-
1
-
-
44449085619
-
TGF-beta and the TGF-beta family
-
Derynck R, Miyazono K, eds, NewYork: Cold Spring Harbor Laboratory Press
-
Derynck R, Miyazono K. TGF-beta and the TGF-beta family. In: Derynck R, Miyazono K, eds. The TGF-beta Family. NewYork: Cold Spring Harbor Laboratory Press, 2008:29-43.
-
(2008)
The TGF-beta Family
, pp. 29-43
-
-
Derynck, R.1
Miyazono, K.2
-
2
-
-
0034644472
-
TGFbeta signaling in growth control, cancer, and heritable disorders
-
Massagué J, Blain SW, Lo RS. TGFbeta signaling in growth control, cancer, and heritable disorders. Cell 2000; 103:295-309.
-
(2000)
Cell
, vol.103
, pp. 295-309
-
-
Massagué, J.1
Blain, S.W.2
Lo, R.S.3
-
3
-
-
34548329486
-
Differentiation plasticity regulated by TGF-beta family proteins in development and disease
-
Derynck R, Akhurst RJ. Differentiation plasticity regulated by TGF-beta family proteins in development and disease. Nat Cell Biol 2007; 9:1000-1004.
-
(2007)
Nat Cell Biol
, vol.9
, pp. 1000-1004
-
-
Derynck, R.1
Akhurst, R.J.2
-
4
-
-
47549090432
-
TGFbeta in cancer
-
Massagué J. TGFbeta in cancer. Cell 2008; 134:215-230.
-
(2008)
Cell
, vol.134
, pp. 215-230
-
-
Massagué, J.1
-
5
-
-
0030265714
-
Intracellular signalling: The mad way to do it
-
Derynck R, Zhang Y. Intracellular signalling: the mad way to do it. Curr Biol 1996; 6:1226-1229.
-
(1996)
Curr Biol
, vol.6
, pp. 1226-1229
-
-
Derynck, R.1
Zhang, Y.2
-
7
-
-
23044466047
-
Specificity and versatility in TGF-beta signaling through Smads
-
Feng XH, Derynck R. Specificity and versatility in TGF-beta signaling through Smads. Annu Rev Cell Dev Biol 2005; 21:659-693.
-
(2005)
Annu Rev Cell Dev Biol
, vol.21
, pp. 659-693
-
-
Feng, X.H.1
Derynck, R.2
-
8
-
-
36448936383
-
TGFbeta-SMAD signal transduction: Molecular specificity and functional flexibility
-
Schmierer B, Hill CS. TGFbeta-SMAD signal transduction: molecular specificity and functional flexibility. Nat Rev Mol Cell Biol 2007; 8:970-982.
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, pp. 970-982
-
-
Schmierer, B.1
Hill, C.S.2
-
9
-
-
0142104985
-
Smad-dependent and Smad-independent pathways in TGF-beta family signalling
-
Derynck R, Zhang YE. Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature 2003; 425:577-584.
-
(2003)
Nature
, vol.425
, pp. 577-584
-
-
Derynck, R.1
Zhang, Y.E.2
-
10
-
-
24944497786
-
Non-Smad TGF-beta signals
-
Moustakas A, Heldin CH. Non-Smad TGF-beta signals. J Cell Sci 2005; 118:3573-3584.
-
(2005)
J Cell Sci
, vol.118
, pp. 3573-3584
-
-
Moustakas, A.1
Heldin, C.H.2
-
11
-
-
0026612306
-
Activation of p21ras by transforming growth factor beta in epithelial cells
-
Mulder KM, Morris SL. Activation of p21ras by transforming growth factor beta in epithelial cells. J Biol Chem 1992; 267:5029-5031.
-
(1992)
J Biol Chem
, vol.267
, pp. 5029-5031
-
-
Mulder, K.M.1
Morris, S.L.2
-
12
-
-
0028361791
-
Two different signal transduction pathways can be activated by transforming growth factor beta 1 in epithelial cells
-
Yan Z, Winawer S, Friedman E. Two different signal transduction pathways can be activated by transforming growth factor beta 1 in epithelial cells. J Biol Chem 1994; 269:13231-13237.
-
(1994)
J Biol Chem
, vol.269
, pp. 13231-13237
-
-
Yan, Z.1
Winawer, S.2
Friedman, E.3
-
13
-
-
0028937610
-
Transforming growth factor beta activation of p44mapk in proliferating cultures of epithelial cells
-
Hartsough MT, Mulder KM. Transforming growth factor beta activation of p44mapk in proliferating cultures of epithelial cells. J Biol Chem 1995; 270:7117-7124.
-
(1995)
J Biol Chem
, vol.270
, pp. 7117-7124
-
-
Hartsough, M.T.1
Mulder, K.M.2
-
14
-
-
0030609939
-
TGFbeta regulation of mitogen-activated protein kinases in human breast cancer cells
-
Frey RS, Mulder KM. TGFbeta regulation of mitogen-activated protein kinases in human breast cancer cells. Cancer Lett 1997; 117:41-50.
-
(1997)
Cancer Lett
, vol.117
, pp. 41-50
-
-
Frey, R.S.1
Mulder, K.M.2
-
15
-
-
0029893734
-
Extracellular signal-regulated kinase and the small GTP-binding protein, Rac, contribute to the effects of transforming growth factor-beta1 on gene expression
-
Mucsi I, Skorecki KL, Goldberg HJ. Extracellular signal-regulated kinase and the small GTP-binding protein, Rac, contribute to the effects of transforming growth factor-beta1 on gene expression. J Biol Chem 1996; 271:16567-16572.
