메뉴 건너뛰기




Volumn 105, Issue 4, 2013, Pages 1079-1089

Coupled reversible and irreversible bistable switches underlying TGFβ-induced epithelial to mesenchymal transition

Author keywords

[No Author keywords available]

Indexed keywords

TRANSFORMING GROWTH FACTOR BETA;

EID: 84883025658     PISSN: 00063495     EISSN: 15420086     Source Type: Journal    
DOI: 10.1016/j.bpj.2013.07.011     Document Type: Article
Times cited : (244)

References (75)
  • 1
    • 27644473229 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition
    • D.C. Radisky Epithelial-mesenchymal transition J. Cell Sci. 118 2005 4325 4326
    • (2005) J. Cell Sci. , vol.118 , pp. 4325-4326
    • Radisky, D.C.1
  • 2
    • 80052712201 scopus 로고    scopus 로고
    • The ins and outs of the epithelial to mesenchymal transition in health and disease
    • M.A. Nieto The ins and outs of the epithelial to mesenchymal transition in health and disease Annu. Rev. Cell Dev. Biol. 27 2011 347 376
    • (2011) Annu. Rev. Cell Dev. Biol. , vol.27 , pp. 347-376
    • Nieto, M.A.1
  • 3
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and disease
    • J.P. Thiery, and H. Acloque M.A. Nieto Epithelial-mesenchymal transitions in development and disease Cell 139 2009 871 890
    • (2009) Cell , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Nieto, M.A.3
  • 4
    • 63749105896 scopus 로고    scopus 로고
    • Mechanism of TGF-β signaling to growth arrest, apoptosis, and epithelial-mesenchymal transition
    • C.-H. Heldin, M. Landström, and A. Moustakas Mechanism of TGF-β signaling to growth arrest, apoptosis, and epithelial-mesenchymal transition Curr. Opin. Cell Biol. 21 2009 166 176
    • (2009) Curr. Opin. Cell Biol. , vol.21 , pp. 166-176
    • Heldin, C.-H.1    Landström, M.2    Moustakas, A.3
  • 5
    • 84877928478 scopus 로고    scopus 로고
    • Regulation of epithelial-mesenchymal and mesenchymal-epithelial transitions by microRNAs
    • S. Lamouille, and D. Subramanyam R. Derynck Regulation of epithelial-mesenchymal and mesenchymal-epithelial transitions by microRNAs Curr. Opin. Cell Biol. 25 2013 200 207
    • (2013) Curr. Opin. Cell Biol. , vol.25 , pp. 200-207
    • Lamouille, S.1    Subramanyam, D.2    Derynck, R.3
  • 6
    • 73049110243 scopus 로고    scopus 로고
    • The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs
    • U. Wellner, and J. Schubert T. Brabletz The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs Nat. Cell Biol. 11 2009 1487 1495
    • (2009) Nat. Cell Biol. , vol.11 , pp. 1487-1495
    • Wellner, U.1    Schubert, J.2    Brabletz, T.3
  • 7
    • 54049084380 scopus 로고    scopus 로고
    • A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition
    • C.P. Bracken, and P.A. Gregory G.J. Goodall A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition Cancer Res. 68 2008 7846 7854
    • (2008) Cancer Res. , vol.68 , pp. 7846-7854
    • Bracken, C.P.1    Gregory, P.A.2    Goodall, G.J.3
  • 8
    • 44649163918 scopus 로고    scopus 로고
    • A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells
    • U. Burk, and J. Schubert T. Brabletz A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells EMBO Rep. 9 2008 582 589
    • (2008) EMBO Rep. , vol.9 , pp. 582-589
    • Burk, U.1    Schubert, J.2    Brabletz, T.3
  • 9
    • 84055184850 scopus 로고    scopus 로고
    • MiR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions
    • H. Siemens, and R. Jackstadt H. Hermeking miR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions Cell Cycle 10 2011 4256 4271
    • (2011) Cell Cycle , vol.10 , pp. 4256-4271
    • Siemens, H.1    Jackstadt, R.2    Hermeking, H.3
  • 10
    • 84855729906 scopus 로고    scopus 로고
