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Volumn 13, Issue 12, 2012, Pages 2328-2339

Targeted blood-to-brain drug delivery - 10 key development criteria

Author keywords

Blood brain barrier; Brain diseases; CNS; Drug targeting; Receptor mediated endocytosis; Transport transcytosis

Indexed keywords

DIPHTHERIA TOXIN; DIPHTHERIA TOXIN RECEPTOR; DOXORUBICIN; ETOPOSIDE; GLUTATHIONE; HYBRID PROTEIN; INSULIN RECEPTOR; LIPOPROTEIN RECEPTOR; LOPERAMIDE; METHOTREXATE; PACLITAXEL; TRANSFERRIN RECEPTOR; UNCLASSIFIED DRUG; ZIDOVUDINE;

EID: 84867717502     PISSN: 13892010     EISSN: 18734316     Source Type: Journal    
DOI: 10.2174/138920112803341815     Document Type: Review
Times cited : (22)

References (135)
  • 1
    • 0042899083 scopus 로고    scopus 로고
    • Blood-brain barrier drug targeting: The future of brain drug development
    • Pardridge, W.M. Blood-brain barrier drug targeting: the future of brain drug development. Mol. Interv., 2003, 3(2), 90-105.
    • (2003) Mol. Interv. , vol.3 , Issue.2 , pp. 90-105
    • Pardridge, W.M.1
  • 2
    • 33745263735 scopus 로고    scopus 로고
    • Endocytosis at the blood-brain barrier: From basic understanding to drug delivery strategies
    • Smith, M.W.; Gumbleton, M. Endocytosis at the blood-brain barrier: from basic understanding to drug delivery strategies. J. Drug Target, 2006, 14(4), 191-214.
    • (2006) J. Drug Target , vol.14 , Issue.4 , pp. 191-214
    • Smith, M.W.1    Gumbleton, M.2
  • 3
    • 0033391691 scopus 로고    scopus 로고
    • Blood-brain barrier biology and methodology
    • Pardridge, W.M. Blood-brain barrier biology and methodology. J. Neurovirol., 1999, 5(6), 556-569.
    • (1999) J. Neurovirol. , vol.5 , Issue.6 , pp. 556-569
    • Pardridge, W.M.1
  • 4
    • 17644364388 scopus 로고    scopus 로고
    • Dynamics of CNS barriers: Evolution, differentiation, and modulation
    • Abbott, N.J. Dynamics of CNS barriers: evolution, differentiation, and modulation. Cell Mol. Neurobiol., 2005, 25(1), 5-23.
    • (2005) Cell Mol. Neurobiol. , vol.25 , Issue.1 , pp. 5-23
    • Abbott, N.J.1
  • 5
    • 34347387938 scopus 로고    scopus 로고
    • Strategies to improve drug delivery across the blood-brain barrier
    • de Boer, A.G.; Gaillard, P.J. Strategies to improve drug delivery across the blood-brain barrier. Clin. Pharmacokinet., 2007, 46(7), 553-576.
    • (2007) Clin. Pharmacokinet. , vol.46 , Issue.7 , pp. 553-576
    • de Boer, A.G.1    Gaillard, P.J.2
  • 7
    • 12344273726 scopus 로고    scopus 로고
    • The blood-brain barrier: Bottleneck in brain drug development
    • Pardridge, W.M. The blood-brain barrier: bottleneck in brain drug development. NeuroRx, 2005, 2(1), 3-14.
    • (2005) NeuroRx , vol.2 , Issue.1 , pp. 3-14
    • Pardridge, W.M.1
  • 8
    • 67649133075 scopus 로고    scopus 로고
    • Novel drug delivery strategies in neuro-oncology
    • Bidros, D.S.; Vogelbaum, M.A. Novel drug delivery strategies in neuro-oncology. Neurotherapeutics, 2009, 6(3), 539-546.
    • (2009) Neurotherapeutics , vol.6 , Issue.3 , pp. 539-546
    • Bidros, D.S.1    Vogelbaum, M.A.2
  • 9
    • 70350151690 scopus 로고    scopus 로고
    • Convection-enhanced delivery for the treatment of brain tumors
    • Debinski, W.; Tatter, S.B. Convection-enhanced delivery for the treatment of brain tumors. Expert. Rev. Neurother., 2009, 9(10), 1519-1527.
    • (2009) Expert. Rev. Neurother. , vol.9 , Issue.10 , pp. 1519-1527
    • Debinski, W.1    Tatter, S.B.2
  • 10
    • 77649219162 scopus 로고    scopus 로고
    • Novel treatments and future perspectives: Outcomes of intrathecal drug delivery
    • Dickson, P.I. Novel treatments and future perspectives: outcomes of intrathecal drug delivery. Int. J. Clin. Pharmacol. Ther., 2009, 47 (Suppl 1), S124-127.
    • (2009) Int. J. Clin. Pharmacol. Ther. , vol.47 , Issue.SUPPL. 1
    • Dickson, P.I.1
  • 11
    • 34548770175 scopus 로고    scopus 로고
    • A novel opportunity for targeted drug delivery to the brain
    • Gaillard, P.J.; de Boer, A.G. A novel opportunity for targeted drug delivery to the brain. J. Control Release, 2006, 116(2), e60-62.
