-
1
-
-
0035496104
-
APC, signal transduction and genetic instability in colorectal cancer
-
Fodde R., Smits R., and Clevers H. APC, signal transduction and genetic instability in colorectal cancer. Nat Rev Cancer 1 (2001) 55-67
-
(2001)
Nat Rev Cancer
, vol.1
, pp. 55-67
-
-
Fodde, R.1
Smits, R.2
Clevers, H.3
-
2
-
-
0030975671
-
Constitutive transcriptional activation by a β-catenin-Tcf complex in APC-/- colon carcinoma
-
Korinek V., Barker N., Morin P.J., van Wichen D., de Weger R., Kinzler K.W., Vogelstein B., and Clevers H. Constitutive transcriptional activation by a β-catenin-Tcf complex in APC-/- colon carcinoma. Science 275 (1997) 1784-1787
-
(1997)
Science
, vol.275
, pp. 1784-1787
-
-
Korinek, V.1
Barker, N.2
Morin, P.J.3
van Wichen, D.4
de Weger, R.5
Kinzler, K.W.6
Vogelstein, B.7
Clevers, H.8
-
3
-
-
0030949463
-
Activation of β-catenin-Tcf signaling in colon cancer by mutations in β-catenin or APC
-
Morin P.J., Sparks A.B., Korinek V., Barker N., Clevers H., Vogelstein B., and Kinzler K.W. Activation of β-catenin-Tcf signaling in colon cancer by mutations in β-catenin or APC. Science 275 (1997) 1787-1790
-
(1997)
Science
, vol.275
, pp. 1787-1790
-
-
Morin, P.J.1
Sparks, A.B.2
Korinek, V.3
Barker, N.4
Clevers, H.5
Vogelstein, B.6
Kinzler, K.W.7
-
4
-
-
18644373146
-
The β-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells
-
van de Wetering M., Sancho E., Verweij C., de Lau W., Oving I., Hurlstone A., van der Horn K., Batlle E., Coudreuse D., Haramis A.P., et al. The β-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. Cell 111 (2002) 241-250
-
(2002)
Cell
, vol.111
, pp. 241-250
-
-
van de Wetering, M.1
Sancho, E.2
Verweij, C.3
de Lau, W.4
Oving, I.5
Hurlstone, A.6
van der Horn, K.7
Batlle, E.8
Coudreuse, D.9
Haramis, A.P.10
-
5
-
-
22344441322
-
Defining the impact of β-catenin/Tcf transactivation on epithelial stem cells
-
By employing gain-of-function mutations and inducible loss-of-function mutations, the authors show that different levels of Wnt/β-catenin signaling have distinct effects on stem cells of the hair follicle and their transient amplifying progenitors.
-
Lowry W.E., Blanpain C., Nowak J.A., Guasch G., Lewis L., and Fuchs E. Defining the impact of β-catenin/Tcf transactivation on epithelial stem cells. Genes Dev 19 (2005) 1596-1611. By employing gain-of-function mutations and inducible loss-of-function mutations, the authors show that different levels of Wnt/β-catenin signaling have distinct effects on stem cells of the hair follicle and their transient amplifying progenitors.
