-
1
-
-
2942623871
-
Evidence for bulk flow of brain interstitial fluid: Significance for physiology and pathology
-
Abbott NJ (2004) Evidence for bulk flow of brain interstitial fluid: significance for physiology and pathology. Neurochem Int 45(4):545–552
-
(2004)
Neurochem Int
, vol.45
, Issue.4
, pp. 545-552
-
-
Abbott, N.J.1
-
2
-
-
70449529433
-
Structure and function of the blood–brain barrier
-
Abbott NJ, Patabendige AA, Dolman DE, Yusof SR, Begley DJ (2010) Structure and function of the blood–brain barrier. Neurobiol Dis 37(1):13–25
-
(2010)
Neurobiol Dis
, vol.37
, Issue.1
, pp. 13-25
-
-
Abbott, N.J.1
Patabendige, A.A.2
Dolman, D.E.3
Yusof, S.R.4
Begley, D.J.5
-
3
-
-
79952213236
-
The permeation of neutral molecules, ions, and ionic species through membranes: Brain permeation as an example
-
Abraham MH (2011) The permeation of neutral molecules, ions, and ionic species through membranes: brain permeation as an example. J Pharm Sci 100(5):1690–1701
-
(2011)
J Pharm Sci
, vol.100
, Issue.5
, pp. 1690-1701
-
-
Abraham, M.H.1
-
4
-
-
84862084237
-
Quantitative proteomics of transporter expression in brain capillary endothelial cells isolated from P-gp, BCRP, and P-gp/BCRP knockout mice
-
Agarwal S, Uchida Y, Mittapalli RK, Sane R, Terasaki T, Elmquist WF (2012) Quantitative proteomics of transporter expression in brain capillary endothelial cells isolated from P-gp, BCRP, and P-gp/BCRP knockout mice. Drug Metab Dispos 40(6):1164–9
-
(2012)
Drug Metab Dispos
, vol.40
, Issue.6
, pp. 1164-1169
-
-
Agarwal, S.1
Uchida, Y.2
Mittapalli, R.K.3
Sane, R.4
Terasaki, T.5
Elmquist, W.F.6
-
5
-
-
0037407697
-
Development and validation of a 96-well equilibrium dialysis apparatus for measuring plasma protein binding
-
Banker MJ, Clark TH, Williams JA (2003) Development and validation of a 96-well equilibrium dialysis apparatus for measuring plasma protein binding. J Pharm Sci 92(5):967–974
-
(2003)
J Pharm Sci
, vol.92
, Issue.5
, pp. 967-974
-
-
Banker, M.J.1
Clark, T.H.2
Williams, J.A.3
-
6
-
-
0023924868
-
Ligand/receptor interactions–the influence of the microenvironment on macroscopic properties. Electrostatic interactions with the membrane phase
-
Bean JW, Sargent DF, Schwyzer R (1988) Ligand/receptor interactions–the influence of the microenvironment on macroscopic properties. Electrostatic interactions with the membrane phase. J Recept Res 8(1–4):375–389
-
(1988)
J Recept Res
, vol.8
, Issue.1-4
, pp. 375-389
-
-
Bean, J.W.1
Sargent, D.F.2
Schwyzer, R.3
-
7
-
-
33645821904
-
Evaluation of the utility of brain slice methods to study brain penetration
-
Becker S, Liu X (2006) Evaluation of the utility of brain slice methods to study brain penetration. Drug Metab Dispos 34(5):855–861
-
(2006)
Drug Metab Dispos
, vol.34
, Issue.5
, pp. 855-861
-
-
Becker, S.1
Liu, X.2
-
8
-
-
0029871091
-
The blood–brain barrier: Principles for targeting peptides and drugs to the central nervous system
-
Begley DJ (1996) The blood–brain barrier: principles for targeting peptides and drugs to the central nervous system. J Pharm Pharmacol 48(2):136–146
-
(1996)
J Pharm Pharmacol
, vol.48
, Issue.2
, pp. 136-146
-
-
Begley, D.J.1
-
9
-
-
6944255523
-
Delivery of therapeutic agents to the central nervous system: The problems and the possibilities
-
Begley DJ (2004) Delivery of therapeutic agents to the central nervous system: the problems and the possibilities. Pharmacol Ther 104(1):29–45
-
(2004)
Pharmacol Ther
, vol.104
, Issue.1
, pp. 29-45
-
-
Begley, D.J.1
-
10
-
-
0036605677
-
Functional expression and localization of P-glycoprotein at the blood brain barrier
-
Bendayan R, Lee G, Bendayan M (2002) Functional expression and localization of P-glycoprotein at the blood brain barrier. Microsc Res Tech 57(5):365–380
-
(2002)
Microsc Res Tech
, vol.57
, Issue.5
, pp. 365-380
-
-
Bendayan, R.1
Lee, G.2
Bendayan, M.3
-
11
-
-
33845942409
-
Determination of the EC50 amnesic concentration of etomidate and its diffusion profile in brain tissue: Implications for in vitro studies
-
Benkwitz C, Liao M, Laster MJ, Sonner JM, Eger EI 2nd, Pearce RA (2007) Determination of the EC50 amnesic concentration of etomidate and its diffusion profile in brain tissue: implications for in vitro studies. Anesthesiology 106(1):114–123
-
(2007)
Anesthesiology
, vol.106
, Issue.1
, pp. 114-123
-
-
Benkwitz, C.1
Liao, M.2
Laster, M.J.3
Sonner, J.M.4
Eger, E.I.5
Pearce, R.A.6
-
12
-
-
73149101270
-
Prediction of V(Ss) from in vitro tissue-binding studies
-
Berry LM, Roberts J, Be X, Zhao Z, Lin MH (2010) Prediction of V(ss) from in vitro tissue-binding studies. Drug Metab Dispos 38(1):115–121
-
(2010)
Drug Metab Dispos
, vol.38
, Issue.1
, pp. 115-121
-
-
Berry, L.M.1
Roberts, J.2
Be, X.3
Zhao, Z.4
Lin, M.H.5
-
13
-
-
0014930215
-
A comparison of inhibition of steady state, new transport, and exchange fluxes of amino acids in brain slices
-
Blasberg R, Levi G, Lajtha A (1970) A comparison of inhibition of steady state, new transport, and exchange fluxes of amino acids in brain slices. Biochim Biophys Acta 203(3):464–483
-
(1970)
Biochim Biophys Acta
, vol.203
, Issue.3
, pp. 464-483
-
-
Blasberg, R.1
Levi, G.2
Lajtha, A.3
-
14
-
-
33747816123
-
In vivo blood–brain barrier transport of oxycodone in the rat: Indications for active influx and implications for pharmacokinetics/pharmacodynamics
-
Bostrom E, Simonsson US, Hammarlund-Udenaes M (2006) In vivo blood–brain barrier transport of oxycodone in the rat: indications for active influx and implications for pharmacokinetics/pharmacodynamics. Drug Metab Dispos 34(9):1624–1631
-
(2006)
Drug Metab Dispos
, vol.34
, Issue.9
, pp. 1624-1631
-
-
Bostrom, E.1
Simonsson, U.S.2
Hammarlund-Udenaes, M.3
-
15
-
-
0035679267
-
Blood–brain barrier transport and brain distribution of morphine-6-glucuronide in relation to the antinociceptive effect in rats–pharmacokinetic/pharmacodynamic modelling
-
Bouw MR, Xie R, Tunblad K, Hammarlund-Udenaes M (2001) Blood–brain barrier transport and brain distribution of morphine-6-glucuronide in relation to the antinociceptive effect in rats–pharmacokinetic/pharmacodynamic modelling. Br J Pharmacol 134(8):1796–1804
-
(2001)
Br J Pharmacol
, vol.134
, Issue.8
, pp. 1796-1804
-
-
Bouw, M.R.1
Xie, R.2
Tunblad, K.3
Hammarlund-Udenaes, M.4
-
16
-
-
0038529617
-
Lysosomal membrane permeabilization induces cell death in a mitochondrion-dependent fashion
-
Boya P, Andreau K, Poncet D, Zamzami N, Perfettini JL, Metivier D, Ojcius DM, Jaattela M, Kroemer G (2003) Lysosomal membrane permeabilization induces cell death in a mitochondrion-dependent fashion. J Exp Med 197(10):1323–1334
-
(2003)
J Exp Med
, vol.197
, Issue.10
, pp. 1323-1334
-
-
Boya, P.1
Reau, K.2
Poncet, D.3
Zamzami, N.4
Perfettini, J.L.5
Metivier, D.6
Ojcius, D.M.7
Jaattela, M.8
Kroemer, G.9
-
17
-
-
54949137644
-
Lysosomal membrane permeabilization in cell death
-
Boya P, Kroemer G (2008) Lysosomal membrane permeabilization in cell death. Oncogene 27(50):6434–6451
-
(2008)
Oncogene
, vol.27
, Issue.50
, pp. 6434-6451
-
-
Boya, P.1
Kroemer, G.2
-
18
-
-
84856374138
-
Comparative psychology and the grand challenge of drug discovery in psychiatry and neurodegeneration
-
Brunner D, Balci F, Ludvig EA (2012) Comparative psychology and the grand challenge of drug discovery in psychiatry and neurodegeneration. Behav Processes 89(2):187–195
-
(2012)
Behav Processes
, vol.89
, Issue.2
, pp. 187-195
-
-
Brunner, D.1
Balci, F.2
Ludvig, E.A.3
-
19
-
-
84857409667
-
Species comparison of in vivo P-glycoprotein-mediated brain efflux using mdr1a-deficient rats and mice
-
Bundgaard C, Jensen CJ, Garmer M (2012a) Species comparison of in vivo P-glycoprotein-mediated brain efflux using mdr1a-deficient rats and mice. Drug Metab Dispos 40(3):461–466
-
(2012)
Drug Metab Dispos
, vol.40
, Issue.3
, pp. 461-466
-
-
Bundgaard, C.1
Jensen, C.J.2
Garmer, M.3
-
20
-
-
33846871218
-
An integrated microdialysis rat model for multiple pharmacokinetic/pharmacodynamic investigations of serotonergic agents
-
Bundgaard C, Jorgensen M, Mork A (2007) An integrated microdialysis rat model for multiple pharmacokinetic/pharmacodynamic investigations of serotonergic agents. J Pharmacol Toxicol Methods 55(2):214–223
-
(2007)
J Pharmacol Toxicol Methods
, vol.55
, Issue.2
, pp. 214-223
-
-
Bundgaard, C.1
Jorgensen, M.2
Mork, A.3
-
21
-
-
84856398719
-
Associating in vitro target binding and in vivo CNS occupancy of serotonin reuptake inhibitors in rats: The role of free drug concentrations
-
Bundgaard C, Sveigaard C, Brennum LT, Stensbol TB (2012b) Associating in vitro target binding and in vivo CNS occupancy of serotonin reuptake inhibitors in rats: the role of free drug concentrations. Xenobiotica 42(3):256–265
-
(2012)
Xenobiotica
, vol.42
, Issue.3
, pp. 256-265
-
-
Bundgaard, C.1
Sveigaard, C.2
Brennum, L.T.3
Stensbol, T.B.4
-
22
-
-
0038449896
-
Differential uptake of volatile agents into brain tissue in vitro. Measurement and application of a diffusion model to determine concentration profiles in brain slices
-
Chesney MA, Perouansky M, Pearce RA (2003) Differential uptake of volatile agents into brain tissue in vitro. Measurement and application of a diffusion model to determine concentration profiles in brain slices. Anesthesiology 99(1):122–130
-
(2003)
Anesthesiology
, vol.99
, Issue.1
, pp. 122-130
-
-
Chesney, M.A.1
Perouansky, M.2
Pearce, R.A.3
-
23
-
-
0029038937
-
The brain slice preparation: A tribute to the pioneer Henry McIlwain
-
Collingridge GL (1995) The brain slice preparation: a tribute to the pioneer Henry McIlwain. J Neurosci Methods 59(1):5–9
-
(1995)
J Neurosci Methods
, vol.59
, Issue.1
, pp. 5-9
-
-
Collingridge, G.L.1
-
25
-
-
0034874453
-
Effect of mdr1a P-glycoprotein gene disruption, gender, and substrate concentration on brain uptake of selected compounds
-
Dagenais C, Zong J, Ducharme J, Pollack GM (2001) Effect of mdr1a P-glycoprotein gene disruption, gender, and substrate concentration on brain uptake of selected compounds. Pharm Res 18(7):957–963
-
(2001)
Pharm Res
, vol.18
, Issue.7
, pp. 957-963
-
-
Dagenais, C.1
Zong, J.2
Ducharme, J.3
Pollack, G.M.4
-
26
-
-
0037307139
-
Mechanisms of cellular distribution of psychotropic drugs. Significance for drug action and interactions
-
Daniel WA (2003) Mechanisms of cellular distribution of psychotropic drugs. Significance for drug action and interactions. Prog Neuropsychopharmacol Biol Psychiatry 27(1):65–73
-
(2003)
Prog Neuropsychopharmacol Biol Psychiatry
, vol.27
, Issue.1
, pp. 65-73
-
-
Daniel, W.A.1
-
27
-
-
0028972540
-
The contribution of lysosomal trapping in the uptake of desipramine and chloroquine by different tissues
-
Daniel WA, Bickel MH, Honegger UE (1995) The contribution of lysosomal trapping in the uptake of desipramine and chloroquine by different tissues. Pharmacol Toxicol 77(6):402–406
-
(1995)