    • (2006) J. Control Release , vol.116 , Issue.2
    • Gaillard, P.J.1    de Boer, A.G.2
  • 12
    • 0037079071 scopus 로고    scopus 로고
    • Drug and gene delivery to the brain: The vascular route
    • Pardridge, W.M. Drug and gene delivery to the brain: the vascular route. Neuron, 2002, 36(4), 555-558.
    • (2002) Neuron , vol.36 , Issue.4 , pp. 555-558
    • Pardridge, W.M.1
  • 14
    • 51249091226 scopus 로고    scopus 로고
    • Recent advances in blood-brain barrier disruption as a CNS delivery strategy
    • Bellavance, M.A.; Blanchette, M.; Fortin, D. Recent advances in blood-brain barrier disruption as a CNS delivery strategy. AAPS. J., 2008, 10(1), 166-177.
    • (2008) AAPS.J. , vol.10 , Issue.1 , pp. 166-177
    • Bellavance, M.A.1    Blanchette, M.2    Fortin, D.3
  • 17
    • 34547633657 scopus 로고    scopus 로고
    • Brain drug development and brain drug targeting
    • Pardridge, W.M. Brain drug development and brain drug targeting. Pharm. Res., 2007, 24(9), 1729-1732.
    • (2007) Pharm. Res. , vol.24 , Issue.9 , pp. 1729-1732
    • Pardridge, W.M.1
  • 18
    • 34547637590 scopus 로고    scopus 로고
    • Drug targeting to the brain
    • Pardridge, W.M. Drug targeting to the brain. Pharm. Res., 2007, 24(9), 1733-1744.
    • (2007) Pharm. Res. , vol.24 , Issue.9 , pp. 1733-1744
    • Pardridge, W.M.1
  • 19
    • 70449529637 scopus 로고    scopus 로고
    • Approaches to transport therapeutic drugs across the blood-brain barrier to treat brain diseases
    • Gabathuler, R. Approaches to transport therapeutic drugs across the blood-brain barrier to treat brain diseases. Neurobiol. Dis., 2010, 37(1), 48-57.
    • (2010) Neurobiol. Dis. , vol.37 , Issue.1 , pp. 48-57
    • Gabathuler, R.1
  • 20
    • 34547642139 scopus 로고    scopus 로고
    • Blood-brain barrier transport of therapeutics via receptor-mediation
    • Jones, A.R.; Shusta, E.V. Blood-brain barrier transport of therapeutics via receptor-mediation. Pharm. Res., 2007, 24(9), 1759-1771.
    • (2007) Pharm. Res. , vol.24 , Issue.9 , pp. 1759-1771
    • Jones, A.R.1    Shusta, E.V.2
  • 21
    • 66149130750 scopus 로고    scopus 로고
    • Differential receptor-mediated drug targeting to the diseased brain
    • Rip, J.; Schenk, G.J.; de Boer, A.G. Differential receptor-mediated drug targeting to the diseased brain. Expert Opin. Drug Deliv., 2009, 6(3), 227-237.
    • (2009) Expert Opin. Drug Deliv. , vol.6 , Issue.3 , pp. 227-237
    • Rip, J.1    Schenk, G.J.2    de Boer, A.G.3
  • 22
    • 0035289779 scopus 로고    scopus 로고
    • Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
    • Lipinski, C.A.; Lombardo, F.; Dominy, B.W.; Feeney, P.J. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv. Drug Deliv. Rev., 2001, 46(1-3), 3-26.
    • (2001) Adv. Drug Deliv. Rev. , vol.46 , Issue.1-3 , pp. 3-26
    • Lipinski, C.A.1    Lombardo, F.2    Dominy, B.W.3    Feeney, P.J.4
  • 23
    • 0032936851 scopus 로고    scopus 로고
    • The cell biology of the blood-brain barrier
    • Rubin, L.L.; Staddon, J.M. The cell biology of the blood-brain barrier. Annu. Rev. Neurosci., 1999, 22, 11-28.
    • (1999) Annu. Rev. Neurosci. , vol.22 , pp. 11-28
    • Rubin, L.L.1    Staddon, J.M.2
  • 25
    • 0024390069 scopus 로고
    • Ultracytochemical characterization of anionic sites in the wall of brain capillaries
    • Vorbrodt, A.W. Ultracytochemical characterization of anionic sites in the wall of brain capillaries. J. Neurocytol., 1989, 18(3), 359-368.
    • (1989) J. Neurocytol. , vol.18 , Issue.3 , pp. 359-368
    • Vorbrodt, A.W.1
  • 26
    • 0030099527 scopus 로고    scopus 로고
    • Transporting therapeutics across the blood-brain barrier
    • Abbott, N.J.; Romero, I.A. Transporting therapeutics across the blood-brain barrier. Mol. Med. Today, 1996, 2(3), 106-113.
    • (1996) Mol. Med. Today , vol.2 , Issue.3 , pp. 106-113
    • Abbott, N.J.1    Romero, I.A.2
  • 27
    • 0016829830 scopus 로고
    • Synthetic amino acids and the nature of L-DOPA transport at the blood-brain barrier
    • Wade, L.A.; Katzman, R. Synthetic amino acids and the nature of L-DOPA transport at the blood-brain barrier. J. Neurochem., 1975, 25(6), 837-842.