-
(2005)
Genes Dev
, vol.19
, pp. 1596-1611
-
-
Lowry, W.E.1
Blanpain, C.2
Nowak, J.A.3
Guasch, G.4
Lewis, L.5
Fuchs, E.6
-
7
-
-
0037737728
-
A role for Wnt signalling in self-renewal of haematopoietic stem cells
-
Reya T., Duncan A.W., Ailles L., Domen J., Scherer D.C., Willert K., Hintz L., Nusse R., and Weissman I.L. A role for Wnt signalling in self-renewal of haematopoietic stem cells. Nature 423 (2003) 409-414
-
(2003)
Nature
, vol.423
, pp. 409-414
-
-
Reya, T.1
Duncan, A.W.2
Ailles, L.3
Domen, J.4
Scherer, D.C.5
Willert, K.6
Hintz, L.7
Nusse, R.8
Weissman, I.L.9
-
8
-
-
0038274074
-
Stem cells in the skin: waste not, Wnt not
-
Alonso L., and Fuchs E. Stem cells in the skin: waste not, Wnt not. Genes Dev 17 (2003) 1189-1200
-
(2003)
Genes Dev
, vol.17
, pp. 1189-1200
-
-
Alonso, L.1
Fuchs, E.2
-
9
-
-
9144269759
-
Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells
-
Li Y., Welm B., Podsypanina K., Huang S., Chamorro M., Zhang X., Rowlands T., Egeblad M., Cowin P., Werb Z., et al. Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells. Proc Natl Acad Sci USA 100 (2003) 15853-15858
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 15853-15858
-
-
Li, Y.1
Welm, B.2
Podsypanina, K.3
Huang, S.4
Chamorro, M.5
Zhang, X.6
Rowlands, T.7
Egeblad, M.8
Cowin, P.9
Werb, Z.10
-
10
-
-
17244376814
-
Wnt signalling in stem cells and cancer
-
Reya T., and Clevers H. Wnt signalling in stem cells and cancer. Nature 434 (2005) 843-850
-
(2005)
Nature
, vol.434
, pp. 843-850
-
-
Reya, T.1
Clevers, H.2
-
11
-
-
0031727409
-
Nuclear overexpression of the oncoprotein beta-catenin in colorectal cancer is localized predominantly at the invasion front
-
Brabletz T., Jung A., Hermann K., Gunther K., Hohenberger W., and Kirchner T. Nuclear overexpression of the oncoprotein beta-catenin in colorectal cancer is localized predominantly at the invasion front. Pathol Res Pract 194 (1998) 701-704
-
(1998)
Pathol Res Pract
, vol.194
, pp. 701-704
-
-
Brabletz, T.1
Jung, A.2
Hermann, K.3
Gunther, K.4
Hohenberger, W.5
Kirchner, T.6
-
12
-
-
0035149139
-
The invasion front of human colorectal adenocarcinomas shows co-localization of nuclear β-catenin, cyclin D1, and p16INK4A and is a region of low proliferation
-
Jung A., Schrauder M., Oswald U., Knoll C., Sellberg P., Palmqvist R., Niedobitek G., Brabletz T., and Kirchner T. The invasion front of human colorectal adenocarcinomas shows co-localization of nuclear β-catenin, cyclin D1, and p16INK4A and is a region of low proliferation. Am J Pathol 159 (2001) 1613-1617
-
(2001)
Am J Pathol
, vol.159
, pp. 1613-1617
-
-
Jung, A.1
Schrauder, M.2
Oswald, U.3
Knoll, C.4
Sellberg, P.5
Palmqvist, R.6
Niedobitek, G.7
Brabletz, T.8
Kirchner, T.9
-
13
-
-
0035964349
-
Variable beta-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment
-
Brabletz T., Jung A., Reu S., Porzner M., Hlubek F., Kunz-Schughart L.A., Knuechel R., and Kirchner T. Variable beta-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment. Proc Natl Acad Sci USA 98 (2001) 10356-10361
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 10356-10361
-
-
Brabletz, T.1
Jung, A.2
Reu, S.3
Porzner, M.4
Hlubek, F.5
Kunz-Schughart, L.A.6
Knuechel, R.7
Kirchner, T.8
-
14
-
-
0033810123
-
Patterning and nuclear beta-catenin expression in the colonic adenoma-carcinoma sequence. Analogies with embryonic gastrulation
-
Kirchner T., and Brabletz T. Patterning and nuclear beta-catenin expression in the colonic adenoma-carcinoma sequence. Analogies with embryonic gastrulation. Am J Pathol 157 (2000) 1113-1121
-
(2000)
Am J Pathol
, vol.157
, pp. 1113-1121
-
-
Kirchner, T.1