    • A p53/miRNA-34 axis regulates Snail1-dependent cancer cell epithelial-mesenchymal transition
    • N.H. Kim, and H.S. Kim J.I. Yook A p53/miRNA-34 axis regulates Snail1-dependent cancer cell epithelial-mesenchymal transition J. Cell Biol. 195 2011 417 433
    • (2011) J. Cell Biol. , vol.195 , pp. 417-433
    • Kim, N.H.1    Kim, H.S.2    Yook, J.I.3
  • 11
    • 79955954699 scopus 로고    scopus 로고
    • An autocrine TGF-β/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition
    • P.A. Gregory, and C.P. Bracken G.J. Goodall An autocrine TGF-β/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition Mol. Biol. Cell 22 2011 1686 1698
    • (2011) Mol. Biol. Cell , vol.22 , pp. 1686-1698
    • Gregory, P.A.1    Bracken, C.P.2    Goodall, G.J.3
  • 12
    • 34248209601 scopus 로고    scopus 로고
    • Slug is required for cell survival during partial epithelial-mesenchymal transition of HGF-induced tubulogenesis
    • P. Leroy, and K.E. Mostov Slug is required for cell survival during partial epithelial-mesenchymal transition of HGF-induced tubulogenesis Mol. Biol. Cell 18 2007 1943 1952
    • (2007) Mol. Biol. Cell , vol.18 , pp. 1943-1952
    • Leroy, P.1    Mostov, K.E.2
  • 13
    • 68949155116 scopus 로고    scopus 로고
    • EMT 2.0: Shaping epithelia through collective migration
    • C. Revenu, and D. Gilmour EMT 2.0: shaping epithelia through collective migration Curr. Opin. Genet. Dev. 19 2009 338 342
    • (2009) Curr. Opin. Genet. Dev. , vol.19 , pp. 338-342
    • Revenu, C.1    Gilmour, D.2
  • 14
    • 65649153358 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition: A cancer researcher's conceptual friend and foe
    • M.W. Klymkowsky, and P. Savagner Epithelial-mesenchymal transition: a cancer researcher's conceptual friend and foe Am. J. Pathol. 174 2009 1588 1593
    • (2009) Am. J. Pathol. , vol.174 , pp. 1588-1593
    • Klymkowsky, M.W.1    Savagner, P.2
  • 15
    • 79953303497 scopus 로고    scopus 로고
    • A systems view of epithelial-mesenchymal transition signaling states
    • S. Thomson, and F. Petti J.D. Haley A systems view of epithelial-mesenchymal transition signaling states Clin. Exp. Metastasis 28 2011 137 155
    • (2011) Clin. Exp. Metastasis , vol.28 , pp. 137-155
    • Thomson, S.1    Petti, F.2    Haley, J.D.3
  • 16
    • 79955712722 scopus 로고    scopus 로고
    • Evidence for partial epithelial-to-mesenchymal transition (pEMT) and recruitment of motile blastoderm edge cells during avian epiboly
    • M.A. Futterman, A.J. García, and E.A. Zamir Evidence for partial epithelial-to-mesenchymal transition (pEMT) and recruitment of motile blastoderm edge cells during avian epiboly Dev. Dyn. 240 2011 1502 1511
    • (2011) Dev. Dyn. , vol.240 , pp. 1502-1511
    • Futterman, M.A.1    García, A.J.2    Zamir, E.A.3
  • 17
    • 77954854837 scopus 로고    scopus 로고
    • Snail family regulation and epithelial mesenchymal transitions in breast cancer progression
    • A.G. de Herreros, and S. Peiró P. Savagner Snail family regulation and epithelial mesenchymal transitions in breast cancer progression J. Mammary Gland Biol. Neoplasia 15 2010 135 147
    • (2010) J. Mammary Gland Biol. Neoplasia , vol.15 , pp. 135-147
    • De Herreros, A.G.1    Peiró, S.2    Savagner, P.3
  • 18
    • 33645302628 scopus 로고    scopus 로고
    • The epithelial-mesenchymal transition: New insights in signaling, development, and disease
    • J.M. Lee, and S. Dedhar E.W. Thompson The epithelial-mesenchymal transition: new insights in signaling, development, and disease J. Cell Biol. 172 2006 973 981
    • (2006) J. Cell Biol. , vol.172 , pp. 973-981
    • Lee, J.M.1    Dedhar, S.2    Thompson, E.W.3
  • 19
    • 33645754505 scopus 로고    scopus 로고