    • (1975) J. Neurochem. , vol.25 , Issue.6 , pp. 837-842
    • Wade, L.A.1    Katzman, R.2
  • 28
    • 0030726198 scopus 로고    scopus 로고
    • Bioavailability and transport of peptides and peptide drugs into the brain
    • Egleton, R.D.; Davis, T.P. Bioavailability and transport of peptides and peptide drugs into the brain. Peptides, 1997, 18(9), 1431-1439.
    • (1997) Peptides , vol.18 , Issue.9 , pp. 1431-1439
    • Egleton, R.D.1    Davis, T.P.2
  • 30
    • 59049097859 scopus 로고    scopus 로고
    • Lactoferrin-conjugated PEG-PLA nanoparticles with improved brain delivery: In vitro and in vivo evaluations
    • Hu, K.; Li, J.; Shen, Y.; Lu, W.; Gao, X.; Zhang, Q.; Jiang, X. Lactoferrin-conjugated PEG-PLA nanoparticles with improved brain delivery: in vitro and in vivo evaluations. J. Control. Release, 2009, 134(1), 55-61.
    • (2009) J. Control. Release , vol.134 , Issue.1 , pp. 55-61
    • Hu, K.1    Li, J.2    Shen, Y.3    Lu, W.4    Gao, X.5    Zhang, Q.6    Jiang, X.7
  • 32
    • 76049106693 scopus 로고    scopus 로고
    • Glutamateconjugated liposomes of dopamine hydrochloride for effective management of parkinsonism's
    • Khare, P.; Jain, A.; Jain, N.K.; Soni, V.; Jain, S.K. Glutamateconjugated liposomes of dopamine hydrochloride for effective management of parkinsonism's. PDA. J. Pharm. Sci. Technol., 2009, 63(5), 372-379.
    • (2009) PDA.J. Pharm. Sci. Technol. , vol.63 , Issue.5 , pp. 372-379
    • Khare, P.1    Jain, A.2    Jain, N.K.3    Soni, V.4    Jain, S.K.5
  • 35
    • 67649887150 scopus 로고    scopus 로고
    • Brain-targeting gene delivery and cellular internalization mechanisms for modified rabies virus glycoprotein RVG29 nanoparticles
    • Liu, Y.; Huang, R.; Han, L.; Ke, W.; Shao, K.; Ye, L.; Lou, J.; Jiang, C. Brain-targeting gene delivery and cellular internalization mechanisms for modified rabies virus glycoprotein RVG29 nanoparticles. Biomaterials, 2009, 30(25), 4195-4202.
    • (2009) Biomaterials , vol.30 , Issue.25 , pp. 4195-4202
    • Liu, Y.1    Huang, R.2    Han, L.3    Ke, W.4    Shao, K.5    Ye, L.6    Lou, J.7    Jiang, C.8
  • 36
    • 77953478343 scopus 로고    scopus 로고
    • Sialic acid and glycopeptides conjugated PLGA nanoparticles for central nervous system targeting: In vivo pharmacological evidence and biodistribution
    • Tosi, G.; Vergoni, A.V.; Ruozi, B.; Bondioli, L.; Badiali, L.; Rivasi, F.; Costantino, L.; Forni, F.; Vandelli, M.A. Sialic acid and glycopeptides conjugated PLGA nanoparticles for central nervous system targeting: In vivo pharmacological evidence and biodistribution. J. Control. Release, 2010.
    • (2010) J. Control. Release
    • Tosi, G.1    Vergoni, A.V.2    Ruozi, B.3    Bondioli, L.4    Badiali, L.5    Rivasi, F.6    Costantino, L.7    Forni, F.8    Vandelli, M.A.9
  • 38
    • 70649114473 scopus 로고    scopus 로고
    • Trimethylated chitosan-conjugated PLGA nanoparticles for the delivery of drugs to the brain
    • Wang, Z.H.; Wang, Z.Y.; Sun, C.S.; Wang, C.Y.; Jiang, T.Y.; Wang, S.L. Trimethylated chitosan-conjugated PLGA nanoparticles for the delivery of drugs to the brain. Biomaterials, 2010, 31(5), 908-915.
    • (2010) Biomaterials , vol.31 , Issue.5 , pp. 908-915
    • Wang, Z.H.1    Wang, Z.Y.2    Sun, C.S.3    Wang, C.Y.4    Jiang, T.Y.5    Wang, S.L.6
  • 39
    • 50849094554 scopus 로고    scopus 로고
    • TATconjugated nanoparticles for the CNS delivery of anti-HIV drugs
    • Rao, K.S.; Reddy, M.K.; Horning, J.L.; Labhasetwar, V. TATconjugated nanoparticles for the CNS delivery of anti-HIV drugs. Biomaterials, 2008, 29(33), 4429-4438.
