An Ovol2-Zeb1 Mutual Inhibitory Circuit Governs Bidirectional and Multi-step Transition between Epithelial and Mesenchymal States

PLoS Computational Biology

Volumn 11, Issue 11, 2015, Pages

  Hong, Tian ^a   Watanabe, Kazuhide ^a,b   Ta, Catherine Ha ^a   Villarreal Ponce, Alvaro ^a,b   Nie, Qing ^a   Dai, Xing ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DISEASES; PLASTICITY; TIMING CIRCUITS;

CANCER METASTASIS; CELLULARS; COMPLEX PROCESSES; EPITHELIAL TO MESENCHYMAL TRANSITIONS; INTERMEDIATE STATE; MULTISTEPS; REGULATORY ELEMENTS; STEP TRANSITIONS; SYSTEMS BIOLOGY; TISSUE DEVELOPMENT;

ENVIRONMENTAL REGULATIONS;

TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR OVOL2; TRANSCRIPTION FACTOR ZEB1; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; HOMEODOMAIN PROTEIN; ZINC FINGER PROTEIN;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CANCER CELL; CELL POPULATION; CONTROLLED STUDY; DOWN REGULATION; EPITHELIAL MESENCHYMAL TRANSITION; EPITHELIUM CELL; HUMAN; NONHUMAN; PHENOTYPE; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; STOCHASTIC MODEL; THERMODYNAMICS; ANIMAL; BIOLOGY; CELL LINE; FEEDBACK SYSTEM; GENETICS; METABOLISM; MOUSE; TUMOR CELL LINE;

ANIMALS; CELL LINE; CELL LINE, TUMOR; COMPUTATIONAL BIOLOGY; EPITHELIAL-MESENCHYMAL TRANSITION; FEEDBACK, PHYSIOLOGICAL; HOMEODOMAIN PROTEINS; HUMANS; MICE; TRANSCRIPTION FACTORS; ZINC FINGERS;

EID: 84949256096     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1004569     Document Type: Article

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