    • Signal processing in the TGF-β superfamily ligand-receptor network
    • J.M.G. Vilar, R. Jansen, and C. Sander Signal processing in the TGF-β superfamily ligand-receptor network PLOS Comput. Biol. 2 2006 e3
    • (2006) PLOS Comput. Biol. , vol.2 , pp. 3
    • Vilar, J.M.G.1    Jansen, R.2    Sander, C.3
  • 20
    • 41549094989 scopus 로고    scopus 로고
    • Constraint-based modeling and kinetic analysis of the Smad dependent TGF-β signaling pathway
    • Z. Zi, and E. Klipp Constraint-based modeling and kinetic analysis of the Smad dependent TGF-β signaling pathway PLoS ONE 2 2007 e936
    • (2007) PLoS ONE , vol.2 , pp. 936
    • Zi, Z.1    Klipp, E.2
  • 21
    • 44349125602 scopus 로고    scopus 로고
    • Mathematical modeling identifies Smad nucleocytoplasmic shuttling as a dynamic signal-interpreting system
    • B. Schmierer, and A.L. Tournier C.S. Hill Mathematical modeling identifies Smad nucleocytoplasmic shuttling as a dynamic signal-interpreting system Proc. Natl. Acad. Sci. USA 105 2008 6608 6613
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 6608-6613
    • Schmierer, B.1    Tournier, A.L.2    Hill, C.S.3
  • 22
    • 77954621247 scopus 로고    scopus 로고
    • Investigating the link between epithelial-mesenchymal transition and the cancer stem cell phenotype: A mathematical approach
    • C. Turner, and M. Kohandel Investigating the link between epithelial-mesenchymal transition and the cancer stem cell phenotype: a mathematical approach J. Theor. Biol. 265 2010 329 335
    • (2010) J. Theor. Biol. , vol.265 , pp. 329-335
    • Turner, C.1    Kohandel, M.2
  • 23
    • 81255184468 scopus 로고    scopus 로고
    • Trafficking coordinate description of intracellular transport control of signaling networks
    • J.M. Vilar, and L. Saiz Trafficking coordinate description of intracellular transport control of signaling networks Biophys. J. 101 2011 2315 2323
    • (2011) Biophys. J. , vol.101 , pp. 2315-2323
    • Vilar, J.M.1    Saiz, L.2
  • 24
    • 0038756636 scopus 로고    scopus 로고
    • Transforming growth factor β-1 induces snail transcription factor in epithelial cell lines: Mechanisms for epithelial mesenchymal transitions
    • H. Peinado, M. Quintanilla, and A. Cano Transforming growth factor β-1 induces snail transcription factor in epithelial cell lines: mechanisms for epithelial mesenchymal transitions J. Biol. Chem. 278 2003 21113 21123
    • (2003) J. Biol. Chem. , vol.278 , pp. 21113-21123
    • Peinado, H.1    Quintanilla, M.2    Cano, A.3
  • 25
    • 15544371346 scopus 로고    scopus 로고
    • Gene regulation at the single-cell level
    • N. Rosenfeld, and J.W. Young M.B. Elowitz Gene regulation at the single-cell level Science 307 2005 1962 1965
    • (2005) Science , vol.307 , pp. 1962-1965
    • Rosenfeld, N.1    Young, J.W.2    Elowitz, M.B.3
  • 27
    • 0842285841 scopus 로고    scopus 로고
    • Summing up the noise in gene networks
    • J. Paulsson Summing up the noise in gene networks Nature 427 2004 415 418
    • (2004) Nature , vol.427 , pp. 415-418
    • Paulsson, J.1
  • 29
    • 34548695913 scopus 로고    scopus 로고
    • Binomial τ-leap spatial stochastic simulation algorithm for applications in chemical kinetics
    • T.T. Marquez-Lago, and K. Burrage Binomial τ-leap spatial stochastic simulation algorithm for applications in chemical kinetics J. Chem. Phys. 127 2007 104101
    • (2007) J. Chem. Phys. , vol.127 , pp. 104101
    • Marquez-Lago, T.T.1    Burrage, K.2
  • 30
    • 34250754425 scopus 로고    scopus 로고
    • Adaptive explicit-implicit tau-leaping method with automatic τ-selection
    • Y. Cao, D.T. Gillespie, and L.R. Petzold Adaptive explicit-implicit tau-leaping method with automatic τ-selection J. Chem. Phys. 126 2007 224101
