang X, Molema G, King S, et al., Tumor infarction in mice by antibody-directed targeting of tissue factor to tumor vasculature. Science 1997; 275: 547-550.
    • (1997) Science , vol.275 , pp. 547-550
    • Huang, X.1    Molema, G.2    King, S.3
  • 152
    • 10744221996 scopus 로고    scopus 로고
    • Selective targeted delivery of TNFα to tumor blood vessels
    • Borsi L, Balza E, Carnemolla B, et al., Selective targeted delivery of TNFα to tumor blood vessels. Blood 2003; 102: 4384-4392.
    • (2003) Blood , vol.102 , pp. 4384-4392
    • Borsi, L.1    Balza, E.2    Carnemolla, B.3
  • 153
    • 63849261384 scopus 로고    scopus 로고
    • Expression of the oncofetal ED-B-containing fibronectin isoform in hematologic tumors enables ED-B-targeted 131I-L19SIP radioimmunotherapy in Hodgkin lymphoma patients
    • Sauer S, Erba PA, Petrini M, et al., Expression of the oncofetal ED-B-containing fibronectin isoform in hematologic tumors enables ED-B-targeted 131I-L19SIP radioimmunotherapy in Hodgkin lymphoma patients. Blood 2009; 113: 2265-2274.
    • (2009) Blood , vol.113 , pp. 2265-2274
    • Sauer, S.1    Erba, P.A.2    Petrini, M.3
  • 154
    • 46249120755 scopus 로고    scopus 로고
    • A clinical study assessing the tolerability and biological effects of infliximab, a TNFα inhibitor, in patients with advanced cancer
    • Brown ER, Charles KA, Hoare SA, et al., A clinical study assessing the tolerability and biological effects of infliximab, a TNFα inhibitor, in patients with advanced cancer. Ann Oncol 2008; 19: 1340-1346.
    • (2008) Ann Oncol , vol.19 , pp. 1340-1346
    • Brown, E.R.1    Charles, K.A.2    Hoare, S.A.3
  • 155
    • 5144231121 scopus 로고    scopus 로고
    • A phase II study of etanercept (Enbrel), a tumor necrosis factor-α inhibitor in patients with metastatic breast cancer
    • Madhusudan S, Foster M, Muthuramalingam SR, et al., A phase II study of etanercept (Enbrel), a tumor necrosis factor-α inhibitor in patients with metastatic breast cancer. Clin Cancer Res 2004; 10: 6528-6534.
    • (2004) Clin Cancer Res , vol.10 , pp. 6528-6534
    • Madhusudan, S.1    Foster, M.2    Muthuramalingam, S.R.3
  • 156
    • 77954618168 scopus 로고    scopus 로고
    • Lenalidomide, bortezomib, and dexamethasone combination therapy in patients with newly diagnosed multiple myeloma
    • Richardson PG, Weller E, Lonial S, et al., Lenalidomide, bortezomib, and dexamethasone combination therapy in patients with newly diagnosed multiple myeloma. Blood 2010; 116: 679-686.
    • (2010) Blood , vol.116 , pp. 679-686
    • Richardson, P.G.1    Weller, E.2    Lonial, S.3
  • 157
    • 77954592430 scopus 로고    scopus 로고
    • The addition of cyclophosphamide to lenalidomide and dexamethasone in multiply relapsed/refractory myeloma patients; A phase I/II study
    • Schey SA, Morgan GJ, Ramasamy K, et al., The addition of cyclophosphamide to lenalidomide and dexamethasone in multiply relapsed/refractory myeloma patients; a phase I/II study. Br J Haematol 2010; 150: 326-333.
    • (2010) Br J Haematol , vol.150 , pp. 326-333
    • Schey, S.A.1    Morgan, G.J.2    Ramasamy, K.3
  • 158
    • 69949096727 scopus 로고    scopus 로고
    • Mechanism of action of lenalidomide in hematological malignancies
    • Kotla V, Goel S, Nischal S, et al., Mechanism of action of lenalidomide in hematological malignancies. J Hematol Oncol 2009; 2: 36.
