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Volumn 16, Issue 1, 2006, Pages 30-37

Inhibition of TGFβ signaling in cancer therapy

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 4 [4 (1,3 BENZODIOXOL 5 YL) 5 (2 PYRIDINYL) 1H IMIDAZOL 2 YL]BENZAMIDE; ANTISENSE OLIGODEOXYNUCLEOTIDE; AP 11014; AP 12009; DOXYCYCLINE FOSFATEX; EPIDERMAL GROWTH FACTOR RECEPTOR 2; GC 1008; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LERDELIMUMAB; LY 580276; MITOGEN ACTIVATED PROTEIN KINASE P38; MONOCLONAL ANTIBODY; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN P85; RAC PROTEIN; RHO FACTOR; SB 505124; SD 093; SD 908; SMAD2 PROTEIN; SMAD3 PROTEIN; SMALL MOLECULE TRANSPORT AGENT; STRESS ACTIVATED PROTEIN KINASE; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA ANTIBODY; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; TRASTUZUMAB; UNCLASSIFIED DRUG; UNINDEXED DRUG; SMAD PROTEIN; TUMOR MARKER;

EID: 30644467227     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.gde.2005.12.009     Document Type: Review
Times cited : (110)

References (61)
  • 1
    • 0019303558 scopus 로고
    • Transforming growth factors: Isolation of polypeptides from virally and chemically transformed cells by acid/ethanol extraction
    • A.B. Roberts, L.C. Lamb, D.L. Newton, M.B. Sporn, J.E. De Larco, and G.J. Todaro Transforming growth factors: isolation of polypeptides from virally and chemically transformed cells by acid/ethanol extraction Proc Natl Acad Sci USA 77 1980 3494 3498
    • (1980) Proc Natl Acad Sci USA , vol.77 , pp. 3494-3498
    • Roberts, A.B.1    Lamb, L.C.2    Newton, D.L.3    Sporn, M.B.4    De Larco, J.E.5    Todaro, G.J.6
  • 2
    • 0019465899 scopus 로고
    • Transforming growth factor production by chemically transformed cells
    • H.L. Moses, E.L. Branum, J.A. Proper, and R.A. Robinson Transforming growth factor production by chemically transformed cells Cancer Res 41 1981 2842 2848
    • (1981) Cancer Res , vol.41 , pp. 2842-2848
    • Moses, H.L.1    Branum, E.L.2    Proper, J.A.3    Robinson, R.A.4
  • 3
    • 0242499448 scopus 로고    scopus 로고
    • Cytostatic and apoptotic actions of TGF-β in homeostasis and cancer
    • P.M. Siegel, and J. Massague Cytostatic and apoptotic actions of TGF-β in homeostasis and cancer Nat Rev Cancer 3 2003 807 820
    • (2003) Nat Rev Cancer , vol.3 , pp. 807-820
    • Siegel, P.M.1    Massague, J.2
  • 4
    • 0038724672 scopus 로고    scopus 로고
    • Targeting the TGFβ signaling network in human neoplasia
    • N. Dumont, and C.L. Arteaga Targeting the TGFβ signaling network in human neoplasia Cancer Cell 3 2003 531 536
    • (2003) Cancer Cell , vol.3 , pp. 531-536
    • Dumont, N.1    Arteaga, C.L.2
  • 5
    • 3042738106 scopus 로고    scopus 로고
    • Smad-binding defective mutant of transforming growth factor β type I receptor enhances tumorigenesis but suppresses metastasis of breast cancer cell lines
    • F. Tian, S.D. Byfield, W.T. Parks, C.H. Stuelten, D. Nemani, Y.E. Zhang, and A.B. Roberts Smad-binding defective mutant of transforming growth factor β type I receptor enhances tumorigenesis but suppresses metastasis of breast cancer cell lines Cancer Res 64 2004 4523 4530 The authors provide an excellent demonstration of the dual role of TGFβ in transformation. In an established model of breast epithelial transformation, abrogation of Smad signaling accelerates tumor formation but delays the metastatic progression of tumors.