Brabletz, T.2
-
15
-
-
25444495269
-
Opinion: migrating cancer stem cells - an integrated concept of malignant tumour progression
-
Brabletz T., Jung A., Spaderna S., Hlubek F., and Kirchner T. Opinion: migrating cancer stem cells - an integrated concept of malignant tumour progression. Nat Rev Cancer 5 (2005) 744-749
-
(2005)
Nat Rev Cancer
, vol.5
, pp. 744-749
-
-
Brabletz, T.1
Jung, A.2
Spaderna, S.3
Hlubek, F.4
Kirchner, T.5
-
16
-
-
5444233462
-
APC dosage effects in tumorigenesis and stem cell differentiation
-
Gaspar C., and Fodde R. APC dosage effects in tumorigenesis and stem cell differentiation. Int J Dev Biol 48 (2004) 377-386
-
(2004)
Int J Dev Biol
, vol.48
, pp. 377-386
-
-
Gaspar, C.1
Fodde, R.2
-
17
-
-
0035499267
-
Stem cells, cancer, and cancer stem cells
-
Reya T., Morrison S.J., Clarke M.F., and Weissman I.L. Stem cells, cancer, and cancer stem cells. Nature 414 (2001) 105-111
-
(2001)
Nature
, vol.414
, pp. 105-111
-
-
Reya, T.1
Morrison, S.J.2
Clarke, M.F.3
Weissman, I.L.4
-
18
-
-
0043026808
-
β-Catenin and ras oncogenes detect most human colorectal cancer
-
Zhang B., Ougolkov A., Yamashita K., Takahashi Y., Mai M., and Minamoto T. β-Catenin and ras oncogenes detect most human colorectal cancer. Clin Cancer Res 9 (2003) 3073-3079
-
(2003)
Clin Cancer Res
, vol.9
, pp. 3073-3079
-
-
Zhang, B.1
Ougolkov, A.2
Yamashita, K.3
Takahashi, Y.4
Mai, M.5
Minamoto, T.6
-
19
-
-
33749320834
-
APC and oncogenic KRAS are synergistic in enhancing Wnt signaling in intestinal tumor formation and progression
-
This paper provides in vivo and in vitro evidence of the synergistic interaction between oncogenic KRAS and loss of APC function in enhancing β-catenin nuclear accumulation and Wnt signaling in intestinal cancer onset and progression to malignancy.
-
Janssen K.P., Alberici P., Fsihi H., Gaspar C., Breukel C., Franken P., Rosty C., Abal M., El Marjou F., Smits R., et al. APC and oncogenic KRAS are synergistic in enhancing Wnt signaling in intestinal tumor formation and progression. Gastroenterology 131 (2006) 1096-1109. This paper provides in vivo and in vitro evidence of the synergistic interaction between oncogenic KRAS and loss of APC function in enhancing β-catenin nuclear accumulation and Wnt signaling in intestinal cancer onset and progression to malignancy.
-
(2006)
Gastroenterology
, vol.131
, pp. 1096-1109
-
-
Janssen, K.P.1
Alberici, P.2
Fsihi, H.3
Gaspar, C.4
Breukel, C.5
Franken, P.6
Rosty, C.7
Abal, M.8
El Marjou, F.9
Smits, R.10
-
20
-
-
0029116143
-
Tyrosine phosphorylation regulates the adhesions of ras-transformed breast epithelia
-
Kinch M.S., Clark G.J., Der C.J., and Burridge K. Tyrosine phosphorylation regulates the adhesions of ras-transformed breast epithelia. J Cell Biol 130 (1995) 461-471
-
(1995)
J Cell Biol
, vol.130
, pp. 461-471
-
-
Kinch, M.S.1
Clark, G.J.2
Der, C.J.3
Burridge, K.4
-
21
-
-
0037194728
-
Tumorigenesis: RAF/RAS oncogenes and mismatch-repair status
-
Rajagopalan H., Bardelli A., Lengauer C., Kinzler K.W., Vogelstein B., and Velculescu V.E. Tumorigenesis: RAF/RAS oncogenes and mismatch-repair status. Nature 418 (2002) 934
-
(2002)
Nature
, vol.418
, pp. 934
-
-
Rajagopalan, H.1
Bardelli, A.2
Lengauer, C.3
Kinzler, K.W.4
Vogelstein, B.5
Velculescu, V.E.6
-
22
-
-
0038670241
-
Mutational analysis of the tyrosine kinome in colorectal cancers
-
Bardelli A., Parsons D.W., Silliman N., Ptak J., Szabo S., Saha S., Markowitz S., Willson J.K., Parmigiani G., Kinzler K.W., et al. Mutational analysis of the tyrosine kinome in colorectal cancers. Science 300 (2003) 949
-
(2003)
Science
, vol.300
, pp. 949
-