-
(1996)
J Biol Chem
, vol.271
, pp. 16567-16572
-
-
Mucsi, I.1
Skorecki, K.L.2
Goldberg, H.J.3
-
16
-
-
0034811165
-
Smad4 mediates activation of mitogen-activated protein kinases by TGF-beta in pancreatic acinar cells
-
Simeone DM, Zhang L, Graziano K, et al. Smad4 mediates activation of mitogen-activated protein kinases by TGF-beta in pancreatic acinar cells. Am J Physiol Cell Physiol 2001; 281:C311-C319.
-
(2001)
Am J Physiol Cell Physiol
, vol.281
-
-
Simeone, D.M.1
Zhang, L.2
Graziano, K.3
-
17
-
-
0034971288
-
Transforming growth factor-beta-mediated mast cell migration depends on mitogen-activated protein kinase activity
-
Olsson N, Piek E, Sundstrom M, ten Dijke P, Nilsson G. Transforming growth factor-beta-mediated mast cell migration depends on mitogen-activated protein kinase activity. Cell Signal 2001; 13:483-490.
-
(2001)
Cell Signal
, vol.13
, pp. 483-490
-
-
Olsson, N.1
Piek, E.2
Sundstrom, M.3
ten Dijke, P.4
Nilsson, G.5
-
18
-
-
0034644539
-
Cell signaling by receptor tyrosine kinases
-
Schlessinger J. Cell signaling by receptor tyrosine kinases. Cell 2000; 103:211-225.
-
(2000)
Cell
, vol.103
, pp. 211-225
-
-
Schlessinger, J.1
-
19
-
-
34248575149
-
Integrating signals from RTKs to ERK/MAPK
-
McKay MM, Morrison DK. Integrating signals from RTKs to ERK/MAPK. Oncogene 2007; 26:3113-3121.
-
(2007)
Oncogene
, vol.26
, pp. 3113-3121
-
-
McKay, M.M.1
Morrison, D.K.2
-
20
-
-
0035474473
-
Signaling via Shc family adapter proteins
-
Ravichandran KS. Signaling via Shc family adapter proteins. Oncogene 2001; 20:6322-6330.
-
(2001)
Oncogene
, vol.20
, pp. 6322-6330
-
-
Ravichandran, K.S.1
-
21
-
-
0030978105
-
The type II transforming growth factor-beta receptor autophosphorylates not only on serine and threonine but also on tyrosine residues
-
Lawler S, Feng XH, Chen RH, et al. The type II transforming growth factor-beta receptor autophosphorylates not only on serine and threonine but also on tyrosine residues. J Biol Chem 1997; 272:14850-14859.
-
(1997)
J Biol Chem
, vol.272
, pp. 14850-14859
-
-
Lawler, S.1
Feng, X.H.2
Chen, R.H.3
-
22
-
-
34248584887
-
Src phosphorylates Tyr284 in TGF-beta type II receptor and regulates TGF-beta stimulation of p38 MAPK during breast cancer cell proliferation and invasion
-
Galliher AJ, Schiemann WP. Src phosphorylates Tyr284 in TGF-beta type II receptor and regulates TGF-beta stimulation of p38 MAPK during breast cancer cell proliferation and invasion. Cancer Res 2007; 67:3752-3758.
-
(2007)
Cancer Res
, vol.67
, pp. 3752-3758
-
-
Galliher, A.J.1
Schiemann, W.P.2
-
23
-
-
34548386720
-
TGF-beta activates Erk MAP kinase signalling through direct phosphorylation of ShcA
-
Lee MK, Pardoux C, Hall MC, et al. TGF-beta activates Erk MAP kinase signalling through direct phosphorylation of ShcA. EMBO J 2007; 26:3957-3967.
-
(2007)
EMBO J
, vol.26
, pp. 3957-3967
-
-
Lee, M.K.1
Pardoux, C.2
Hall, M.C.3
-
24
-
-
0344845003
-
Epithelial-mesenchymal transitions in development and pathologies
-
Thiery JP. Epithelial-mesenchymal transitions in development and pathologies. Curr Opin Cell Biol 2003; 15:740-746.
-
(2003)
Curr Opin Cell Biol
, vol.15
, pp. 740-746
-
-
Thiery, J.P.1
-
25
-
-
33645302628
-
The epithelial-mesenchymal transition: New insights in signaling, development, and disease
-
Lee JM, Dedhar S, Kalluri R, Thompson EW. The epithelial-mesenchymal transition: new insights in signaling, development, and disease. J Cell Biol 2006; 172:973-981.
-
(2006)
J Cell Biol
, vol.172
, pp. 973-981
-
-
Lee, J.M.1
Dedhar, S.2
Kalluri, R.3
Thompson, E.W.4
-
26
-
-
0035810944
-
Genetic programs of epithelial cell plasticity directed by transforming growth factor-beta
-
Zavadil J, Bitzer M, Liang D, et al. Genetic programs of epithelial cell plasticity directed by transforming growth factor-beta. Proc Natl Acad Sci USA 2001; 98:6686-6691.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 6686-6691
-
-
Zavadil, J.1
Bitzer, M.2
Liang, D.3
-
27
-
-
26444560222
-
Induction of an epithelial to mesenchymal transition in human immortal and malignant keratinocytes by TGF-beta1 involves MAPK, Smad and AP-1 signalling pathways
-
Davies M, Robinson M, Smith E, et al. Induction of an epithelial to mesenchymal transition in human immortal and malignant keratinocytes by TGF-beta1 involves MAPK, Smad and AP-1 signalling pathways. J Cell Biochem 2005; 95:918-931.
