-
1
-
-
0025114459
-
Central nervous system toxicity of quinolones: Human and animal findings
-
W. Christ: Central nervous system toxicity of quinolones: human and animal findings. J. Antimicrob. Chemother. 26 (Suppl. B), 219-225 (1990).
-
(1990)
J. Antimicrob. Chemother.
, vol.26
, Issue.SUPPL. B
, pp. 219-225
-
-
Christ, W.1
-
3
-
-
0024444018
-
Structure-epileptogenicity relationship of quinolones with special reference to their interaction with γ-aminobutyric acid receptor sites
-
K. Akahane, M. Sekiguchi, T. Une, and Y. Osada: Structure-epileptogenicity relationship of quinolones with special reference to their interaction with γ-aminobutyric acid receptor sites. Antimicrob. Agents Chemother. 33, 1704-1708 (1989).
-
(1989)
Antimicrob. Agents Chemother.
, vol.33
, pp. 1704-1708
-
-
Akahane, K.1
Sekiguchi, M.2
Une, T.3
Osada, Y.4
-
5
-
-
0024273132
-
Structure-tissue distribution relationship based on physiological pharmacokinetics for NY-198, a new antimicrobial agent, and the related pyridonecarboxylic acids
-
E. Okezaki, T. Terasaki, M. Nakamura, O. Nagata, H. Kato, and A. Tsuji: Structure-tissue distribution relationship based on physiological pharmacokinetics for NY-198, a new antimicrobial agent, and the related pyridonecarboxylic acids. Drug Metab. Dispos. 16, 865-874 (1988).
-
(1988)
Drug Metab. Dispos.
, vol.16
, pp. 865-874
-
-
Okezaki, E.1
Terasaki, T.2
Nakamura, M.3
Nagata, O.4
Kato, H.5
Tsuji, A.6
-
6
-
-
0026042053
-
Enhanced entry of ciprofloxacin into the rat central nervous system induced by fenbufen
-
K. Naora, Y. Katagiri, N. Ichikawa, M. Hayashibara, and K. Iwamoto: Enhanced entry of ciprofloxacin into the rat central nervous system induced by fenbufen. J. Pharmacol. Exp. Ther. 258, 1033-1037 (1991).
-
(1991)
J. Pharmacol. Exp. Ther.
, vol.258
, pp. 1033-1037
-
-
Naora, K.1
Katagiri, Y.2
Ichikawa, N.3
Hayashibara, M.4
Iwamoto, K.5
-
7
-
-
0026459756
-
Effect of fenbufen on the entry of new quinolones, norfloxacin and ofloxacin, into the central nervous system in rats
-
N. Ichikawa, K. Naora, M. Hayashibara, Y. Katagiri, and K. Iwamoto: Effect of fenbufen on the entry of new quinolones, norfloxacin and ofloxacin, into the central nervous system in rats. J. Pharm. Pharmacol. 44, 915-920 (1992).
-
(1992)
J. Pharm. Pharmacol.
, vol.44
, pp. 915-920
-
-
Ichikawa, N.1
Naora, K.2
Hayashibara, M.3
Katagiri, Y.4
Iwamoto, K.5
-
8
-
-
0023773226
-
Entry of the new quinolone antibacterial agents of ofloxacin and NY-198 into the central nervous system in rats
-
H. Sato, E. Okezaki, S. Yamamoto, O. Nagata, H. Kato, and A. Tsuji: Entry of the new quinolone antibacterial agents of ofloxacin and NY-198 into the central nervous system in rats. J. Pharmacobio-Dyn. 11, 386-394 (1988).
-
(1988)
J. Pharmacobio-Dyn.
, vol.11
, pp. 386-394
-
-
Sato, H.1
Okezaki, E.2
Yamamoto, S.3
Nagata, O.4
Kato, H.5
Tsuji, A.6
-
9
-
-
0028135126
-
Prediction of brain delivery of ofloxacin, a new quinolone, in the human from animal data
-
J. Kawakami, K. Yamamoto, Y. Sawada, and T. Iga: Prediction of brain delivery of ofloxacin, a new quinolone, in the human from animal data. J. Pharmacokinet. Biopharm. 22, 207-227 (1994).
