Determination of the EC50 amnesic concentration of etomidate and its diffusion profile in brain tissue: Implications for in vitro studies

Anesthesiology

Volumn 106, Issue 1, 2007, Pages 114-123

  Benkwitz, Claudia ^a   Liao, Mark ^b   Laster, Michael J ^b   Sonner, James M ^b   Eger II, Edmond I ^b   Pearce, Robert A ^a,c  

^a UNIVERSITY OF WISCONSIN   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ETOMIDATE; ISOFLURANE;

AMNESIA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN SLICE; BRAIN TISSUE; CEREBROSPINAL FLUID; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; CONTROLLED STUDY; DIFFUSION; DRUG BRAIN LEVEL; DRUG DETERMINATION; DRUG MECHANISM; ELECTROPHYSIOLOGY; EQUILIBRIUM CONSTANT; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIPPOCAMPUS; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PARTITION COEFFICIENT; PRIORITY JOURNAL; SINGLE DRUG DOSE;

AMNESIA; ANESTHETICS, INTRAVENOUS; ANIMALS; BRAIN; DIFFUSION; DOSE-RESPONSE RELATIONSHIP, DRUG; ETOMIDATE; LEARNING; MICE; MICE, INBRED C57BL; MOTOR ACTIVITY;

EID: 33845942409     PISSN: 00033022     EISSN: 15281175     Source Type: Journal    
DOI: 10.1097/00000542-200701000-00020     Document Type: Article

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