-
(2005)
J Cell Biochem
, vol.95
, pp. 918-931
-
-
Davies, M.1
Robinson, M.2
Smith, E.3
-
28
-
-
40549115658
-
Grb2 binding to Tyr284 in TbetaR-II is essential for mammary tumor growth and metastasis stimulated by TGF-beta
-
Galliher-Beckley AJ, Schiemann WP. Grb2 binding to Tyr284 in TbetaR-II is essential for mammary tumor growth and metastasis stimulated by TGF-beta. Carcinogenesis 2008; 29:244-251.
-
(2008)
Carcinogenesis
, vol.29
, pp. 244-251
-
-
Galliher-Beckley, A.J.1
Schiemann, W.P.2
-
29
-
-
43249109660
-
Signaling through ShcA is required for transforming growth factor beta- and Neu/ErbB-2-induced breast cancer cell motility and invasion
-
Northey JJ, Chmielecki J, Ngan E, et al. Signaling through ShcA is required for transforming growth factor beta- and Neu/ErbB-2-induced breast cancer cell motility and invasion. Mol Cell Biol 2008; 28:3162-3176.
-
(2008)
Mol Cell Biol
, vol.28
, pp. 3162-3176
-
-
Northey, J.J.1
Chmielecki, J.2
Ngan, E.3
-
30
-
-
0030773834
-
Opposing BMP and EGF signalling pathways converge on the TGF-beta family mediator Smad1
-
Kretzschmar M, Doody J, Massagué J. Opposing BMP and EGF signalling pathways converge on the TGF-beta family mediator Smad1. Nature 1997; 389:618-622.
-
(1997)
Nature
, vol.389
, pp. 618-622
-
-
Kretzschmar, M.1
Doody, J.2
Massagué, J.3
-
31
-
-
0033106484
-
A mechanism of repression of TGFbeta/ Smad signaling by oncogenic Ras
-
Kretzschmar M, Doody J, Timokhina I, Massagué J. A mechanism of repression of TGFbeta/ Smad signaling by oncogenic Ras. Genes Dev 1999; 13:804-816.
-
(1999)
Genes Dev
, vol.13
, pp. 804-816
-
-
Kretzschmar, M.1
Doody, J.2
Timokhina, I.3
Massagué, J.4
-
32
-
-
0036829567
-
Modulation of Smad2-mediated signaling by extracellular signal-regulated kinase
-
Funaba M, Zimmerman CM, Mathews LS. Modulation of Smad2-mediated signaling by extracellular signal-regulated kinase. J Biol Chem 2002; 277:41361-41368.
-
(2002)
J Biol Chem
, vol.277
, pp. 41361-41368
-
-
Funaba, M.1
Zimmerman, C.M.2
Mathews, L.S.3
-
33
-
-
24944439828
-
Identification and characterization of ERK MAP kinase phosphorylation sites in Smad3
-
Matsuura I, Wang G, He D, Liu F. Identification and characterization of ERK MAP kinase phosphorylation sites in Smad3. Biochemistry 2005; 44:12546-12553.
-
(2005)
Biochemistry
, vol.44
, pp. 12546-12553
-
-
Matsuura, I.1
Wang, G.2
He, D.3
Liu, F.4
-
34
-
-
0032572723
-
Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription
-
Zhang Y, Feng XH, Derynck R. Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription. Nature 1998; 394:909-913.
-
(1998)
Nature
, vol.394
, pp. 909-913
-
-
Zhang, Y.1
Feng, X.H.2
Derynck, R.3
-
35
-
-
0038532305
-
The comparative role of activator protein 1 and Smad factors in the regulation of Timp-1 and MMP-1 gene expression by transforming growth factorbeta 1
-
Hall MC, Young DA, Waters JG, et al. The comparative role of activator protein 1 and Smad factors in the regulation of Timp-1 and MMP-1 gene expression by transforming growth factorbeta 1. J Biol Chem 2003; 278:10304-10313.
-
(2003)
J Biol Chem
, vol.278
, pp. 10304-10313
-
-
Hall, M.C.1
Young, D.A.2
Waters, J.G.3
-
36
-
-
33847754623
-
The JNK signal transduction pathway
-
Weston CR, Davis RJ. The JNK signal transduction pathway. Curr Opin Cell Biol 2007; 19:142-149.
-
(2007)
Curr Opin Cell Biol
, vol.19
, pp. 142-149
-
-
Weston, C.R.1
Davis, R.J.2
-
37
-
-
0031059867
-
Involvement of extracellular signal-regulated kinase 2 and stress-activated protein kinase/Jun N-terminal kinase activation by transforming growth factor beta in the negative growth control of breast cancer cells
-
Frey RS, Mulder KM. Involvement of extracellular signal-regulated kinase 2 and stress-activated protein kinase/Jun N-terminal kinase activation by transforming growth factor beta in the negative growth control of breast cancer cells. Cancer Res 1997; 57:628-633.
-
(1997)
Cancer Res
, vol.57
, pp. 628-633
-
-
Frey, R.S.1
Mulder, K.M.2
-
38
-
-
0033601179
-
Interdependent SMAD and JNK signaling in transforming growth factor-beta-mediated transcription
-
Engel ME, McDonnell MA, Law BK, Moses HL. Interdependent SMAD and JNK signaling in transforming growth factor-beta-mediated transcription. J Biol Chem 1999; 274:37413-37420.
-
(1999)
J Biol Chem
, vol.274
, pp. 37413-37420
-
-
Engel, M.E.1
McDonnell, M.A.2
Law, B.K.3
Moses, H.L.4
-
39
-
-
0033104505
-
TGF-beta induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathway
-
Hocevar BA, Brown TL, Howe PH. TGF-beta induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathway. EMBO J 1999; 18:1345-1356.