-
(1994)
J. Pharmacokinet. Biopharm.
, vol.22
, pp. 207-227
-
-
Kawakami, J.1
Yamamoto, K.2
Sawada, Y.3
Iga, T.4
-
10
-
-
0021020420
-
Brain metabolism: A perspective from the blood-brain barrier
-
W. M. Pardridge: Brain metabolism: a perspective from the blood-brain barrier. Physiol. Rev. 63, 1481-1535 (1983).
-
(1983)
Physiol. Rev.
, vol.63
, pp. 1481-1535
-
-
Pardridge, W.M.1
-
11
-
-
0026525408
-
Determination of in vivo steady-state unbound drug concentration in the brain interstitial fluid by microdialysis
-
T. Terasaki, Y. Deguchi, Y. Kasama, W. M. Pardridge, and A. Tsuji: Determination of in vivo steady-state unbound drug concentration in the brain interstitial fluid by microdialysis. Int. J. Pharmaceut. 81, 143-152 (1992).
-
(1992)
Int. J. Pharmaceut.
, vol.81
, pp. 143-152
-
-
Terasaki, T.1
Deguchi, Y.2
Kasama, Y.3
Pardridge, W.M.4
Tsuji, A.5
-
12
-
-
0002966531
-
Measurements of neurotransmitter release by intracranial dialysis
-
C. A. Marsden, ed. Wiley, New York
-
U. Ungerstedt: Measurements of neurotransmitter release by intracranial dialysis. In "Measurement of Neurotransmitter Release In Vivo" (C. A. Marsden, ed.), pp. 81-105. Wiley, New York, 1984.
-
(1984)
Measurement of Neurotransmitter Release in Vivo
, pp. 81-105
-
-
Ungerstedt, U.1
-
13
-
-
0026002719
-
Muscle microdialysis as a model study to relate the drug concentration in tissue interstitial fluid and dialysate
-
Y. Deguchi, T. Terasaki, S. Kawasaki, and A. Tsuji: Muscle microdialysis as a model study to relate the drug concentration in tissue interstitial fluid and dialysate. J. Pharmacobio-Dyn. 14, 483-492 (1991).
-
(1991)
J. Pharmacobio-Dyn.
, vol.14
, pp. 483-492
-
-
Deguchi, Y.1
Terasaki, T.2
Kawasaki, S.3
Tsuji, A.4
-
14
-
-
0030425696
-
Comparative distribution of quinolone antibiotics in cerebrospinal fluid and brain in rats and dogs
-
T. Ooie, H. Suzuki, T. Terasaki, and Y. Sugiyama: Comparative distribution of quinolone antibiotics in cerebrospinal fluid and brain in rats and dogs. J. Pharmacol. Exp. Ther. 278, 590-596 (1996).
-
(1996)
J. Pharmacol. Exp. Ther.
, vol.278
, pp. 590-596
-
-
Ooie, T.1
Suzuki, H.2
Terasaki, T.3
Sugiyama, Y.4
-
15
-
-
0026341402
-
Facilitated transport of cefodizime into the rat central nervous system
-
H. Matsushita, H. Suzuki, Y. Sugiyama, Y. Sawada, T. Iga, Y. Kawaguchi, and M. Hanano: Facilitated transport of cefodizime into the rat central nervous system. J. Pharmacol. Exp. Ther. 259, 620-625 (1991).
-
(1991)
J. Pharmacol. Exp. Ther.
, vol.259
, pp. 620-625
-
-
Matsushita, H.1
Suzuki, H.2
Sugiyama, Y.3
Sawada, Y.4
Iga, T.5
Kawaguchi, Y.6
Hanano, M.7
-
17
-
-
0023804204
-
Clinical pharmacokinetics and tolerance of fleroxacin in healthy male volunteers
-
M. Nakashima, M. Kanamaru, T. Uematsu, A. Takiguchi, A. Mizuno, T. Itaya, F. Kawahara, T. Ooie, S. Saito, H. Uchida, and K. Masuzawa: Clinical pharmacokinetics and tolerance of fleroxacin in healthy male volunteers. J. Antimicrob. Chemother. 22 (Suppl. D), 133-144 (1988).