Pharmacol Toxicol
, vol.77
, Issue.6
, pp. 402-406
-
-
Daniel, W.A.1
Bickel, M.H.2
Honegger, U.E.3
-
28
-
-
0032466598
-
Pharmacokinetics of phenothiazine neuroleptics after chronic coadministration of carbamazepine
-
Daniel WA, Syrek M, Haduch A, Wojcikowski J (1998) Pharmacokinetics of phenothiazine neuroleptics after chronic coadministration of carbamazepine. Pol J Pharmacol 50(6):431–442
-
(1998)
Pol J Pharmacol
, vol.50
, Issue.6
, pp. 431-442
-
-
Daniel, W.A.1
Syrek, M.2
Haduch, A.3
Wojcikowski, J.4
-
29
-
-
0034534454
-
Different effects of amitriptyline and imipramine on the pharmacokinetics and metabolism of perazine in rats
-
Daniel WA, Syrek M, Haduch A, Wojcikowski J (2000) Different effects of amitriptyline and imipramine on the pharmacokinetics and metabolism of perazine in rats. J Pharm Pharmacol 52(12):1473–1481
-
(2000)
J Pharm Pharmacol
, vol.52
, Issue.12
, pp. 1473-1481
-
-
Daniel, W.A.1
Syrek, M.2
Haduch, A.3
Wojcikowski, J.4
-
30
-
-
0031047587
-
Contribution of lysosomal trapping to the total tissue uptake of psychotropic drugs
-
Daniel WA, Wojcikowski J (1997) Contribution of lysosomal trapping to the total tissue uptake of psychotropic drugs. Pharmacol Toxicol 80(2):62–68
-
(1997)
Pharmacol Toxicol
, vol.80
, Issue.2
, pp. 62-68
-
-
Daniel, W.A.1
Wojcikowski, J.2
-
31
-
-
0342614869
-
Lysosomal trapping as an important mechanism involved in the cellular distribution of perazine and in pharmacokinetic interaction with antidepressants
-
Daniel WA, Wojcikowski J (1999a) Lysosomal trapping as an important mechanism involved in the cellular distribution of perazine and in pharmacokinetic interaction with antidepressants. Eur Neuropsychopharmacol 9(6):483–491
-
(1999)
Eur Neuropsychopharmacol
, vol.9
, Issue.6
, pp. 483-491
-
-
Daniel, W.A.1
Wojcikowski, J.2
-
32
-
-
0344004865
-
The role of lysosomes in the cellular distribution of thioridazine and potential drug interactions
-
Daniel WA, Wojcikowski J (1999b) The role of lysosomes in the cellular distribution of thioridazine and potential drug interactions. Toxicol Appl Pharmacol 158(2):115–124
-
(1999)
Toxicol Appl Pharmacol
, vol.158
, Issue.2
, pp. 115-124
-
-
Daniel, W.A.1
Wojcikowski, J.2
-
33
-
-
0014887081
-
The mechanism of drainage of the cerebrospinal fluid
-
Davson H, Hollingsworth G, Segal MB (1970) The mechanism of drainage of the cerebrospinal fluid. Brain 93(4):665–678
-
(1970)
Brain
, vol.93
, Issue.4
, pp. 665-678
-
-
Davson, H.1
Hollingsworth, G.2
Segal, M.B.3
-
36
-
-
0014907390
-
The role of lysosomes in cellular pathology
-
De Duve C (1970) The role of lysosomes in cellular pathology. Triangle 9(6):200–208
-
(1970)
Triangle
, vol.9
, Issue.6
, pp. 200-208
-
-
De Duve, C.1
-
37
-
-
0015099032
-
Tissue fractionation. Past and present
-
De Duve C (1971) Tissue fractionation. Past and present. J Cell Biol 50(1):20d–55d
-
(1971)
J Cell Biol
, vol.50
, Issue.1
, pp. 20-55
-
-
De Duve, C.1
-
38
-
-
0017120892
-
The role of lysosomes in the pathogeny of disease
-
de Duve C (1975) The role of lysosomes in the pathogeny of disease. Scand J Rheumatol Suppl 12:63–66
-
(1975)
Scand J Rheumatol Suppl
, vol.12
, pp. 63-66
-
-
De Duve, C.1
-
39
-
-
84878760086
-
The mastermind approach to CNS drug therapy: Translational prediction of human brain distribution, target site kinetics, and therapeutic effects
-
de Lange EC (2013a) The mastermind approach to CNS drug therapy: translational prediction of human brain distribution, target site kinetics, and therapeutic effects. Fluids Barriers CNS 10(1):12
-
(2013)
Fluids Barriers CNS
, vol.10
, Issue.1
, pp. 12
-
-
De Lange, E.C.1
-
40
-
-
84878763676
-
Utility of CSF in translational neuroscience
-
de Lange EC (2013b) Utility of CSF in translational neuroscience. J Pharmacokinet Pharmacodyn 40(3):315–26
-
(2013)
J Pharmacokinet Pharmacodyn
, vol.40
, Issue.3
, pp. 315-326
-
-
De Lange, E.C.1
-
41
-
-
0036349375
-
Considerations in the use of cerebrospinal fluid pharmacokinetics to predict brain target concentrations in the clinical setting: Implications of the barriers between blood and brain
-
de Lange EC, Danhof M (2002) Considerations in the use of cerebrospinal fluid pharmacokinetics to predict brain target concentrations in the clinical setting: implications of the barriers between blood and brain. Clin Pharmacokinet 41(10):691–703
-
(2002)
Clin Pharmacokinet
, vol.41
, Issue.10
, pp. 691-703
-
-
De Lange, E.C.1
Danhof, M.2
-
42
-
-
0033526157
-
Microdialysis for pharmacokinetic analysis of drug transport to the brain
-
de Lange EC, de Boer BA, Breimer DD (1999) Microdialysis for pharmacokinetic analysis of drug transport to the brain. Adv Drug Deliv Rev 36(2–3):211–227
-
(1999)
Adv Drug Deliv Rev
, vol.36
, Issue.23
, pp. 211-227
-
-
De Lange, E.C.1
De Boer, B.A.2
Breimer, D.D.3
-
43
-
-
33644812284
-
Toward the prediction of CNS drug-effect profiles in physiological and pathological conditions using microdialysis and mechanism-based pharmacokinetic-pharmacodynamic modeling
-
de Lange EC, Ravenstijn PG, Groenendaal D, van Steeg TJ (2005) Toward the prediction of CNS drug-effect profiles in physiological and pathological conditions using microdialysis and mechanism-based pharmacokinetic-pharmacodynamic modeling. AAPS J 7(3):E532–543
-
(2005)
AAPS J
, vol.7
, Issue.3
, pp. 532-543
-
-
De Lange, E.C.1
Ravenstijn, P.G.2
Groenendaal, D.3
Van Steeg, T.J.4
-
44
-
-
0036627484
-
Drug transport to the brain: Key roles for the efflux pump P-glycoprotein in the blood–brain barrier
-
Demeule M, Regina A, Jodoin J, Laplante A, Dagenais C, Berthelet F, Moghrabi A, Beliveau R (2002) Drug transport to the brain: key roles for the efflux pump P-glycoprotein in the blood–brain barrier. Vascul Pharmacol 38(6):339–348
-
(2002)
Vascul Pharmacol
, vol.38
, Issue.6
, pp. 339-348
-
-
Demeule, M.1
Regina, A.2
Jodoin, J.3
Laplante, A.4
Dagenais, C.5
Berthelet, F.6
Moghrabi, A.7
Beliveau, R.8
-
45
-
-
84875485383
-
Confounding parameters in preclinical assessment of blood–brain barrier permeation: An overview with emphasis on species differences and effect of disease states
-
Deo AK, Theil FP, Nicolas JM (2013) Confounding parameters in preclinical assessment of blood–brain barrier permeation: an overview with emphasis on species differences and effect of disease states. Mol Pharm 10(5):1581–95
-
(2013)
Mol Pharm
, vol.10
, Issue.5
, pp. 1581-1595
-
-
Deo, A.K.1
Theil, F.P.2
Nicolas, J.M.3
-
46
-
-
84872319925
-
Demystifying brain penetration in central nervous system drug discovery
-
Di L, Rong H, Feng B (2012a) Demystifying brain penetration in central nervous system drug discovery. J Med Chem 56(1):2–12
-
(2012)
J Med Chem
, vol.56
, Issue.1
, pp. 2-12
-
-
Di, L.1
Rong, H.2
Feng, B.3
-
47
-
-
79959417881
-
Species independence in brain tissue binding using brain homogenates
-
Di L, Umland JP, Chang G, Huang Y, Lin Z, Scott DO, Troutman MD, Liston TE (2011) Species independence in brain tissue binding using brain homogenates. Drug Metab Dispos 39(7):1270–1277
-
(2011)
Drug Metab Dispos
, vol.39
, Issue.7
, pp. 1270-1277
-
-
Di, L.1
Umland, J.P.2
Chang, G.3
Huang, Y.4
Lin, Z.5
Scott, D.O.6
Troutman, M.D.7
Liston, T.E.8
-
48
-
-
84855884254
-
Impact of recovery on fraction unbound using equilibrium dialysis
-
Di L, Umland JP, Trapa PE, Maurer TS (2012b) Impact of recovery on fraction unbound using equilibrium dialysis. J Pharm Sci 101(3):1327–1335
-
(2012)
J Pharm Sci
, vol.101
, Issue.3
, pp. 1327-1335
-
-
Di, L.1
Umland, J.P.2
Trapa, P.E.3
Maurer, T.S.4
-
49
-
-
19944425121
-
The impact of P-glycoprotein on the disposition of drugs targeted for indications of the central nervous system: Evaluation using the MDR1A/1B knockout mouse model
-
Doran A, Obach RS, Smith BJ, Hosea NA, Becker S, Callegari E, Chen C, Chen X, Choo E, Cianfrogna J, Cox LM, Gibbs JP, Gibbs MA, Hatch H, Hop CE, Kasman IN, Laperle J, Liu J, Liu X, Logman M, Maclin D, Nedza FM, Nelson F, Olson E, Rahematpura S, Raunig D, Rogers S, Schmidt K, Spracklin DK, Szewc M, Troutman M, Tseng E, Tu M, Van Deusen JW, Venkatakrishnan K, Walens G, Wang EQ, Wong D, Yasgar AS, Zhang C (2005) The impact of P-glycoprotein on the disposition of drugs targeted for indications of the central nervous system: evaluation using the MDR1A/1B knockout mouse model. Drug Metab Dispos 33(1):165–174
-
(2005)
Drug Metab Dispos
, vol.33
, Issue.1
, pp. 165-174
-
-
Doran, A.1
Obach, R.S.2
Smith, B.J.3
Hosea, N.A.4
Becker, S.5
Callegari, E.6
Chen, C.7
Chen, X.8
Choo, E.9
Cianfrogna, J.10
Cox, L.M.11
Gibbs, J.P.12
Gibbs, M.A.13
Hatch, H.14
Hop, C.E.15
Kasman, I.N.16
Laperle, J.17
Liu, J.18
Liu, X.19
Logman, M.20
Maclin, D.21
Nedza, F.M.22
Nelson, F.23
Olson, E.24
Rahematpura, S.25
Raunig, D.26
Rogers, S.27
Schmidt, K.28
Spracklin, D.K.29
Szewc, M.30
Troutman, M.31
Tseng, E.32
Tu, M.33
Van Deusen, J.W.34
Venkatakrishnan, K.35
Walens, G.36
Wang, E.Q.37
Wong, D.38
Yasgar, A.S.39
Zhang, C.40
more..
-
50
-
-
84867669201
-
An evaluation of using rat-derived single-dose neuropharmacokinetic parameters to project accurately large animal unbound brain drug concentrations
-
Doran AC, Osgood SM, Mancuso JY, Shaffer CL (2012) An evaluation of using rat-derived single-dose neuropharmacokinetic parameters to project accurately large animal unbound brain drug concentrations. Drug Metab Dispos 40(11):2162–73
-
(2012)
Drug Metab Dispos
, vol.40
, Issue.11
, pp. 2162-2173
-
-
Doran, A.C.1
Osgood, S.M.2
Mancuso, J.Y.3
Shaffer, C.L.4
-
51
-
-
43849097415
-
Quantitative gene expression analysis in a brain slice model: Influence of temperature and incubation media
-
Dos-Anjos S, Martinez-Villayandre B, Montori S, Salas A, Perez-Garcia CC, Fernandez-Lopez A (2008) Quantitative gene expression analysis in a brain slice model: influence of temperature and incubation media. Anal Biochem 378(1):99–101
-
(2008)
Anal Biochem
, vol.378
, Issue.1
, pp. 99-101
-
-
Dos-Anjos, S.1
Martinez-Villayandre, B.2
Montori, S.3
Salas, A.4
Perez-Garcia, C.C.5
Fernandez-Lopez, A.6
-
52
-
-
28544452083
-
A novel assay reveals that weakly basic model compounds concentrate in lysosomes to an extent greater than pH-partitioning theory would predict
-
Duvvuri M, Krise JP (2005) A novel assay reveals that weakly basic model compounds concentrate in lysosomes to an extent greater than pH-partitioning theory would predict. Mol Pharm 2(6):440–448
-
(2005)
Mol Pharm
, vol.2
, Issue.6
, pp. 440-448
-
-
Duvvuri, M.1
Krise, J.P.2
-
53
-
-
55249087036
-
The burden of mental disorders
-
Eaton WW, Martins SS, Nestadt G, Bienvenu OJ, Clarke D, Alexandre P (2008) The burden of mental disorders. Epidemiol Rev 30:1–14
-
(2008)
Epidemiol Rev
, vol.30
, pp. 1-14
-
-
Eaton, W.W.1
Martins, S.S.2
Nestadt, G.3
Bienvenu, O.J.4
Clarke, D.5
Alexandre, P.6
-
54
-
-
84868123881
-
What is the most important approach in current drug discovery: Doing the right things or doing things right?