-
(1999)
EMBO J
, vol.18
, pp. 1345-1356
-
-
Hocevar, B.A.1
Brown, T.L.2
Howe, P.H.3
-
40
-
-
0033578721
-
Involvement of the p38 mitogen-activated protein kinase pathway in transforming growth factor-beta-induced gene expression
-
Hanafusa H, Ninomiya-Tsuji J, Masuyama N, et al. Involvement of the p38 mitogen-activated protein kinase pathway in transforming growth factor-beta-induced gene expression. J Biol Chem 1999; 274:27161-27167.
-
(1999)
J Biol Chem
, vol.274
, pp. 27161-27167
-
-
Hanafusa, H.1
Ninomiya-Tsuji, J.2
Masuyama, N.3
-
41
-
-
0033605562
-
ATF-2 is a common nuclear target of Smad and TAK1 pathways in transforming growth factor-beta signaling
-
Sano Y, Harada J, Tashiro S, et al. ATF-2 is a common nuclear target of Smad and TAK1 pathways in transforming growth factor-beta signaling. J Biol Chem 1999; 274:8949-8957.
-
(1999)
J Biol Chem
, vol.274
, pp. 8949-8957
-
-
Sano, Y.1
Harada, J.2
Tashiro, S.3
-
42
-
-
0035861541
-
Integrin beta 1 signaling is necessary for transforming growth factor-beta activation of p38MAPK and epithelial plasticity
-
Bhowmick NA, Zent R, Ghiassi M, McDonnell M, Moses HL. Integrin beta 1 signaling is necessary for transforming growth factor-beta activation of p38MAPK and epithelial plasticity. J Biol Chem 2001; 276:46707-46713.
-
(2001)
J Biol Chem
, vol.276
, pp. 46707-46713
-
-
Bhowmick, N.A.1
Zent, R.2
Ghiassi, M.3
McDonnell, M.4
Moses, H.L.5
-
43
-
-
0037099745
-
TGF-beta receptor-activated p38 MAP kinase mediates Smad-independent TGF-beta responses
-
Yu L, Hebert MC, Zhang YE. TGF-beta receptor-activated p38 MAP kinase mediates Smad-independent TGF-beta responses. EMBO J 2002; 21:3749-3759.
-
(2002)
EMBO J
, vol.21
, pp. 3749-3759
-
-
Yu, L.1
Hebert, M.C.2
Zhang, Y.E.3
-
44
-
-
0037423374
-
Elucidation of Smad requirement in transforming growth factor-beta type I receptor-induced responses
-
Itoh S, Thorikay M, Kowanetz M, et al. Elucidation of Smad requirement in transforming growth factor-beta type I receptor-induced responses. J Biol Chem 2003; 278:3751-3761.
-
(2003)
J Biol Chem
, vol.278
, pp. 3751-3761
-
-
Itoh, S.1
Thorikay, M.2
Kowanetz, M.3
-
45
-
-
0029551805
-
Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction
-
Yamaguchi K, Shirakabe K, Shibuya H, et al. Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction. Science 1995; 270:2008-2011.
-
(1995)
Science
, vol.270
, pp. 2008-2011
-
-
Yamaguchi, K.1
Shirakabe, K.2
Shibuya, H.3
-
46
-
-
0032481312
-
Role of TAK1 and TAB1 in BMP signaling in early Xenopus development
-
Shibuya H, Iwata H, Masuyama N, et al. Role of TAK1 and TAB1 in BMP signaling in early Xenopus development. EMBO J 1998; 17:1019-1028.
-
(1998)
EMBO J
, vol.17
, pp. 1019-1028
-
-
Shibuya, H.1
Iwata, H.2
Masuyama, N.3
-
47
-
-
27744577296
-
TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo
-
Shim JH, Xiao C, Paschal AE, et al. TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo. Genes Dev 2005; 19:2668-2681.
-
(2005)
Genes Dev
, vol.19
, pp. 2668-2681
-
-
Shim, J.H.1
Xiao, C.2
Paschal, A.E.3
-
48
-
-
33646713486
-
The TGF beta activated kinase TAK1 regulates vascular development in vivo
-
Jadrich JL, O'Connor MB, Coucouvanis E. The TGF beta activated kinase TAK1 regulates vascular development in vivo. Development 2006; 133:1529-1541.
-
(2006)
Development
, vol.133
, pp. 1529-1541
-
-
Jadrich, J.L.1
O'Connor, M.B.2
Coucouvanis, E.3
-
49
-
-
30744469899
-
A direct interaction between TGFbeta activated kinase 1 and the TGFbeta type II receptor: Implications for TGFbeta signalling and cardiac hypertrophy
-
Watkins SJ, Jonker L, Arthur HM. A direct interaction between TGFbeta activated kinase 1 and the TGFbeta type II receptor: implications for TGFbeta signalling and cardiac hypertrophy. Cardiovasc Res 2006; 69:432-439.
-
(2006)
Cardiovasc Res
, vol.69
, pp. 432-439
-
-
Watkins, S.J.1
Jonker, L.2
Arthur, H.M.3
-
50
-
-
53349164136
-
The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner
-
Sorrentino A, Thakur N, Grimsby S, et al. The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner. Nat Cell Biol 2008; 10:1199-1207.
-
(2008)
Nat Cell Biol
, vol.10
, pp. 1199-1207
-
-
Sorrentino, A.1
Thakur, N.2
Grimsby, S.3
-
51
-
-
52049111663
-
TRAF6 mediates Smad-independent activation of JNK and p38 by TGF-beta
-
Yamashita M, Fatyol K, Jin C, et al. TRAF6 mediates Smad-independent activation of JNK and p38 by TGF-beta. Mol Cell 2008; 31:918-924.