-
(1988)
J. Antimicrob. Chemother.
, vol.22
, Issue.SUPPL. D
, pp. 133-144
-
-
Nakashima, M.1
Kanamaru, M.2
Uematsu, T.3
Takiguchi, A.4
Mizuno, A.5
Itaya, T.6
Kawahara, F.7
Ooie, T.8
Saito, S.9
Uchida, H.10
Masuzawa, K.11
-
18
-
-
0025836586
-
Selective transport of antitransferrin receptor antibody through the blood-brain barrier in vivo
-
W. M. Pardridge, J. L. Buciak, and P. M. Friden: Selective transport of antitransferrin receptor antibody through the blood-brain barrier in vivo. J. Pharmacol. Exp. Ther. 259, 66-70 (1991).
-
(1991)
J. Pharmacol. Exp. Ther.
, vol.259
, pp. 66-70
-
-
Pardridge, W.M.1
Buciak, J.L.2
Friden, P.M.3
-
19
-
-
0026978845
-
Cerebrospinal fluid transport and disposition of the quinolones ciprofloxacin and pefloxacin in rats
-
U. Jaehde, M. W. E. Langemeijer, A. G. de Boer, and D. D. Breimer: Cerebrospinal fluid transport and disposition of the quinolones ciprofloxacin and pefloxacin in rats. J. Pharmacol. Exp. Ther. 263, 1140-1146 (1992).
-
(1992)
J. Pharmacol. Exp. Ther.
, vol.263
, pp. 1140-1146
-
-
Jaehde, U.1
Langemeijer, M.W.E.2
De Boer, A.G.3
Breimer, D.D.4
-
20
-
-
0027373329
-
Bisubstrates: Substances that interact with both, renal contraluminal organic anion and organic cation transport systems. II. Zwitterionic substrates: dipeptides. cephalosporins, quinolone-carboxylate gyrase inhibitors and phosphamide thiazine carboxylates; nonionizable substrates: steroid hormones and cyclophosphamides
-
K. J. Ullrich, G. Rumrich. C. David, and G. Fritzsch: Bisubstrates: substances that interact with both, renal contraluminal organic anion and organic cation transport systems. II. Zwitterionic substrates: dipeptides. cephalosporins, quinolone-carboxylate gyrase inhibitors and phosphamide thiazine carboxylates; nonionizable substrates: steroid hormones and cyclophosphamides. Eur. J. Physiol. 425, 300-312 (1993).
-
(1993)
Eur. J. Physiol.
, vol.425
, pp. 300-312
-
-
Ullrich, K.J.1
Rumrich, G.2
David, C.3
Fritzsch, G.4
-
21
-
-
0025672578
-
Interaction of ofloxacin with organic cation transport system in rat renal brush-border membranes
-
T. Okano, H. Maegawa, K. Inui, and R. Hori: Interaction of ofloxacin with organic cation transport system in rat renal brush-border membranes. J. Pharmacol. Exp. Ther. 255, 1033-1037 (1990).
-
(1990)
J. Pharmacol. Exp. Ther.
, vol.255
, pp. 1033-1037
-
-
Okano, T.1
Maegawa, H.2
Inui, K.3
Hori, R.4
-
22
-
-
0025986785
-
Transport of the new quinolone antibacterial agents of lomefloxacin and ofloxacin by rat erythrocytes, and its relation to the nicotinic acid transport system
-
M. T. Simanjuntak, H. Sato, I. Tamai, T. Terasaki, and A. Tsuji: Transport of the new quinolone antibacterial agents of lomefloxacin and ofloxacin by rat erythrocytes, and its relation to the nicotinic acid transport system. J. Pharmacobio-Dyn. 14, 475-481 (1991).