    • (2004) Cancer Res , vol.64 , pp. 4523-4530
    • Tian, F.1    Byfield, S.D.2    Parks, W.T.3    Stuelten, C.H.4    Nemani, D.5    Zhang, Y.E.6    Roberts, A.B.7
  • 6
    • 0037816160 scopus 로고    scopus 로고
    • Transforming growth factor β signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis
    • P.M. Siegel, W. Shu, R.D. Cardiff, W.J. Muller, and J. Massague Transforming growth factor β signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis Proc Natl Acad Sci USA 100 2003 8430 8435
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 8430-8435
    • Siegel, P.M.1    Shu, W.2    Cardiff, R.D.3    Muller, W.J.4    Massague, J.5
  • 9
    • 33745050200 scopus 로고    scopus 로고
    • Activated type I TGFβ receptor kinase enhances the survival of mammary epithelial cells and accelerates tumor progression
    • DOI:10.1038/sj.onc.1208964.
    • Muraoka-Cook RS, Shin I, Yi JY, Easterly E, Barcellos-Hoff MH, Yingling JM, Zent R, Arteaga CL: Activated type I TGFβ receptor kinase enhances the survival of mammary epithelial cells and accelerates tumor progression. Oncogene 2005, DOI:10.1038/sj.onc.1208964. One of the first demonstrations of TGFβ-mediated activation of the PI3K pathway in vivo. Expression of an active mutant of Alk5 in the mammary gland of transgenic mice enhanced PI3K-dependent epithelial cell survival and synergized with Neu in accelerating metastatic progression of Neu-induced mammary tumors.
    • (2005) Oncogene
    • Muraoka-Cook, R.S.1    Shin, I.2    Yi, J.Y.3    Easterly, E.4    Barcellos-Hoff, M.H.5    Yingling, J.M.6    Zent, R.7    Arteaga, C.L.8
  • 10
    • 0036304111 scopus 로고    scopus 로고
    • Metastasis is driven by sequential elevation of H-ras and Smad2 levels
    • M. Oft, R.J. Akhurst, and A. Balmain Metastasis is driven by sequential elevation of H-ras and Smad2 levels Nat Cell Biol 4 2002 487 494
    • (2002) Nat Cell Biol , vol.4 , pp. 487-494
    • Oft, M.1    Akhurst, R.J.2    Balmain, A.3
  • 11
    • 16844373628 scopus 로고    scopus 로고
    • Effect of conditional knockout of the type II TGF-β receptor gene in mammary epithelia on mammary gland development and polyomavirus middle T antigen induced tumor formation and metastasis
    • E. Forrester, A. Chytil, B. Bierie, M. Aakre, A.E. Gorska, A.R. Sharif-Afshar, W.J. Muller, and H.L. Moses Effect of conditional knockout of the type II TGF-β receptor gene in mammary epithelia on mammary gland development and polyomavirus middle T antigen induced tumor formation and metastasis Cancer Res 65 2005 2296 2302
    • (2005) Cancer Res , vol.65 , pp. 2296-2302
    • Forrester, E.1    Chytil, A.2    Bierie, B.3    Aakre, M.4    Gorska, A.E.5    Sharif-Afshar, A.R.6    Muller, W.J.7    Moses, H.L.8
  • 12
    • 0035853883 scopus 로고    scopus 로고
    • Association between the T29C polymorphism in the transforming growth factor β1 gene and breast cancer among elderly white women: The study of osteoporotic fractures
    • E. Ziv, J. Cauley, P.A. Morin, R. Saiz, and W.S. Browner Association between the T29C polymorphism in the transforming growth factor β1 gene and breast cancer among elderly white women: the study of osteoporotic fractures JAMA 285 2001 2859 2863
    • (2001) JAMA , vol.285 , pp. 2859-2863
    • Ziv, E.1    Cauley, J.2    Morin, P.A.3    Saiz, R.4    Browner, W.S.5
  • 14
    • 0842282633 scopus 로고    scopus 로고
    • Genetic polymorphisms in the TGF-β 1 gene and breast cancer survival: A report from the Shanghai breast cancer study
    • X.O. Shu, Y.T. Gao, Q. Cai, L. Pierce, H. Cai, Z.X. Ruan, G. Yang, F. Jin, and W. Zheng Genetic polymorphisms in the TGF-β 1 gene and breast cancer survival: a report from the Shanghai breast cancer study Cancer Res 64 2004 836 839
    • (2004) Cancer Res , vol.64 , pp. 836-839
    • Shu, X.O.1    Gao, Y.T.2    Cai, Q.3    Pierce, L.4    Cai, H.5    Ruan, Z.X.6    Yang, G.7    Jin, F.8    Zheng, W.9
  • 16
    • 26044435160 scopus 로고    scopus 로고
    • Somatic acquisition and signaling of TGFBR1*6A in cancer
    • B. Pasche, T.J. Knobloch, Y. Bian, J. Liu, S. Phukan, D. Rosman, V. Kaklamani, L. Baddi, F.S. Siddiqui, and W. Frankel Somatic acquisition and signaling of TGFBR1*6A in cancer JAMA 294 2005 1634 1646 First demonstration of a somatically acquired polymorphism in the TGFBRI gene in colon, head and neck cancers. This polymorphism can bestow cancer cells with a growth advantage in the presence of TGFβ and represents a potential biomarker for the selection of patients into trials with TGFβ inhibitors.
