TGF-β1 induces human alveolar epithelial to mesenchymal cell transition (EMT)

Respiratory Research

Volumn 6, Issue , 2005, Pages

  Kasai, Hidenori ^a   Allen, Jeremy T ^b   Mason, Roger M ^c   Kamimura, Takashi ^d   Zhang, Zhi ^a  

^a MEDICAL RESEARCH COUNCIL   (United Kingdom)

^b UNIVERSITY OF SALFORD   (United Kingdom)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

^d TEIJIN PHARMA LIMITED   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; CELL MARKER; COLLAGEN; COLLAGEN TYPE 1; COLLAGEN TYPE 3; CONNECTIVE TISSUE GROWTH FACTOR; FIBRONECTIN; GELATINASE A; INTERLEUKIN 1BETA; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MONOCLONAL ANTIBODY; SMAD2 PROTEIN; SMALL INTERFERING RNA; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA; UVOMORULIN; VIMENTIN; CADHERIN; TGFB1 PROTEIN, HUMAN; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; CELL LINE; CELL TRANSFORMATION; CELL TYPE; CONTROLLED STUDY; CYTOKINE PRODUCTION; EPITHELIAL MESENCHYMAL TRANSITION; FIBROGENESIS; HUMAN; HUMAN CELL; IDIOPATHIC DISEASE; LUNG ALVEOLUS CELL TYPE 2; LUNG ALVEOLUS EPITHELIUM; LUNG FIBROSIS; LUNG PARENCHYMA; MESENCHYME CELL; PHENOTYPE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; CELL DIFFERENTIATION; CYTOLOGY; DOSE RESPONSE; DRUG EFFECTS; EPITHELIUM CELL; LUNG ALVEOLUS; MESENCHYMAL STROMA CELL; METABOLISM; RESPIRATORY TRACT MUCOSA;

CADHERINS; CELL DIFFERENTIATION; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITHELIAL CELLS; FIBRONECTINS; HUMANS; MESENCHYMAL STROMAL CELLS; PULMONARY ALVEOLI; RESPIRATORY MUCOSA; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1;

EID: 26244458018     PISSN: 1465993X     EISSN: 1465993X     Source Type: Journal    
DOI: 10.1186/1465-9921-6-56     Document Type: Article

References (51)

