Semi-automated protein binding methodology using equilibrium dialysis and a novel mixed-matrix cassette approach

Journal of Pharmaceutical Sciences

Volumn 99, Issue 12, 2010, Pages 5070-5078

  Plise, Emile G ^a   Tran, Daniel ^a   Salphati, Laurent ^a  

^a GENENTECH INC   (United States)

Author keywords

Albumin; Alpha 1 acid glycoprotein; Distribution; Equilibrium dialysis; High throughput technologies; Mass spectrometry; Mixed matrix; Pharmacokinetics; Protein binding; Robotics

Indexed keywords

AMITRIPTYLINE; AMPRENAVIR; CARBAMAZEPINE; DEXAMETHASONE; IMIPRAMINE; KETAMINE; OROSOMUCOID; PARACETAMOL; SERUM ALBUMIN; TERBUTALINE; TIMOLOL; TOLBUTAMIDE; TRIAMTERENE; TRIMETHOPRIM; WARFARIN;

ARTICLE; BINDING ASSAY; DILUTION; DRUG DETERMINATION; EQUILIBRIUM DIALYSIS; HUMAN; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METHODOLOGY; MOUSE; NONHUMAN; PLASMA PROTEIN BINDING; RAT; SEMI AUTOMATED MIXED MATRIX ASSAY; STANDARD; TRADITIONAL MIXED MATRIX ASSAY; ULTRAFILTRATION;

EID: 78049496543     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.22188     Document Type: Article

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