    • (2005) JAMA , vol.294 , pp. 1634-1646
    • Pasche, B.1    Knobloch, T.J.2    Bian, Y.3    Liu, J.4    Phukan, S.5    Rosman, D.6    Kaklamani, V.7    Baddi, L.8    Siddiqui, F.S.9    Frankel, W.10
  • 17
    • 2342510148 scopus 로고    scopus 로고
    • Secreted transforming growth factor β2 activates NFκB, blocks apoptosis, and is essential for the survival of some tumor cells
    • T. Lu, L.G. Burdelya, S.M. Swiatkowski, A.D. Boiko, P.H. Howe, G.R. Stark, and A.V. Gudkov Secreted transforming growth factor β2 activates NFκB, blocks apoptosis, and is essential for the survival of some tumor cells Proc Natl Acad Sci USA 101 2004 7112 7117
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 7112-7117
    • Lu, T.1    Burdelya, L.G.2    Swiatkowski, S.M.3    Boiko, A.D.4    Howe, P.H.5    Stark, G.R.6    Gudkov, A.V.7
  • 18
    • 15444372825 scopus 로고    scopus 로고
    • Type I transforming growth factor β receptor binds to and activates phosphatidylinositol 3-kinase
    • J.Y. Yi, I. Shin, and C.L. Arteaga Type I transforming growth factor β receptor binds to and activates phosphatidylinositol 3-kinase J Biol Chem 280 2005 10870 10876
    • (2005) J Biol Chem , vol.280 , pp. 10870-10876
    • Yi, J.Y.1    Shin, I.2    Arteaga, C.L.3
  • 19
    • 0345832090 scopus 로고    scopus 로고
    • Activation of the pro-survival phosphatidylinositol 3-kinase/AKT pathway by transforming growth factor-β1 in mesenchymal cells is mediated by p38 MAPK-dependent induction of an autocrine growth factor
    • J.C. Horowitz, D.Y. Lee, M. Waghray, V.G. Keshamouni, P.E. Thomas, H. Zhang, Z. Cui, and V.J. Thannickal Activation of the pro-survival phosphatidylinositol 3-kinase/AKT pathway by transforming growth factor-β1 in mesenchymal cells is mediated by p38 MAPK-dependent induction of an autocrine growth factor J Biol Chem 279 2004 1359 1367
    • (2004) J Biol Chem , vol.279 , pp. 1359-1367
    • Horowitz, J.C.1    Lee, D.Y.2    Waghray, M.3    Keshamouni, V.G.4    Thomas, P.E.5    Zhang, H.6    Cui, Z.7    Thannickal, V.J.8
  • 20
    • 0035196587 scopus 로고    scopus 로고
    • Transforming growth factor β enhances epithelial cell survival via Akt-dependent regulation of FKHRL1
    • I. Shin, A.V. Bakin, U. Rodeck, A. Brunet, and C.L. Arteaga Transforming growth factor β enhances epithelial cell survival via Akt-dependent regulation of FKHRL1 Mol Biol Cell 12 2001 3328 3339
    • (2001) Mol Biol Cell , vol.12 , pp. 3328-3339
    • Shin, I.1    Bakin, A.V.2    Rodeck, U.3    Brunet, A.4    Arteaga, C.L.5
  • 21
    • 0034674542 scopus 로고    scopus 로고
    • Transforming growth factor-β 1 suppresses serum deprivation-induced death of A549 cells through differential effects on c-Jun and JNK activities
    • Y. Huang, D. Hutter, Y. Liu, X. Wang, M.S. Sheikh, A.M. Chan, and N.J. Holbrook Transforming growth factor-β 1 suppresses serum deprivation-induced death of A549 cells through differential effects on c-Jun and JNK activities J Biol Chem 275 2000 18234 18242
    • (2000) J Biol Chem , vol.275 , pp. 18234-18242