-
Elebring T, Gill A, Plowright AT (2012) What is the most important approach in current drug discovery: doing the right things or doing things right? Drug Discov Today 17(21–22): 1166–1169
-
(2012)
Drug Discov Today
, vol.17
, Issue.21-22
, pp. 1166-1169
-
-
Elebring, T.1
Gill, A.2
Plowright, A.T.3
-
55
-
-
0030942858
-
Application of microdialysis in pharmacokinetic studies
-
Elmquist WF, Sawchuk RJ (1997) Application of microdialysis in pharmacokinetic studies. Pharm Res 14(3):267–288
-
(1997)
Pharm Res
, vol.14
, Issue.3
, pp. 267-288
-
-
Elmquist, W.F.1
Sawchuk, R.J.2
-
56
-
-
0034672524
-
Use of microdialysis in drug delivery studies
-
Elmquist WF, Sawchuk RJ (2000) Use of microdialysis in drug delivery studies. Adv Drug Deliv Rev 45(2–3):123–124
-
(2000)
Adv Drug Deliv Rev
, vol.45
, Issue.23
, pp. 123-124
-
-
Elmquist, W.F.1
Sawchuk, R.J.2
-
58
-
-
0027007966
-
The blood–brain barrier is not a “barrier” for many drugs
-
Fenstermacher JD (1992) The blood–brain barrier is not a “barrier” for many drugs. NIDA Res Monogr 120:108–120
-
(1992)
NIDA Res Monogr
, vol.120
, pp. 108-120
-
-
Fenstermacher, J.D.1
-
59
-
-
0025916671
-
Tissue binding versus plasma binding of drugs: General principles and pharmacokinetic consequences
-
In: Testa B, Academic Press, London
-
Fichtl B, v Nieciecki A, Walter K (1991a) Tissue binding versus plasma binding of drugs: general principles and pharmacokinetic consequences. In: Testa B (ed) Advances in drug research , vol 20. Academic Press, London, pp 117–166
-
(1991)
Advances in Drug Research
, vol.20
, pp. 117-166
-
-
Fichtl, B.1
V Nieciecki, A.2
Walter, K.3
-
60
-
-
85081149780
-
ChemInform abstract: Tissue binding versus plasma binding of drugs: General principles and pharmacokinetic consequences
-
Fichtl B, Von Nieciecki A, Walter K (1991b) ChemInform abstract: tissue binding versus plasma binding of drugs: general principles and pharmacokinetic consequences. ChemInform 22
-
(1991)
Cheminform
, pp. 22
-
-
Fichtl, B.1
Von Nieciecki, A.2
Walter, K.3
-
61
-
-
79951865101
-
Measurement of unbound drug exposure in brain: Modeling of pH partitioning explains diverging results between the brain slice and brain homogenate methods
-
Friden M, Bergstrom F, Wan H, Rehngren M, Ahlin G, Hammarlund-Udenaes M, Bredberg U (2011) Measurement of unbound drug exposure in brain: modeling of pH partitioning explains diverging results between the brain slice and brain homogenate methods. Drug Metab Dispos 39(3):353–362
-
(2011)
Drug Metab Dispos
, vol.39
, Issue.3
, pp. 353-362
-
-
Friden, M.1
Bergstrom, F.2
Wan, H.3
Rehngren, M.4
Ahlin, G.5
Hammarlund-Udenaes, M.6
Bredberg, U.7
-
62
-
-
66649119187
-
Development of a high-throughput brain slice method for studying drug distribution in the central nervous system
-
Friden M, Ducrozet F, Middleton B, Antonsson M, Bredberg U, Hammarlund-Udenaes M (2009a) Development of a high-throughput brain slice method for studying drug distribution in the central nervous system. Drug Metab Dispos 37(6):1226–1233
-
(2009)
Drug Metab Dispos
, vol.37
, Issue.6
, pp. 1226-1233
-
-
Friden, M.1
Ducrozet, F.2
Middleton, B.3
Antonsson, M.4
Bredberg, U.5
Hammarlund-Udenaes, M.6
-
63
-
-
34548071206
-
In vitro methods for estimating unbound drug concentrations in the brain interstitial and intracellular fluids
-
Friden M, Gupta A, Antonsson M, Bredberg U, Hammarlund-Udenaes M (2007) In vitro methods for estimating unbound drug concentrations in the brain interstitial and intracellular fluids. Drug Metab Dispos 35(9):1711–1719
-
(2007)
Drug Metab Dispos
, vol.35
, Issue.9
, pp. 1711-1719
-
-
Friden, M.1
Gupta, A.2
Antonsson, M.3
Bredberg, U.4
Hammarlund-Udenaes, M.5
-
64
-
-
73949148635
-
Improved measurement of drug exposure in the brain using drug-specific correction for residual blood
-
Friden M, Ljungqvist H, Middleton B, Bredberg U, Hammarlund-Udenaes M (2010) Improved measurement of drug exposure in the brain using drug-specific correction for residual blood. J Cereb Blood Flow Metab 30(1):150–161
-
(2010)
J Cereb Blood Flow Metab
, vol.30
, Issue.1
, pp. 150-161
-
-
Friden, M.1
Ljungqvist, H.2
Middleton, B.3
Bredberg, U.4
Hammarlund-Udenaes, M.5
-
65
-
-
70350054854
-
Structure-brain exposure relationships in rat and human using a novel data set of unbound drug concentrations in brain interstitial and cerebrospinal fluids
-
Friden M, Winiwarter S, Jerndal G, Bengtsson O, Wan H, Bredberg U, Hammarlund-Udenaes M, Antonsson M (2009b) Structure-brain exposure relationships in rat and human using a novel data set of unbound drug concentrations in brain interstitial and cerebrospinal fluids. J Med Chem 52(20):6233–6243
-
(2009)
J Med Chem
, vol.52
, Issue.20
, pp. 6233-6243
-
-
Friden, M.1
Winiwarter, S.2
Jerndal, G.3
Bengtsson, O.4
Wan, H.5
Bredberg, U.6
Hammarlund-Udenaes, M.7
Antonsson, M.8
-
66
-
-
0141537961
-
Semi-automatic high-throughput determination of plasma protein binding using a 96-well plate filtrate assembly and fast liquid chromatography-tandem mass spectrometry
-
Fung EN, Chen YH, Lau YY (2003) Semi-automatic high-throughput determination of plasma protein binding using a 96-well plate filtrate assembly and fast liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 795(2):187–194
-
(2003)
J Chromatogr B Analyt Technol Biomed Life Sci
, vol.795
, Issue.2
, pp. 187-194
-
-
Fung, E.N.1
Chen, Y.H.2
Lau, Y.Y.3
-
67
-
-
0033692507
-
Relationship between permeability status of the blood–brain barrier and in vitro permeability coefficient of a drug
-
Gaillard PJ, de Boer AG (2000) Relationship between permeability status of the blood–brain barrier and in vitro permeability coefficient of a drug. Eur J Pharm Sci 12(2):95–102
-
(2000)
Eur J Pharm Sci
, vol.12
, Issue.2
, pp. 95-102
-
-
Gaillard, P.J.1
De Boer, A.G.2
-
68
-
-
84867717502
-
Targeted blood-to-brain drug delivery – 10 key development criteria
-
Gaillard PJ, Visser CC, Appeldoorn CC, Rip J (2012) Targeted blood-to-brain drug delivery – 10 key development criteria. Curr Pharm Biotechnol 13(12):2328–2339
-
(2012)
Curr Pharm Biotechnol
, vol.13
, Issue.12
, pp. 2328-2339
-
-
Gaillard, P.J.1
Visser, C.C.2
Appeldoorn, C.C.3
Rip, J.4
-
69
-
-
13844299532
-
In vitro models for the blood–brain barrier
-
Garberg P, Ball M, Borg N, Cecchelli R, Fenart L, Hurst RD, Lindmark T, Mabondzo A, Nilsson JE, Raub TJ, Stanimirovic D, Terasaki T, Oberg JO, Osterberg T (2005) In vitro models for the blood–brain barrier. Toxicol In Vitro 19(3):299–334
-
(2005)
Toxicol in Vitro
, vol.19
, Issue.3
, pp. 299-334
-
-
Garberg, P.1
Ball, M.2
Borg, N.3
Cecchelli, R.4
Fenart, L.5
Hurst, R.D.6
Lindmark, T.7
Mabondzo, A.8
Nilsson, J.E.9
Raub, T.J.10
Stanimirovic, D.11
Terasaki, T.12
Oberg, J.O.13
Osterberg, T.14
-
70
-
-
21344451667
-
Colloidal carriers and blood–brain barrier (BBB) translocation: A way to deliver drugs to the brain?
-
Garcia-Garcia E, Andrieux K, Gil S, Couvreur P (2005) Colloidal carriers and blood–brain barrier (BBB) translocation: a way to deliver drugs to the brain? Int J Pharm 298(2):274–292
-
(2005)
Int J Pharm
, vol.298
, Issue.2
, pp. 274-292
-
-
Garcia-Garcia, E.1
Rieux, K.2
Gil, S.3
Couvreur, P.4
-
71
-
-
84856046963
-
Knowledge-based, central nervous system (CNS) lead selection and lead optimization for CNS drug discovery
-
Ghose AK, Herbertz T, Hudkins RL, Dorsey BD, Mallamo JP (2012) Knowledge-based, central nervous system (CNS) lead selection and lead optimization for CNS drug discovery. ACS Chem Neurosci 3(1):50–68
-
(2012)
ACS Chem Neurosci
, vol.3
, Issue.1
, pp. 50-68
-
-
Ghose, A.K.1
Herbertz, T.2
Hudkins, R.L.3
Dorsey, B.D.4
Mallamo, J.P.5
-
72
-
-
0032600640
-
A knowledge-based approach in designing combinatorial or medicinal chemistry libraries for drug discovery. 1. A qualitative and quantitative characterization of known drug databases
-
Ghose AK, Viswanadhan VN, Wendoloski JJ (1999) A knowledge-based approach in designing combinatorial or medicinal chemistry libraries for drug discovery. 1. A qualitative and quantitative characterization of known drug databases. J Comb Chem 1(1):55–68
-
(1999)
J Comb Chem
, vol.1
, Issue.1
, pp. 55-68
-
-
Ghose, A.K.1
Viswanadhan, V.N.2
Wendoloski, J.J.3
-
73
-
-
0014486131
-
Effect of mode of administration on drug distribution in a two-compartment open system
-
Gibaldi M (1969) Effect of mode of administration on drug distribution in a two-compartment open system. J Pharm Sci 58(3):327–331
-
(1969)
J Pharm Sci
, vol.58
, Issue.3
, pp. 327-331
-
-
Gibaldi, M.1
-
74
-
-
0024261409
-
Clinical and ultrastructural observations of maturing human frontal cortex. Part I (Biopsy material of hydrocephalic infants)
-
Glees P, Voth D (1988) Clinical and ultrastructural observations of maturing human frontal cortex. Part I (Biopsy material of hydrocephalic infants). Neurosurg Rev 11(3–4):273–278
-
(1988)
Neurosurg Rev
, vol.11
, Issue.3-4
, pp. 273-278
-
-
Glees, P.1
Voth, D.2
-
75
-
-
9744244185
-
Determination of diffusion and partition coefficients of propofol in rat brain tissue: Implications for studies of drug action in vitro
-
Gredell JA, Turnquist PA, Maciver MB, Pearce RA (2004) Determination of diffusion and partition coefficients of propofol in rat brain tissue: implications for studies of drug action in vitro. Br J Anaesth 93(6):810–817
-
(2004)
Br J Anaesth
, vol.93
, Issue.6
, pp. 810-817
-
-
Gredell, J.A.1
Turnquist, P.A.2
Maciver, M.B.3
Pearce, R.A.4
-
76
-
-
84860487619
-
Combining PET biodistribution and equilibrium dialysis assays to assess the free brain concentration and BBB transport of CNS drugs
-
Gunn RN, Summerfield SG, Salinas CA, Read KD, Guo Q, Searle GE, Parker CA, Jeffrey P, Laruelle M (2012) Combining PET biodistribution and equilibrium dialysis assays to assess the free brain concentration and BBB transport of CNS drugs. J Cereb Blood Flow Metab 32(5):874–83
-
(2012)
J Cereb Blood Flow Metab
, vol.32
, Issue.5
, pp. 874-883
-
-
Gunn, R.N.1
Summerfield, S.G.2
Salinas, C.A.3
Read, K.D.4
Guo, Q.5
Searle, G.E.6
Parker, C.A.7
Jeffrey, P.8
Laruelle, M.9
-
77
-
-
31344440034
-
Brain distribution of cetirizine enantiomers: Comparison of three different tissue-to-plasma partition coefficients: K(p), K(p, u), and K(p, uu)
-
Gupta A, Chatelain P, Massingham R, Jonsson EN, Hammarlund-Udenaes M (2006) Brain distribution of cetirizine enantiomers: comparison of three different tissue-to-plasma partition coefficients: K(p), K(p, u), and K(p, uu). Drug Metab Dispos 34(2):318–323
-
(2006)
Drug Metab Dispos
, vol.34
, Issue.2
, pp. 318-323
-
-
Gupta, A.1
Chatelain, P.2
Massingham, R.3
Jonsson, E.N.4
Hammarlund-Udenaes, M.5
-
78
-
-
77149131218
-
Active-site concentrations of chemicals - are they a better predictor of effect than plasma/organ/tissue concentrations?