    • (2008) Biomaterials , vol.29 , Issue.33 , pp. 4429-4438
    • Rao, K.S.1    Reddy, M.K.2    Horning, J.L.3    Labhasetwar, V.4
  • 40
    • 28244432240 scopus 로고    scopus 로고
    • The blood-brain barrier transmigrating single domain antibody: Mechanisms of transport and antigenic epitopes in human brain endothelial cells
    • Abulrob, A.; Sprong, H.; Van Bergen en Henegouwen, P.; Stanimirovic, D. The blood-brain barrier transmigrating single domain antibody: mechanisms of transport and antigenic epitopes in human brain endothelial cells. J. Neurochem., 2005, 95(4), 1201-1214.
    • (2005) J. Neurochem. , vol.95 , Issue.4 , pp. 1201-1214
    • Abulrob, A.1    Sprong, H.2    van Bergen en Henegouwen, P.3    Stanimirovic, D.4
  • 41
    • 70450222924 scopus 로고    scopus 로고
    • Synthesis, radiolabeling and biological evaluation of a neutral tripeptide and its derivatives for potential nuclear medicine applications
    • Chandra, S.; De, K.; Ganguly, S.; Sarkar, B.; Misra, M. Synthesis, radiolabeling and biological evaluation of a neutral tripeptide and its derivatives for potential nuclear medicine applications. Peptides, 2009, 30(12), 2399-2408.
    • (2009) Peptides , vol.30 , Issue.12 , pp. 2399-2408
    • Chandra, S.1    de, K.2    Ganguly, S.3    Sarkar, B.4    Misra, M.5
  • 42
    • 77949850475 scopus 로고    scopus 로고
    • N-methyl phenylalanine-rich peptides as highly versatile blood-brain barrier shuttles
    • Malakoutikhah, M.; Prades, R.; Teixido, M.; Giralt, E. N-methyl phenylalanine-rich peptides as highly versatile blood-brain barrier shuttles. J. Med. Chem., 2010, 53(6), 2354-2363.
    • (2010) J. Med. Chem. , vol.53 , Issue.6 , pp. 2354-2363
    • Malakoutikhah, M.1    Prades, R.2    Teixido, M.3    Giralt, E.4
  • 43
    • 77649178520 scopus 로고    scopus 로고
    • Characterization of two blood-brain barrier mimicking cell lines: Distribution of lectin-binding sites and perspectives for drug delivery
    • Plattner, V.E.; Germann, B.; Neuhaus, W.; Noe, C.R.; Gabor, F.; Wirth, M. Characterization of two blood-brain barrier mimicking cell lines: distribution of lectin-binding sites and perspectives for drug delivery. Int. J. Pharm, 2010, 387(1-2), 34-41.
    • (2010) Int. J. Pharm , vol.387 , Issue.1-2 , pp. 34-41
    • Plattner, V.E.1    Germann, B.2    Neuhaus, W.3    Noe, C.R.4    Gabor, F.5    Wirth, M.6
  • 44
    • 77950517892 scopus 로고    scopus 로고
    • Leptin-derived peptide, a targeting ligand for mouse brain-derived endothelial cells via macropinocytosis
    • Tamaru, M.; Akita, H.; Fujiwara, T.; Kajimoto, K.; Harashima, H. Leptin-derived peptide, a targeting ligand for mouse brain-derived endothelial cells via macropinocytosis. Biochem. Biophys. Res. Commun., 2010, 394(3), 587-592.
    • (2010) Biochem. Biophys. Res. Commun. , vol.394 , Issue.3 , pp. 587-592
    • Tamaru, M.1    Akita, H.2    Fujiwara, T.3    Kajimoto, K.4    Harashima, H.5
  • 45
    • 69549130862 scopus 로고    scopus 로고
    • Synthesis, radiosynthesis and biological evaluation of 1,4-dihydroquinoline derivatives as new carriers for specific brain delivery
    • Foucout, L.; Gourand, F.; Dhilly, M.; Bohn, P.; Dupas, G.; Costentin, J.; Abbas, A.; Marsais, F.; Barre, L.; Levacher, V. Synthesis, radiosynthesis and biological evaluation of 1,4-dihydroquinoline derivatives as new carriers for specific brain delivery. Org. Biomol. Chem., 2009, 7(18), 3666-3673.
    • (2009) Org. Biomol. Chem. , vol.7 , Issue.18 , pp. 3666-3673
    • Foucout, L.1    Gourand, F.2    Dhilly, M.3    Bohn, P.4    Dupas, G.5    Costentin, J.6    Abbas, A.7    Marsais, F.8    Barre, L.9    Levacher, V.10
  • 47
    • 0032830130 scopus 로고    scopus 로고
    • The transferrin receptor: Role in health and disease
    • Ponka, P.; Lok, C.N. The transferrin receptor: role in health and disease. Int. J. Biochem. Cell. Biol., 1999, 31(10), 1111-1137.
    • (1999) Int. J. Biochem. Cell. Biol. , vol.31 , Issue.10 , pp. 1111-1137
    • Ponka, P.1    Lok, C.N.2
  • 48
    • 0033961913 scopus 로고    scopus 로고
    • Transferrin and transferrin receptor function in brain barrier systems
    • Moos, T.; Morgan, E.H. Transferrin and transferrin receptor function in brain barrier systems. Cell Mol. Neurobiol., 2000, 20(1), 77-95.