-
(2008)
Mol Cell
, vol.31
, pp. 918-924
-
-
Yamashita, M.1
Fatyol, K.2
Jin, C.3
-
52
-
-
0035475338
-
Tumor necrosis factor receptor-associated factors (TRAFs)
-
Bradley JR, Pober JS. Tumor necrosis factor receptor-associated factors (TRAFs). Oncogene 2001; 20:6482-6491.
-
(2001)
Oncogene
, vol.20
, pp. 6482-6491
-
-
Bradley, J.R.1
Pober, J.S.2
-
53
-
-
27144529182
-
Ubiquitylation and cell signaling
-
Haglund K, Dikic I. Ubiquitylation and cell signaling. EMBO J 2005; 24:3353-3359.
-
(2005)
EMBO J
, vol.24
, pp. 3353-3359
-
-
Haglund, K.1
Dikic, I.2
-
54
-
-
0035913278
-
TAK1 is a ubiquitin-dependent kinase of MKK and IKK
-
Wang C, Deng L, Hong M, et al. TAK1 is a ubiquitin-dependent kinase of MKK and IKK. Nature 2001; 412:346-351.
-
(2001)
Nature
, vol.412
, pp. 346-351
-
-
Wang, C.1
Deng, L.2
Hong, M.3
-
55
-
-
0031035582
-
Evidence for a role of Rho-like GTPases and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) in transforming growth factor beta-mediated signaling
-
Atfi A, Djelloul S, Chastre E, Davis R, Gespach C. Evidence for a role of Rho-like GTPases and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) in transforming growth factor beta-mediated signaling. J Biol Chem 1997; 272:1429-1432.
-
(1997)
J Biol Chem
, vol.272
, pp. 1429-1432
-
-
Atfi, A.1
Djelloul, S.2
Chastre, E.3
Davis, R.4
Gespach, C.5
-
56
-
-
0033605559
-
MEKK-1, a component of the stress (stress-activated protein kinase/c-Jun N-terminal kinase) pathway, can selectively activate Smad2-mediated transcriptional activation in endothelial cells
-
Brown JD, DiChiara MR, Anderson KR, Gimbrone Jr MA, Topper JN. MEKK-1, a component of the stress (stress-activated protein kinase/c-Jun N-terminal kinase) pathway, can selectively activate Smad2-mediated transcriptional activation in endothelial cells. J Biol Chem 1999; 274:8797-8805.
-
(1999)
J Biol Chem
, vol.274
, pp. 8797-8805
-
-
Brown, J.D.1
DiChiara, M.R.2
Anderson, K.R.3
Gimbrone Jr, M.A.4
Topper, J.N.5
-
57
-
-
0042237016
-
A role for MEK kinase 1 in TGF-beta/activin-induced epithelium movement and embryonic eyelid closure
-
Zhang L, Wang W, Hayashi Y, et al. A role for MEK kinase 1 in TGF-beta/activin-induced epithelium movement and embryonic eyelid closure. EMBO J 2003; 22:4443-4454.
-
(2003)
EMBO J
, vol.22
, pp. 4443-4454
-
-
Zhang, L.1
Wang, W.2
Hayashi, Y.3
-
58
-
-
3142741044
-
Mixed lineage kinase 3 (MLK3)-activated p38 MAP kinase mediates transforming growth factor-beta-induced apoptosis in hepatoma cells
-
Kim KY, Kim BC, Xu Z, Kim SJ. Mixed lineage kinase 3 (MLK3)-activated p38 MAP kinase mediates transforming growth factor-beta-induced apoptosis in hepatoma cells. J Biol Chem 2004; 279:29478-29484.
-
(2004)
J Biol Chem
, vol.279
, pp. 29478-29484
-
-
Kim, K.Y.1
Kim, B.C.2
Xu, Z.3
Kim, S.J.4
-
59
-
-
0034625342
-
BMP2-induced apoptosis is mediated by activation of the TAK1-p38 kinase pathway that is negatively regulated by Smad6
-
Kimura N, Matsuo R, Shibuya H, Nakashima K, Taga T. BMP2-induced apoptosis is mediated by activation of the TAK1-p38 kinase pathway that is negatively regulated by Smad6. J Biol Chem 2000; 275:17647-17652.
-
(2000)
J Biol Chem
, vol.275
, pp. 17647-17652
-
-
Kimura, N.1
Matsuo, R.2
Shibuya, H.3
Nakashima, K.4
Taga, T.5
-
60
-
-
0037326526
-
Transforming growth factor-beta1 (TGF-beta)-induced apoptosis of prostate cancer cells involves Smad7-dependent activation of p38 by TGF-beta-activated kinase 1 and mitogen-activated protein kinase kinase 3
-
Edlund S, Bu S, Schuster N, et al. Transforming growth factor-beta1 (TGF-beta)-induced apoptosis of prostate cancer cells involves Smad7-dependent activation of p38 by TGF-beta-activated kinase 1 and mitogen-activated protein kinase kinase 3. Mol Biol Cell 2003; 14:529-544.
-
(2003)
Mol Biol Cell
, vol.14
, pp. 529-544
-
-
Edlund, S.1
Bu, S.2
Schuster, N.3
-
61
-
-
0035378992
-
The involvement of p38 MAPK in transforming growth factor beta1-induced apoptosis in murine hepatocytes
-
Liao JH, Chen JS, Chai MQ, Zhao S, Song JG. The involvement of p38 MAPK in transforming growth factor beta1-induced apoptosis in murine hepatocytes. Cell Res 2001; 11:89-94.