    • (2009) J Hematol Oncol , vol.2 , pp. 36
    • Kotla, V.1    Goel, S.2    Nischal, S.3
  • 159
    • 45149134605 scopus 로고    scopus 로고
    • 'Re-educating' tumor-associated macrophages by targeting NF-κB
    • Hagemann T, Lawrence T, McNeish I, et al., 'Re-educating' tumor-associated macrophages by targeting NF-κB. J Exp Med 2008; 205: 1261-1268.
    • (2008) J Exp Med , vol.205 , pp. 1261-1268
    • Hagemann, T.1    Lawrence, T.2    McNeish, I.3
  • 160
    • 45849120148 scopus 로고    scopus 로고
    • KINK-1, a novel small-molecule inhibitor of IKKβ, and the susceptibility of melanoma cells to antitumoral treatment
    • Schon M, Wienrich BG, Kneitz S, et al., KINK-1, a novel small-molecule inhibitor of IKKβ, and the susceptibility of melanoma cells to antitumoral treatment. J Natl Cancer Inst 2008; 100: 862-875.
    • (2008) J Natl Cancer Inst , vol.100 , pp. 862-875
    • Schon, M.1    Wienrich, B.G.2    Kneitz, S.3
  • 161
    • 70349782995 scopus 로고    scopus 로고
    • Early response to COX-2 inhibitors as a predictor of overall response in osteoarthritis: Pooled results from two identical trials comparing etoricoxib, celecoxib and placebo
    • Bingham CO III, Smugar SS, Wang H, et al., Early response to COX-2 inhibitors as a predictor of overall response in osteoarthritis: pooled results from two identical trials comparing etoricoxib, celecoxib and placebo. Rheumatology (Oxf) 2009; 48: 1122-1127.
    • (2009) Rheumatology (Oxf) , vol.48 , pp. 1122-1127
    • Bingham Iii, C.O.1    Smugar, S.S.2    Wang, H.3
  • 162
    • 77955049924 scopus 로고    scopus 로고
    • Celecoxib versus omeprazole and diclofenac in patients with osteoarthritis and rheumatoid arthritis (CONDOR): A randomised trial
    • Chan FK, Lanas A, Scheiman J, et al., Celecoxib versus omeprazole and diclofenac in patients with osteoarthritis and rheumatoid arthritis (CONDOR): a randomised trial. Lancet 2010; 376: 173-179.
    • (2010) Lancet , vol.376 , pp. 173-179
    • Chan, F.K.1    Lanas, A.2    Scheiman, J.3
  • 163
    • 77950243302 scopus 로고    scopus 로고
    • A phase 2 pilot trial of low-dose, continuous infusion, or 'metronomic' paclitaxel and oral celecoxib in patients with metastatic melanoma
    • Bhatt RS, Merchan J, Parker R, et al., A phase 2 pilot trial of low-dose, continuous infusion, or 'metronomic' paclitaxel and oral celecoxib in patients with metastatic melanoma. Cancer 2010; 116: 1751-1756.
    • (2010) Cancer , vol.116 , pp. 1751-1756
    • Bhatt, R.S.1    Merchan, J.2    Parker, R.3
  • 164
    • 77950006166 scopus 로고    scopus 로고
    • Phase II trial of gemcitabine, irinotecan, and celecoxib in patients with advanced pancreatic cancer
    • Lipton A, Campbell-Baird C, Witters L, et al., Phase II trial of gemcitabine, irinotecan, and celecoxib in patients with advanced pancreatic cancer. J Clin Gastroenterol 2010; 44: 286-288.