    • Huang, Y.1    Hutter, D.2    Liu, Y.3    Wang, X.4    Sheikh, M.S.5    Chan, A.M.6    Holbrook, N.J.7
  • 22
    • 0037087507 scopus 로고    scopus 로고
    • Hepatocytes convert to a fibroblastoid phenotype through the cooperation of TGF-β1 and Ha-Ras: Steps towards invasiveness
    • J. Gotzmann, H. Huber, C. Thallinger, M. Wolschek, B. Jansen, R. Schulte-Hermann, H. Beug, and W. Mikulits Hepatocytes convert to a fibroblastoid phenotype through the cooperation of TGF-β1 and Ha-Ras: steps towards invasiveness J Cell Sci 115 2002 1189 1202
    • (2002) J Cell Sci , vol.115 , pp. 1189-1202
    • Gotzmann, J.1    Huber, H.2    Thallinger, C.3    Wolschek, M.4    Jansen, B.5    Schulte-Hermann, R.6    Beug, H.7    Mikulits, W.8
  • 23
    • 1642332084 scopus 로고    scopus 로고
    • Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation
    • J. Seoane, H.V. Le, L. Shen, S.A. Anderson, and J. Massague Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation Cell 117 2004 211 223 Elegant molecular demonstration of how PI3K, by modulation of Foxo transcription factors, attenuates the Smad-dependent anti-mitogenic effect of TGFβ on glioma cells.
    • (2004) Cell , vol.117 , pp. 211-223
    • Seoane, J.1    Le, H.V.2    Shen, L.3    Anderson, S.A.4    Massague, J.5
  • 24
    • 2342471301 scopus 로고    scopus 로고
    • Akt interacts directly with Smad3 to regulate the sensitivity to TGF-β induced apoptosis
    • A.R. Conery, Y. Cao, E.A. Thompson, C.M. Townsend Jr., T.C. Ko, and K. Luo Akt interacts directly with Smad3 to regulate the sensitivity to TGF-β induced apoptosis Nat Cell Biol 6 2004 366 372
    • (2004) Nat Cell Biol , vol.6 , pp. 366-372
    • Conery, A.R.1    Cao, Y.2    Thompson, E.A.3    Townsend Jr., C.M.4    Ko, T.C.5    Luo, K.6
  • 25
    • 2342647439 scopus 로고    scopus 로고
    • PKB/Akt modulates TGF-β signalling through a direct interaction with Smad3
    • I. Remy, A. Montmarquette, and S.W. Michnick PKB/Akt modulates TGF-β signalling through a direct interaction with Smad3 Nat Cell Biol 6 2004 358 365
    • (2004) Nat Cell Biol , vol.6 , pp. 358-365
    • Remy, I.1    Montmarquette, A.2    Michnick, S.W.3
  • 26
    • 0041342109 scopus 로고    scopus 로고
    • Evaluation of anti-TGF-β2 antibody as a new postoperative anti-scarring agent in glaucoma surgery
    • A.L. Mead, T.T. Wong, M.F. Cordeiro, I.K. Anderson, and P.T. Khaw Evaluation of anti-TGF-β2 antibody as a new postoperative anti-scarring agent in glaucoma surgery Invest Ophthalmol Vis Sci 44 2003 3394 3401
    • (2003) Invest Ophthalmol Vis Sci , vol.44 , pp. 3394-3401
    • Mead, A.L.1    Wong, T.T.2    Cordeiro, M.F.3    Anderson, I.K.4    Khaw, P.T.5
  • 29
    • 10444261212 scopus 로고    scopus 로고
    • Development of TGF-β signalling inhibitors for cancer therapy
    • J.M. Yingling, K.L. Blanchard, and J.S. Sawyer Development of TGF-β signalling inhibitors for cancer therapy Nat Rev Drug Discov 3 2004 1011 1022 An up-to-date and outstanding review of the medicinal chemistry and status of the clinical development of TGFβ inhibitors in cancer.