-
(2001)
Cell Res
, vol.11
, pp. 89-94
-
-
Liao, J.H.1
Chen, J.S.2
Chai, M.Q.3
Zhao, S.4
Song, J.G.5
-
62
-
-
0036674213
-
p38 mitogen-activated protein kinase is required for TGFbeta-mediated fibroblastic transdifferentiation and cell migration
-
Bakin AV, Rinehart C, Tomlinson AK, Arteaga CL. p38 mitogen-activated protein kinase is required for TGFbeta-mediated fibroblastic transdifferentiation and cell migration. J Cell Sci 2002; 115:3193-3206.
-
(2002)
J Cell Sci
, vol.115
, pp. 3193-3206
-
-
Bakin, A.V.1
Rinehart, C.2
Tomlinson, A.K.3
Arteaga, C.L.4
-
63
-
-
27944479854
-
Rho GTPases: Biochemistry and biology
-
Jaffe AB, Hall A. Rho GTPases: biochemistry and biology. Annu Rev Cell Dev Biol 2005; 21:247-269.
-
(2005)
Annu Rev Cell Dev Biol
, vol.21
, pp. 247-269
-
-
Jaffe, A.B.1
Hall, A.2
-
64
-
-
0035185853
-
Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism
-
Bhowmick NA, Ghiassi M, Bakin A, et al. Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism. Mol Biol Cell 2001; 12:27-36.
-
(2001)
Mol Biol Cell
, vol.12
, pp. 27-36
-
-
Bhowmick, N.A.1
Ghiassi, M.2
Bakin, A.3
-
65
-
-
0036197606
-
Transforming growth factor-beta-induced mobilization of actin cytoskeleton requires signaling by small GTPases Cdc42 and RhoA
-
Edlund S, Landstrom M, Heldin CH, Aspenstrom P. Transforming growth factor-beta-induced mobilization of actin cytoskeleton requires signaling by small GTPases Cdc42 and RhoA. Mol Biol Cell 2002; 13:902-914.
-
(2002)
Mol Biol Cell
, vol.13
, pp. 902-914
-
-
Edlund, S.1
Landstrom, M.2
Heldin, C.H.3
Aspenstrom, P.4
-
66
-
-
0035805595
-
The activity of guanine exchange factor NET1 is essential for transforming growth factor-beta-mediated stress fiber formation
-
Shen X, Li J, Hu PP, et al. The activity of guanine exchange factor NET1 is essential for transforming growth factor-beta-mediated stress fiber formation. J Biol Chem 2001; 276:15362-15368.
-
(2001)
J Biol Chem
, vol.276
, pp. 15362-15368
-
-
Shen, X.1
Li, J.2
Hu, P.P.3
-
67
-
-
14844364701
-
Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity
-
Ozdamar B, Bose R, Barrios-Rodiles M, et al. Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity. Science 2005; 307:1603-1609.
-
(2005)
Science
, vol.307
, pp. 1603-1609
-
-
Ozdamar, B.1
Bose, R.2
Barrios-Rodiles, M.3
-
68
-
-
0037022122
-
Assembly of epithelial tight junctions is negatively regulated by Par6
-
Gao L, Joberty G, Macara IG. Assembly of epithelial tight junctions is negatively regulated by Par6. Curr Biol 2002; 12:221-225.
-
(2002)
Curr Biol
, vol.12
, pp. 221-225
-
-
Gao, L.1
Joberty, G.2
Macara, I.G.3
-
69
-
-
0344758986
-
Regulation of cell polarity and protrusion formation by targeting RhoA for degradation
-
Wang HR, Zhang Y, Ozdamar B, et al. Regulation of cell polarity and protrusion formation by targeting RhoA for degradation. Science 2003; 302:1775-1779.
-
(2003)
Science
, vol.302
, pp. 1775-1779
-
-
Wang, H.R.1
Zhang, Y.2
Ozdamar, B.3
-
70
-
-
0242721599
-
Cell-typespecific activation of PAK2 by transforming growth factor beta independent of Smad2 and Smad3
-
Wilkes MC, Murphy SJ, Garamszegi N, Leof EB. Cell-typespecific activation of PAK2 by transforming growth factor beta independent of Smad2 and Smad3. Mol Cell Biol 2003; 23:8878-8889.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 8878-8889
-
-
Wilkes, M.C.1
Murphy, S.J.2
Garamszegi, N.3
Leof, E.B.4
-
71
-
-
20144372620
-
High-throughput mapping of a dynamic signaling network in mammalian cells
-
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. High-throughput mapping of a dynamic signaling network in mammalian cells. Science 2005; 307:1621-1625.
-
(2005)
Science
, vol.307
, pp. 1621-1625
-
-
Barrios-Rodiles, M.1
Brown, K.R.2
Ozdamar, B.3
-
72
-
-
0141656297
-
Direct signaling by the BMP type II receptor via the cytoskeletal regulator LIMK1
-
Foletta VC, Lim MA, Soosairajah J, et al. Direct signaling by the BMP type II receptor via the cytoskeletal regulator LIMK1. J Cell Biol 2003; 162:1089-1098.
-
(2003)
J Cell Biol
, vol.162
, pp. 1089-1098
-
-
Foletta, V.C.1
Lim, M.A.2
Soosairajah, J.3
-
73
-
-
11244313831
-
Activation of LIMK1 by binding to the BMP receptor, BMPRII, regulates BMP-dependent dendritogenesis
-
Lee-Hoeflich ST, Causing CG, Podkowa M, et al. Activation of LIMK1 by binding to the BMP receptor, BMPRII, regulates BMP-dependent dendritogenesis. EMBO J 2004; 23:4792-4801.