    • (2010) J Clin Gastroenterol , vol.44 , pp. 286-288
    • Lipton, A.1    Campbell-Baird, C.2    Witters, L.3
  • 165
    • 67549105888 scopus 로고    scopus 로고
    • Five-year efficacy and safety analysis of the Adenoma Prevention with Celecoxib Trial
    • Bertagnolli MM, Eagle CJ, Zauber AG, et al., Five-year efficacy and safety analysis of the Adenoma Prevention with Celecoxib Trial. Cancer Prev Res 2009; 2: 310-321.
    • (2009) Cancer Prev Res , vol.2 , pp. 310-321
    • Bertagnolli, M.M.1    Eagle, C.J.2    Zauber, A.G.3
  • 166
    • 0036114348 scopus 로고    scopus 로고
    • A randomised, double blind, placebo controlled study of celecoxib, a selective cyclooxygenase 2 inhibitor, on duodenal polyposis in familial adenomatous polyposis
    • Phillips RK, Wallace MH, Lynch PM, et al., A randomised, double blind, placebo controlled study of celecoxib, a selective cyclooxygenase 2 inhibitor, on duodenal polyposis in familial adenomatous polyposis. Gut 2002; 50: 857-860.
    • (2002) Gut , vol.50 , pp. 857-860
    • Phillips, R.K.1    Wallace, M.H.2    Lynch, P.M.3
  • 167
    • 33846188062 scopus 로고    scopus 로고
    • Direct targeting of αvβ3 integrin on tumor cells with a monoclonal antibody, abegrin
    • Mulgrew K, Kinneer K, Yao XT, et al., Direct targeting of αvβ3 integrin on tumor cells with a monoclonal antibody, abegrin. Mol Cancer Ther 2006; 5: 3122-3129.
    • (2006) Mol Cancer Ther , vol.5 , pp. 3122-3129
    • Mulgrew, K.1    Kinneer, K.2    Yao, X.T.3
  • 168
    • 39049171151 scopus 로고    scopus 로고
    • A function blocking anti-mouse integrin α5β1 antibody inhibits angiogenesis and impedes tumor growth in vivo
    • Bhaskar V, Zhang D, Fox M, et al., A function blocking anti-mouse integrin α5β1 antibody inhibits angiogenesis and impedes tumor growth in vivo. J Transl Med 2007; 5: 61.
    • (2007) J Transl Med , vol.5 , pp. 61
    • Bhaskar, V.1    Zhang, D.2    Fox, M.3
  • 169
    • 33749349945 scopus 로고    scopus 로고
    • Preclinical evaluation of an anti-α5β1 integrin antibody as a novel anti-angiogenic agent
    • Ramakrishnan V, Bhaskar V, Law DA, et al., Preclinical evaluation of an anti-α5β1 integrin antibody as a novel anti-angiogenic agent. J Exp Ther Oncol 2006; 5: 273-286.
    • (2006) J Exp Ther Oncol , vol.5 , pp. 273-286
    • Ramakrishnan, V.1    Bhaskar, V.2    Law, D.A.3
  • 170
    • 44449168998 scopus 로고    scopus 로고
    • Radiosensitization of human vascular endothelial cells through Hsp90 inhibition with 17-N-allilamino-17-demethoxygeldanamycin
    • Kabakov AE, Makarova YM, Malyutina YV,. Radiosensitization of human vascular endothelial cells through Hsp90 inhibition with 17-N-allilamino-17- demethoxygeldanamycin. Int J Radiat Oncol Biol Phys 2008; 71: 858-865.
    • (2008) Int J Radiat Oncol Biol Phys , vol.71 , pp. 858-865
    • Kabakov, A.E.1    Makarova, Y.M.2    Malyutina, Y.V.3
  • 171
    • 0037208589 scopus 로고    scopus 로고
    • Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer
    • Kabbinavar F, Hurwitz HI, Fehrenbacher L, et al., Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer. J Clin Oncol 2003; 21: 60-65.