-
(1991)
J. Pharmacobio-Dyn.
, vol.14
, pp. 475-481
-
-
Simanjuntak, M.T.1
Sato, H.2
Tamai, I.3
Terasaki, T.4
Tsuji, A.5
-
23
-
-
0026760889
-
P-glycoprotein as the drug efflux pump in primary cultured bovine brain capillary endothelial cells
-
A. Tsuji, T. Terasaki, Y. Takabatake, Y. Tenda, I. Tamai, T. Yamashima, S. Moritani, T. Tsuruo, and J. Yamashita: P-glycoprotein as the drug efflux pump in primary cultured bovine brain capillary endothelial cells. Life Sci. 51, 1427-1437 (1992).
-
(1992)
Life Sci.
, vol.51
, pp. 1427-1437
-
-
Tsuji, A.1
Terasaki, T.2
Takabatake, Y.3
Tenda, Y.4
Tamai, I.5
Yamashima, T.6
Moritani, S.7
Tsuruo, T.8
Yamashita, J.9
-
24
-
-
0026669192
-
Functional involvement of P-glycoprotein in blood-brain barrier
-
T. Tatsuta, M. Naito, T. Oh-hara, I. Sugawara, and T. Tsuruo: Functional involvement of P-glycoprotein in blood-brain barrier. J. Biol. Chem. 267, 20383-20391 (1992).
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 20383-20391
-
-
Tatsuta, T.1
Naito, M.2
Oh-hara, T.3
Sugawara, I.4
Tsuruo, T.5
-
25
-
-
0027290876
-
Restricted transport of cyclosporin A across the blood-brain barrier by a multidrug transporter, P-glycoprotein
-
A. Tsuji, I. Tamai, A. Sakata, Y. Tenda, and T. Terasaki: Restricted transport of cyclosporin A across the blood-brain barrier by a multidrug transporter, P-glycoprotein. Biochem. Pharmacol. 46, 1096-1099 (1993).
-
(1993)
Biochem. Pharmacol.
, vol.46
, pp. 1096-1099
-
-
Tsuji, A.1
Tamai, I.2
Sakata, A.3
Tenda, Y.4
Terasaki, T.5
-
26
-
-
0028229150
-
Disruption of the mouse mdrla P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs
-
A. H. Schinkel, J. J. M. Smit, O. van Tellingen, J. H. Beijnen, E. Wagenaar, L. van Deemter, C. A. A. M. Mol, M. A. van der Valk, E. C. Robanus-Maandag, H. P. J. te Riele, A. J. M. Berns, and P. Borst: Disruption of the mouse mdrla P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs. Cell 77, 491-502 (1994).
-
(1994)
Cell
, vol.77
, pp. 491-502
-
-
Schinkel, A.H.1
Smit, J.J.M.2
Van Tellingen, O.3
Beijnen, J.H.4
Wagenaar, E.5
Van Deemter, L.6
Mol, C.A.A.M.7
Van Der Valk, M.A.8
Robanus-Maandag, E.C.9
Te Riele, H.P.J.10
Berns, A.J.M.11
Borst, P.12
-
27
-
-
0027768971
-
Microdialysis study of zidovudine (AZT) transport in rat brain
-
K. H. Dykstra, A. Arya, D. M. Arriola, P. M. Bungay, P. F. Morrison, and R. L. Dedrick: Microdialysis study of zidovudine (AZT) transport in rat brain. J. Pharmacol. Exp. Ther. 267, 1227-1236 (1993).
-
(1993)
J. Pharmacol. Exp. Ther.
, vol.267
, pp. 1227-1236
-
-
Dykstra, K.H.1
Arya, A.2
Arriola, D.M.3
Bungay, P.M.4
Morrison, P.F.5
Dedrick, R.L.6
-
28
-
-
0030977086
-
In vivo evidence for carrier-mediated efflux transport of 3′-azido-3′-deoxythymidine and 2',3'-dideoxyinosine across the blood-brain barrier via a probenecid-sensitive transport system
-
K. Takasawa, T. Terasaki, H. Suzuki, and Y. Sugiyama: In vivo evidence for carrier-mediated efflux transport of 3′-azido-3′-deoxythymidine and 2',3'-dideoxyinosine across the blood-brain barrier via a probenecid-sensitive transport system. J. Pharmacol. Exp. Ther. 281, 369-375 (1997).