    • (2007) J. Chem. Phys. , vol.126 , pp. 224101
    • Cao, Y.1    Gillespie, D.T.2    Petzold, L.R.3
  • 31
    • 0037376655 scopus 로고    scopus 로고
    • Sniffers, buzzers, toggles and blinkers: Dynamics of regulatory and signaling pathways in the cell
    • J.J. Tyson, K.C. Chen, and B. Novak Sniffers, buzzers, toggles and blinkers: dynamics of regulatory and signaling pathways in the cell Curr. Opin. Cell Biol. 15 2003 221 231
    • (2003) Curr. Opin. Cell Biol. , vol.15 , pp. 221-231
    • Tyson, J.J.1    Chen, K.C.2    Novak, B.3
  • 32
    • 0036532226 scopus 로고    scopus 로고
    • Self-perpetuating states in signal transduction: Positive feedback, double-negative feedback and bistability
    • J.E. Ferrell Jr. Self-perpetuating states in signal transduction: positive feedback, double-negative feedback and bistability Curr. Opin. Cell Biol. 14 2002 140 148
    • (2002) Curr. Opin. Cell Biol. , vol.14 , pp. 140-148
    • Ferrell, Jr.J.E.1
  • 33
    • 43149108161 scopus 로고    scopus 로고
    • A bistable Rb-E2F switch underlies the restriction point
    • G. Yao, and T.J. Lee L. You A bistable Rb-E2F switch underlies the restriction point Nat. Cell Biol. 10 2008 476 482
    • (2008) Nat. Cell Biol. , vol.10 , pp. 476-482
    • Yao, G.1    Lee, T.J.2    You, L.3
  • 34
    • 68949136612 scopus 로고    scopus 로고
    • Interlinking positive and negative feedback loops creates a tunable motif in gene regulatory networks
    • X.J. Tian, and X.P. Zhang W. Wang Interlinking positive and negative feedback loops creates a tunable motif in gene regulatory networks Phys. Rev. E. 80 2009 011926
    • (2009) Phys. Rev. E. , vol.80 , pp. 011926
    • Tian, X.J.1    Zhang, X.P.2    Wang, W.3
  • 35
    • 39749157093 scopus 로고    scopus 로고
    • Sustained TGF β-exposure suppresses Smad and non-Smad signaling in mammary epithelial cells, leading to EMT and inhibition of growth arrest and apoptosis
    • A. Gal, and T. Sjöblom A. Moustakas Sustained TGF β-exposure suppresses Smad and non-Smad signaling in mammary epithelial cells, leading to EMT and inhibition of growth arrest and apoptosis Oncogene 27 2008 1218 1230
    • (2008) Oncogene , vol.27 , pp. 1218-1230
    • Gal, A.1    Sjöblom, T.2    Moustakas, A.3
  • 36
    • 77957551870 scopus 로고    scopus 로고
    • A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts
    • R. Li, and J. Liang D. Pei A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts Cell Stem Cell 7 2010 51 63
    • (2010) Cell Stem Cell , vol.7 , pp. 51-63
    • Li, R.1    Liang, J.2    Pei, D.3
  • 37
    • 77956320116 scopus 로고    scopus 로고
    • Functional genomics reveals a BMP-driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogramming
    • P. Samavarchi-Tehrani, and A. Golipour J.L. Wrana Functional genomics reveals a BMP-driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogramming Cell Stem Cell 7 2010 64 77
    • (2010) Cell Stem Cell , vol.7 , pp. 64-77
    • Samavarchi-Tehrani, P.1    Golipour, A.2    Wrana, J.L.3
  • 38
    • 84874225673 scopus 로고    scopus 로고
    • Critical regulation of miR-200/ZEB2 pathway in Oct4/Sox2-induced mesenchymal-to-epithelial transition and induced pluripotent stem cell generation
    • G. Wang, and X. Guo J. Kang Critical regulation of miR-200/ZEB2 pathway in Oct4/Sox2-induced mesenchymal-to-epithelial transition and induced pluripotent stem cell generation Proc. Natl. Acad. Sci. USA 110 2013 2858 2863
    • (2013) Proc. Natl. Acad. Sci. USA , vol.110 , pp. 2858-2863
    • Wang, G.1    Guo, X.2    Kang, J.3
  • 39
    • 84860608896 scopus 로고    scopus 로고
    • Partial mesenchymal to epithelial reverting transition in breast and prostate cancer metastases