    • (2000) Cell Mol. Neurobiol. , vol.20 , Issue.1 , pp. 77-95
    • Moos, T.1    Morgan, E.H.2
  • 49
    • 19444381236 scopus 로고    scopus 로고
    • Delivery of beta-galactosidase to mouse brain via the blood-brain barrier transferrin receptor
    • Zhang, Y.; Pardridge, W.M. Delivery of beta-galactosidase to mouse brain via the blood-brain barrier transferrin receptor. J. Pharmacol. Exp. Ther., 2005, 313(3), 1075-1081.
    • (2005) J. Pharmacol. Exp. Ther. , vol.313 , Issue.3 , pp. 1075-1081
    • Zhang, Y.1    Pardridge, W.M.2
  • 50
    • 33748438120 scopus 로고    scopus 로고
    • Blood-brain barrier targeting of BDNF improves motor function in rats with middle cerebral artery occlusion
    • Zhang, Y.; Pardridge, W.M. Blood-brain barrier targeting of BDNF improves motor function in rats with middle cerebral artery occlusion. Brain Res., 2006, 1111(1), 227-229.
    • (2006) Brain Res. , vol.1111 , Issue.1 , pp. 227-229
    • Zhang, Y.1    Pardridge, W.M.2
  • 51
    • 39149083089 scopus 로고    scopus 로고
    • Lysosomal enzyme replacement of the brain with intravenous non-viral gene transfer
    • Zhang, Y.; Wang, Y.; Boado, R.J.; Pardridge, W.M. Lysosomal enzyme replacement of the brain with intravenous non-viral gene transfer. Pharm. Res., 2008, 25(2), 400-406.
    • (2008) Pharm. Res. , vol.25 , Issue.2 , pp. 400-406
    • Zhang, Y.1    Wang, Y.2    Boado, R.J.3    Pardridge, W.M.4
  • 52
    • 60549101321 scopus 로고    scopus 로고
    • Engineering and expression of a chimeric transferrin receptor monoclonal antibody for blood-brain barrier delivery in the mouse
    • Boado, R.J.; Zhang, Y.; Wang, Y.; Pardridge, W.M. Engineering and expression of a chimeric transferrin receptor monoclonal antibody for blood-brain barrier delivery in the mouse. Biotechnol. Bioeng., 2009, 102(4), 1251-1258.
    • (2009) Biotechnol. Bioeng. , vol.102 , Issue.4 , pp. 1251-1258
    • Boado, R.J.1    Zhang, Y.2    Wang, Y.3    Pardridge, W.M.4
  • 53
    • 76249087751 scopus 로고    scopus 로고
    • Pharmacokinetics and brain uptake of a genetically engineered bifunctional fusion antibody targeting the mouse transferrin receptor
    • Boado, R.J.; Zhou, Q.H.; Lu, J.Z.; Hui, E.K.; Pardridge, W.M. Pharmacokinetics and brain uptake of a genetically engineered bifunctional fusion antibody targeting the mouse transferrin receptor. Mol. Pharm., 2010, 7(1), 237-244.
    • (2010) Mol. Pharm. , vol.7 , Issue.1 , pp. 237-244
    • Boado, R.J.1    Zhou, Q.H.2    Lu, J.Z.3    Hui, E.K.4    Pardridge, W.M.5
  • 54
    • 77950269160 scopus 로고    scopus 로고
    • Monoclonal antibody-glial-derived neurotrophic factor fusion protein penetrates the blood-brain barrier in the mouse
    • Zhou, Q.H.; Boado, R.J.; Lu, J.Z.; Hui, E.K.; Pardridge, W.M. Monoclonal antibody-glial-derived neurotrophic factor fusion protein penetrates the blood-brain barrier in the mouse. Drug Metab. Dispos., 2010, 38(4), 566-572.
    • (2010) Drug Metab. Dispos. , vol.38 , Issue.4 , pp. 566-572
    • Zhou, Q.H.1    Boado, R.J.2    Lu, J.Z.3    Hui, E.K.4    Pardridge, W.M.5
  • 55
    • 35848935409 scopus 로고    scopus 로고
    • Intravenous siRNA of brain cancer with receptor targeting and avidin-biotin technology
    • Xia, C.F.; Zhang, Y.; Boado, R.J.; Pardridge, W.M. Intravenous siRNA of brain cancer with receptor targeting and avidin-biotin technology. Pharm. Res., 2007, 24(12), 2309-2316.
    • (2007) Pharm. Res. , vol.24 , Issue.12 , pp. 2309-2316
    • Xia, C.F.1    Zhang, Y.2    Boado, R.J.3    Pardridge, W.M.4
  • 56
    • 63949084137 scopus 로고    scopus 로고
    • Near complete rescue of experimental Parkinson's disease with intravenous, non-viral GDNF gene therapy
    • Zhang, Y.; Pardridge, W.M. Near complete rescue of experimental Parkinson's disease with intravenous, non-viral GDNF gene therapy. Pharm. Res., 2009, 26(5), 1059-1063.