1. Selman M, King TE, Pardo A: Idiopathic pulmonary fibrosis: prevailing and evolving hypotheses about its pathogenesis and implications for therapy. Ann Intern Med 2001, 134:136-151.
2. King TE Jr, Schwarz MI, Brown K, Tooze JA, Colby TV, Waldron JA Jr, Flint A, Thurlbeck W, Cherniack RM: Idiopathic pulmonary fibrosis: relationship between histopathologic features and mortality. Am J Respir Crit Care Med 2001, 164:1025-1032.
3. Selman M, Pardo A: Idiopathic pulmonary fibrosis: an epithelial/fibroblastic cross-talk disorder. Respir Res 2002, 3:3.
4. Allen JT, Spiteri MA: Growth factors in idiopathic pulmonary fibrosis: relative roles. Respir Res 2002, 3:13.
5. Gauldie J, Kolb M, Sime PJ: A new direction in the pathogenesis of idiopathic pulmonary fibrosis? Respir Res 2002, 3:1.
6. Kelly M, Kolb M, Bonniaud P, Gauldie J: Re-evaluation of fibrogenic cytokines in lung fibrosis. Curr Pharm Des 2003, 9:39-49.
7. Khalil N, O'Connor RN, Unruh HW, Warren PW, Flanders KC, Kemp A, Bereznay OH, Greenberg AH: Increased production and immunohistochemical localization of transforming growth factor-beta in idiopathic pulmonary fibrosis. Am J Respir Cell Mol Biol 1991, 5:155-162.
8. Khalil N, Parekh TV, O'Connor R, Antman N, Kepron W, Yehaulaeshet T, Xu YD, Gold LI: Regulation of the effects of TGF-beta 1 by activation of latent TGF-beta 1 and differential expression of TGF-beta receptors (T beta R-I and T beta R-II) in idiopathic pulmonary fibrosis. Thorax 2001, 56:907-915.
9. Sime PJ, Xing Z, Graham FL, Csaky KG, Gauldie J: Adenovector-mediated Gene Transfer of Active Transforming Growth Factor-β1 Induces Prolonged Severe Fibrosis in Rat Lung. J Clin Invest 1997, 100:768-776.
10. Kalluri R, Neilson EG: Epithelial-mesenchymal transition and its implications for fibrosis. J Clin Invest 2003, 112:1776-1784.
11. Liu Y: Epithelial to mesenchymal transition in renal fibrogenesis: pathologic significance, molecular mechanism, and therapeutic intervention. J Am Soc Nephrol 2004, 15:1-12.
12. Desmouliere A, Darby IA, Gabbiani G: Normal and pathologic soft tissue remodeling: role of the myofibroblast, with special emphasis on liver and kidney fibrosis. Lab Invest 2003, 83:1689-1707.
13. Desmouliere A: Factors influencing myofibroblast differentiation during wound healing and fibrosis. Cell Biol Int 1995, 19:471-476.
14. Nightingale J, Patel S, Suzuki N, Buxton R, Takagi KI, Suzuki J, Sumi Y, Imaizumi A, Mason RM, Zhang Z: Oncostatin M, a cytokine released by activated mononuclear cells, induces epithelial cell-myofibroblast transdifferentiation via Jak/Stat pathway activation. J Am Soc Nephrol 2004, 15:21-32.
15. Yao HW, Xie QM, Chen JQ, Deng YM, Tang HF: TGF-beta1 induces alveolar epithelial to mesenchymal transition in vitro. Life Sci 2004, 76:29-37.
16. Vleminckx K, Kemler R: Cadherins and tissue formation: integrating adhesion and signaling. Bioessays 1999, 21:211-220.
17. Higashimoto Y, Keicho N, Elliott WM, Hogg JC, Hayashi S: Effect of adenovirus E1A on ICAM-1 promoter activity in human alveolar and bronchial epithelial cells. Gene Expr 1999, 8:287-297.
18. Maeyama T, Kuwano K, Kawasaki M, Kunitake R, Hagimoto N, Matsuba T, Yoshimi M, Inoshima I, Yoshida K, Hara N: Upregulation of Fas-signalling molecules in lung epithelial cells from patients with idiopathic pulmonary fibrosis. Eur Respir J 2001, 17:180-189.
19. 2-induced alveolar epithelial cell DNA damage: role of MAPK activation and DNA repair. Am J Respir Cell Mol Biol 2004, 31:107-113.
20. Vesey DA, Cheung CWY, Cuttle L, Endre Z, Gobe G, Johnson DW: Interleukin-1β induces human proximal tubule cell injury, α-smooth muscle actin expression and fibronectin production. Kidney Int 2002, 62:31-40.
21. Fan J, Huang X, Ng Y, Nikolic-Paterson DJ, Mu W, Atkins RC, Lan HY: Interleukin-1 induces tubular epithelial-myofibroblast transdifferentiation through a transforming growth factor-β1-dependent mechanism in vitro. Am J Kidney Dis 2001, 37:820-831.
22. Bonniaud P, Margetts PJ, Kolb M, Haberberger T, Kelly M, Robertson J, Gauldie J: Adenoviral gene transfer of connective tissue growth factor in the lung induces transient fibrosis. Am J Respir Crit Care Med 2003, 168:770-778.
23. Wahab NA, Yevdokimova N, Weston BS, Roberts T, Li XJ, Brinkman H, Mason RM: Role of connective tissue growth factor in the pathogenesis of diabetic nephropathy. Biochem J 2001, 35:77-87.
24. Bottinger EP, Bitzer M: TGF-beta signaling in renal disease. J Am Soc Nephrol 2002, 13:2600-2610.
25. Gross TJ, Hunninghake GW: Idiopathic pulmonary fibrosis. N Engl J Med 2001, 345:517-525.