    • (2004) Nat Rev Drug Discov , vol.3 , pp. 1011-1022
    • Yingling, J.M.1    Blanchard, K.L.2    Sawyer, J.S.3
  • 30
    • 3442894138 scopus 로고    scopus 로고
    • Targeting endogenous transforming growth factor β receptor signaling in SMAD4-deficient human pancreatic carcinoma cells inhibits their invasive phenotype1
    • G. Subramanian, R.E. Schwarz, L. Higgins, G. McEnroe, S. Chakravarty, S. Dugar, and M. Reiss Targeting endogenous transforming growth factor β receptor signaling in SMAD4-deficient human pancreatic carcinoma cells inhibits their invasive phenotype1 Cancer Res 64 2004 5200 5211
    • (2004) Cancer Res , vol.64 , pp. 5200-5211
    • Subramanian, G.1    Schwarz, R.E.2    Higgins, L.3    McEnroe, G.4    Chakravarty, S.5    Dugar, S.6    Reiss, M.7
  • 31
    • 20044375562 scopus 로고    scopus 로고
    • Kinetic characterization of novel pyrazole tgf-β receptor I kinase inhibitors and their blockade of the epithelial-mesenchymal transition
    • S.B. Peng, L. Yan, X. Xia, S.A. Watkins, H.B. Brooks, D. Beight, D.K. Herron, M.L. Jones, J.W. Lampe, and W.T. McMillen Kinetic characterization of novel pyrazole tgf-β receptor I kinase inhibitors and their blockade of the epithelial-mesenchymal transition Biochemistry 44 2005 2293 2304
    • (2005) Biochemistry , vol.44 , pp. 2293-2304
    • Peng, S.B.1    Yan, L.2    Xia, X.3    Watkins, S.A.4    Brooks, H.B.5    Beight, D.6    Herron, D.K.7    Jones, M.L.8    Lampe, J.W.9    McMillen, W.T.10
  • 32
    • 20344385003 scopus 로고    scopus 로고
    • A specific inhibitor of TGF-β receptor kinase, SB-431542, as a potent antitumor agent for human cancers
    • S.K. Halder, R.D. Beauchamp, and P.K. Datta A specific inhibitor of TGF-β receptor kinase, SB-431542, as a potent antitumor agent for human cancers Neoplasia 7 2005 509 521
    • (2005) Neoplasia , vol.7 , pp. 509-521
    • Halder, S.K.1    Beauchamp, R.D.2    Datta, P.K.3
  • 33
    • 7444226411 scopus 로고    scopus 로고
    • SD-208, a novel transforming growth factor β receptor I kinase inhibitor, inhibits growth and invasiveness and enhances immunogenicity of murine and human glioma cells in vitro and in vivo
    • M. Uhl, S. Aulwurm, J. Wischhusen, M. Weiler, J.Y. Ma, R. Almirez, R. Mangadu, Y.W. Liu, M. Platten, and U. Herrlinger SD-208, a novel transforming growth factor β receptor I kinase inhibitor, inhibits growth and invasiveness and enhances immunogenicity of murine and human glioma cells in vitro and in vivo Cancer Res 64 2004 7954 7961
    • (2004) Cancer Res , vol.64 , pp. 7954-7961
    • Uhl, M.1    Aulwurm, S.2    Wischhusen, J.3    Weiler, M.4    Ma, J.Y.5    Almirez, R.6    Mangadu, R.7    Liu, Y.W.8    Platten, M.9    Herrlinger, U.10
  • 34
    • 1342265719 scopus 로고    scopus 로고
    • SB-505124 is a selective inhibitor of transforming growth factor-β type I receptors ALK4, ALK5, and ALK7
    • S. DaCosta Byfield, C. Major, N.J. Laping, and A.B. Roberts SB-505124 is a selective inhibitor of transforming growth factor-β type I receptors ALK4, ALK5, and ALK7 Mol Pharmacol 65 2004 744 752
    • (2004) Mol Pharmacol , vol.65 , pp. 744-752
    • Dacosta Byfield, S.1    Major, C.2    Laping, N.J.3    Roberts, A.B.4
  • 35
    • 0036085920 scopus 로고    scopus 로고
    • SB-431542 is a potent and specific inhibitor of transforming growth factor-β superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7