-
Hammarlund-Udenaes M (2010) Active-site concentrations of chemicals - are they a better predictor of effect than plasma/organ/tissue concentrations? Basic Clin Pharmacol Toxicol 106(3): 215–220
-
(2010)
Basic Clin Pharmacol Toxicol
, vol.106
, Issue.3
, pp. 215-220
-
-
Hammarlund-Udenaes, M.1
-
79
-
-
63349088174
-
Methodologies to assess brain drug delivery in lead optimization
-
Hammarlund-Udenaes M, Bredberg U, Friden M (2009) Methodologies to assess brain drug delivery in lead optimization. Curr Top Med Chem 9(2):148–162
-
(2009)
Curr Top Med Chem
, vol.9
, Issue.2
, pp. 148-162
-
-
Hammarlund-Udenaes, M.1
Bredberg, U.2
Friden, M.3
-
80
-
-
45949107902
-
On the rate and extent of drug delivery to the brain
-
Hammarlund-Udenaes M, Friden M, Syvanen S, Gupta A (2008) On the rate and extent of drug delivery to the brain. Pharm Res 25(8):1737–1750
-
(2008)
Pharm Res
, vol.25
, Issue.8
, pp. 1737-1750
-
-
Hammarlund-Udenaes, M.1
Friden, M.2
Syvanen, S.3
Gupta, A.4
-
81
-
-
0030898087
-
Drug equilibration across the blood–brain barrier–pharmacokinetic considerations based on the microdialysis method
-
Hammarlund-Udenaes M, Paalzow LK, de Lange EC (1997) Drug equilibration across the blood–brain barrier–pharmacokinetic considerations based on the microdialysis method. Pharm Res 14(2):128–134
-
(1997)
Pharm Res
, vol.14
, Issue.2
, pp. 128-134
-
-
Hammarlund-Udenaes, M.1
Paalzow, L.K.2
De Lange, E.C.3
-
82
-
-
0021245003
-
Comparison between in-vivo and in-vitro tissue-to-plasma unbound concentration ratios (Kp, f) of quinidine in rats
-
Harashima H, Sugiyama Y, Sawada Y, Iga T, Hanano M (1984) Comparison between in-vivo and in-vitro tissue-to-plasma unbound concentration ratios (Kp, f) of quinidine in rats. J Pharm Pharmacol 36(5):340–342
-
(1984)
J Pharm Pharmacol
, vol.36
, Issue.5
, pp. 340-342
-
-
Harashima, H.1
Sugiyama, Y.2
Sawada, Y.3
Iga, T.4
Hanano, M.5
-
83
-
-
74149083982
-
Deregulation of sphingolipid metabolism in Alzheimer’s disease
-
He X, Huang Y, Li B, Gong CX, Schuchman EH (2010) Deregulation of sphingolipid metabolism in Alzheimer’s disease. Neurobiol Aging 31(3):398–408
-
(2010)
Neurobiol Aging
, vol.31
, Issue.3
, pp. 398-408
-
-
He, X.1
Huang, Y.2
Li, B.3
Gong, C.X.4
Schuchman, E.H.5
-
84
-
-
33845937770
-
Structure-brain exposure relationships
-
Hitchcock SA, Pennington LD (2006) Structure-brain exposure relationships. J Med Chem 49(26):7559–7583
-
(2006)
J Med Chem
, vol.49
, Issue.26
, pp. 7559-7583
-
-
Hitchcock, S.A.1
Pennington, L.D.2
-
85
-
-
0021044384
-
Errors in estimating the unbound fraction of drugs due to the volume shift in equilibrium dialysis
-
Huang JD (1983) Errors in estimating the unbound fraction of drugs due to the volume shift in equilibrium dialysis. J Pharm Sci 72(11):1368–1369
-
(1983)
J Pharm Sci
, vol.72
, Issue.11
, pp. 1368-1369
-
-
Huang, J.D.1
-
86
-
-
0030447660
-
Brain drug delivery of small molecules using immunoliposomes
-
Huwyler J, Wu D, Pardridge WM (1996) Brain drug delivery of small molecules using immunoliposomes. Proc Natl Acad Sci U S A 93(24):14164–14169
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, Issue.24
, pp. 14164-14169
-
-
Huwyler, J.1
Wu, D.2
Pardridge, W.M.3
-
87
-
-
35748977617
-
Challenges for blood–brain barrier (BBB) screening
-
Jeffrey P, Summerfield SG (2007) Challenges for blood–brain barrier (BBB) screening. Xenobiotica 37(10–11):1135–1151
-
(2007)
Xenobiotica
, vol.37
, Issue.10-11
, pp. 1135-1151
-
-
Jeffrey, P.1
Summerfield, S.G.2
-
88
-
-
78951480503
-
Pharmaceutical innovation in the 21st century: New drug approvals in the first decade, 2000-2009
-
Kaitin KI, DiMasi JA (2011) Pharmaceutical innovation in the 21st century: new drug approvals in the first decade, 2000-2009. Clin Pharmacol Ther 89(2):183–188
-
(2011)
Clin Pharmacol Ther
, vol.89
, Issue.2
, pp. 183-188
-
-
Kaitin, K.I.1
Dimasi, J.A.2
-
89
-
-
0030426820
-
Brain efflux index as a novel method of analyzing efflux transport at the blood–brain barrier
-
Kakee A, Terasaki T, Sugiyama Y (1996) Brain efflux index as a novel method of analyzing efflux transport at the blood–brain barrier. J Pharmacol Exp Ther 277(3):1550–1559
-
(1996)
J Pharmacol Exp Ther
, vol.277
, Issue.3
, pp. 1550-1559
-
-
Kakee, A.1
Terasaki, T.2
Sugiyama, Y.3
-
90
-
-
0031456590
-
Selective brain to blood efflux transport of para-aminohippuric acid across the blood–brain barrier: In vivo evidence by use of the brain efflux index method
-
Kakee A, Terasaki T, Sugiyama Y (1997) Selective brain to blood efflux transport of para-aminohippuric acid across the blood–brain barrier: in vivo evidence by use of the brain efflux index method. J Pharmacol Exp Ther 283(3):1018–1025
-
(1997)
J Pharmacol Exp Ther
, vol.283
, Issue.3
, pp. 1018-1025
-
-
Kakee, A.1
Terasaki, T.2
Sugiyama, Y.3
-
91
-
-
0036874825
-
Influence of nonspecific brain and plasma binding on CNS exposure: Implications for rational drug discovery
-
Kalvass JC, Maurer TS (2002) Influence of nonspecific brain and plasma binding on CNS exposure: implications for rational drug discovery. Biopharm Drug Dispos 23(8):327–338
-
(2002)
Biopharm Drug Dispos
, vol.23
, Issue.8
, pp. 327-338
-
-
Kalvass, J.C.1
Maurer, T.S.2
-
92
-
-
34047114789
-
Use of plasma and brain unbound fractions to assess the extent of brain distribution of 34 drugs: Comparison of unbound concentration ratios to in vivo p-glycoprotein efflux ratios
-
Kalvass JC, Maurer TS, Pollack GM (2007a) Use of plasma and brain unbound fractions to assess the extent of brain distribution of 34 drugs: comparison of unbound concentration ratios to in vivo p-glycoprotein efflux ratios. Drug Metab Dispos 35(4):660–666
-
(2007)
Drug Metab Dispos
, vol.35
, Issue.4
, pp. 660-666
-
-
Kalvass, J.C.1
Maurer, T.S.2
Pollack, G.M.3
-
93
-
-
34548842800
-
Pharmacokinetics and pharmacodynamics of seven opioids in P-glycoprotein-competent mice: Assessment of unbound brain EC50, u and correlation of in vitro, preclinical, and clinical data
-
Kalvass JC, Olson ER, Cassidy MP, Selley DE, Pollack GM (2007b) Pharmacokinetics and pharmacodynamics of seven opioids in P-glycoprotein-competent mice: assessment of unbound brain EC50, u and correlation of in vitro, preclinical, and clinical data. J Pharmacol Exp Ther 323(1):346–355
-
(2007)
J Pharmacol Exp Ther
, vol.323
, Issue.1
, pp. 346-355
-
-
Kalvass, J.C.1
Olson, E.R.2
Cassidy, M.P.3
Selley, D.E.4
Pollack, G.M.5
-
94
-
-
0035038596
-
Development of a high throughput equilibrium dialysis method
-
Kariv I, Cao H, Oldenburg KR (2001) Development of a high throughput equilibrium dialysis method. J Pharm Sci 90(5):580–587
-
(2001)
J Pharm Sci
, vol.90
, Issue.5
, pp. 580-587
-
-
Kariv, I.1
Cao, H.2
Oldenburg, K.R.3
-
95
-
-
34247490248
-
Lysosomal sequestration of amine-containing drugs: Analysis and therapeutic implications
-
Kaufmann AM, Krise JP (2007) Lysosomal sequestration of amine-containing drugs: analysis and therapeutic implications. J Pharm Sci 96(4):729–746
-
(2007)
J Pharm Sci
, vol.96
, Issue.4
, pp. 729-746
-
-
Kaufmann, A.M.1
Krise, J.P.2
-
96
-
-
84874688353
-
The promiscuous binding of pharmaceutical drugs and their transporter-mediated uptake into cells: What we (need to) know and how we can do so
-
Kell DB, Dobson PD, Bilsland E, Oliver SG (2013) The promiscuous binding of pharmaceutical drugs and their transporter-mediated uptake into cells: what we (need to) know and how we can do so. Drug Discov Today 18(5–6):218–239
-
(2013)
Drug Discov Today
, vol.18
, Issue.5-6
, pp. 218-239
-
-
Kell, D.B.1
Dobson, P.D.2
Bilsland, E.3
Oliver, S.G.4
-
97
-
-
80051666394
-
Pharmaceutical drug transport: The issues and the implications that it is essentially carrier-mediated only
-
Kell DB, Dobson PD, Oliver SG (2011) Pharmaceutical drug transport: the issues and the implications that it is essentially carrier-mediated only. Drug Discov Today 16(15–16):704–714
-
(2011)
Drug Discov Today
, vol.16
, Issue.15-16
, pp. 704-714
-
-
Kell, D.B.1
Dobson, P.D.2
Oliver, S.G.3
-
98
-
-
85081149995
-
Principles of CNS drug development: From test tube to clinic and beyond Kielbasa W, Stratford RE Jr (2012) Exploratory translational modeling approach in drug development to predict human brain pharmacokinetics and pharmacologically relevant clinical doses
-
Kelly J (2009) Principles of CNS drug development: from test tube to clinic and beyond Kielbasa W, Stratford RE Jr (2012) Exploratory translational modeling approach in drug development to predict human brain pharmacokinetics and pharmacologically relevant clinical doses. Drug Metab Dispos 40(5):877–883
-
(2009)
Drug Metab Dispos
, vol.40
, Issue.5
, pp. 877-883
-
-
Kelly, J.1
-
99
-
-
0015936843
-
Physiochemical aspects of drug-protein interactions: A general perspective
-
Klotz IM (1973) Physiochemical aspects of drug-protein interactions: a general perspective. Ann N Y Acad Sci 226:18–35
-
(1973)
Ann N Y Acad Sci
, vol.226
, pp. 18-35
-
-
Klotz, I.M.1
-
100
-
-
81555210969
-
Quantitative evaluation of the impact of active efflux by p-glycoprotein and breast cancer resistance protein at the blood–brain barrier on the predictability of the unbound concentrations of drugs in the brain using cerebrospinal fluid concentration as a surrogate
-
Kodaira H, Kusuhara H, Fujita T, Ushiki J, Fuse E, Sugiyama Y (2011) Quantitative evaluation of the impact of active efflux by p-glycoprotein and breast cancer resistance protein at the blood–brain barrier on the predictability of the unbound concentrations of drugs in the brain using cerebrospinal fluid concentration as a surrogate. J Pharmacol Exp Ther 339(3):935–944
-
(2011)
J Pharmacol Exp Ther
, vol.339
, Issue.3
, pp. 935-944
-
-
Kodaira, H.1
Kusuhara, H.2
Fujita, T.3
Ushiki, J.4
Fuse, E.5
Sugiyama, Y.6
-
101
-
-
80052314330
-
Identification of novel functional inhibitors of acid sphingomyelinase
-
Kornhuber J, Muehlbacher M, Trapp S, Pechmann S, Friedl A, Reichel M, Muhle C, Terfloth L, Groemer TW, Spitzer GM, Liedl KR, Gulbins E, Tripal P (2011) Identification of novel functional inhibitors of acid sphingomyelinase. PLoS One 6(8):e23852
-
(2011)
Plos One
, vol.6
, Issue.8
, pp. 23852
-
-
Kornhuber, J.1
Muehlbacher, M.2
Trapp, S.3
Pechmann, S.4
Friedl, A.5
Reichel, M.6
Muhle, C.7
Terfloth, L.8
Groemer, T.W.9
Spitzer, G.M.10
Liedl, K.R.11
Gulbins, E.12
Tripal, P.13
-
102
-
-
0020564631
-
Binding of drugs to tissues
-
Kurz H, Fichtl B (1983) Binding of drugs to tissues. Drug Metab Rev 14(3):467–510
-
(1983)
Drug Metab Rev
, vol.14
, Issue.3
, pp. 467-510
-
-
Kurz, H.1
Fichtl, B.2
-
103
-
-
0037122743
-
Role of transporters in the tissue-selective distribution and elimination of drugs: Transporters in the liver, small intestine, brain and kidney
-
Kusuhara H, Sugiyama Y (2002) Role of transporters in the tissue-selective distribution and elimination of drugs: transporters in the liver, small intestine, brain and kidney. J Control Release 78(1–3):43–54
-
(2002)
J Control Release
, vol.78
, Issue.1-3
, pp. 43-54
-
-
Kusuhara, H.1
Sugiyama, Y.2
-
104
-
-
0035212257
-
Drug transporters in the central nervous system: Brain barriers and brain parenchyma considerations
-
Lee G, Dallas S, Hong M, Bendayan R (2001a) Drug transporters in the central nervous system: brain barriers and brain parenchyma considerations. Pharmacol Rev 53(4):569–596
-
(2001)
Pharmacol Rev
, vol.53
, Issue.4
, pp. 569-596
-
-
Lee, G.1
Dallas, S.2
Hong, M.3
Bendayan, R.4
-
105
-
-
0034802307
-
Functional expression of P-glycoprotein in rat brain microglia
-
Lee G, Schlichter L, Bendayan M, Bendayan R (2001b) Functional expression of P-glycoprotein in rat brain microglia. J Pharmacol Exp Ther 299(1):204–212
-
(2001)
J Pharmacol Exp Ther
, vol.299
, Issue.1
, pp. 204-212
-
-
Lee, G.1
Schlichter, L.2
Bendayan, M.3
Bendayan, R.4
-
106
-
-
0032824986
-
Genetically engineered brain drug delivery vectors: Cloning, expression and in vivo application of an anti-transferrin receptor single chain antibody-streptavidin fusion gene and protein
-
Li JY, Sugimura K, Boado RJ, Lee HJ, Zhang C, Duebel S, Pardridge WM (1999) Genetically engineered brain drug delivery vectors: cloning, expression and in vivo application of an anti-transferrin receptor single chain antibody-streptavidin fusion gene and protein. Protein Eng 12(9):787–796
-
(1999)
Protein Eng
, vol.12
, Issue.9
, pp. 787-796
-
-
Li, J.Y.1
Sugimura, K.2
Boado, R.J.3
Lee, H.J.4
Zhang, C.5
Duebel, S.6
Pardridge, W.M.7
-
107
-
-
1442301563
-
How significant is the role of P-glycoprotein in drug absorption and brain uptake?