-
(2004)
EMBO J
, vol.23
, pp. 4792-4801
-
-
Lee-Hoeflich, S.T.1
Causing, C.G.2
Podkowa, M.3
-
74
-
-
2342436038
-
Smad7 is required for TGF-beta-induced activation of the small GTPase Cdc42
-
Edlund S, Landstrom M, Heldin CH, Aspenstrom P. Smad7 is required for TGF-beta-induced activation of the small GTPase Cdc42. J Cell Sci 2004; 117:1835-1847.
-
(2004)
J Cell Sci
, vol.117
, pp. 1835-1847
-
-
Edlund, S.1
Landstrom, M.2
Heldin, C.H.3
Aspenstrom, P.4
-
75
-
-
0034711307
-
Phosphatidylinositol 3-kinase function is required for transforming growth factor beta-mediated epithelial to mesenchymal transition and cell migration
-
Bakin AV, Tomlinson AK, Bhowmick NA, Moses HL, Arteaga CL. Phosphatidylinositol 3-kinase function is required for transforming growth factor beta-mediated epithelial to mesenchymal transition and cell migration. J Biol Chem 2000; 275:36803-36810.
-
(2000)
J Biol Chem
, vol.275
, pp. 36803-36810
-
-
Bakin, A.V.1
Tomlinson, A.K.2
Bhowmick, N.A.3
Moses, H.L.4
Arteaga, C.L.5
-
76
-
-
0035196587
-
Transforming growth factor beta enhances epithelial cell survival via Akt-dependent regulation of FKHRL1
-
Shin I, Bakin AV, Rodeck U, Brunet A, Arteaga CL. Transforming growth factor beta enhances epithelial cell survival via Akt-dependent regulation of FKHRL1. Mol Biol Cell 2001; 12:3328-3339.
-
(2001)
Mol Biol Cell
, vol.12
, pp. 3328-3339
-
-
Shin, I.1
Bakin, A.V.2
Rodeck, U.3
Brunet, A.4
Arteaga, C.L.5
-
77
-
-
0034791087
-
Transforming growth factor beta1 (TGF-beta1) promotes endothelial cell survival during in vitro angiogenesis via an autocrine mechanism implicating TGF-alpha signaling
-
Vinals F, Pouyssegur J. Transforming growth factor beta1 (TGF-beta1) promotes endothelial cell survival during in vitro angiogenesis via an autocrine mechanism implicating TGF-alpha signaling. Mol Cell Biol 2001; 21:7218-7230.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 7218-7230
-
-
Vinals, F.1
Pouyssegur, J.2
-
78
-
-
28544450380
-
Transforming growth factor-beta activation of phosphatidylinositol 3-kinase is independent of Smad2 and Smad3 and regulates fibroblast responses via p21-activated kinase-2
-
Wilkes MC, Mitchell H, Penheiter SG, et al. Transforming growth factor-beta activation of phosphatidylinositol 3-kinase is independent of Smad2 and Smad3 and regulates fibroblast responses via p21-activated kinase-2. Cancer Res 2005; 65:10431-10440.
-
(2005)
Cancer Res
, vol.65
, pp. 10431-10440
-
-
Wilkes, M.C.1
Mitchell, H.2
Penheiter, S.G.3
-
79
-
-
34547587877
-
Cell size and invasion in TGF-beta-induced epithelial to mesenchymal transition is regulated by activation of the mTOR pathway
-
Lamouille S, Derynck R. Cell size and invasion in TGF-beta-induced epithelial to mesenchymal transition is regulated by activation of the mTOR pathway. J Cell Biol 2007; 178:437-451.
-
(2007)
J Cell Biol
, vol.178
, pp. 437-451
-
-
Lamouille, S.1
Derynck, R.2
-
80
-
-
15444372825
-
Type I transforming growth factor beta receptor binds to and activates phosphatidylinositol 3-kinase
-
Yi JY, Shin I, Arteaga CL. Type I transforming growth factor beta receptor binds to and activates phosphatidylinositol 3-kinase. J Biol Chem 2005; 280:10870-10876.
-
(2005)
J Biol Chem
, vol.280
, pp. 10870-10876
-
-
Yi, J.Y.1
Shin, I.2
Arteaga, C.L.3
-
81
-
-
0036902409
-
Activin/TGF-beta induce apoptosis through Smad-dependent expression of the lipid phosphatase SHIP
-
Valderrama-Carvajal H, Cocolakis E, Lacerte A, et al. Activin/TGF-beta induce apoptosis through Smad-dependent expression of the lipid phosphatase SHIP. Nat Cell Biol 2002; 4:963-969.
-
(2002)
Nat Cell Biol
, vol.4
, pp. 963-969
-
-
Valderrama-Carvajal, H.1
Cocolakis, E.2
Lacerte, A.3
-
82
-
-
0032428684
-
-
Tsukazaki T, Chiang TA, Davison AF, Attisano L, Wrana JL. SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor. Cell 1998; 95:779-791.
-
Tsukazaki T, Chiang TA, Davison AF, Attisano L, Wrana JL. SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor. Cell 1998; 95:779-791.
-
-
-
-
83
-
-
0037144841
-
TGF beta receptor internalization into EEA1-enriched early endosomes: Role in signaling to Smad2
-
Hayes S, Chawla A, Corvera S. TGF beta receptor internalization into EEA1-enriched early endosomes: role in signaling to Smad2. J Cell Biol 2002; 158:1239-1249.