    • G.J. Inman, F.J. Nicolas, J.F. Callahan, J.D. Harling, L.M. Gaster, A.D. Reith, N.J. Laping, and C.S. Hill SB-431542 is a potent and specific inhibitor of transforming growth factor-β superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7 Mol Pharmacol 62 2002 65 74
    • (2002) Mol Pharmacol , vol.62 , pp. 65-74
    • Inman, G.J.1    Nicolas, F.J.2    Callahan, J.F.3    Harling, J.D.4    Gaster, L.M.5    Reith, A.D.6    Laping, N.J.7    Hill, C.S.8
  • 36
    • 3142618508 scopus 로고    scopus 로고
    • Activin receptor-like kinase-7 induces apoptosis through activation of MAPKs in a Smad3-dependent mechanism in hepatoma cells
    • B.C. Kim, H. van Gelder, T.A. Kim, H.J. Lee, K.G. Baik, H.H. Chun, D.A. Lee, K.S. Choi, and S.J. Kim Activin receptor-like kinase-7 induces apoptosis through activation of MAPKs in a Smad3-dependent mechanism in hepatoma cells J Biol Chem 279 2004 28458 28465
    • (2004) J Biol Chem , vol.279 , pp. 28458-28465
    • Kim, B.C.1    Van Gelder, H.2    Kim, T.A.3    Lee, H.J.4    Baik, K.G.5    Chun, H.H.6    Lee, D.A.7    Choi, K.S.8    Kim, S.J.9
  • 37
    • 23444434936 scopus 로고    scopus 로고
    • Gene expression profiling of cancer progression reveals intrinsic regulation of transforming growth factor-β signaling in ErbB2/Neu-induced tumors from transgenic mice
    • M.D. Landis, D.D. Seachrist, M.E. Montanez-Wiscovich, D. Danielpour, and R.A. Keri Gene expression profiling of cancer progression reveals intrinsic regulation of transforming growth factor-β signaling in ErbB2/Neu-induced tumors from transgenic mice Oncogene 24 2005 5173 5190
    • (2005) Oncogene , vol.24 , pp. 5173-5190
    • Landis, M.D.1    Seachrist, D.D.2    Montanez-Wiscovich, M.E.3    Danielpour, D.4    Keri, R.A.5
  • 38
    • 8744286786 scopus 로고    scopus 로고
    • Nodal induces apoptosis and inhibits proliferation in human epithelial ovarian cancer cells via activin receptor-like kinase 7
    • G. Xu, Y. Zhong, S. Munir, B.B. Yang, B.K. Tsang, and C. Peng Nodal induces apoptosis and inhibits proliferation in human epithelial ovarian cancer cells via activin receptor-like kinase 7 J Clin Endocrinol Metab 89 2004 5523 5534
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 5523-5534
    • Xu, G.1    Zhong, Y.2    Munir, S.3    Yang, B.B.4    Tsang, B.K.5    Peng, C.6
  • 43
    • 0036190919 scopus 로고    scopus 로고
    • Human antitransforming growth factor beta(2) monoclonal antibody-a new modulator of wound healing in trabeculectomy: A randomized placebo controlled clinical study
    • D. Siriwardena, P.T. Khaw, A.J. King, M.L. Donaldson, B.M. Overton, C. Migdal, and M.F. Cordeiro Human antitransforming growth factor beta(2) monoclonal antibody-a new modulator of wound healing in trabeculectomy: a randomized placebo controlled clinical study Ophthalmology 109 2002 427 431
    • (2002) Ophthalmology , vol.109 , pp. 427-431
    • Siriwardena, D.1    Khaw, P.T.2    King, A.J.3    Donaldson, M.L.4    Overton, B.M.5    Migdal, C.6    Cordeiro, M.F.7
  • 44
    • 0037474223 scopus 로고    scopus 로고
    • Autocrine transforming growth factor-β Signaling mediates smad- independent motility in human cancer cells
    • N. Dumont, A.V. Bakin, and C.L. Arteaga Autocrine transforming growth factor-β Signaling mediates smad- independent motility in human cancer cells J Biol Chem 278 2003 3275 3285
    • (2003) J Biol Chem , vol.278 , pp. 3275-3285
    • Dumont, N.1    Bakin, A.V.2    Arteaga, C.L.3
  • 45
    • 0035185853 scopus 로고    scopus 로고
    • Transforming growth factor-β1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism
    • N.A. Bhowmick, M. Ghiassi, A. Bakin, M. Aakre, C.A. Lundquist, M.E. Engel, C.L. Arteaga, and H.L. Moses Transforming growth factor-β1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism Mol Biol Cell 12 2001 27 36
    • (2001) Mol Biol Cell , vol.12 , pp. 27-36
    • Bhowmick, N.A.1    Ghiassi, M.2    Bakin, A.3    Aakre, M.4    Lundquist, C.A.5    Engel, M.E.6    Arteaga, C.L.7    Moses, H.L.8
  • 46
    • 22144490495 scopus 로고    scopus 로고
    • Distinct mechanisms of TGF-β1-mediated epithelial-to-mesenchymal transition and metastasis during skin carcinogenesis
    • G. Han, S.L. Lu, A.G. Li, W. He, C.L. Corless, M. Kulesz-Martin, and X.J. Wang Distinct mechanisms of TGF-β1-mediated epithelial-to-mesenchymal transition and metastasis during skin carcinogenesis J Clin Invest 115 2005 1714 1723 Expression of dominant-negative truncated TβRII and TGFβ in transgenic skin cancers accelerates tumor formation and metastases. These metastases did not exhibit molecular evidence of EMT. This study suggests that attenuated TGFβ-signaling cooperates with high levels of TGFβ ligand in tumor progression.
    • (2005) J Clin Invest , vol.115 , pp. 1714-1723
    • Han, G.1    Lu, S.L.2    Li, A.G.3    He, W.4    Corless, C.L.5    Kulesz-Martin, M.6    Wang, X.J.7
  • 48
    • 0034710545 scopus 로고    scopus 로고
    • Blockade of Smad4 in transformed keratinocytes containing a Ras oncogene leads to hyperactivation of the Ras-dependent Erk signalling pathway associated with progression to undifferentiated carcinomas
    • M. Iglesias, P. Frontelo, C. Gamallo, and M. Quintanilla Blockade of Smad4 in transformed keratinocytes containing a Ras oncogene leads to hyperactivation of the Ras-dependent Erk signalling pathway associated with progression to undifferentiated carcinomas Oncogene 19 2000 4134 4145
    • (2000) Oncogene , vol.19 , pp. 4134-4145
    • Iglesias, M.1    Frontelo, P.2    Gamallo, C.3    Quintanilla, M.4
  • 50
    • 0032711157 scopus 로고    scopus 로고
    • Enhanced expression of the type II transforming growth factor-β receptor is associated with decreased survival in human pancreatic cancer
    • M. Wagner, J. Kleeff, H. Friess, M.W. Buchler, and M. Korc Enhanced expression of the type II transforming growth factor-β receptor is associated with decreased survival in human pancreatic cancer Pancreas 19 1999 370 376
    • (1999) Pancreas , vol.19 , pp. 370-376
    • Wagner, M.1    Kleeff, J.2    Friess, H.3    Buchler, M.W.4    Korc, M.5
  • 51
    • 0033926458 scopus 로고    scopus 로고
    • The progression of invasiveness regarding the role of transforming growth factor β receptor type II in gastric cancer
    • M. Tateishi, I. Kusaba, H. Masuda, T. Tanaka, T. Matsumata, and K. Sugimachi The progression of invasiveness regarding the role of transforming growth factor β receptor type II in gastric cancer Eur J Surg Oncol 26 2000 377 380
    • (2000) Eur J Surg Oncol , vol.26 , pp. 377-380
    • Tateishi, M.1    Kusaba, I.2    Masuda, H.3    Tanaka, T.4    Matsumata, T.5    Sugimachi, K.6
  • 52
    • 0034146017 scopus 로고    scopus 로고
    • Transforming growth factor-β and response to anticancer therapies in human liver and gastric tumors in vitro and in vivo
    • P. Liu, K. Menon, E. Alvarez, K. Lu, and B.A. Teicher Transforming growth factor-β and response to anticancer therapies in human liver and gastric tumors in vitro and in vivo Int J Oncol 16 2000 599 610
    • (2000) Int J Oncol , vol.16 , pp. 599-610
