In vitro methods for estimating unbound drug concentrations in the brain interstitial and intracellular fluids

Drug Metabolism and Disposition

Volumn 35, Issue 9, 2007, Pages 1711-1719

  Fridén, Markus ^a,b   Gupta, Anubha ^a   Antonsson, Madeleine ^b   Bredberg, Ulf ^b   Hammarlund Udenaes, Margareta ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b ASTRAZENECA R AND D   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

3 (2 METHOXY 5 TRIFLUOROMETHOXYBENZYLAMINO) 2 PHENYLPIPERIDINE; 3' FLUOROTHYMIDINE; APOMORPHINE; CETIRIZINE; CODEINE; DIAZEPAM; GABAPENTIN; MORPHINE; NORFLOXACIN; OXYCODONE; THIOPENTAL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN HOMOGENATE; BRAIN SLICE; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG BRAIN LEVEL; DRUG DETERMINATION; DRUG DISTRIBUTION; DRUG POTENCY; DRUG UPTAKE; FEMALE; GUINEA PIG; IN VITRO STUDY; INTERSTITIAL FLUID; INTRACELLULAR FLUID; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; VALIDATION STUDY;

ALGORITHMS; ANIMALS; BRAIN; CHEMISTRY, PHYSICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; EXTRACELLULAR FLUID; FEMALE; INTRACELLULAR FLUID; MALE; MICRODIALYSIS; PHARMACEUTICAL PREPARATIONS; PIPERIDINES; RATS; RATS, SPRAGUE-DAWLEY; SPECTROPHOTOMETRY, ULTRAVIOLET; TANDEM MASS SPECTROMETRY;

EID: 34548071206     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.107.015222     Document Type: Article

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