-
Lin JH (2004) How significant is the role of P-glycoprotein in drug absorption and brain uptake? Drugs Today (Barc) 40(1):5–22
-
(2004)
Drugs Today (Barc)
, vol.40
, Issue.1
, pp. 5-22
-
-
Lin, J.H.1
-
108
-
-
38849136513
-
CSF as a surrogate for assessing CNS exposure: An industrial perspective
-
Lin JH (2008) CSF as a surrogate for assessing CNS exposure: an industrial perspective. Curr Drug Metab 9(1):46–59
-
(2008)
Curr Drug Metab
, vol.9
, Issue.1
, pp. 46-59
-
-
Lin, J.H.1
-
109
-
-
0020307011
-
In vitro and in vivo evaluation of the tissue-to-blood partition coefficient for physiological pharmacokinetic models
-
Lin JH, Sugiyama Y, Awazu S, Hanano M (1982) In vitro and in vivo evaluation of the tissue-to-blood partition coefficient for physiological pharmacokinetic models. J Pharmacokinet Biopharm 10(6):637–647
-
(1982)
J Pharmacokinet Biopharm
, vol.10
, Issue.6
, pp. 637-647
-
-
Lin, J.H.1
Sugiyama, Y.2
Awazu, S.3
Hanano, M.4
-
110
-
-
0025319162
-
Effects of protein binding and experimental disease states on brain uptake of benzodiazepines in rats
-
Lin TH, Lin JH (1990) Effects of protein binding and experimental disease states on brain uptake of benzodiazepines in rats. J Pharmacol Exp Ther 253(1):45–50
-
(1990)
J Pharmacol Exp Ther
, vol.253
, Issue.1
, pp. 45-50
-
-
Lin, T.H.1
Lin, J.H.2
-
111
-
-
42449100856
-
Progress in brain penetration evaluation in drug discovery and development
-
Liu X, Chen C, Smith BJ (2008) Progress in brain penetration evaluation in drug discovery and development. J Pharmacol Exp Ther 325(2):349–356
-
(2008)
J Pharmacol Exp Ther
, vol.325
, Issue.2
, pp. 349-356
-
-
Liu, X.1
Chen, C.2
Smith, B.J.3
-
112
-
-
84859885983
-
Use of cassette dosing approach to assess brain penetration in drug discovery
-
Liu X, Ding X, Deshmukh G, Liederer BM, Hop CE (2012) Use of cassette dosing approach to assess brain penetration in drug discovery. Drug Metab Dispos 40(5):963–9
-
(2012)
Drug Metab Dispos
, vol.40
, Issue.5
, pp. 963-969
-
-
Liu, X.1
Ding, X.2
Deshmukh, G.3
Liederer, B.M.4
Hop, C.E.5
-
113
-
-
21144451475
-
Use of a physiologically based pharmacokinetic model to study the time to reach brain equilibrium: An experimental analysis of the role of blood–brain barrier permeability, plasma protein binding, and brain tissue binding
-
Liu X, Smith BJ, Chen C, Callegari E, Becker SL, Chen X, Cianfrogna J, Doran AC, Doran SD, Gibbs JP, Hosea N, Liu J, Nelson FR, Szewc MA, Van Deusen J (2005) Use of a physiologically based pharmacokinetic model to study the time to reach brain equilibrium: an experimental analysis of the role of blood–brain barrier permeability, plasma protein binding, and brain tissue binding. J Pharmacol Exp Ther 313(3):1254–1262
-
(2005)
J Pharmacol Exp Ther
, vol.313
, Issue.3
, pp. 1254-1262
-
-
Liu, X.1
Smith, B.J.2
Chen, C.3
Callegari, E.4
Becker, S.L.5
Chen, X.6
Cianfrogna, J.7
Doran, A.C.8
Doran, S.D.9
Gibbs, J.P.10
Hosea, N.11
Liu, J.12
Nelson, F.R.13
Szewc, M.A.14
Van Deusen, J.15
-
114
-
-
33747860858
-
Evaluation of cerebrospinal fluid concentration and plasma free concentration as a surrogate measurement for brain free concentration
-
Liu X, Smith BJ, Chen C, Callegari E, Becker SL, Chen X, Cianfrogna J, Doran AC, Doran SD, Gibbs JP, Hosea N, Liu J, Nelson FR, Szewc MA, Van Deusen J (2006) Evaluation of cerebrospinal fluid concentration and plasma free concentration as a surrogate measurement for brain free concentration. Drug Metab Dispos 34(9):1443–1447
-
(2006)
Drug Metab Dispos
, vol.34
, Issue.9
, pp. 1443-1447
-
-
Liu, X.1
Smith, B.J.2
Chen, C.3
Callegari, E.4
Becker, S.L.5
Chen, X.6
Cianfrogna, J.7
Doran, A.C.8
Doran, S.D.9
Gibbs, J.P.10
Hosea, N.11
Liu, J.12
Nelson, F.R.13
Szewc, M.A.14
Van Deusen, J.15
-
115
-
-
63849149894
-
Unbound drug concentration in brain homogenate and cerebral spinal fluid at steady state as a surrogate for unbound concentration in brain interstitial fluid
-
Liu X, Van Natta K, Yeo H, Vilenski O, Weller PE, Worboys PD, Monshouwer M (2009a) Unbound drug concentration in brain homogenate and cerebral spinal fluid at steady state as a surrogate for unbound concentration in brain interstitial fluid. Drug Metab Dispos 37(4): 787–793
-
(2009)
Drug Metab Dispos
, vol.37
, Issue.4
, pp. 787-793
-
-
Liu, X.1
Van Natta, K.2
Yeo, H.3
Vilenski, O.4
Weller, P.E.5
Worboys, P.D.6
Monshouwer, M.7
-
116
-
-
67649408864
-
Unbound brain concentration determines receptor occupancy: A correlation of drug concentration and brain serotonin and dopamine reuptake transporter occupancy for eighteen compounds in rats
-
Liu X, Vilenski O, Kwan J, Apparsundaram S, Weikert R (2009b) Unbound brain concentration determines receptor occupancy: a correlation of drug concentration and brain serotonin and dopamine reuptake transporter occupancy for eighteen compounds in rats. Drug Metab Dispos 37(7):1548–1556
-
(2009)
Drug Metab Dispos
, vol.37
, Issue.7
, pp. 1548-1556
-
-
Liu, X.1
Vilenski, O.2
Kwan, J.3
Apparsundaram, S.4
Weikert, R.5
-
117
-
-
0343067073
-
Lysosome membrane permeability: Implications for drug delivery
-
Lloyd JB (2000) Lysosome membrane permeability: implications for drug delivery. Adv Drug Deliv Rev 41(2):189–200
-
(2000)
Adv Drug Deliv Rev
, vol.41
, Issue.2
, pp. 189-200
-
-
Lloyd, J.B.1
-
118
-
-
84864031724
-
Drug-drug interactions involving lysosomes: Mechanisms and potential clinical implications
-
Logan R, Funk RS, Axcell E, Krise JP (2012) Drug-drug interactions involving lysosomes: mechanisms and potential clinical implications. Expert Opin Drug Metab Toxicol 8(8):943–958
-
(2012)
Expert Opin Drug Metab Toxicol
, vol.8
, Issue.8
, pp. 943-958
-
-
Logan, R.1
Funk, R.S.2
Axcell, E.3
Krise, J.P.4
-
119
-
-
79251492055
-
Brain tissue binding of drugs: Evaluation and validation of solid supported porcine brain membrane vesicles (TRANSIL) as a novel high-throughput method
-
Longhi R, Corbioli S, Fontana S, Vinco F, Braggio S, Helmdach L, Schiller J, Boriss H (2011) Brain tissue binding of drugs: evaluation and validation of solid supported porcine brain membrane vesicles (TRANSIL) as a novel high-throughput method. Drug Metab Dispos 39(2):312–321
-
(2011)
Drug Metab Dispos
, vol.39
, Issue.2
, pp. 312-321
-
-
Longhi, R.1
Corbioli, S.2
Fontana, S.3
Vinco, F.4
Braggio, S.5
Helmdach, L.6
Schiller, J.7
Boriss, H.8
-
120
-
-
84875283780
-
The brain slice method for studying drug distribution in the CNS
-
Loryan I, Friden M, Hammarlund-Udenaes M (2013) The brain slice method for studying drug distribution in the CNS. Fluids Barriers CNS 10(1):6
-
(2013)
Fluids Barriers CNS
, vol.10
, Issue.1
, pp. 6
-
-
Loryan, I.1
Friden, M.2
Hammarlund-Udenaes, M.3
-
121
-
-
0023792145
-
The potential role of lysosomes in tissue distribution of weak bases
-
MacIntyre AC, Cutler DJ (1988) The potential role of lysosomes in tissue distribution of weak bases. Biopharm Drug Dispos 9(6):513–526
-
(1988)
Biopharm Drug Dispos
, vol.9
, Issue.6
, pp. 513-526
-
-
Macintyre, A.C.1
Cutler, D.J.2
-
122
-
-
3242778456
-
Whatever happened to cassette-dosing pharmacokinetics?
-
Manitpisitkul P, White RE (2004) Whatever happened to cassette-dosing pharmacokinetics? Drug Discov Today 9(15):652–658
-
(2004)
Drug Discov Today
, vol.9
, Issue.15
, pp. 652-658
-
-
Manitpisitkul, P.1
White, R.E.2
-
123
-
-
12244305837
-
Investigation of the high partition of YM992, a novel antidepressant, in rat brain - in vitro and in vivo evidence for the high binding in brain and the high permeability at the BBB
-
Mano Y, Higuchi S, Kamimura H (2002) Investigation of the high partition of YM992, a novel antidepressant, in rat brain - in vitro and in vivo evidence for the high binding in brain and the high permeability at the BBB. Biopharm Drug Dispos 23(9):351–360
-
(2002)
Biopharm Drug Dispos
, vol.23
, Issue.9
, pp. 351-360
-
-
Mano, Y.1
Higuchi, S.2
Kamimura, H.3
-
124
-
-
11144290156
-
Relationship between exposure and nonspecific binding of thirty-three central nervous system drugs in mice
-
Maurer TS, Debartolo DB, Tess DA, Scott DO (2005) Relationship between exposure and nonspecific binding of thirty-three central nervous system drugs in mice. Drug Metab Dispos 33(1):175–181
-
(2005)
Drug Metab Dispos
, vol.33
, Issue.1
, pp. 175-181
-
-
Maurer, T.S.1
Debartolo, D.B.2
Tess, D.A.3
Scott, D.O.4
-
125
-
-
79954580805
-
Glutamic acid and glucose as substrates for mammalian brain
-
McIlwain H (1951a) Glutamic acid and glucose as substrates for mammalian brain. J Ment Sci 97(409):674–680
-
(1951)
J Ment Sci
, vol.97
, Issue.409
, pp. 674-680
-
-
McIlwain, H.1
-
126
-
-
76549254202
-
Metabolic response in vitro to electrical stimulation of sections of mammalian brain
-
McIlwain H (1951b) Metabolic response in vitro to electrical stimulation of sections of mammalian brain. Biochem J 48(4):1vi
-
(1951)
Biochem J
, vol.48
, Issue.4
, pp. 11
-
-
McIlwain, H.1
-
127
-
-
0042468096
-
Impact of drug transporter studies on drug discovery and development
-
Mizuno N, Niwa T, Yotsumoto Y, Sugiyama Y (2003) Impact of drug transporter studies on drug discovery and development. Pharmacol Rev 55(3):425–461
-
(2003)
Pharmacol Rev
, vol.55
, Issue.3
, pp. 425-461
-
-
Mizuno, N.1
Niwa, T.2
Yotsumoto, Y.3
Sugiyama, Y.4
-
129
-
-
79952037605
-
A high content screening assay for identifying lysosomotropic compounds
-
Nadanaciva S, Lu S, Gebhard DF, Jessen BA, Pennie WD, Will Y (2011) A high content screening assay for identifying lysosomotropic compounds. Toxicol In Vitro 25(3):715–723
-
(2011)
Toxicol in Vitro
, vol.25
, Issue.3
, pp. 715-723
-
-
Nadanaciva, S.1
Lu, S.2
Gebhard, D.F.3
Jessen, B.A.4
Pennie, W.D.5
Will, Y.6
-
130
-
-
63849290250
-
Spinal ceramide modulates the development of morphine antinociceptive tolerance via peroxynitrite-mediated nitroxidative stress and neuroimmune activation
-
Ndengele MM, Cuzzocrea S, Masini E, Vinci MC, Esposito E, Muscoli C, Petrusca DN, Mollace V, Mazzon E, Li D, Petrache I, Matuschak GM, Salvemini D (2009) Spinal ceramide modulates the development of morphine antinociceptive tolerance via peroxynitrite-mediated nitroxidative stress and neuroimmune activation. J Pharmacol Exp Ther 329(1):64–75
-
(2009)
J Pharmacol Exp Ther
, vol.329
, Issue.1
, pp. 64-75
-
-
Ndengele, M.M.1
Cuzzocrea, S.2
Masini, E.3
Vinci, M.C.4
Esposito, E.5
Muscoli, C.6
Petrusca, D.N.7