-
Bardelli, A.1
Parsons, D.W.2
Silliman, N.3
Ptak, J.4
Szabo, S.5
Saha, S.6
Markowitz, S.7
Willson, J.K.8
Parmigiani, G.9
Kinzler, K.W.10
-
23
-
-
2442648882
-
Mutational analysis of the tyrosine phosphatome in colorectal cancers
-
Wang Z., Shen D., Parsons D.W., Bardelli A., Sager J., Szabo S., Ptak J., Silliman N., Peters B.A., van der Heijden M.S., et al. Mutational analysis of the tyrosine phosphatome in colorectal cancers. Science 304 (2004) 1164-1166
-
(2004)
Science
, vol.304
, pp. 1164-1166
-
-
Wang, Z.1
Shen, D.2
Parsons, D.W.3
Bardelli, A.4
Sager, J.5
Szabo, S.6
Ptak, J.7
Silliman, N.8
Peters, B.A.9
van der Heijden, M.S.10
-
24
-
-
7944230668
-
An autocrine mechanism for constitutive Wnt pathway activation in human cancer cells
-
The authors demonstrate the existence of an autocrine loop for canonical Wnt signaling in human breast, ovarian and colorectal cancer cells.
-
Bafico A., Liu G., Goldin L., Harris V., and Aaronson S.A. An autocrine mechanism for constitutive Wnt pathway activation in human cancer cells. Cancer Cell 6 (2004) 497-506. The authors demonstrate the existence of an autocrine loop for canonical Wnt signaling in human breast, ovarian and colorectal cancer cells.
-
(2004)
Cancer Cell
, vol.6
, pp. 497-506
-
-
Bafico, A.1
Liu, G.2
Goldin, L.3
Harris, V.4
Aaronson, S.A.5
-
25
-
-
33746218212
-
Repressor roles for TCF-4 and Sfrp1 in Wnt signaling in breast cancer
-
Shulewitz M., Soloviev I., Wu T., Koeppen H., Polakis P., and Sakanaka C. Repressor roles for TCF-4 and Sfrp1 in Wnt signaling in breast cancer. Oncogene 25 (2006) 4361-4369
-
(2006)
Oncogene
, vol.25
, pp. 4361-4369
-
-
Shulewitz, M.1
Soloviev, I.2
Wu, T.3
Koeppen, H.4
Polakis, P.5
Sakanaka, C.6
-
26
-
-
0034636153
-
β-catenin, a novel prognostic marker for breast cancer: its roles in cyclin D1 expression and cancer progression
-
Lin S.Y., Xia W., Wang J.C., Kwong K.Y., Spohn B., Wen Y., Pestell R.G., and Hung M.C. β-catenin, a novel prognostic marker for breast cancer: its roles in cyclin D1 expression and cancer progression. Proc Natl Acad Sci USA 97 (2000) 4262-4266
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 4262-4266
-
-
Lin, S.Y.1
Xia, W.2
Wang, J.C.3
Kwong, K.Y.4
Spohn, B.5
Wen, Y.6
Pestell, R.G.7
Hung, M.C.8
-
27
-
-
5444248307
-
Tenascin-C and SF/HGF produced by myofibroblasts in vitro provide convergent pro-invasive signals to human colon cancer cells through RhoA and Rac
-
De Wever O., Nguyen Q.D., Van Hoorde L., Bracke M., Bruyneel E., Gespach C., and Mareel M. Tenascin-C and SF/HGF produced by myofibroblasts in vitro provide convergent pro-invasive signals to human colon cancer cells through RhoA and Rac. FASEB J 18 (2004) 1016-1018
-
(2004)
FASEB J
, vol.18
, pp. 1016-1018
-
-
De Wever, O.1
Nguyen, Q.D.2
Van Hoorde, L.3
Bracke, M.4
Bruyneel, E.5
Gespach, C.6
Mareel, M.7
-
28
-
-
23244448347
-
Expression pattern of Wnt signaling components in the adult intestine
-
Gregorieff A., Pinto D., Begthel H., Destree O., Kielman M., and Clevers H. Expression pattern of Wnt signaling components in the adult intestine. Gastroenterology 129 (2005) 626-638
-
(2005)
Gastroenterology
, vol.129
, pp. 626-638
-
-
Gregorieff, A.1
Pinto, D.2
Begthel, H.3
Destree, O.4
Kielman, M.5
Clevers, H.6
-
29
-
-
33645535002
-
Foxf1 and Foxf2 control murine gut development by limiting mesenchymal Wnt signaling and promoting extracellular matrix production
-
By targeting murine Foxf1 and Foxf2, which encode forkhead transcription factors, the authors show that these mesenchymal factors control epithelial proliferation and survival, and link hedgehog to Bmp and Wnt signaling.