    • (2009) Pharm. Res. , vol.26 , Issue.5 , pp. 1059-1063
    • Zhang, Y.1    Pardridge, W.M.2
  • 57
    • 40549111959 scopus 로고    scopus 로고
    • Intravenous glial-derived neurotrophic factor gene therapy of experimental Parkinson's disease with Trojan horse liposomes and a tyrosine hydroxylase promoter
    • Xia, C.F.; Boado, R.J.; Zhang, Y.; Chu, C.; Pardridge, W.M. Intravenous glial-derived neurotrophic factor gene therapy of experimental Parkinson's disease with Trojan horse liposomes and a tyrosine hydroxylase promoter. J. Gene Med., 2008, 10(3), 306-315.
    • (2008) J. Gene Med. , vol.10 , Issue.3 , pp. 306-315
    • Xia, C.F.1    Boado, R.J.2    Zhang, Y.3    Chu, C.4    Pardridge, W.M.5
  • 58
    • 43449094024 scopus 로고    scopus 로고
    • Preparation and brain delivery property of biodegradable polymersomes conjugated with OX26
    • Pang, Z.; Lu, W.; Gao, H.; Hu, K.; Chen, J.; Zhang, C.; Gao, X.; Jiang, X.; Zhu, C. Preparation and brain delivery property of biodegradable polymersomes conjugated with OX26. J. Control. Release, 2008, 128(2), 120-127.
    • (2008) J. Control. Release , vol.128 , Issue.2 , pp. 120-127
    • Pang, Z.1    Lu, W.2    Gao, H.3    Hu, K.4    Chen, J.5    Zhang, C.6    Gao, X.7    Jiang, X.8    Zhu, C.9
  • 61
    • 0002595302 scopus 로고    scopus 로고
    • Targeting rat anti-mouse transferrin receptor monoclonal antibodies through blood-brain barrier in mouse
    • Lee, H.J.; Engelhardt, B.; Lesley, J.; Bickel, U.; Pardridge, W.M. Targeting rat anti-mouse transferrin receptor monoclonal antibodies through blood-brain barrier in mouse. J. Pharmacol. Exp. Ther., 2000, 292(3), 1048-1052.
    • (2000) J. Pharmacol. Exp. Ther. , vol.292 , Issue.3 , pp. 1048-1052
    • Lee, H.J.1    Engelhardt, B.2    Lesley, J.3    Bickel, U.4    Pardridge, W.M.5
  • 62
    • 59649102668 scopus 로고    scopus 로고
    • Transferrinand transferrin-receptor-antibody-modified nanoparticles enable drug delivery across the blood-brain barrier (BBB)
    • Ulbrich, K.; Hekmatara, T.; Herbert, E.; Kreuter, J. Transferrinand transferrin-receptor-antibody-modified nanoparticles enable drug delivery across the blood-brain barrier (BBB). Eur. J. Pharm. Biopharm., 2009, 71(2), 251-256.
    • (2009) Eur. J. Pharm. Biopharm. , vol.71 , Issue.2 , pp. 251-256
    • Ulbrich, K.1    Hekmatara, T.2    Herbert, E.3    Kreuter, J.4
  • 63
    • 33645781775 scopus 로고    scopus 로고
    • Targeted brain delivery of AZT via transferrin anchored pegylated albumin nanoparticles
    • Mishra, V.; Mahor, S.; Rawat, A.; Gupta, P.N.; Dubey, P.; Khatri, K.; Vyas, S.P. Targeted brain delivery of AZT via transferrin anchored pegylated albumin nanoparticles. J. Drug Target, 2006, 14(1), 45-53.
    • (2006) J. Drug Target , vol.14 , Issue.1 , pp. 45-53
    • Mishra, V.1    Mahor, S.2    Rawat, A.3    Gupta, P.N.4    Dubey, P.5    Khatri, K.6    Vyas, S.P.7
  • 64
    • 23144445489 scopus 로고    scopus 로고
    • Transferrin coupled liposomes as drug delivery carriers for brain targeting of 5-florouracil
    • Soni, V.; Kohli, D.V.; Jain, S.K. Transferrin coupled liposomes as drug delivery carriers for brain targeting of 5-florouracil. J. Drug Target, 2005, 13(4), 245-250.
    • (2005) J. Drug Target , vol.13 , Issue.4 , pp. 245-250
    • Soni, V.1    Kohli, D.V.2    Jain, S.K.3
  • 65
    • 33947625559 scopus 로고    scopus 로고
    • Efficient gene delivery targeted to the brain using a transferrinconjugated polyethyleneglycol-modified polyamidoamine dendrimer
    • Huang, R.Q.; Qu, Y.H.; Ke, W.L.; Zhu, J.H.; Pei, Y.Y.; Jiang, C. Efficient gene delivery targeted to the brain using a transferrinconjugated polyethyleneglycol-modified polyamidoamine dendrimer. FASEB. J., 2007, 21(4), 1117-1125.