Mollace, V.8
Mazzon, E.9
Li, D.10
Petrache, I.11
Matuschak, G.M.12
Salvemini, D.13
-
131
-
-
37149034911
-
Strategies to advance translational research into brain barriers
-
Neuwelt E, Abbott NJ, Abrey L, Banks WA, Blakley B, Davis T, Engelhardt B, Grammas P, Nedergaard M, Nutt J, Pardridge W, Rosenberg GA, Smith Q, Drewes LR (2008) Strategies to advance translational research into brain barriers. Lancet Neurol 7(1):84–96
-
(2008)
Lancet Neurol
, vol.7
, Issue.1
, pp. 84-96
-
-
Neuwelt, E.1
Abbott, N.J.2
Abrey, L.3
Banks, W.A.4
Blakley, B.5
Davis, T.6
Engelhardt, B.7
Grammas, P.8
Nedergaard, M.9
Nutt, J.10
Pardridge, W.11
Rosenberg, G.A.12
Smith, Q.13
Drewes, L.R.14
-
133
-
-
0025753891
-
Ischemic brain slice glucose utilization: Effects of slice thickness, acidosis, and K+
-
Newman GC, Hospod FE, Schissel SL (1991) Ischemic brain slice glucose utilization: effects of slice thickness, acidosis, and K+. J Cereb Blood Flow Metab 11(3):398–406
-
(1991)
J Cereb Blood Flow Metab
, vol.11
, Issue.3
, pp. 398-406
-
-
Newman, G.C.1
Hospod, F.E.2
Schissel, S.L.3
-
135
-
-
0032079334
-
Extracellular space structure revealed by diffusion analysis
-
Nicholson C, Sykova E (1998) Extracellular space structure revealed by diffusion analysis. Trends Neurosci 21(5):207–215
-
(1998)
Trends Neurosci
, vol.21
, Issue.5
, pp. 207-215
-
-
Nicholson, C.1
Sykova, E.2
-
136
-
-
3342999996
-
Localization of organic anion transporting polypeptide 3 (Oatp3) in mouse brain parenchymal and capillary endothelial cells
-
Ohtsuki S, Takizawa T, Takanaga H, Hori S, Hosoya K, Terasaki T (2004) Localization of organic anion transporting polypeptide 3 (oatp3) in mouse brain parenchymal and capillary endothelial cells. J Neurochem 90(3):743–749
-
(2004)
J Neurochem
, vol.90
, Issue.3
, pp. 743-749
-
-
Ohtsuki, S.1
Takizawa, T.2
Takanaga, H.3
Hori, S.4
Hosoya, K.5
Terasaki, T.6
-
137
-
-
0030610838
-
Quantitative brain microdialysis study on the mechanism of quinolones distribution in the central nervous system
-
Ooie T, Terasaki T, Suzuki H, Sugiyama Y (1997) Quantitative brain microdialysis study on the mechanism of quinolones distribution in the central nervous system. Drug Metab Dispos 25(7):784–789
-
(1997)
Drug Metab Dispos
, vol.25
, Issue.7
, pp. 784-789
-
-
Ooie, T.1
Terasaki, T.2
Suzuki, H.3
Sugiyama, Y.4
-
138
-
-
84855672040
-
The influence of distributional kinetics into a peripheral compartment on the pharmacokinetics of substrate partitioning between blood and brain tissue
-
Padowski JM, Pollack GM (2011a) The influence of distributional kinetics into a peripheral compartment on the pharmacokinetics of substrate partitioning between blood and brain tissue. J Pharmacokinet Pharmacodyn 38(6):743–767
-
(2011)
J Pharmacokinet Pharmacodyn
, vol.38
, Issue.6
, pp. 743-767
-
-
Padowski, J.M.1
Pollack, G.M.2
-
139
-
-
81155131309
-
Influence of time to achieve substrate distribution equilibrium between brain tissue and blood on quantitation of the blood–brain barrier P-glycoprotein effect
-
Padowski JM, Pollack GM (2011b) Influence of time to achieve substrate distribution equilibrium between brain tissue and blood on quantitation of the blood–brain barrier P-glycoprotein effect. Brain Res 1426:1–17
-
(2011)
Brain Res
, vol.1426
, pp. 1-17
-
-
Padowski, J.M.1
Pollack, G.M.2
-
140
-
-
0024401638
-
Strategies for drug delivery through the blood–brain barrier
-
Pardridge WM (1989) Strategies for drug delivery through the blood–brain barrier. Neurobiol Aging 10(5):636–637, discussion 648-650
-
(1989)
Neurobiol Aging
, vol.10
, Issue.5
, pp. 636-637
-
-
Pardridge, W.M.1
-
141
-
-
0030869483
-
Drug delivery to the brain
-
Pardridge WM (1997) Drug delivery to the brain. J Cereb Blood Flow Metab 17(7):713–731
-
(1997)
J Cereb Blood Flow Metab
, vol.17
, Issue.7
, pp. 713-731
-
-
Pardridge, W.M.1
-
142
-
-
33748452503
-
Molecular Trojan horses for blood–brain barrier drug delivery
-
Pardridge WM (2006) Molecular Trojan horses for blood–brain barrier drug delivery. Curr Opin Pharmacol 6(5):494–500
-
(2006)
Curr Opin Pharmacol
, vol.6
, Issue.5
, pp. 494-500
-
-
Pardridge, W.M.1
-
143
-
-
0026509831
-
Blood–brain barrier and new approaches to brain drug delivery
-
Pardridge WM, Boado RJ, Black KL, Cancilla PA (1992) Blood–brain barrier and new approaches to brain drug delivery. West J Med 156(3):281–286
-
(1992)
West J Med
, vol.156
, Issue.3
, pp. 281-286
-
-
Pardridge, W.M.1
Boado, R.J.2
Black, K.L.3
Cancilla, P.A.4
-
144
-
-
0031801258
-
Diffusion of radiotracers in normal and ischemic brain slices
-
Patlak CS, Hospod FE, Trowbridge SD, Newman GC (1998) Diffusion of radiotracers in normal and ischemic brain slices. J Cereb Blood Flow Metab 18(7):776–802
-
(1998)
J Cereb Blood Flow Metab
, vol.18
, Issue.7
, pp. 776-802
-
-
Patlak, C.S.1
Hospod, F.E.2
Trowbridge, S.D.3
Newman, G.C.4
-
145
-
-
78049496543
-
Semi-automated protein binding methodology using equilibrium dialysis and a novel mixed-matrix cassette approach
-
Plise EG, Tran D, Salphati L (2010) Semi-automated protein binding methodology using equilibrium dialysis and a novel mixed-matrix cassette approach. J Pharm Sci 99(12):5070–5078
-
(2010)
J Pharm Sci
, vol.99
, Issue.12
, pp. 5070-5078
-
-
Plise, E.G.1
Tran, D.2
Salphati, L.3
-
146
-
-
27144503706
-
Early preclinical evaluation of brain exposure in support of hit identification and lead optimization
-
In: Borchardt RT, Middagh CR, Am Assoc Pharm Sci Press, Arlington, VA
-
Raub TJL, Lutzke BS, Andrus PK, Sawada GA, Staton BA (2006) Early preclinical evaluation of brain exposure in support of hit identification and lead optimization. In: Borchardt RT, Middagh CR (eds) Optimization of drug-like properties during lead optimization, Biotechnology: pharmaceutical aspects series. Am Assoc Pharm Sci Press, Arlington, VA
-
(2006)
Optimization of Drug-Like Properties during Lead Optimization, Biotechnology: Pharmaceutical Aspects Series
-
-
Raub, T.1
Lutzke, B.S.2
Rus, P.K.3
Sawada, G.A.4
Staton, B.A.5
-
147
-
-
77249142484
-
Assessing brain free fraction in early drug discovery
-
Read KD, Braggio S (2010) Assessing brain free fraction in early drug discovery. Expert Opin Drug Metab Toxicol 6(3):337–344
-
(2010)
Expert Opin Drug Metab Toxicol
, vol.6
, Issue.3
, pp. 337-344
-
-
Read, K.D.1
Braggio, S.2
-
148
-
-
33644900716
-
The role of blood–brain barrier studies in the pharmaceutical industry
-
Reichel A (2006) The role of blood–brain barrier studies in the pharmaceutical industry. Curr Drug Metab 7(2):183–203
-
(2006)
Curr Drug Metab
, vol.7
, Issue.2
, pp. 183-203
-
-
Reichel, A.1
-
149
-
-
72449185642
-
Addressing central nervous system (CNS) penetration in drug discovery: Basics and implications of the evolving new concept
-
Reichel A (2009) Addressing central nervous system (CNS) penetration in drug discovery: basics and implications of the evolving new concept. Chem Biodivers 6(11):2030–2049
-
(2009)
Chem Biodivers
, vol.6
, Issue.11
, pp. 2030-2049
-
-
Reichel, A.1
-
150
-
-
0642372727
-
An overview of in vitro techniques for blood–brain barrier studies
-
In: Nag S, Humana Press Inc., Totowa, NJ
-
Reichel A, Begley D, Abbott N (2003) An overview of in vitro techniques for blood–brain barrier studies. In: Nag S (ed) The blood–brain barrier: biology and research tools, Methods in molecular medicine (Vol. 89). Humana Press Inc., Totowa, NJ
-
(2003)
The blood–brain Barrier: Biology and Research Tools, Methods in Molecular Medicine
, vol.89
-
-
Reichel, A.1
Begley, D.2
Abbott, N.3
-
151
-
-
0032853938
-
Use of ascorbate in the preparation and maintenance of brain slices
-
Rice ME (1999) Use of ascorbate in the preparation and maintenance of brain slices. Methods 18(2):144–149
-
(1999)
Methods
, vol.18
, Issue.2
, pp. 144-149
-
-
Rice, M.E.1
-
152
-
-
84868204415
-
Tissue lipids and drug distribution: Dog versus rat
-
Rodgers T, Jones HM, Rowland M (2012) Tissue lipids and drug distribution: dog versus rat. J Pharm Sci 101(12):4615–4626
-
(2012)
J Pharm Sci
, vol.101
, Issue.12
, pp. 4615-4626
-
-
Rodgers, T.1
Jones, H.M.2
Rowland, M.3
-
153
-
-
0018412659
-
A method to estimate binding constants at variable protein concentrations
-
Romer J, Bickel MH (1979) A method to estimate binding constants at variable protein concentrations. J Pharm Pharmacol 31(1):7–11
-
(1979)
J Pharm Pharmacol
, vol.31
, Issue.1
, pp. 7-11
-
-
Romer, J.1
Bickel, M.H.2
-
154
-
-
0014601237
-
Species variations in phospholipid class distribution of organs. I. Kidney, liver and spleen
-
Rouser G, Simon G, Kritchevsky G (1969) Species variations in phospholipid class distribution of organs. I. Kidney, liver and spleen. Lipids 4(6):599–606
-
(1969)
Lipids
, vol.4
, Issue.6
, pp. 599-606
-
-
Rouser, G.1
Simon, G.2
Kritchevsky, G.3
-
155
-
-
0023752362
-
Conformation and orientation of regulatory peptides on lipid membranes. Key to the molecular mechanism of receptor selection
-
Sargent DF, Bean JW, Schwyzer R (1988) Conformation and orientation of regulatory peptides on lipid membranes. Key to the molecular mechanism of receptor selection. Biophys Chem 31(1–2):183–193
-
(1988)
Biophys Chem
, vol.31
, Issue.1-2
, pp. 183-193
-
-
Sargent, D.F.1
Bean, J.W.2
Schwyzer, R.3
-
156
-
-
0038757797
-
Membrane lipid phase as catalyst for peptide-receptor interactions
-
Sargent DF, Schwyzer R (1986) Membrane lipid phase as catalyst for peptide-receptor interactions. Proc Natl Acad Sci U S A 83(16):5774–5778
-
(1986)
Proc Natl Acad Sci U S A
, vol.83
, Issue.16
, pp. 5774-5778
-
-
Sargent, D.F.1
Schwyzer, R.2
-
157
-
-
0021746592
-
Prediction of the volumes of distribution of basic drugs in humans based on data from animals
-
Sawada Y, Hanano M, Sugiyama Y, Harashima H, Iga T (1984) Prediction of the volumes of distribution of basic drugs in humans based on data from animals. J Pharmacokinet Biopharm 12(6):587–596
-
(1984)
J Pharmacokinet Biopharm
, vol.12
, Issue.6
, pp. 587-596
-
-
Sawada, Y.1
Hanano, M.2
Sugiyama, Y.3
Harashima, H.4
Iga, T.5
-
158
-
-
0036627481
-
Drug delivery to brain via the blood–brain barrier
-
Scherrmann JM (2002) Drug delivery to brain via the blood–brain barrier. Vascul Pharmacol 38(6):349–354
-
(2002)
Vascul Pharmacol
, vol.38
, Issue.6
, pp. 349-354
-
-
Scherrmann, J.M.1
-
159
-
-
80053554135
-
Where will new neuroscience therapies come from?
-
Schoepp DD (2011) Where will new neuroscience therapies come from? Nat Rev Drug Discov 10(10):715–716
-
(2011)
Nat Rev Drug Discov
, vol.10
, Issue.10
, pp. 715-716
-
-
Schoepp, D.D.1
-
160
-
-
79960961365
-
Clarifying lysosomal storage diseases
-
Schultz ML, Tecedor L, Chang M, Davidson BL (2011) Clarifying lysosomal storage diseases. Trends Neurosci 34(8):401–410
-
(2011)
Trends Neurosci
, vol.34
, Issue.8
, pp. 401-410
-
-
Schultz, M.L.1
Tecedor, L.2
Chang, M.3
Davidson, B.L.4
-
161
-
-
84858264245
-
Drug research: Plug the real brain drain
-
Schwab ME, Buchli AD (2012) Drug research: plug the real brain drain. Nature 483(7389): 267–268
-
(2012)
Nature
, vol.483
, Issue.7389
, pp. 267-268
-
-
Schwab, M.E.1
Buchli, A.D.2
-
162
-
-
55949089964
-
High throughput lipidomic profiling of schizophrenia and bipolar disorder brain tissue reveals alterations of free fatty acids, phosphatidylcholines, and ceramides
-
Schwarz E, Prabakaran S, Whitfield P, Major H, Leweke FM, Koethe D, McKenna P, Bahn S (2008) High throughput lipidomic profiling of schizophrenia and bipolar disorder brain tissue reveals alterations of free fatty acids, phosphatidylcholines, and ceramides. J Proteome Res 7(10):4266–4277
-
(2008)
J Proteome Res
, vol.7
, Issue.10
, pp. 4266-4277
-
-
Schwarz, E.1
Prabakaran, S.2
Whitfield, P.3
Major, H.4
Leweke, F.M.5
Koethe, D.6
McKenna, P.7
Bahn, S.8
-
163
-
-
84857737608
-
Multi-parameter optimization: Identifying high quality compounds with a balance of properties
-
Segall MD (2012) Multi-parameter optimization: identifying high quality compounds with a balance of properties. Curr Pharm Des 18(9):1292–1310
-
(2012)
Curr Pharm Des
, vol.18
, Issue.9
, pp. 1292-1310
-
-
Segall, M.D.1
-
164
-
-
77957806870
-
Defining neuropharmacokinetic parameters in CNS drug discovery to determine cross-species pharmacologic exposure-response relationships
-
Shaffer CL (2010) Defining neuropharmacokinetic parameters in CNS drug discovery to determine cross-species pharmacologic exposure-response relationships. Annu Rep Med Chem 45:55–70
-
(2010)
Annu Rep Med Chem
, vol.45
, pp. 55-70
-
-
Shaffer, C.L.1
-
165
-
-
4744353974
-
Principles and applicability of CSF sampling for the assessment of CNS drug delivery and pharmacodynamics
-
Shen DD, Artru AA, Adkison KK (2004) Principles and applicability of CSF sampling for the assessment of CNS drug delivery and pharmacodynamics. Adv Drug Deliv Rev 56(12): 1825–1857
-
(2004)
Adv Drug Deliv Rev
, vol.56
, Issue.12
, pp. 1825-1857
-
-
Shen, D.D.1
Artru, A.A.2
Adkison, K.K.3
-
166
-
-
0014603132
-
Species variations in phospholipid class distribution of organs. II. Heart and skeletal muscle
-
Simon G, Rouser G (1969) Species variations in phospholipid class distribution of organs. II. Heart and skeletal muscle. Lipids 4(6):607–614
-
(1969)
Lipids
, vol.4
, Issue.6
, pp. 607-614
-
-
Simon, G.1
Rouser, G.2
-
167
-
-
78649706279
-
The effect of plasma protein binding on in vivo efficacy: Misconceptions in drug discovery
-
Smith DA, Di L, Kerns EH (2010) The effect of plasma protein binding on in vivo efficacy: misconceptions in drug discovery. Nat Rev Drug Discov 9(12):929–939
-
(2010)
Nat Rev Drug Discov
, vol.9
, Issue.12
, pp. 929-939
-
-
Smith, D.A.1
Di, L.2
Kerns, E.H.3
-
168
-
-
0025741116
-
The blood–brain barrier and the regulation of amino acid uptake and availability to brain
-
Smith QR (1991) The blood–brain barrier and the regulation of amino acid uptake and availability to brain. Adv Exp Med Biol 291:55–71
-
(1991)
Adv Exp Med Biol
, vol.291
, pp. 55-71
-
-
Smith, Q.R.1
-
169
-
-
84870441696
-
Mechanism-based PK-PD model for the prolactin biological system response following an acute dopamine inhibition challenge: Quantitative extrapolation to humans
-
Stevens J, Ploeger BA, Hammarlund-Udenaes M, Osswald G, van der Graaf PH, Danhof M, de Lange EC (2012) Mechanism-based PK-PD model for the prolactin biological system response following an acute dopamine inhibition challenge: quantitative extrapolation to humans. J Pharmacokinet Pharmacodyn 39(5):463–477
-
(2012)
J Pharmacokinet Pharmacodyn
, vol.39
, Issue.5
, pp. 463-477
-
-
Stevens, J.1
Ploeger, B.A.2
Hammarlund-Udenaes, M.3
Osswald, G.4
Van Der Graaf, P.H.5
Danhof, M.6
De Lange, E.C.7
-
170
-
-
0038784719
-
Dynamics of a transgene expression in acute rat brain slices transfected with adenoviral vectors
-
Stokes CE, Murphy D, Paton JF, Kasparov S (2003) Dynamics of a transgene expression in acute rat brain slices transfected with adenoviral vectors. Exp Physiol 88(4):459–466
-
(2003)
Exp Physiol
, vol.88
, Issue.4
, pp. 459-466
-
-
Stokes, C.E.1
Murphy, D.2
Paton, J.F.3
Kasparov, S.4
-
171
-
-
0028986069
-
Transport of gabapentin, a gamma-amino acid drug, by system l alpha-amino acid transporters: A comparative study in astrocytes, synaptosomes, and CHO cells
-
Su TZ, Lunney E, Campbell G, Oxender DL (1995) Transport of gabapentin, a gamma-amino acid drug, by system l alpha-amino acid transporters: a comparative study in astrocytes, synaptosomes, and CHO cells. J Neurochem 64(5):2125–2131
-
(1995)
J Neurochem
, vol.64
, Issue.5
, pp. 2125-2131
-
-
Su, T.Z.1
Lunney, E.2
Campbell, G.3
Oxender, D.L.4
-
172
-
-
34250744722
-
Central nervous system drug disposition: The relationship between in situ brain permeability and brain free fraction
-
Summerfield SG, Read K, Begley DJ, Obradovic T, Hidalgo IJ, Coggon S, Lewis AV, Porter RA, Jeffrey P (2007) Central nervous system drug disposition: the relationship between in situ brain permeability and brain free fraction. J Pharmacol Exp Ther 322(1):205–213
-
(2007)
J Pharmacol Exp Ther
, vol.322
, Issue.1
, pp. 205-213
-
-
Summerfield, S.G.1
Read, K.2
Begley, D.J.3
Obradovic, T.4
Hidalgo, I.J.5
Coggon, S.6
Lewis, A.V.7
Porter, R.A.8
Jeffrey, P.9
-
173
-
-
33644756715
-
Improving the in vitro prediction of in vivo central nervous system penetration: Integrating permeability, P-glycoprotein efflux, and free fractions in blood and brain
-
Summerfield SG, Stevens AJ, Cutler L, del Carmen OM, Hammond B, Tang SP, Hersey A, Spalding DJ, Jeffrey P (2006) Improving the in vitro prediction of in vivo central nervous system penetration: integrating permeability, P-glycoprotein efflux, and free fractions in blood and brain. J Pharmacol Exp Ther 316(3):1282–1290
-
(2006)
J Pharmacol Exp Ther
, vol.316
, Issue.3
, pp. 1282-1290
-
-
Summerfield, S.G.1
Stevens, A.J.2
Cutler, L.3
Del Carmen, O.M.4
Hammond, B.5
Tang, S.P.6
Hersey, A.7
Spalding, D.J.8
Jeffrey, P.9
-
174
-
-
79960033800
-
Biorelevant pK(A) (37 degrees C) predicted from the 2D structure of the molecule and its pK(a) at 25 degrees C
-
Sun N, Avdeef A (2011) Biorelevant pK(a) (37 degrees C) predicted from the 2D structure of the molecule and its pK(a) at 25 degrees C. J Pharm Biomed Anal 56(2):173–182
-
(2011)
J Pharm Biomed Anal
, vol.56
, Issue.2
, pp. 173-182
-
-
Sun, N.1
Avdeef, A.2
-
175
-
-
9344269388
-
Extrasynaptic volume transmission and diffusion parameters of the extracellular space
-
Sykova E (2004) Extrasynaptic volume transmission and diffusion parameters of the extracellular space. Neuroscience 129(4):861–876
-
(2004)
Neuroscience
, vol.129
, Issue.4
, pp. 861-876
-
-
Sykova, E.1
-
176
-
-
55949130305
-
Diffusion in brain extracellular space
-
Sykova E, Nicholson C (2008) Diffusion in brain extracellular space. Physiol Rev 88(4): 1277–1340
-
(2008)
Physiol Rev
, vol.88
, Issue.4
, pp. 1277-1340
-
-
Sykova, E.1
Nicholson, C.2
-
177
-
-
57349085135
-
Pharmacokinetics of P-glycoprotein inhibition in the rat blood–brain barrier
-
Syvanen S, Hooker A, Rahman O, Wilking H, Blomquist G, Langstrom B, Bergstrom M, Hammarlund-Udenaes M (2008) Pharmacokinetics of P-glycoprotein inhibition in the rat blood–brain barrier. J Pharm Sci 97(12):5386–5400
-
(2008)
J Pharm Sci
, vol.97
, Issue.12
, pp. 5386-5400
-
-
Syvanen, S.1
Hooker, A.2
Rahman, O.3
Wilking, H.4
Blomquist, G.5
Langstrom, B.6
Bergstrom, M.7
Hammarlund-Udenaes, M.8
-
178
-
-
61449118888
-
Species differences in blood–brain barrier transport of three positron emission tomography radioligands with emphasis on P-glycoprotein transport
-
Syvanen S, Lindhe O, Palner M, Kornum BR, Rahman O, Langstrom B, Knudsen GM, Hammarlund-Udenaes M (2009) Species differences in blood–brain barrier transport of three positron emission tomography radioligands with emphasis on P-glycoprotein transport. Drug Metab Dispos 37(3):635–643
-
(2009)
Drug Metab Dispos
, vol.37
, Issue.3
, pp. 635-643
-
-
Syvanen, S.1
Lindhe, O.2
Palner, M.3
Kornum, B.R.4
Rahman, O.5
Langstrom, B.6
Knudsen, G.M.7
Hammarlund-Udenaes, M.8
-
179
-
-
84857630809
-
Alteration in P-glycoprotein functionality affects intrabrain distribution of quinidine more than brain entry-a study in rats subjected to status epilepticus by kainate
-
Syvanen S, Schenke M, van den Berg DJ, Voskuyl RA, de Lange EC (2012) Alteration in P-glycoprotein functionality affects intrabrain distribution of quinidine more than brain entry-a study in rats subjected to status epilepticus by kainate. AAPS J 14(1):87–96
-
(2012)
AAPS J
, vol.14
, Issue.1
, pp. 87-96
-
-
Syvanen, S.1
Schenke, M.2
Van Den Berg, D.J.3
Voskuyl, R.A.4
De Lange, E.C.5
-
180
-
-
0032982421
-
Drug-protein binding and blood–brain barrier permeability
-
Tanaka H, Mizojiri K (1999) Drug-protein binding and blood–brain barrier permeability. J Pharmacol Exp Ther 288(3):912–918
-
(1999)
J Pharmacol Exp Ther
, vol.288
, Issue.3
, pp. 912-918
-
-
Tanaka, H.1
Mizojiri, K.2
-
181
-
-
0033526186
-
The blood–brain barrier efflux transporters as a detoxifying system for the brain
-
Terasaki T, Hosoya K (1999) The blood–brain barrier efflux transporters as a detoxifying system for the brain. Adv Drug Deliv Rev 36(2–3):195–209
-
(1999)
Adv Drug Deliv Rev
, vol.36
, Issue.2-3
, pp. 195-209
-
-
Terasaki, T.1
Hosoya, K.2
-
182
-
-
12344327823
-
Brain-to-blood transporters for endogenous substrates and xenobiotics at the blood–brain barrier: An overview of biology and methodology
-
Terasaki T, Ohtsuki S (2005) Brain-to-blood transporters for endogenous substrates and xenobiotics at the blood–brain barrier: an overview of biology and methodology. NeuroRx 2(1):63–72
-
(2005)
Neurorx
, vol.2
, Issue.1
, pp. 63-72
-
-
Terasaki, T.1
Ohtsuki, S.2
-
183
-
-
0029026040
-
Quantitative analysis of the olfactory pathway for drug delivery to the brain
-
Thorne RG, Emory CR, Ala TA, Frey WH 2nd (1995) Quantitative analysis of the olfactory pathway for drug delivery to the brain. Brain Res 692(1–2):278–282
-
(1995)
Brain Res
, vol.692
, Issue.1-2
, pp. 278-282
-
-
Thorne, R.G.1
Emory, C.R.2
Ala, T.A.3
Frey, W.H.4
-
184
-
-
8644244647
-
Diffusion of epidermal growth factor in rat brain extracellular space measured by integrative optical imaging
-
Thorne RG, Hrabetova S, Nicholson C (2004) Diffusion of epidermal growth factor in rat brain extracellular space measured by integrative optical imaging. J Neurophysiol 92(6):3471–3481
-
(2004)
J Neurophysiol
, vol.92
, Issue.6
, pp. 3471-3481
-
-
Thorne, R.G.1
Hrabetova, S.2
Nicholson, C.3
-
185
-
-
46149090133
-
In vivo diffusion of lactoferrin in brain extracellular space is regulated by interactions with heparan sulfate
-
Thorne RG, Lakkaraju A, Rodriguez-Boulan E, Nicholson C (2008) In vivo diffusion of lactoferrin in brain extracellular space is regulated by interactions with heparan sulfate. Proc Natl Acad Sci U S A 105(24):8416–8421
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, Issue.24
, pp. 8416-8421
-
-
Thorne, R.G.1
Lakkaraju, A.2
Rodriguez-Boulan, E.3
Nicholson, C.4
-
186
-
-
33645791896
-
In vivo diffusion analysis with quantum dots and dextrans predicts the width of brain extracellular space
-
Thorne RG, Nicholson C (2006) In vivo diffusion analysis with quantum dots and dextrans predicts the width of brain extracellular space. Proc Natl Acad Sci U S A 103(14):5567–5572
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, Issue.14
, pp. 5567-5572
-
-
Thorne, R.G.1
Nicholson, C.2
-
187
-
-
0027290876
-
Restricted transport of cyclosporin A across the blood–brain barrier by a multidrug transporter, P-glycoprotein
-
Tsuji A, Tamai I, Sakata A, Tenda Y, Terasaki T (1993) Restricted transport of cyclosporin A across the blood–brain barrier by a multidrug transporter, P-glycoprotein. Biochem Pharmacol 46(6):1096–1099
-
(1993)
Biochem Pharmacol
, vol.46
, Issue.6
, pp. 1096-1099
-
-
Tsuji, A.1
Tamai, I.2
Sakata, A.3
Tenda, Y.4
Terasaki, T.5
-
188
-
-
0026760889
-
P-glycoprotein as the drug efflux pump in primary cultured bovine brain capillary endothelial cells
-
Tsuji A, Terasaki T, Takabatake Y, Tenda Y, Tamai I, Yamashima T, Moritani S, Tsuruo T, Yamashita J (1992) P-glycoprotein as the drug efflux pump in primary cultured bovine brain capillary endothelial cells. Life Sci 51(18):1427–1437
-
(1992)
Life Sci
, vol.51
, Issue.18
, pp. 1427-1437
-
-
Tsuji, A.1
Terasaki, T.2
Takabatake, Y.3
Tenda, Y.4
Tamai, I.5
Yamashima, T.6
Moritani, S.7
Tsuruo, T.8
Yamashita, J.9
-
189
-
-
80054792485
-
Blood–brain barrier (BBB) pharmacoproteomics: Reconstruction of in vivo brain distribution of 11 P-glycoprotein substrates based on the BBB transporter protein concentration, in vitro intrinsic transport activity, and unbound fraction in plasma and brain in mice
-
Uchida Y, Ohtsuki S, Kamiie J, Terasaki T (2011a) Blood–brain barrier (BBB) pharmacoproteomics: reconstruction of in vivo brain distribution of 11 P-glycoprotein substrates based on the BBB transporter protein concentration, in vitro intrinsic transport activity, and unbound fraction in plasma and brain in mice. J Pharmacol Exp Ther 339(2):579–588
-
(2011)
J Pharmacol Exp Ther
, vol.339
, Issue.2
, pp. 579-588
-
-
Uchida, Y.1
Ohtsuki, S.2
Kamiie, J.3
Terasaki, T.4
-
190
-
-
79953686193
-
Quantitative targeted absolute proteomics of human blood–brain barrier transporters and receptors
-
Uchida Y, Ohtsuki S, Katsukura Y, Ikeda C, Suzuki T, Kamiie J, Terasaki T (2011b) Quantitative targeted absolute proteomics of human blood–brain barrier transporters and receptors. J Neurochem 117(2):333–345
-
(2011)
J Neurochem
, vol.117
, Issue.2
, pp. 333-345
-
-
Uchida, Y.1
Ohtsuki, S.2
Katsukura, Y.3
Ikeda, C.4
Suzuki, T.5
Kamiie, J.6
Terasaki, T.7
-
191
-
-
67650133971
-
Validation of bioanalytical LC-MS/MS assays: Evaluation of matrix effects
-
Van Eeckhaut A, Lanckmans K, Sarre S, Smolders I, Michotte Y (2009) Validation of bioanalytical LC-MS/MS assays: evaluation of matrix effects. J Chromatogr B Analyt Technol Biomed Life Sci 877(23):2198–2207
-
(2009)
J Chromatogr B Analyt Technol Biomed Life Sci
, vol.877
, Issue.23
, pp. 2198-2207
-
-
Van Eeckhaut, A.1
Lanckmans, K.2
Sarre, S.3
Smolders, I.4
Michotte, Y.5
-
192
-
-
79955007487
-
Development and validation of a higher-throughput equilibrium dialysis assay for plasma protein binding
-
van Liempd S, Morrison D, Sysmans L, Nelis P, Mortishire-Smith R (2011) Development and validation of a higher-throughput equilibrium dialysis assay for plasma protein binding. J Lab Autom 16(1):56–67
-
(2011)
J Lab Autom
, vol.16
, Issue.1
, pp. 56-67
-
-
Van Liempd, S.1
Morrison, D.2
Sysmans, L.3
Nelis, P.4
Mortishire-Smith, R.5
-
193
-
-
0019350991
-
Binding of drugs in serum, blood cells and tissues of rabbits with experimental acute renal failure
-
Van Peer AP, Belpaire FM, Bogaert MG (1981) Binding of drugs in serum, blood cells and tissues of rabbits with experimental acute renal failure. Pharmacology 22(2):146–152
-
(1981)
Pharmacology
, vol.22
, Issue.2
, pp. 146-152
-
-
Van Peer, A.P.1
Belpaire, F.M.2
Bogaert, M.G.3
-
194
-
-
84862869593
-
Clozapine, atypical antipsychotics, and the benefits of fast-off D(2) dopamine receptor antagonism
-
Vauquelin G, Bostoen S, Vanderheyden P, Seeman P (2012) Clozapine, atypical antipsychotics, and the benefits of fast-off D(2) dopamine receptor antagonism. Naunyn Schmiedebergs Arch Pharmacol 385(4):337–372
-
(2012)
Naunyn Schmiedebergs Arch Pharmacol
, vol.385
, Issue.4
, pp. 337-372
-
-
Vauquelin, G.1
Bostoen, S.2
Vanderheyden, P.3
Seeman, P.4
-
195
-
-
69249210978
-
Ligands, their receptors and … plasma membranes
-
Vauquelin G, Packeu A (2009) Ligands, their receptors and … plasma membranes. Mol Cell Endocrinol 311(1–2):1–10
-
(2009)
Mol Cell Endocrinol
, vol.311
, Issue.1-2
, pp. 1-10
-
-
Vauquelin, G.1
Packeu, A.2
-
196
-
-
13444261019
-
G protein-coupled receptors: A count of 1001 conformations
-
Vauquelin G, Van Liefde I (2005) G protein-coupled receptors: a count of 1001 conformations. Fundam Clin Pharmacol 19(1):45–56
-
(2005)
Fundam Clin Pharmacol
, vol.19
, Issue.1
, pp. 45-56
-
-
Vauquelin, G.1
Van Liefde, I.2
-
197
-
-
77955933364
-
Drug-protein binding: A critical review of analytical tools
-
Vuignier K, Schappler J, Veuthey JL, Carrupt PA, Martel S (2010) Drug-protein binding: a critical review of analytical tools. Anal Bioanal Chem 398(1):53–66
-
(2010)
Anal Bioanal Chem
, vol.398
, Issue.1
, pp. 53-66
-
-
Vuignier, K.1
Schappler, J.2
Veuthey, J.L.3
Carrupt, P.A.4
Martel, S.5
-
198
-
-
84860001254
-
Strategies to minimize CNS toxicity: In vitro high-throughput assays and computational modeling
-
Wager TT, Liras JL, Mente S, Trapa P (2012) Strategies to minimize CNS toxicity: in vitro high-throughput assays and computational modeling. Expert Opin Drug Metab Toxicol 8(5): 531–542
-
(2012)
Expert Opin Drug Metab Toxicol
, vol.8
, Issue.5
, pp. 531-542
-
-
Wager, T.T.1
Liras, J.L.2
Mente, S.3
Trapa, P.4
-
199
-
-
64349123113
-
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs
-
Wan H, Ahman M, Holmen AG (2009) Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs. J Med Chem 52(6):1693–1700
-
(2009)
J Med Chem
, vol.52
, Issue.6
, pp. 1693-1700
-
-
Wan, H.1
Ahman, M.2
Holmen, A.G.3
-
200
-
-
34648813134
-
High-throughput screening of drug-brain tissue binding and in silico prediction for assessment of central nervous system drug delivery
-
Wan H, Rehngren M, Giordanetto F, Bergstrom F, Tunek A (2007) High-throughput screening of drug-brain tissue binding and in silico prediction for assessment of central nervous system drug delivery. J Med Chem 50(19):4606–4615
-
(2007)
J Med Chem
, vol.50
, Issue.19
, pp. 4606-4615
-
-
Wan, H.1
Rehngren, M.2
Giordanetto, F.3
Bergstrom, F.4
Tunek, A.5
-
201
-
-
0029876793
-
The simultaneous estimation of the influx and efflux blood–brain barrier permeabilities of gabapentin using a microdialysis-pharmacokinetic approach
-
Wang Y, Welty DF (1996) The simultaneous estimation of the influx and efflux blood–brain barrier permeabilities of gabapentin using a microdialysis-pharmacokinetic approach. Pharm Res 13(3):398–403
-
(1996)
Pharm Res
, vol.13
, Issue.3
, pp. 398-403
-
-
Wang, Y.1
Welty, D.F.2
-
202
-
-
77953397089
-
Receptor-mediated therapeutic transport across the blood–brain barrier
-
Wang YY, Lui PC, Li JY (2009) Receptor-mediated therapeutic transport across the blood–brain barrier. Immunotherapy 1(6):983–993
-
(2009)
Immunotherapy
, vol.1
, Issue.6
, pp. 983-993
-
-
Wang, Y.Y.1
Lui, P.C.2
Li, J.Y.3
-
203
-
-
63849337048
-
Receptor occupancy and brain free fraction
-
Watson J, Wright S, Lucas A, Clarke KL, Viggers J, Cheetham S, Jeffrey P, Porter R, Read KD (2009) Receptor occupancy and brain free fraction. Drug Metab Dispos 37(4):753–760
-
(2009)
Drug Metab Dispos
, vol.37
, Issue.4
, pp. 753-760
-
-
Watson, J.1
Wright, S.2
Lucas, A.3
Clarke, K.L.4
Viggers, J.5
Cheetham, S.6
Jeffrey, P.7
Porter, R.8
Read, K.D.9
-
204
-
-
78650401399
-
Exploring neurotherapeutic space: How many neurological drugs exist (Or could exist)?
-
Weaver DF, Weaver CA (2011) Exploring neurotherapeutic space: how many neurological drugs exist (or could exist)? J Pharm Pharmacol 63(1):136–139
-
(2011)
J Pharm Pharmacol
, vol.63
, Issue.1
, pp. 136-139
-
-
Weaver, D.F.1
Weaver, C.A.2
-
205
-
-
0032705581
-
Optimized protocol for biolistic transfection of brain slices and dissociated cultured neurons with a hand-held gene gun
-
Wellmann H, Kaltschmidt B, Kaltschmidt C (1999) Optimized protocol for biolistic transfection of brain slices and dissociated cultured neurons with a hand-held gene gun. J Neurosci Methods 92(1–2):55–64
-
(1999)
J Neurosci Methods
, vol.92
, Issue.1-2
, pp. 55-64
-
-
Wellmann, H.1
Kaltschmidt, B.2
Kaltschmidt, C.3
-
206
-
-
79960159776
-
Preclinical prediction of human brain target site concentrations: Considerations in extrapolating to the clinical setting
-
Westerhout J, Danhof M, De Lange EC (2011) Preclinical prediction of human brain target site concentrations: considerations in extrapolating to the clinical setting. J Pharm Sci 100(9): 3577–3593
-
(2011)
J Pharm Sci
, vol.100
, Issue.9
, pp. 3577-3593
-
-
Westerhout, J.1
Danhof, M.2
De Lange, E.C.3
-
207
-
-
84862768064
-
Physiologically based pharmacokinetic modeling to investigate regional brain distribution kinetics in rats
-
Westerhout J, Ploeger B, Smeets J, Danhof M, de Lange EC (2012) Physiologically based pharmacokinetic modeling to investigate regional brain distribution kinetics in rats. AAPS J 14(3):543–553
-
(2012)
AAPS J
, vol.14
, Issue.3
, pp. 543-553
-
-
Westerhout, J.1
Ploeger, B.2
Smeets, J.3
Danhof, M.4
De Lange, E.C.5
-
208
-
-
84877292573
-
Diffusion of macromolecules in the brain: Implications for drug delivery
-
Wolak D, Thorne R (2013) Diffusion of macromolecules in the brain: implications for drug delivery. Mol Pharm 10(5):1492–504
-
(2013)
Mol Pharm
, vol.10
, Issue.5
, pp. 1492-1504
-
-
Wolak, D.1
Thorne, R.2
-
209
-
-
0036227660
-
Influence of lipophilicity and lysosomal accumulation on tissue distribution kinetics of basic drugs: A physiologically based pharmacokinetic model
-
Yokogawa K, Ishizaki J, Ohkuma S, Miyamoto K (2002) Influence of lipophilicity and lysosomal accumulation on tissue distribution kinetics of basic drugs: a physiologically based pharmacokinetic model. Methods Find Exp Clin Pharmacol 24(2):81–93
-
(2002)
Methods Find Exp Clin Pharmacol
, vol.24
, Issue.2
, pp. 81-93
-
-
Yokogawa, K.1
Ishizaki, J.2
Ohkuma, S.3
Miyamoto, K.4
-
210
-
-
0023902147
-
Development of a new physicochemical model for brain penetration and its application to the design of centrally acting H2 receptor histamine antagonists
-
Young RC, Mitchell RC, Brown TH, Ganellin CR, Griffiths R, Jones M, Rana KK, Saunders D, Smith IR, Sore NE et al (1988) Development of a new physicochemical model for brain penetration and its application to the design of centrally acting H2 receptor histamine antagonists. J Med Chem 31(3):656–671
-
(1988)
J Med Chem
, vol.31
, Issue.3
, pp. 656-671
-
-
Young, R.C.1
Mitchell, R.C.2
Brown, T.H.3
Ganellin, C.R.4
Griffiths, R.5
Jones, M.6
Rana, K.K.7
Saunders, D.8
Smith, I.R.9
Sore, N.E.10
-
211
-
-
67349191878
-
Assessment of blood–brain barrier permeability using the in situ mouse brain perfusion technique
-
Zhao R, Kalvass JC, Pollack GM (2009) Assessment of blood–brain barrier permeability using the in situ mouse brain perfusion technique. Pharm Res 26(7):1657–1664
-
(2009)
Pharm Res
, vol.26
, Issue.7
, pp. 1657-1664
-
-
Zhao, R.1
Kalvass, J.C.2
Pollack, G.M.3
|