    • Y. Chao, and Q. Wu A. Wells Partial mesenchymal to epithelial reverting transition in breast and prostate cancer metastases Cancer Microenviron 5 2012 19 28
    • (2012) Cancer Microenviron , vol.5 , pp. 19-28
    • Chao, Y.1    Wu, Q.2    Wells, A.3
  • 40
    • 34249079154 scopus 로고    scopus 로고
    • Network motifs: Theory and experimental approaches
    • U. Alon Network motifs: theory and experimental approaches Nat. Rev. Genet. 8 2007 450 461
    • (2007) Nat. Rev. Genet. , vol.8 , pp. 450-461
    • Alon, U.1
  • 41
    • 0001631778 scopus 로고
    • Rate processes with dynamical disorder
    • R. Zwanzig Rate processes with dynamical disorder Acc. Chem. Res. 23 1990 148 152
    • (1990) Acc. Chem. Res. , vol.23 , pp. 148-152
    • Zwanzig, R.1
  • 42
    • 33644910749 scopus 로고    scopus 로고
    • Ever-fluctuating single enzyme molecules: Michaelis-Menten equation revisited
    • B.P. English, and W. Min X.S. Xie Ever-fluctuating single enzyme molecules: Michaelis-Menten equation revisited Nat. Chem. Biol. 2 2006 87 94
    • (2006) Nat. Chem. Biol. , vol.2 , pp. 87-94
    • English, B.P.1    Min, W.2    Xie, X.S.3
  • 43
    • 0037417803 scopus 로고    scopus 로고
    • Hysteresis drives cell-cycle transitions in Xenopus laevis egg extracts
    • W. Sha, and J. Moore J.C. Sible Hysteresis drives cell-cycle transitions in Xenopus laevis egg extracts Proc. Natl. Acad. Sci. USA 100 2003 975 980
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 975-980
    • Sha, W.1    Moore, J.2    Sible, J.C.3
  • 44
    • 0345700833 scopus 로고    scopus 로고
    • Building a cell cycle oscillator: Hysteresis and bistability in the activation of Cdc2
    • J.R. Pomerening, E.D. Sontag, and J.E. Ferrell Jr. Building a cell cycle oscillator: hysteresis and bistability in the activation of Cdc2 Nat. Cell Biol. 5 2003 346 351
    • (2003) Nat. Cell Biol. , vol.5 , pp. 346-351
    • Pomerening, J.R.1    Sontag, E.D.2    Ferrell, Jr.J.E.3
  • 45
    • 0027716813 scopus 로고
    • Numerical analysis of a comprehensive model of M-phase control in Xenopus oocyte extracts and intact embryos
    • B. Novak, and J.J. Tyson Numerical analysis of a comprehensive model of M-phase control in Xenopus oocyte extracts and intact embryos J. Cell Sci. 106 1993 1153 1168
    • (1993) J. Cell Sci. , vol.106 , pp. 1153-1168
    • Novak, B.1    Tyson, J.J.2
  • 46
    • 80052213072 scopus 로고    scopus 로고
    • Analysis of microRNA turnover in mammalian cells following Dicer1 ablation
    • M.P. Gantier, and C.E. McCoy B.R.G. Williams Analysis of microRNA turnover in mammalian cells following Dicer1 ablation Nucleic Acids Res. 39 2011 5692 5703
    • (2011) Nucleic Acids Res. , vol.39 , pp. 5692-5703
    • Gantier, M.P.1    McCoy, C.E.2    Williams, B.R.G.3
  • 47
    • 77951964981 scopus 로고    scopus 로고
    • Posttranscriptional regulation of microRNA biogenesis in animals
    • H. Siomi, and M.C. Siomi Posttranscriptional regulation of microRNA biogenesis in animals Mol. Cell 38 2010 323 332
    • (2010) Mol. Cell , vol.38 , pp. 323-332
    • Siomi, H.1    Siomi, M.C.2
  • 48
    • 34548316982 scopus 로고    scopus 로고
    • MicroRNA sponges: Competitive inhibitors of small RNAs in mammalian cells
    • M.S. Ebert, J.R. Neilson, and P.A. Sharp MicroRNA sponges: competitive inhibitors of small RNAs in mammalian cells Nat. Methods 4 2007 721 726
    • (2007) Nat. Methods , vol.4 , pp. 721-726
    • Ebert, M.S.1    Neilson, J.R.2    Sharp, P.A.3
  • 49
    • 84873050284 scopus 로고    scopus 로고
    • Regulatory networks defining EMT during cancer initiation and progression