    • (2007) FASEB.J. , vol.21 , Issue.4 , pp. 1117-1125
    • Huang, R.Q.1    Qu, Y.H.2    Ke, W.L.3    Zhu, J.H.4    Pei, Y.Y.5    Jiang, C.6
  • 66
    • 48349136519 scopus 로고    scopus 로고
    • Targeting of the CNS in MPS-IH using a nonviral transferrinalpha-L-iduronidase fusion gene product
    • Osborn, M.J.; McElmurry, R.T.; Peacock, B.; Tolar, J.; Blazar, B.R. Targeting of the CNS in MPS-IH using a nonviral transferrinalpha-L-iduronidase fusion gene product. Mol. Ther., 2008, 16(8), 1459-1466.
    • (2008) Mol. Ther. , vol.16 , Issue.8 , pp. 1459-1466
    • Osborn, M.J.1    McElmurry, R.T.2    Peacock, B.3    Tolar, J.4    Blazar, B.R.5
  • 67
    • 0035292828 scopus 로고    scopus 로고
    • Delivery of peptides and proteins through the blood-brain barrier
    • Bickel, U.; Yoshikawa, T.; Pardridge, W.M. Delivery of peptides and proteins through the blood-brain barrier. Adv. Drug Deliv. Rev., 2001, 46(1-3), 247-279.
    • (2001) Adv. Drug Deliv. Rev. , vol.46 , Issue.1-3 , pp. 247-279
    • Bickel, U.1    Yoshikawa, T.2    Pardridge, W.M.3
  • 68
    • 33846897981 scopus 로고    scopus 로고
    • Humanization of antihuman insulin receptor antibody for drug targeting across the human blood-brain barrier
    • Boado, R.J.; Zhang, Y.; Pardridge, W.M. Humanization of antihuman insulin receptor antibody for drug targeting across the human blood-brain barrier. Biotechnol. Bioeng., 2007, 96(2), 381-391.
    • (2007) Biotechnol. Bioeng. , vol.96 , Issue.2 , pp. 381-391
    • Boado, R.J.1    Zhang, Y.2    Pardridge, W.M.3
  • 69
    • 70350236476 scopus 로고    scopus 로고
    • AGT-181: Expression in CHO cells and pharmacokinetics, safety, and plasma iduronidase enzyme activity in Rhesus monkeys
    • Boado, R.J.; Hui, E.K.; Lu, J.Z.; Pardridge, W.M. AGT-181: expression in CHO cells and pharmacokinetics, safety, and plasma iduronidase enzyme activity in Rhesus monkeys. J. Biotechnol., 2009, 144(2), 135-141.
    • (2009) J. Biotechnol. , vol.144 , Issue.2 , pp. 135-141
    • Boado, R.J.1    Hui, E.K.2    Lu, J.Z.3    Pardridge, W.M.4
  • 70
    • 38449110954 scopus 로고    scopus 로고
    • Genetic engineering of a lysosomal enzyme fusion protein for targeted delivery across the human blood-brain barrier
    • Boado, R.J.; Zhang, Y.; Xia, C.F.; Wang, Y.; Pardridge, W.M. Genetic engineering of a lysosomal enzyme fusion protein for targeted delivery across the human blood-brain barrier. Biotechnol. Bioeng., 2008, 99(2), 475-484.
    • (2008) Biotechnol. Bioeng. , vol.99 , Issue.2 , pp. 475-484
    • Boado, R.J.1    Zhang, Y.2    Xia, C.F.3    Wang, Y.4    Pardridge, W.M.5
  • 71
    • 74949139623 scopus 로고    scopus 로고
    • Genetic engineering of a bifunctional IgG fusion protein with iduronate-2-sulfatase
    • Lu, J.Z.; Hui, E.K.; Boado, R.J.; Pardridge, W.M. Genetic engineering of a bifunctional IgG fusion protein with iduronate-2-sulfatase. Bioconjug. Chem., 2010, 21(1), 151-156.
    • (2010) Bioconjug. Chem. , vol.21 , Issue.1 , pp. 151-156
    • Lu, J.Z.1    Hui, E.K.2    Boado, R.J.3    Pardridge, W.M.4
  • 72
    • 44449128659 scopus 로고    scopus 로고
    • GDNF fusion protein for targeted-drug delivery across the human blood-brain barrier
    • Boado, R.J.; Zhang, Y.; Wang, Y.; Pardridge, W.M. GDNF fusion protein for targeted-drug delivery across the human blood-brain barrier. Biotechnol. Bioeng., 2008, 100(2), 387-396.
    • (2008) Biotechnol. Bioeng. , vol.100 , Issue.2 , pp. 387-396
    • Boado, R.J.1    Zhang, Y.2    Wang, Y.3    Pardridge, W.M.4
  • 73
    • 71049162181 scopus 로고    scopus 로고
    • Comparison of blood-brain barrier transport of glial-derived neurotrophic factor (GDNF) and an IgGGDNF fusion protein in the rhesus monkey
    • Boado, R.J.; Pardridge, W.M. Comparison of blood-brain barrier transport of glial-derived neurotrophic factor (GDNF) and an IgGGDNF fusion protein in the rhesus monkey. Drug. Metab. Dispos., 2009, 37(12), 2299-2304.