-
Ormestad M., Astorga J., Landgren H., Wang T., Johansson B.R., Miura N., and Carlsson P. Foxf1 and Foxf2 control murine gut development by limiting mesenchymal Wnt signaling and promoting extracellular matrix production. Development 133 (2006) 833-843. By targeting murine Foxf1 and Foxf2, which encode forkhead transcription factors, the authors show that these mesenchymal factors control epithelial proliferation and survival, and link hedgehog to Bmp and Wnt signaling.
-
(2006)
Development
, vol.133
, pp. 833-843
-
-
Ormestad, M.1
Astorga, J.2
Landgren, H.3
Wang, T.4
Johansson, B.R.5
Miura, N.6
Carlsson, P.7
-
30
-
-
0030907001
-
The mesenchymal winged helix transcription factor Fkh6 is required for the control of gastrointestinal proliferation and differentiation
-
Kaestner K.H., Silberg D.G., Traber P.G., and Schutz G. The mesenchymal winged helix transcription factor Fkh6 is required for the control of gastrointestinal proliferation and differentiation. Genes Dev 11 (1997) 1583-1595
-
(1997)
Genes Dev
, vol.11
, pp. 1583-1595
-
-
Kaestner, K.H.1
Silberg, D.G.2
Traber, P.G.3
Schutz, G.4
-
31
-
-
0035900666
-
Foxl1 controls the Wnt/β-catenin pathway by modulating the expression of proteoglycans in the gut
-
Perreault N., Katz J.P., Sackett S.D., and Kaestner K.H. Foxl1 controls the Wnt/β-catenin pathway by modulating the expression of proteoglycans in the gut. J Biol Chem 276 (2001) 43328-43333
-
(2001)
J Biol Chem
, vol.276
, pp. 43328-43333
-
-
Perreault, N.1
Katz, J.P.2
Sackett, S.D.3
Kaestner, K.H.4
-
32
-
-
13244273712
-
Foxl1 is a mesenchymal Modifier of Min in carcinogenesis of stomach and colon
-
The authors show that loss of the mesenchymal transcription factor Foxl1 leads to a marked increase in tumor numbers in the colon of Apc(Min) mice. This is the first example of a mesenchymal modifier of Apc-driven tumorigenesis.
-
Perreault N., Sackett S.D., Katz J.P., Furth E.E., and Kaestner K.H. Foxl1 is a mesenchymal Modifier of Min in carcinogenesis of stomach and colon. Genes Dev 19 (2005) 311-315. The authors show that loss of the mesenchymal transcription factor Foxl1 leads to a marked increase in tumor numbers in the colon of Apc(Min) mice. This is the first example of a mesenchymal modifier of Apc-driven tumorigenesis.