    • Liu, P.1    Menon, K.2    Alvarez, E.3    Lu, K.4    Teicher, B.A.5
  • 53
    • 0031418669 scopus 로고    scopus 로고
    • Prostate carcinoma response to cytotoxic therapy: In vivo resistance
    • B.A. Teicher, Y. Kakeji, G. Ara, R.S. Herbst, and D. Northey Prostate carcinoma response to cytotoxic therapy: in vivo resistance In Vivo 11 1997 453 461
    • (1997) In Vivo , vol.11 , pp. 453-461
    • Teicher, B.A.1    Kakeji, Y.2    Ara, G.3    Herbst, R.S.4    Northey, D.5
  • 54
    • 0031420122 scopus 로고    scopus 로고
    • Transforming growth factor-β 1 overexpression produces drug resistance in vivo: Reversal by dEcoRIn
    • B.A. Teicher, M. Ikebe, G. Ara, S.R. Keyes, and R.S. Herbst Transforming growth factor-β 1 overexpression produces drug resistance in vivo: reversal by dEcoRIn In Vivo 11 1997 463 472
    • (1997) In Vivo , vol.11 , pp. 463-472
    • Teicher, B.A.1    Ikebe, M.2    Ara, G.3    Keyes, S.R.4    Herbst, R.S.5
  • 55
    • 0037148532 scopus 로고    scopus 로고
    • Ras and TGFβ cooperatively regulate epithelial cell plasticity and metastasis: Dissection of Ras signaling pathways
    • E. Janda, K. Lehmann, I. Killisch, M. Jechlinger, M. Herzig, J. Downward, H. Beug, and S. Grunert Ras and TGFβ cooperatively regulate epithelial cell plasticity and metastasis: dissection of Ras signaling pathways J Cell Biol 156 2002 299 313
    • (2002) J Cell Biol , vol.156 , pp. 299-313
    • Janda, E.1    Lehmann, K.2    Killisch, I.3    Jechlinger, M.4    Herzig, M.5    Downward, J.6    Beug, H.7    Grunert, S.8
  • 56
    • 0035800838 scopus 로고    scopus 로고
    • Oncogenic ras represses transforming growth factor-β/Smad signaling by degrading tumor suppressor Smad4
    • D. Saha, P.K. Datta, and R.D. Beauchamp Oncogenic ras represses transforming growth factor-β/Smad signaling by degrading tumor suppressor Smad4 J Biol Chem 276 2001 29531 29537
    • (2001) J Biol Chem , vol.276 , pp. 29531-29537
    • Saha, D.1    Datta, P.K.2    Beauchamp, R.D.3
  • 57
    • 0034023127 scopus 로고    scopus 로고
    • Role of Ras and Mapks in TGFβ signaling
    • K.M. Mulder Role of Ras and Mapks in TGFβ signaling Cytokine Growth Factor Rev 11 2000 23 35
    • (2000) Cytokine Growth Factor Rev , vol.11 , pp. 23-35
    • Mulder, K.M.1
  • 59
    • 0842320996 scopus 로고    scopus 로고
    • Cooperation of the ErbB2 receptor and transforming growth factor β in induction of migration and invasion in mammary epithelial cells
    • S.E. Seton-Rogers, Y. Lu, L.M. Hines, M. Koundinya, J. LaBaer, S.K. Muthuswamy, and J.S. Brugge Cooperation of the ErbB2 receptor and transforming growth factor β in induction of migration and invasion in mammary epithelial cells Proc Natl Acad Sci USA 101 2004 1257 1262
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 1257-1262
    • Seton-Rogers, S.E.1    Lu, Y.2    Hines, L.M.3    Koundinya, M.4    Labaer, J.5    Muthuswamy, S.K.6    Brugge, J.S.7
  • 60
    • 2642521235 scopus 로고    scopus 로고
    • Overexpression of HER2 (erbB2) in human breast epithelial cells unmasks transforming growth factor β-induced cell motility
    • Y. Ueda, S. Wang, N. Dumont, J.Y. Yi, Y. Koh, and C.L. Arteaga Overexpression of HER2 (erbB2) in human breast epithelial cells unmasks transforming growth factor β-induced cell motility J Biol Chem 279 2004 24505 24513
    • (2004) J Biol Chem , vol.279 , pp. 24505-24513
    • Ueda, Y.1    Wang, S.2    Dumont, N.3    Yi, J.Y.4    Koh, Y.5    Arteaga, C.L.6


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