    • B. De Craene, and G. Berx Regulatory networks defining EMT during cancer initiation and progression Nat. Rev. Cancer 13 2013 97 110
    • (2013) Nat. Rev. Cancer , vol.13 , pp. 97-110
    • De Craene, B.1    Berx, G.2
  • 50
    • 79961023271 scopus 로고    scopus 로고
    • Genome-scale epigenetic reprogramming during epithelial-to-mesenchymal transition
    • O.G. McDonald, and H. Wu A.P. Feinberg Genome-scale epigenetic reprogramming during epithelial-to-mesenchymal transition Nat. Struct. Mol. Biol. 18 2011 867 874
    • (2011) Nat. Struct. Mol. Biol. , vol.18 , pp. 867-874
    • McDonald, O.G.1    Wu, H.2    Feinberg, A.P.3
  • 51
    • 79953325707 scopus 로고    scopus 로고
    • Functional cooperation between Snail1 and twist in the regulation of ZEB1 expression during epithelial to mesenchymal transition
    • N. Dave, and S. Guaita-Esteruelas A.G. de Herreros Functional cooperation between Snail1 and twist in the regulation of ZEB1 expression during epithelial to mesenchymal transition J. Biol. Chem. 286 2011 12024 12032
    • (2011) J. Biol. Chem. , vol.286 , pp. 12024-12032
    • Dave, N.1    Guaita-Esteruelas, S.2    De Herreros, A.G.3
  • 52
    • 84866423871 scopus 로고    scopus 로고
    • MicroRNAs in the p53 network: Micromanagement of tumor suppression
    • H. Hermeking MicroRNAs in the p53 network: micromanagement of tumor suppression Nat. Rev. Cancer 12 2012 613 626
    • (2012) Nat. Rev. Cancer , vol.12 , pp. 613-626
    • Hermeking, H.1
  • 53
    • 79953147370 scopus 로고    scopus 로고
    • A perspective on cancer cell metastasis
    • C.L. Chaffer, and R.A. Weinberg A perspective on cancer cell metastasis Science 331 2011 1559 1564
    • (2011) Science , vol.331 , pp. 1559-1564
    • Chaffer, C.L.1    Weinberg, R.A.2
  • 54
    • 84861594264 scopus 로고    scopus 로고
    • Cadherin switch from E- to N-cadherin in melanoma progression is regulated by the PI3K/PTEN pathway through Twist and Snail
    • L. Hao, and J.R. Ha S. Persad Cadherin switch from E- to N-cadherin in melanoma progression is regulated by the PI3K/PTEN pathway through Twist and Snail Br. J. Dermatol. 166 2012 1184 1197
    • (2012) Br. J. Dermatol. , vol.166 , pp. 1184-1197
    • Hao, L.1    Ha, J.R.2    Persad, S.3
  • 55
    • 79959343390 scopus 로고    scopus 로고
    • Two-phase dynamics of p53 in the DNA damage response
    • X.P. Zhang, F. Liu, and W. Wang Two-phase dynamics of p53 in the DNA damage response Proc. Natl. Acad. Sci. USA 108 2011 8990 8995
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 8990-8995
    • Zhang, X.P.1    Liu, F.2    Wang, W.3
  • 56
    • 84861910774 scopus 로고    scopus 로고
    • A two-step mechanism for cell fate decision by coordination of nuclear and mitochondrial p53 activities
    • X.-J. Tian, and F. Liu W. Wang A two-step mechanism for cell fate decision by coordination of nuclear and mitochondrial p53 activities PLoS ONE 7 2012 e38164
    • (2012) PLoS ONE , vol.7 , pp. 38164
    • Tian, X.-J.1    Liu, F.2    Wang, W.3
  • 57
    • 77950502330 scopus 로고    scopus 로고
    • ZEB proteins link cell motility with cell cycle control and cell survival in cancer
    • G. Browne, A.E. Sayan, and E. Tulchinsky ZEB proteins link cell motility with cell cycle control and cell survival in cancer Cell Cycle 9 2010 886 891
    • (2010) Cell Cycle , vol.9 , pp. 886-891
    • Browne, G.1    Sayan, A.E.2    Tulchinsky, E.3
  • 58
    • 45849087087 scopus 로고    scopus 로고
    • Induction of EMT by twist proteins as a collateral effect of tumor-promoting inactivation of premature senescence
    • S. Ansieau, and J. Bastid A. Puisieux Induction of EMT by twist proteins as a collateral effect of tumor-promoting inactivation of premature senescence Cancer Cell 14 2008 79 89