-
(2005)
Genes Dev
, vol.19
, pp. 311-315
-
-
Perreault, N.1
Sackett, S.D.2
Katz, J.P.3
Furth, E.E.4
Kaestner, K.H.5
-
33
-
-
0033709223
-
Expression of c-Met and heparan-sulfate proteoglycan forms of CD44 in colorectal cancer
-
Wielenga V.J., van der Voort R., Taher T.E., Smit L., Beuling E.A., van Krimpen C., Spaargaren M., and Pals S.T. Expression of c-Met and heparan-sulfate proteoglycan forms of CD44 in colorectal cancer. Am J Pathol 157 (2000) 1563-1573
-
(2000)
Am J Pathol
, vol.157
, pp. 1563-1573
-
-
Wielenga, V.J.1
van der Voort, R.2
Taher, T.E.3
Smit, L.4
Beuling, E.A.5
van Krimpen, C.6
Spaargaren, M.7
Pals, S.T.8
-
34
-
-
33847726845
-
A positive feedback loop between hepatocyte growth factor receptor and beta-catenin sustains colorectal cancer cell invasive growth
-
In this paper, the authors demonstrate that functional crosstalk exists in colorectal cancer between MET and Wnt/β-catenin signaling. HGF stimulation of colorectal cancer cells triggers β-catenin tyrosine phosphorylation and its dissociation from MET, thus leading to its nuclear accumulation and increasing invasive properties.
-
Rasola A., Fassetta M., De Bacco F., D'Alessandro L., Gramaglia D., Di Renzo M.F., and Comoglio P.M. A positive feedback loop between hepatocyte growth factor receptor and beta-catenin sustains colorectal cancer cell invasive growth. Oncogene (2006). In this paper, the authors demonstrate that functional crosstalk exists in colorectal cancer between MET and Wnt/β-catenin signaling. HGF stimulation of colorectal cancer cells triggers β-catenin tyrosine phosphorylation and its dissociation from MET, thus leading to its nuclear accumulation and increasing invasive properties.
-
(2006)
Oncogene
-
-
Rasola, A.1
Fassetta, M.2
De Bacco, F.3
D'Alessandro, L.4
Gramaglia, D.5
Di Renzo, M.F.6
Comoglio, P.M.7
-
35
-
-
0032875460
-
Mechanism of action and in vivo role of platelet-derived growth factor
-
Heldin C.H., and Westermark B. Mechanism of action and in vivo role of platelet-derived growth factor. Physiol Rev 79 (1999) 1283-1316
-
(1999)
Physiol Rev
, vol.79
, pp. 1283-1316
-
-
Heldin, C.H.1
Westermark, B.2
-
36
-
-
33749078750
-
P68 RNA helicase mediates PDGF-induced epithelial mesenchymal transition by displacing axin from β-catenin
-
The authors demonstrate a novel mechanism involving the RNA helicase p68 in mediating EMT and tumor invasion. PDGF stimulation of colorectal cancer cells results in tyrosine phosphorylation of p68. Tyr-P p68 binds β-catenin and facilitates its signaling to the nucleus by inhibiting GSK3β phosphorylation and by displacing Axin from β-catenin.
-
Yang L., Lin C., and Liu Z.R. P68 RNA helicase mediates PDGF-induced epithelial mesenchymal transition by displacing axin from β-catenin. Cell 127 (2006) 139-155. The authors demonstrate a novel mechanism involving the RNA helicase p68 in mediating EMT and tumor invasion. PDGF stimulation of colorectal cancer cells results in tyrosine phosphorylation of p68. Tyr-P p68 binds β-catenin and facilitates its signaling to the nucleus by inhibiting GSK3β phosphorylation and by displacing Axin from β-catenin.
-
(2006)
Cell
, vol.127
, pp. 139-155
-
-
Yang, L.1
Lin, C.2
Liu, Z.R.3
-
37
-
-
33749067198
-
Unwinding a path to nuclear β-catenin
-
He X. Unwinding a path to nuclear β-catenin. Cell 127 (2006) 40-42
-
(2006)
Cell
, vol.127
, pp. 40-42
-
-
He, X.1
-
38
-
-
0032837683
-
Up-regulation of macrophage wnt gene expression in adenoma-carcinoma progression of human colorectal cancer
-
Smith K., Bui T.D., Poulsom R., Kaklamanis L., Williams G., and Harris A.L. Up-regulation of macrophage wnt gene expression in adenoma-carcinoma progression of human colorectal cancer. Br J Cancer 81 (1999) 496-502
-
(1999)
Br J Cancer
, vol.81
, pp. 496-502
-
-
Smith, K.1
Bui, T.D.2
Poulsom, R.3
Kaklamanis, L.4
Williams, G.5
Harris, A.L.6
-
39
-
-
18444408375
-
COX-2: a molecular target for colorectal cancer prevention
-
Brown J.R., and DuBois R.N. COX-2: a molecular target for colorectal cancer prevention. J Clin Oncol 23 (2005) 2840-2855
-
(2005)
J Clin Oncol
, vol.23
, pp. 2840-2855
-
-
Brown, J.R.1
DuBois, R.N.2
-
40
-
-
28544444039
-
Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-β-catenin signaling axis
-
A link is established between proinflammatory metabolites and Wnt signaling activation in promoting tumor growth. The authors show that PGE2 stimulates colon cancer cell growth through a signaling route that leads to the inactivation and release of GSKβ from the destruction complex with axin, thereby activating Wnt signaling.