-
(1997)
J. Pharmacol. Exp. Ther.
, vol.281
, pp. 369-375
-
-
Takasawa, K.1
Terasaki, T.2
Suzuki, H.3
Sugiyama, Y.4
-
29
-
-
0028299479
-
Contribution of probenecid-sensitive anion transport processes at the brain capillary endothelium and choroid plexus to the efficient efflux of valproic acid from the central nervous system
-
K. D. K. Adkison, A. A. Artru, K. M. Powers, and D. D. Shen: Contribution of probenecid-sensitive anion transport processes at the brain capillary endothelium and choroid plexus to the efficient efflux of valproic acid from the central nervous system. J. Pharmacol. Exp. Ther. 268, 797-805 (1994).
-
(1994)
J. Pharmacol. Exp. Ther.
, vol.268
, pp. 797-805
-
-
Adkison, K.D.K.1
Artru, A.A.2
Powers, K.M.3
Shen, D.D.4
-
30
-
-
85058206348
-
Role of efflux transport across the blood-brain barrier and blood-cerebrospinal fluid barrier on the disposition of xenobiotics in the central nervous system
-
in press
-
H. Suzuki, T. Terasaki, and Y. Sugiyama: Role of efflux transport across the blood-brain barrier and blood-cerebrospinal fluid barrier on the disposition of xenobiotics in the central nervous system. Adv. Drug Deliv. Rev. in press.
-
Adv. Drug Deliv. Rev.
-
-
Suzuki, H.1
Terasaki, T.2
Sugiyama, Y.3
-
31
-
-
0027729568
-
Blood-brain barrier transport rate of quinolone antibacterials evaluated in cerebrovascular endothelial cell cultures
-
U. Jaehde, T. Goto, A. G. de Boer, and D. D. Breimer: Blood-brain barrier transport rate of quinolone antibacterials evaluated in cerebrovascular endothelial cell cultures. Eur. J. Pharmaceut. Sci. 1, 49-55 (1993).
-
(1993)
Eur. J. Pharmaceut. Sci.
, vol.1
, pp. 49-55
-
-
Jaehde, U.1
Goto, T.2
De Boer, A.G.3
Breimer, D.D.4
-
32
-
-
0024497807
-
Stimulation of glucose analogue uptake by cerebral microvessel endothelial cells by a product released by astrocytes
-
K. Maxwell, J. A. Berliner, and P. A. Cancilla: Stimulation of glucose analogue uptake by cerebral microvessel endothelial cells by a product released by astrocytes. J. Neuropathol. Exp. Neurol. 48, 69-80 (1989).
-
(1989)
J. Neuropathol. Exp. Neurol.
, vol.48
, pp. 69-80
-
-
Maxwell, K.1
Berliner, J.A.2
Cancilla, P.A.3
-
33
-
-
0025329190
-
Comparison of in vitro and in vivo models of drug transcytosis through the blood-brain barrier
-
W. M. Pardridge, D. Triguero, J. Yang, and P. A. Cancilla: Comparison of in vitro and in vivo models of drug transcytosis through the blood-brain barrier. J. Pharmacol. Exp. Ther. 253, 884-891 (1990).
-
(1990)
J. Pharmacol. Exp. Ther.
, vol.253
, pp. 884-891
-
-
Pardridge, W.M.1
Triguero, D.2
Yang, J.3
Cancilla, P.A.4
-
34
-
-
0027244155
-
A survey on quantitative microdialysis: Theoretical models and practical implications
-
J. Kehr: A survey on quantitative microdialysis: theoretical models and practical implications. J. Neurosci. Methods 48, 251-261 (1993).
-
(1993)
J. Neurosci. Methods
, vol.48
, pp. 251-261
-
-
Kehr, J.1
-
35
-
-
0026566537
-
In vivo calibration of microdialysis probes for exogenous compounds
-
S. Menacherry, W. Hubert, and J. B. Justice Jr.: In vivo calibration of microdialysis probes for exogenous compounds. Anal. Chem. 64, 577-583, (1992).