    • (2003) J Clin Oncol , vol.21 , pp. 60-65
    • Kabbinavar, F.1    Hurwitz, H.I.2    Fehrenbacher, L.3
  • 172
    • 33646351795 scopus 로고    scopus 로고
    • Phase II study of gemcitabine and oxaliplatin in combination with bevacizumab in patients with advanced hepatocellular carcinoma
    • Zhu AX, Blaszkowsky LS, Ryan DP, et al., Phase II study of gemcitabine and oxaliplatin in combination with bevacizumab in patients with advanced hepatocellular carcinoma. J Clin Oncol 2006; 24: 1898-1903.
    • (2006) J Clin Oncol , vol.24 , pp. 1898-1903
    • Zhu, A.X.1    Blaszkowsky, L.S.2    Ryan, D.P.3
  • 173
    • 70350225520 scopus 로고    scopus 로고
    • Direct evidence that bevacizumab, an anti-VEGF antibody, up-regulates SDF1α, CXCR4, CXCL6, and neuropilin 1 in tumors from patients with rectal cancer
    • Xu L, Duda DG, di Tomaso E, et al., Direct evidence that bevacizumab, an anti-VEGF antibody, up-regulates SDF1α, CXCR4, CXCL6, and neuropilin 1 in tumors from patients with rectal cancer. Cancer Res 2009; 69: 7905-7910.
    • (2009) Cancer Res , vol.69 , pp. 7905-7910
    • Xu, L.1    Duda, D.G.2    Di Tomaso, E.3
  • 174
    • 34247847960 scopus 로고    scopus 로고
    • Complete pathological response to bevacizumab and chemoradiation in advanced rectal cancer
    • Willett CG, Duda DG, di Tomaso E, et al., Complete pathological response to bevacizumab and chemoradiation in advanced rectal cancer. Nat Clin Pract Oncol 2007; 4: 316-321.
    • (2007) Nat Clin Pract Oncol , vol.4 , pp. 316-321
    • Willett, C.G.1    Duda, D.G.2    Di Tomaso, E.3
  • 175
    • 11144354392 scopus 로고    scopus 로고
    • Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer
    • Willett CG, Boucher Y, di Tomaso E, et al., Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer. Nat Med 2004; 10: 145-147.
    • (2004) Nat Med , vol.10 , pp. 145-147
    • Willett, C.G.1    Boucher, Y.2    Di Tomaso, E.3
  • 176
    • 7444263583 scopus 로고    scopus 로고
    • A prostate-specific membrane antigen-targeted monoclonal antibody-chemotherapeutic conjugate designed for the treatment of prostate cancer
    • Henry MD, Wen S, Silva MD, et al., A prostate-specific membrane antigen-targeted monoclonal antibody-chemotherapeutic conjugate designed for the treatment of prostate cancer. Cancer Res 2004; 64: 7995-8001.
    • (2004) Cancer Res , vol.64 , pp. 7995-8001
    • Henry, M.D.1    Wen, S.2    Silva, M.D.3
  • 177
    • 33646385331 scopus 로고    scopus 로고
    • Potent antitumor activity of an auristatin-conjugated, fully human monoclonal antibody to prostate-specific membrane antigen
    • Ma D, Hopf CE, Malewicz AD, et al., Potent antitumor activity of an auristatin-conjugated, fully human monoclonal antibody to prostate-specific membrane antigen. Clin Cancer Res 2006; 12: 2591-2596.
    • (2006) Clin Cancer Res , vol.12 , pp. 2591-2596
    • Ma, D.1    Hopf, C.E.2    Malewicz, A.D.3
  • 178
    • 33746881380 scopus 로고    scopus 로고
    • A recombinant PSMA-specific single-chain immunotoxin has potent and selective toxicity against prostate cancer cells
    • Wolf P, Gierschner D, Buhler P, et al., A recombinant PSMA-specific single-chain immunotoxin has potent and selective toxicity against prostate cancer cells. Cancer Immunol Immunother 2006; 55: 1367-1373.