    • (2008) Cancer Cell , vol.14 , pp. 79-89
    • Ansieau, S.1    Bastid, J.2    Puisieux, A.3
  • 59
    • 33745192635 scopus 로고    scopus 로고
    • Autocrine PDGFR signaling promotes mammary cancer metastasis
    • M. Jechlinger, and A. Sommer S. Grünert Autocrine PDGFR signaling promotes mammary cancer metastasis J. Clin. Invest. 116 2006 1561 1570
    • (2006) J. Clin. Invest. , vol.116 , pp. 1561-1570
    • Jechlinger, M.1    Sommer, A.2    Grünert, S.3
  • 60
    • 33748168727 scopus 로고    scopus 로고
    • ILEI: A cytokine essential for EMT, tumor formation, and late events in metastasis in epithelial cells
    • T. Waerner, and M. Alacakaptan H. Beug ILEI: a cytokine essential for EMT, tumor formation, and late events in metastasis in epithelial cells Cancer Cell 10 2006 227 239
    • (2006) Cancer Cell , vol.10 , pp. 227-239
    • Waerner, T.1    Alacakaptan, M.2    Beug, H.3
  • 61
    • 57749114754 scopus 로고    scopus 로고
    • HMGA2 and Smads co-regulate SNAIL1 expression during induction of epithelial-to-mesenchymal transition
    • S. Thuault, and E.-J. Tan A. Moustakas HMGA2 and Smads co-regulate SNAIL1 expression during induction of epithelial-to-mesenchymal transition J. Biol. Chem. 283 2008 33437 33446
    • (2008) J. Biol. Chem. , vol.283 , pp. 33437-33446
    • Thuault, S.1    Tan, E.-J.2    Moustakas, A.3
  • 62
    • 34249289041 scopus 로고    scopus 로고
    • Snail, Zeb and bHLH factors in tumor progression: An alliance against the epithelial phenotype?
    • H. Peinado, D. Olmeda, and A. Cano Snail, Zeb and bHLH factors in tumor progression: an alliance against the epithelial phenotype? Nat. Rev. Cancer 7 2007 415 428
    • (2007) Nat. Rev. Cancer , vol.7 , pp. 415-428
    • Peinado, H.1    Olmeda, D.2    Cano, A.3
  • 63
    • 77956230322 scopus 로고    scopus 로고
    • The ZEB/miR-200 feedback loop - A motor of cellular plasticity in development and cancer?
    • S. Brabletz, and T. Brabletz The ZEB/miR-200 feedback loop - a motor of cellular plasticity in development and cancer? EMBO Rep. 11 2010 670 677
    • (2010) EMBO Rep. , vol.11 , pp. 670-677
    • Brabletz, S.1    Brabletz, T.2
  • 64
    • 84856102456 scopus 로고    scopus 로고
    • MiR-34 and SNAIL: Another double-negative feedback loop controlling cellular plasticity/EMT governed by p53
    • T. Brabletz MiR-34 and SNAIL: another double-negative feedback loop controlling cellular plasticity/EMT governed by p53 Cell Cycle 11 2012 215 216
    • (2012) Cell Cycle , vol.11 , pp. 215-216
    • Brabletz, T.1
  • 65
    • 77954956544 scopus 로고    scopus 로고
    • Downregulation of microRNAs directs the EMT and invasive potential of anaplastic thyroid carcinomas
    • J. Braun, and C. Hoang-Vu S. Hüttelmaier Downregulation of microRNAs directs the EMT and invasive potential of anaplastic thyroid carcinomas Oncogene 29 2010 4237 4244
    • (2010) Oncogene , vol.29 , pp. 4237-4244
    • Braun, J.1    Hoang-Vu, C.2    Hüttelmaier, S.3
  • 66
    • 78751516162 scopus 로고    scopus 로고
    • MiR-200a prevents renal fibrogenesis through repression of TGF-β2 expression
    • B. Wang, and P. Koh P. Kantharidis miR-200a prevents renal fibrogenesis through repression of TGF-β2 expression Diabetes 60 2011 280 287
    • (2011) Diabetes , vol.60 , pp. 280-287
    • Wang, B.1    Koh, P.2    Kantharidis, P.3
  • 67
    • 0033784843 scopus 로고    scopus 로고
    • The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression
    • A. Cano, and M.A. Pérez-Moreno M.A. Nieto The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression Nat. Cell Biol. 2 2000 76 83
    • (2000) Nat. Cell Biol. , vol.2 , pp. 76-83
    • Cano, A.1    Pérez-Moreno, M.A.2    Nieto, M.A.3
  • 68