-
(1992)
Anal. Chem.
, vol.64
, pp. 577-583
-
-
Menacherry, S.1
Hubert, W.2
Justice Jr., J.B.3
-
36
-
-
0022404730
-
Mass transfer in brain dialysis devices - A new method for the estimation of extracellular amino acids concentration
-
I. Jacobson, M. Sandberg, and A. Hamberger: Mass transfer in brain dialysis devices - a new method for the estimation of extracellular amino acids concentration. J. Neurosci. Methods 15, 263-268 (1985).
-
(1985)
J. Neurosci. Methods
, vol.15
, pp. 263-268
-
-
Jacobson, I.1
Sandberg, M.2
Hamberger, A.3
-
37
-
-
0024597804
-
Microdialysis of intercellular adenosine concentration in subcutaneous tissue in humans
-
P. Lonnroth, P. A. Jansson, B. B. Fredholm, and U. Smith: Microdialysis of intercellular adenosine concentration in subcutaneous tissue in humans. Am. J. Physiol. 256, E250-E255 (1989).
-
(1989)
Am. J. Physiol.
, vol.256
-
-
Lonnroth, P.1
Jansson, P.A.2
Fredholm, B.B.3
Smith, U.4
-
38
-
-
0024343821
-
Intracerebral microdialysis. I. Experimental studies of diffusion kinetics
-
N. Lindefors, G. Amberg, and U. Ungerstedt: Intracerebral microdialysis. I. Experimental studies of diffusion kinetics. J. Pharmacol. Methods 22, 141-156 (1989).
-
(1989)
J. Pharmacol. Methods
, vol.22
, pp. 141-156
-
-
Lindefors, N.1
Amberg, G.2
Ungerstedt, U.3
-
39
-
-
0027507925
-
In vitro and in vivo microdialysis calibration for the measurement of carbamazepine and its metabolites in rat brain tissue using the internal reference technique
-
K. van Belle, T. Dzeka, S. Sarre, G. Ebinger, and Y. Michotte: In vitro and in vivo microdialysis calibration for the measurement of carbamazepine and its metabolites in rat brain tissue using the internal reference technique. J. Neurosci. Methods 49, 167-173 (1993).
-
(1993)
J. Neurosci. Methods
, vol.49
, pp. 167-173
-
-
Van Belle, K.1
Dzeka, T.2
Sarre, S.3
Ebinger, G.4
Michotte, Y.5
-
40
-
-
0025051997
-
Steady-state theory for quantitative microdialysis of solutes and water in vivo and in vitro
-
P. M. Bungay, P. F. Morrison, and R. L. Dedrick: Steady-state theory for quantitative microdialysis of solutes and water in vivo and in vitro. Life Sci. 46, 105-119 (1990).
-
(1990)
Life Sci.
, vol.46
, pp. 105-119
-
-
Bungay, P.M.1
Morrison, P.F.2
Dedrick, R.L.3
-
41
-
-
0020826160
-
Distributed model for drug delivery to CSF and brain tissue
-
J. M. Collins and R. L. Dedrick: Distributed model for drug delivery to CSF and brain tissue. Am. J. Physiol. 245, R303-R310 (1983).
-
(1983)
Am. J. Physiol.
, vol.245
-
-
Collins, J.M.1
Dedrick, R.L.2
-
42
-
-
0028010511
-
Kinetics of active efflux via choroid plexus of β-lactam antibiotics from the CSF into the circulation
-
M. Ogawa, H. Suzuki, Y. Sawada, M. Hanano, and Y. Sugiyama: Kinetics of active efflux via choroid plexus of β-lactam antibiotics from the CSF into the circulation. Am. J. Physiol. 266, R392-R399 (1994).
-
(1994)
Am. J. Physiol.
, vol.266
-
-
Ogawa, M.1
Suzuki, H.2
Sawada, Y.3
Hanano, M.4
Sugiyama, Y.5
|