    • (2006) Cancer Immunol Immunother , vol.55 , pp. 1367-1373
    • Wolf, P.1    Gierschner, D.2    Buhler, P.3
  • 179
    • 33745247375 scopus 로고    scopus 로고
    • Connective tissue growth factor-specific monoclonal antibody therapy inhibits pancreatic tumor growth and metastasis
    • Dornhofer N, Spong S, Bennewith K, et al., Connective tissue growth factor-specific monoclonal antibody therapy inhibits pancreatic tumor growth and metastasis. Cancer Res 2006; 66: 5816-5827.
    • (2006) Cancer Res , vol.66 , pp. 5816-5827
    • Dornhofer, N.1    Spong, S.2    Bennewith, K.3
  • 180
    • 33644870698 scopus 로고    scopus 로고
    • Novel angiogenic inhibitor DN-9693 that inhibits post-transcriptional induction of connective tissue growth factor (CTGF/CCN2) by vascular endothelial growth factor in human endothelial cells
    • Kondo S, Tanaka N, Kubota S, et al., Novel angiogenic inhibitor DN-9693 that inhibits post-transcriptional induction of connective tissue growth factor (CTGF/CCN2) by vascular endothelial growth factor in human endothelial cells. Mol Cancer Ther 2006; 5: 129-137.
    • (2006) Mol Cancer Ther , vol.5 , pp. 129-137
    • Kondo, S.1    Tanaka, N.2    Kubota, S.3
  • 181
    • 57349113716 scopus 로고    scopus 로고
    • Carcinoma-associated fibroblasts activate progesterone receptors and induce hormone independent mammary tumor growth: A role for the FGF-2/FGFR-2 axis
    • Giulianelli S, Cerliani JP, Lamb CA, et al., Carcinoma-associated fibroblasts activate progesterone receptors and induce hormone independent mammary tumor growth: a role for the FGF-2/FGFR-2 axis. Int J Cancer 2008; 123: 2518-2531.
    • (2008) Int J Cancer , vol.123 , pp. 2518-2531
    • Giulianelli, S.1    Cerliani, J.P.2    Lamb, C.A.3
  • 182
    • 55749088215 scopus 로고    scopus 로고
    • Fibroblast growth factor receptor-mediated signals contribute to the malignant phenotype of non-small cell lung cancer cells: Therapeutic implications and synergism with epidermal growth factor receptor inhibition
    • Fischer H, Taylor N, Allerstorfer S, et al., Fibroblast growth factor receptor-mediated signals contribute to the malignant phenotype of non-small cell lung cancer cells: therapeutic implications and synergism with epidermal growth factor receptor inhibition. Mol Cancer Ther 2008; 7: 3408-3419.
    • (2008) Mol Cancer Ther , vol.7 , pp. 3408-3419
    • Fischer, H.1    Taylor, N.2    Allerstorfer, S.3
  • 183
    • 2342640981 scopus 로고    scopus 로고
    • Radiation to stromal fibroblasts increases invasiveness of pancreatic cancer cells through tumor-stromal interactions
    • Ohuchida K, Mizumoto K, Murakami M, et al., Radiation to stromal fibroblasts increases invasiveness of pancreatic cancer cells through tumor-stromal interactions. Cancer Res 2004; 64: 3215-3222.
    • (2004) Cancer Res , vol.64 , pp. 3215-3222
    • Ohuchida, K.1    Mizumoto, K.2    Murakami, M.3
  • 184
    • 31544464931 scopus 로고    scopus 로고
    • Fibronectin stimulates non-small cell lung carcinoma cell growth through activation of Akt/mammalian target of rapamycin/S6 kinase and inactivation of LKB1/AMP-activated protein kinase signal pathways
    • Han S, Khuri FR, Roman J,. Fibronectin stimulates non-small cell lung carcinoma cell growth through activation of Akt/mammalian target of rapamycin/S6 kinase and inactivation of LKB1/AMP-activated protein kinase signal pathways. Cancer Res 2006; 66: 315-323.