-
Castellone M.D., Teramoto H., Williams B.O., Druey K.M., and Gutkind J.S. Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-β-catenin signaling axis. Science 310 (2005) 1504-1510. A link is established between proinflammatory metabolites and Wnt signaling activation in promoting tumor growth. The authors show that PGE2 stimulates colon cancer cell growth through a signaling route that leads to the inactivation and release of GSKβ from the destruction complex with axin, thereby activating Wnt signaling.
-
(2005)
Science
, vol.310
, pp. 1504-1510
-
-
Castellone, M.D.1
Teramoto, H.2
Williams, B.O.3
Druey, K.M.4
Gutkind, J.S.5
-
41
-
-
33645244470
-
Controlling the stem cell niche: right time, right place, right strength
-
Niemann C. Controlling the stem cell niche: right time, right place, right strength. Bioessays 28 (2006) 1-5
-
(2006)
Bioessays
, vol.28
, pp. 1-5
-
-
Niemann, C.1
-
42
-
-
30644458570
-
Balancing cell adhesion and Wnt signaling, the key role of beta-catenin
-
Brembeck F.H., Rosario M., and Birchmeier W. Balancing cell adhesion and Wnt signaling, the key role of beta-catenin. Curr Opin Genet Dev 16 (2006) 51-59
-
(2006)
Curr Opin Genet Dev
, vol.16
, pp. 51-59
-
-
Brembeck, F.H.1
Rosario, M.2
Birchmeier, W.3
-
43
-
-
4444276194
-
Essential role of BCL9-2 in the switch between β-catenin's adhesive and transcriptional functions
-
The switch between β-catenin's adhesive and transcriptional functions is here shown to be modulated by Tyr-phosphorylation of β-catenin, which favors BCL9-2 binding and precludes interaction with α-catenin. Thus, BCL9-2 induces EMT of non-transformed cells by increasing Wnt/β-catenin signaling.
-
Brembeck F.H., Schwarz-Romond T., Bakkers J., Wilhelm S., Hammerschmidt M., and Birchmeier W. Essential role of BCL9-2 in the switch between β-catenin's adhesive and transcriptional functions. Genes Dev 18 (2004) 2225-2230. The switch between β-catenin's adhesive and transcriptional functions is here shown to be modulated by Tyr-phosphorylation of β-catenin, which favors BCL9-2 binding and precludes interaction with α-catenin. Thus, BCL9-2 induces EMT of non-transformed cells by increasing Wnt/β-catenin signaling.
-
(2004)
Genes Dev
, vol.18
, pp. 2225-2230
-
-
Brembeck, F.H.1
Schwarz-Romond, T.2
Bakkers, J.3
Wilhelm, S.4
Hammerschmidt, M.5
Birchmeier, W.6
-
44
-
-
9244233875
-
Role of a BCL9-related β-catenin-binding protein, B9L, in tumorigenesis induced by aberrant activation of Wnt signaling
-
BCL9-2 is required for enhanced β-catenin-TCF-mediated transcription in colorectal cancer cells and for their malignant transformation. BCL9-2 expression is shown to be up-regulated in ∼40% of colorectal tumors when compared to non-cancerous tissues.
