Influence of lipophilicity and lysosomal accumulation on tissue distribution kinetics of basic drugs: A physiologically based pharmacokinetic model

Methods and Findings in Experimental and Clinical Pharmacology

Volumn 24, Issue 2, 2002, Pages 81-93

  Yokogawa, K ^a   Ishizaki, J ^a   Ohkuma, S ^a   Miyamoto, Ken Ichi ^a  

^a KANAZAWA UNIVERSITY   (Japan)

Author keywords

Basic drug; Disposition kinetics; Distribution; Lipophilicity; Lysosome

Indexed keywords

BIPERIDEN; CHLORPROMAZINE; IMIPRAMINE; OCTANOL;

CELL AGGREGATION; CELLULAR DISTRIBUTION; DRUG BINDING; DRUG DISPOSITION; DRUG DISTRIBUTION; LIPOPHILICITY; LYSOSOME; LYSOSOME MEMBRANE; MITOCHONDRION; PH; REVIEW; TISSUE LEVEL;

ANIMALS; BIPERIDEN; DOGS; LIPIDS; LYSOSOMES; MODELS, BIOLOGICAL; PHARMACEUTICAL PREPARATIONS; PHARMACOKINETICS; RABBITS; RATS; SOLUBILITY; TISSUE DISTRIBUTION;

EID: 0036227660     PISSN: 03790355     EISSN: None     Source Type: Journal    
DOI: 10.1358/mf.2002.24.2.677131     Document Type: Review

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