    • (2006) Cancer Res , vol.66 , pp. 315-323
    • Han, S.1    Khuri, F.R.2    Roman, J.3
  • 185
    • 55349083640 scopus 로고    scopus 로고
    • Bryostatin-5 blocks stromal cell-derived factor-1 induced chemotaxis via desensitization and down-regulation of cell surface CXCR4 receptors
    • He X, Fang L, Wang J, et al., Bryostatin-5 blocks stromal cell-derived factor-1 induced chemotaxis via desensitization and down-regulation of cell surface CXCR4 receptors. Cancer Res 2008; 68: 8678-8686.
    • (2008) Cancer Res , vol.68 , pp. 8678-8686
    • He, X.1    Fang, L.2    Wang, J.3
  • 186
    • 21344441462 scopus 로고    scopus 로고
    • Blockade of the stromal cell-derived factor-1/CXCR4 axis attenuates in vivo tumor growth by inhibiting angiogenesis in a vascular endothelial growth factor-independent manner
    • Guleng B, Tateishi K, Ohta M, et al., Blockade of the stromal cell-derived factor-1/CXCR4 axis attenuates in vivo tumor growth by inhibiting angiogenesis in a vascular endothelial growth factor-independent manner. Cancer Res 2005; 65: 5864-5871.
    • (2005) Cancer Res , vol.65 , pp. 5864-5871
    • Guleng, B.1    Tateishi, K.2    Ohta, M.3
  • 187
    • 0035503538 scopus 로고    scopus 로고
    • Antiangiogenic therapy of established tumors in human skin/severe combined immunodeficiency mouse chimeras by anti-endoglin (CD105) monoclonal antibodies, and synergy between anti-endoglin antibody and cyclophosphamide
    • Takahashi N, Haba A, Matsuno F, et al., Antiangiogenic therapy of established tumors in human skin/severe combined immunodeficiency mouse chimeras by anti-endoglin (CD105) monoclonal antibodies, and synergy between anti-endoglin antibody and cyclophosphamide. Cancer Res 2001; 61: 7846-7854.
    • (2001) Cancer Res , vol.61 , pp. 7846-7854
    • Takahashi, N.1    Haba, A.2    Matsuno, F.3
  • 188
    • 33745837774 scopus 로고    scopus 로고
    • Targeting tumor-associated fibroblasts improves cancer chemotherapy by increasing intratumoral drug uptake
    • Loeffler M, Kruger JA, Niethammer AG, et al., Targeting tumor-associated fibroblasts improves cancer chemotherapy by increasing intratumoral drug uptake. J Clin Invest 2006; 116: 1955-1962.
    • (2006) J Clin Invest , vol.116 , pp. 1955-1962
    • Loeffler, M.1    Kruger, J.A.2    Niethammer, A.G.3
  • 189
    • 0037219532 scopus 로고    scopus 로고
    • Stromal antigen targeting by a humanised monoclonal antibody: An early phase II trial of sibrotuzumab in patients with metastatic colorectal cancer
    • Hofheinz RD, al-Batran SE, Hartmann F, et al., Stromal antigen targeting by a humanised monoclonal antibody: an early phase II trial of sibrotuzumab in patients with metastatic colorectal cancer. Onkologie 2003; 26: 44-48.
    • (2003) Onkologie , vol.26 , pp. 44-48
    • Hofheinz, R.D.1    Al-Batran, S.E.2    Hartmann, F.3
  • 190
    • 33644833474 scopus 로고    scopus 로고
    • Salvage radioimmunotherapy with murine iodine-131-labeled antitenascin monoclonal antibody 81C6 for patients with recurrent primary and metastatic malignant brain tumors: Phase II study results
    • Reardon DA, Akabani G, Coleman RE, et al., Salvage radioimmunotherapy with murine iodine-131-labeled antitenascin monoclonal antibody 81C6 for patients with recurrent primary and metastatic malignant brain tumors: phase II study results. J Clin Oncol 2006; 24: 115-122.