    • 0033789680 scopus 로고    scopus 로고
    • The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumor cells
    • E. Batlle, and E. Sancho A. García De Herreros The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumor cells Nat. Cell Biol. 2 2000 84 89
    • (2000) Nat. Cell Biol. , vol.2 , pp. 84-89
    • Batlle, E.1    Sancho, E.2    García De Herreros, A.3
  • 69
    • 34548496683 scopus 로고    scopus 로고
    • Differential regulation of epithelial and mesenchymal markers by δeF1 proteins in epithelial mesenchymal transition induced by TGF-β
    • T. Shirakihara, M. Saitoh, and K. Miyazono Differential regulation of epithelial and mesenchymal markers by δEF1 proteins in epithelial mesenchymal transition induced by TGF-β Mol. Biol. Cell 18 2007 3533 3544
    • (2007) Mol. Biol. Cell , vol.18 , pp. 3533-3544
    • Shirakihara, T.1    Saitoh, M.2    Miyazono, K.3
  • 70
    • 33750358078 scopus 로고    scopus 로고
    • Genetic profiling of epithelial cells expressing E-cadherin repressors reveals a distinct role for Snail, Slug, and E47 factors in epithelial- mesenchymal transition
    • G. Moreno-Bueno, and E. Cubillo A. Cano Genetic profiling of epithelial cells expressing E-cadherin repressors reveals a distinct role for Snail, Slug, and E47 factors in epithelial-mesenchymal transition Cancer Res. 66 2006 9543 9556
    • (2006) Cancer Res. , vol.66 , pp. 9543-9556
    • Moreno-Bueno, G.1    Cubillo, E.2    Cano, A.3
  • 71
    • 5444269904 scopus 로고    scopus 로고
    • Dual regulation of Snail by GSK-3β-mediated phosphorylation in control of epithelial-mesenchymal transition
    • B.P. Zhou, and J. Deng M.-C. Hung Dual regulation of Snail by GSK-3β-mediated phosphorylation in control of epithelial-mesenchymal transition Nat. Cell Biol. 6 2004 931 940
    • (2004) Nat. Cell Biol. , vol.6 , pp. 931-940
    • Zhou, B.P.1    Deng, J.2    Hung, M.-C.3
  • 72
    • 29144485712 scopus 로고    scopus 로고
    • SIP1/ZEB2 induces EMT by repressing genes of different epithelial cell-cell junctions
    • C. Vandewalle, and J. Comijn G. Berx SIP1/ZEB2 induces EMT by repressing genes of different epithelial cell-cell junctions Nucleic Acids Res. 33 2005 6566 6578
    • (2005) Nucleic Acids Res. , vol.33 , pp. 6566-6578
    • Vandewalle, C.1    Comijn, J.2    Berx, G.3
  • 73
    • 65249141709 scopus 로고    scopus 로고
    • Database for mRNA half-life of 19 977 genes obtained by DNA microarray analysis of pluripotent and differentiating mouse embryonic stem cells
    • L.V. Sharova, and A.A. Sharov M.S. Ko Database for mRNA half-life of 19 977 genes obtained by DNA microarray analysis of pluripotent and differentiating mouse embryonic stem cells DNA Res. 16 2009 45 58
    • (2009) DNA Res. , vol.16 , pp. 45-58
    • Sharova, L.V.1    Sharov, A.A.2    Ko, M.S.3
  • 74
    • 79956322553 scopus 로고    scopus 로고
    • Global quantification of mammalian gene expression control
    • B. Schwanhäusser, and D. Busse M. Selbach Global quantification of mammalian gene expression control Nature 473 2011 337 342
    • (2011) Nature , vol.473 , pp. 337-342
    • Schwanhäusser, B.1    Busse, D.2    Selbach, M.3
  • 75
    • 84055216937 scopus 로고    scopus 로고
    • Temporal and spatial cooperation of Snail1 and Twist1 during epithelial-mesenchymal transition predicts for human breast cancer recurrence
    • D.D. Tran, and C.A.S. Corsa G.D. Longmore Temporal and spatial cooperation of Snail1 and Twist1 during epithelial-mesenchymal transition predicts for human breast cancer recurrence Mol. Cancer Res. 9 2011 1644 1657
    • (2011) Mol. Cancer Res. , vol.9 , pp. 1644-1657
    • Tran, D.D.1    Corsa, C.A.S.2    Longmore, G.D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.