    • (2009) Drug. Metab. Dispos. , vol.37 , Issue.12 , pp. 2299-2304
    • Boado, R.J.1    Pardridge, W.M.2
  • 74
    • 69949114874 scopus 로고    scopus 로고
    • Pharmacokinetics and safety in rhesus monkeys of a monoclonal antibody-GDNF fusion protein for targeted blood-brain barrier delivery
    • Pardridge, W.M.; Boado, R.J. Pharmacokinetics and safety in rhesus monkeys of a monoclonal antibody-GDNF fusion protein for targeted blood-brain barrier delivery. Pharm. Res., 2009, 26(10), 2227-2236.
    • (2009) Pharm. Res. , vol.26 , Issue.10 , pp. 2227-2236
    • Pardridge, W.M.1    Boado, R.J.2
  • 75
    • 74849088013 scopus 로고    scopus 로고
    • IgG-single chain Fv fusion protein therapeutic for Alzheimer's disease: Expression in CHO cells and pharmacokinetics and brain delivery in the rhesus monkey
    • Boado, R.J.; Lu, J.Z.; Hui, E.K.; Pardridge, W.M. IgG-single chain Fv fusion protein therapeutic for Alzheimer's disease: Expression in CHO cells and pharmacokinetics and brain delivery in the rhesus monkey. Biotechnol. Bioeng., 2010, 105(3), 627-635.
    • (2010) Biotechnol. Bioeng. , vol.105 , Issue.3 , pp. 627-635
    • Boado, R.J.1    Lu, J.Z.2    Hui, E.K.3    Pardridge, W.M.4
  • 76
    • 77952329581 scopus 로고    scopus 로고
    • Drug targeting of erythropoietin across the primate blood-brain barrier with an igg molecular trojan horse
    • Boado, R.J.; Hui, E.K.; Lu, J.Z.; Pardridge, W.M. Drug targeting of erythropoietin across the primate blood-brain barrier with an igg molecular trojan horse. J. Pharmacol. Exp. Ther., 2010.
    • (2010) J Pharmacol Exp. Ther.
    • Boado, R.J.1    Hui, E.K.2    Lu, J.Z.3    Pardridge, W.M.4
  • 77
    • 77249163613 scopus 로고    scopus 로고
    • Selective targeting of a TNFR decoy receptor pharmaceutical to the primate brain as a receptor-specific IgG fusion protein
    • Boado, R.J.; Hui, E.K.; Lu, J.Z.; Zhou, Q.H.; Pardridge, W.M. Selective targeting of a TNFR decoy receptor pharmaceutical to the primate brain as a receptor-specific IgG fusion protein. J. Biotechnol., 2010, 146(1-2), 84-91.
    • (2010) J. Biotechnol. , vol.146 , Issue.1-2 , pp. 84-91
    • Boado, R.J.1    Hui, E.K.2    Lu, J.Z.3    Zhou, Q.H.4    Pardridge, W.M.5
  • 80
    • 4644228996 scopus 로고    scopus 로고
    • The transferrin homologue, melanotransferrin (p97), is rapidly catabolized by the liver of the rat and does not effectively donate iron to the brain
    • Richardson, D.R.; Morgan, E.H. The transferrin homologue, melanotransferrin (p97), is rapidly catabolized by the liver of the rat and does not effectively donate iron to the brain. Biochim. Biophys. Acta, 2004, 1690(2), 124-133.
    • (2004) Biochim. Biophys. Acta , vol.1690 , Issue.2 , pp. 124-133
    • Richardson, D.R.1    Morgan, E.H.2
  • 82
    • 8744266243 scopus 로고    scopus 로고
    • Efficient transfer of receptor-associated protein (RAP) across the blood-brain barrier
    • Pan, W.; Kastin, A.J.; Zankel, T.C.; van Kerkhof, P.; Terasaki, T.; Bu, G. Efficient transfer of receptor-associated protein (RAP) across the blood-brain barrier. J. Cell Sci., 2004, 117(Pt 21), 5071-5078.
    • (2004) J. Cell Sci. , vol.117 , Issue.PART 21 , pp. 5071-5078
    • Pan, W.1    Kastin, A.J.2    Zankel, T.C.3    van Kerkhof, P.4    Terasaki, T.5    Bu, G.6
  • 85
    • 48749095941 scopus 로고    scopus 로고
    • Involvement of the low-density lipoprotein receptor-related protein in the transcytosis of the brain delivery vector angiopep-2
    • Demeule, M.; Currie, J.C.; Bertrand, Y.; Che, C.; Nguyen, T.; Regina, A.; Gabathuler, R.; Castaigne, J.P.; Beliveau, R. Involvement of the low-density lipoprotein receptor-related protein in the transcytosis of the brain delivery vector angiopep-2. J. Neurochem., 2008, 106(4), 1534-1544.
    • (2008) J. Neurochem. , vol.106 , Issue.4 , pp. 1534-1544
    • Demeule, M.1    Currie, J.C.2    Bertrand, Y.3    Che, C.4    Nguyen, T.5    Regina, A.6    Gabathuler, R.7    Castaigne, J.P.8    Beliveau, R.9
  • 90
    • 77950563375 scopus 로고    scopus 로고
    • New Angiopepmodified doxorubicin (ANG1007) and etoposide (ANG1009) chemotherapeutics with increased brain penetration
    • Che, C.; Yang, G.; Thiot, C.; Lacoste, M.C.; Currie, J.C.; