Impact of recovery on fraction unbound using equilibrium dialysis

Journal of Pharmaceutical Sciences

Volumn 101, Issue 3, 2012, Pages 1327-1335

  Di, Li ^a   Umland, John P ^a   Trapa, Patrick E ^a   Maurer, Tristan S ^a  

^a PFIZER INC   (United States)

Author keywords

ADME; Brain homogenate binding; Equilibrium dialysis; Nonspecific binding; Plasma protein binding; Recovery; Simulation; Stability

Indexed keywords

ANIMAL TISSUE; ARTICLE; BRAIN HOMOGENATE; CONCENTRATION (PARAMETERS); EQUILIBRIUM DIALYSIS; HUMAN; HUMAN TISSUE; INCUBATION TIME; LIPOPHILICITY; MATHEMATICAL ANALYSIS; NONHUMAN; PLASMA PROTEIN BINDING; PROTEIN STABILITY; RAT; SAMPLING; SOLUBILITY;

EID: 84855884254     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.23013     Document Type: Article

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