-
(2002)
J Cell Biol
, vol.158
, pp. 1239-1249
-
-
Hayes, S.1
Chawla, A.2
Corvera, S.3
-
84
-
-
15244339164
-
Imatinib mesylate inhibits the profibrogenic activity of TGF-beta and prevents bleomycin-mediated lung fibrosis
-
Daniels CE, Wilkes MC, Edens M, et al. Imatinib mesylate inhibits the profibrogenic activity of TGF-beta and prevents bleomycin-mediated lung fibrosis. J Clin Invest 2004; 114:1308-1316.
-
(2004)
J Clin Invest
, vol.114
, pp. 1308-1316
-
-
Daniels, C.E.1
Wilkes, M.C.2
Edens, M.3
-
85
-
-
11244292291
-
Imatinib mesylate blocks a non-Smad TGF-beta pathway and reduces renal fibrogenesis in vivo
-
Wang S, Wilkes MC, Leof EB, Hirschberg R. Imatinib mesylate blocks a non-Smad TGF-beta pathway and reduces renal fibrogenesis in vivo. FASEB J 2005; 19:1-11.
-
(2005)
FASEB J
, vol.19
, pp. 1-11
-
-
Wang, S.1
Wilkes, M.C.2
Leof, E.B.3
Hirschberg, R.4
-
86
-
-
0032532206
-
Suppression of transforming growth factor-beta-induced apoptosis through a phosphatidylinositol 3-kinase/Akt-dependent pathway
-
Chen RH, Su YH, Chuang RL, Chang TY. Suppression of transforming growth factor-beta-induced apoptosis through a phosphatidylinositol 3-kinase/Akt-dependent pathway. Oncogene 1998; 17:1959-1968.
-
(1998)
Oncogene
, vol.17
, pp. 1959-1968
-
-
Chen, R.H.1
Su, Y.H.2
Chuang, R.L.3
Chang, T.Y.4
-
87
-
-
30444434212
-
Novel roles of Akt and mTOR in suppressing TGF-beta/ALK5-mediated Smad3 activation
-
Song K, Wang H, Krebs TL, Danielpour D. Novel roles of Akt and mTOR in suppressing TGF-beta/ALK5-mediated Smad3 activation. EMBO J 2006; 25:58-69.
-
(2006)
EMBO J
, vol.25
, pp. 58-69
-
-
Song, K.1
Wang, H.2
Krebs, T.L.3
Danielpour, D.4
-
88
-
-
2342471301
-
Akt interacts directly with Smad3 to regulate the sensitivity to TGF-beta induced apoptosis
-
Conery AR, Cao Y, Thompson EA, et al. Akt interacts directly with Smad3 to regulate the sensitivity to TGF-beta induced apoptosis. Nat Cell Biol 2004; 6:366-372.
-
(2004)
Nat Cell Biol
, vol.6
, pp. 366-372
-
-
Conery, A.R.1
Cao, Y.2
Thompson, E.A.3
-
89
-
-
2342647439
-
PKB/Akt modulates TGF-beta signalling through a direct interaction with Smad3
-
Remy I, Montmarquette A, Michnick SW. PKB/Akt modulates TGF-beta signalling through a direct interaction with Smad3. Nat Cell Biol 2004; 6:358-365.
-
(2004)
Nat Cell Biol
, vol.6
, pp. 358-365
-
-
Remy, I.1
Montmarquette, A.2
Michnick, S.W.3
-
90
-
-
1642332084
-
Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation
-
Seoane J, Le HV, Shen L, Anderson SA, Massagué J. Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation. Cell 2004; 117:211-223.
-
(2004)
Cell
, vol.117
, pp. 211-223
-
-
Seoane, J.1
Le, H.V.2
Shen, L.3
Anderson, S.A.4
Massagué, J.5
-
91
-
-
33748075143
-
A FoxO-Smad synexpression group in human keratinocytes
-
Gomis RR, Alarcon C, He W, et al. A FoxO-Smad synexpression group in human keratinocytes. Proc Natl Acad Sci USA 2006; 103:12747- 12752.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 12747-12752
-
-
Gomis, R.R.1
Alarcon, C.2
He, W.3
-
92
-
-
0034671578
-
TGF-beta inhibits p70 S6 kinase via protein phosphatase 2A to induce G(1) arrest
-
Petritsch C, Beug H, Balmain A, Oft M. TGF-beta inhibits p70 S6 kinase via protein phosphatase 2A to induce G(1) arrest. Genes Dev 2000; 14:3093-3101.
-
(2000)
Genes Dev
, vol.14
, pp. 3093-3101
-
-
Petritsch, C.1
Beug, H.2
Balmain, A.3
Oft, M.4
-
93
-
-
0031741865
-
Physical and functional interactions between type I transforming growth factor beta receptors and Balpha, a WD-40 repeat subunit of phosphatase 2A
-
Griswold-Prenner I, Kamibayashi C, Maruoka EM, Mumby MC, Derynck R. Physical and functional interactions between type I transforming growth factor beta receptors and Balpha, a WD-40 repeat subunit of phosphatase 2A. Mol Cell Biol 1998; 18:6595-6604.
-
(1998)
Mol Cell Biol
, vol.18
, pp. 6595-6604
-
-
Griswold-Prenner, I.1
Kamibayashi, C.2
Maruoka, E.M.3
Mumby, M.C.4
Derynck, R.5
-
94
-
-
0035252894
-
Protein phosphatase 2A: A highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling
-
Janssens V, Goris J. Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling. Biochem J 2001; 353:417-439.
-
(2001)
Biochem J
, vol.353
, pp. 417-439
-
-
Janssens, V.1
Goris, J.2
|