-
Adachi S., Jigami T., Yasui T., Nakano T., Ohwada S., Omori Y., Sugano S., Ohkawara B., Shibuya H., Nakamura T., et al. Role of a BCL9-related β-catenin-binding protein, B9L, in tumorigenesis induced by aberrant activation of Wnt signaling. Cancer Res 64 (2004) 8496-8501. BCL9-2 is required for enhanced β-catenin-TCF-mediated transcription in colorectal cancer cells and for their malignant transformation. BCL9-2 expression is shown to be up-regulated in ∼40% of colorectal tumors when compared to non-cancerous tissues.
-
(2004)
Cancer Res
, vol.64
, pp. 8496-8501
-
-
Adachi, S.1
Jigami, T.2
Yasui, T.3
Nakano, T.4
Ohwada, S.5
Omori, Y.6
Sugano, S.7
Ohkawara, B.8
Shibuya, H.9
Nakamura, T.10
-
45
-
-
33751342503
-
Up-regulation of a BCL9-related β-catenin-binding protein, B9L, in different stages of sporadic colorectal adenoma
-
Sakamoto I., Ohwada S., Toya H., Togo N., Kashiwabara K., Oyama T., Nakajima T., Ito H., Adachi S., Jigami T., et al. Up-regulation of a BCL9-related β-catenin-binding protein, B9L, in different stages of sporadic colorectal adenoma. Cancer Sci (2006)
-
(2006)
Cancer Sci
-
-
Sakamoto, I.1
Ohwada, S.2
Toya, H.3
Togo, N.4
Kashiwabara, K.5
Oyama, T.6
Nakajima, T.7
Ito, H.8
Adachi, S.9
Jigami, T.10
-
46
-
-
33751514601
-
A Wnt-Axin2-GSK3β cascade regulates Snail1 activity in breast cancer cells
-
This study demonstrates that canonical Wnt signaling prompts tumor cell de-differentiation and tissue invasion through an Axin2-dependent pathway that stabilizes Snail1, a key regulator of normal and neoplastic EMT programs. Axin2 regulates EMT by controlling intracellular distribution of GSK3β, the kinase responsible for controlling Snail1 protein turnover and activity.
-
Yook J.I., Li X.Y., Ota I., Hu C., Kim H.S., Kim N.H., Cha S.Y., Ryu J.K., Choi Y.J., Kim J., et al. A Wnt-Axin2-GSK3β cascade regulates Snail1 activity in breast cancer cells. Nat Cell Biol (2006). This study demonstrates that canonical Wnt signaling prompts tumor cell de-differentiation and tissue invasion through an Axin2-dependent pathway that stabilizes Snail1, a key regulator of normal and neoplastic EMT programs. Axin2 regulates EMT by controlling intracellular distribution of GSK3β, the kinase responsible for controlling Snail1 protein turnover and activity.
-
(2006)
Nat Cell Biol
-
-
Yook, J.I.1
Li, X.Y.2
Ota, I.3
Hu, C.4
Kim, H.S.5
Kim, N.H.6
Cha, S.Y.7
Ryu, J.K.8
Choi, Y.J.9
Kim, J.10
-
47
-
-
0442276554
-
The glamour and gloom of glycogen synthase kinase-3
-
Jope R.S., and Johnson G.V. The glamour and gloom of glycogen synthase kinase-3. Trends Biochem Sci 29 (2004) 95-102
-
(2004)
Trends Biochem Sci
, vol.29
, pp. 95-102
-
-
Jope, R.S.1
Johnson, G.V.2
-
48
-
-
15044348490
-
The links between axin and carcinogenesis
-
Salahshor S., and Woodgett J.R. The links between axin and carcinogenesis. J Clin Pathol 58 (2005) 225-236
-
(2005)
J Clin Pathol
, vol.58
, pp. 225-236
-
-
Salahshor, S.1
Woodgett, J.R.2
-
49
-
-
33749993417
-
The consensus coding sequences of human breast and colorectal cancers
-
Sjoblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., et al. The consensus coding sequences of human breast and colorectal cancers. Science 314 (2006) 268-274
-
(2006)
Science
, vol.314
, pp. 268-274
-
-
Sjoblom, T.1
Jones, S.2
Wood, L.D.3
Parsons, D.W.4
Lin, J.5
Barber, T.D.6
Mandelker, D.7
Leary, R.J.8
Ptak, J.9
Silliman, N.10
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