26. Ewing CM, Ru N, Morton RA, Robinson JC, Wheelock MJ, Johnson KR, Barrett JC, Isaacs WB: Chromosome 5 suppresses tumorigenicity of PC3 prostate cancer cells: correction with re-expression of alpha-catenin and restoration of E-cadherin function. Cancer Res 1995, 55:4813-4817.
27. Yang J, Liu Y: Dissection of key events in tubular epithelial to myofibroblast transition and its implications in renal interstitial fibrosis. Am J Pathol 2001, 159:1465-1475.
28. Miettinen PJ, Ebner R, Lopez AR, Derynck R: TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors. J Cell Biol 1994, 127:2021-2036.
29. Bhowmick NA, Ghiassi M, Bakin A, Aakre M, Lundquist CA, Engel ME, Arteaga CL, Moses HL: Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism. Mol Biol Cell 2001, 12:27-36.
30. Foster KA, Oster CG, Mayer MM, Avery ML, Audus KL: Characterization of the A549 cell line as a type II pulmonary epithelial cell model for drug metabolism. Exp Cell Res 1998, 243:359-366.
31. Strutz F, Zeisberg M, Ziyadeh FN, Yang CQ, Kalluri R, Muller GA, Neilson EG: Role of basic fibroblast growth factor-2 in epithelial-mesenchymal transformation. Kidney Int 2002, 61:1714-1728.
32. Sharmila P, Takagi K, Suzuki J, Imaizumi A, Kimura T, Mason RM, Kamimura T, Zhang Z: RhoGTPase activation is a key step in renal epithelial mesenchymal transdifferentiation. J Am Soc Nephrol 2005, 16(7):1977-1984.
33. Healy E, Leonard M, Madrigal-Estebas L, O'Farrelly C, Watson AJ, Ryan MP: Factors produced by activated leukocytes alter renal epithelial cell differentiation. Kidney Int 1999, 56:1266-1269.
34. Mermall V, Post PL, Mooseker MS: Unconventional myosins in cell movement, membrane traffic, and signal transduction. Science 1998, 279:527-533.
35. Powell DW, Mifflin RC, Valentich JD, Crowe SE, Saada JI, West AB: Myofibroblasts. I. Paracrine cells important in health and disease. Am J Physiol 1999, 277:C1-C9.
36. Powell DW, Mifflin RC, Valentich JD, Crowe SE, Saada JI, West AB: Myofibroblasts. II. Intestinal subepithelial myofibroblasts. Am J Physiol 1999, 277:C183-C201.
37. Derynck R, Feng XH: TGF-β receptor signaling. Biochim Biophys Acta 1997, 1333:F105-F150.
38. Hoyt DG., Lazo JS: Alterations in pulmonary mRNA encoding procollagens, fibronectin, and transforming growth factor-β precedes bleomycin-induced pulmonary fibrosis in mice. J Pharmacol Exp Ther 1988, 246:765-771.
39. Khalil N, O'Conner RN, Flanders KC, Umruh H: TGF-β1, but not TGF-β2 or TGF-β3, is differentially present in epithelial cells of advanced pulmonary fibrosis: an immunohistochemical study. Am J Respir Cell Mol Biol 1996, 14:131-138.
40. Raghu G, Masta S, Meyers D, Narayanan AS: Collagen synthesis by normal and fibrotic human lung fibroblasts and the effect of transforming growth factor-beta. Am Rev Respir Dis 1989, 140:95-100.
41. Whitman M: Smads and early developmental signaling by the TGFβ superfamily. Genes Dev 1998, 12:2445-2462.
42. Atfi A, Djellou S, Chastre E, Davis R, Gespach C: Evidence for a role of Rho-like GTPase and stress-activated protein kinase/c-Jun-N-terminal kinase (SAPK/JNK) in transforming growth factorβ-mediated signaling. J Biol Chem 1997, 272:1429-1432.
43. 2-terminal kinase-dependent pathway. Am J Respir Crit Care Med 2001, 163:152-157.
44. Piek E, Moustakas A, Kurisaki A, Heldin CH, ten Dijke P: TGF-(beta) type I receptor/ALK-5 and Smad proteins mediate epithelial to mesenchymal transdifferentation in NMuMG breast epithelial cells. J Cell Sci 1999, 112:4557-4568.
45. Rhyu DY, Yang Y, Ha L, Lee GT, Song JS, Uh ST, Lee HB: Role of reactive oxygen species in TGF-beta1-induced mitogen-activated protein kinase activation and epithelial-mesenchymal transition in renal tubular epithelials cells. J Am Soc Nephrol 2005, 16:667-675.
46. Allen JT, Knight RA, Bloor CA, Spiteri MA: Enhanced insulin-like growth factor binding protein-related protein 2 (Connective tissue growth factor) expression in patients with idiopathic pulmonary fibrosis and pulmonary sarcoidosis. Am J Respir Cell Mol Biol 1999, 21:693-700.
47. Pan LH, Yamauchi K, Uzuki M, Nakanishi T, Takigawa M, Inoue H, Sawai T: Type II alveolar epithelial cells and interstitial fibroblasts express connective tissue growth factor in IPF. Eur Respir J 2001, 17:1220-1227.
48. Grotendorst GR: Connective tissue growth factor: a mediator of TGF-beta action on fibroblasts. Cytokine Growth Factor Rev 1997, 8:171-179.
49. Moussad EE, Brigstock DR: Connective tissue growth factor: what's in a name? Mol Genet Metab 2000, 71:276-292.
50. Wahab NA, Weston BS, Mason RM: Connective tissue growth factor (CTGF, CCN2) interacts with and activates the tyrosine kinase receptor TrkA. J Am Soc Nephrol 2005, 16:340-351.
51. Wahab NA, Mason RM: Connective tissue growth factor and renal diseases: some answers, more questions. Curr Opin Nephrol Hypertens 2004, 13:53-58.