    • (2006) J Clin Oncol , vol.24 , pp. 115-122
    • Reardon, D.A.1    Akabani, G.2    Coleman, R.E.3
  • 191
  • 192
    • 25144437350 scopus 로고    scopus 로고
    • A6, a urokinase plasminogen activator (uPA)-derived peptide in patients with advanced gynecologic cancer: A phase i trial
    • Berkenblit A, Matulonis UA, Kroener JF, et al., A6, a urokinase plasminogen activator (uPA)-derived peptide in patients with advanced gynecologic cancer: a phase I trial. Gynecol Oncol 2005; 99: 50-57.
    • (2005) Gynecol Oncol , vol.99 , pp. 50-57
    • Berkenblit, A.1    Matulonis, U.A.2    Kroener, J.F.3
  • 193
    • 20444484501 scopus 로고    scopus 로고
    • Marimastat in the treatment of patients with biochemically relapsed prostate cancer: A prospective randomized, double-blind, phase I/II trial
    • Rosenbaum E, Zahurak M, Sinibaldi V, et al., Marimastat in the treatment of patients with biochemically relapsed prostate cancer: a prospective randomized, double-blind, phase I/II trial. Clin Cancer Res 2005; 11: 4437-4443.
    • (2005) Clin Cancer Res , vol.11 , pp. 4437-4443
    • Rosenbaum, E.1    Zahurak, M.2    Sinibaldi, V.3
  • 194
    • 18244399611 scopus 로고    scopus 로고
    • Phase i trial of the matrix metalloproteinase inhibitor marimastat combined with carboplatin and paclitaxel in patients with advanced non-small cell lung cancer
    • Goffin JR, Anderson IC, Supko JG, et al., Phase I trial of the matrix metalloproteinase inhibitor marimastat combined with carboplatin and paclitaxel in patients with advanced non-small cell lung cancer. Clin Cancer Res 2005; 11: 3417-3424.
    • (2005) Clin Cancer Res , vol.11 , pp. 3417-3424
    • Goffin, J.R.1    Anderson, I.C.2    Supko, J.G.3
  • 195
    • 33645080175 scopus 로고    scopus 로고
    • A randomized phase II trial of the matrix metalloproteinase inhibitor BMS-275291 in hormone-refractory prostate cancer patients with bone metastases
    • Lara PN Jr, Stadler WM, Longmate J, et al., A randomized phase II trial of the matrix metalloproteinase inhibitor BMS-275291 in hormone-refractory prostate cancer patients with bone metastases. Clin Cancer Res 2006; 12: 1556-1563.
    • (2006) Clin Cancer Res , vol.12 , pp. 1556-1563
    • Lara, Jr.P.N.1    Stadler, W.M.2    Longmate, J.3
  • 196
    • 78751644601 scopus 로고    scopus 로고
    • A clinical phase I/II trial with the monoclonal antibody cG250 (RENCAREX((R))) and interferon-α-2a in metastatic renal cell carcinoma patients
    • Siebels M, Rohrmann K, Oberneder R, et al., A clinical phase I/II trial with the monoclonal antibody cG250 (RENCAREX((R))) and interferon-α-2a in metastatic renal cell carcinoma patients. World J Urol 2010.
    • (2010) World J Urol
    • Siebels, M.1    Rohrmann, K.2    Oberneder, R.3
  • 197
    • 29144503225 scopus 로고    scopus 로고
    • A clinical trial with chimeric monoclonal antibody WX-G250 and low dose interleukin-2 pulsing scheme for advanced renal cell carcinoma
    • Bleumer I, Oosterwijk E, Oosterwijk-Wakka JC, et al., A clinical trial with chimeric monoclonal antibody WX-G250 and low dose interleukin-2 pulsing scheme for advanced renal cell carcinoma. J Urol 2006; 175: 57-62.
    • (2006) J Urol , vol.175 , pp. 57-62
    • Bleumer, I.1    Oosterwijk, E.2    Oosterwijk-Wakka, J.C.3


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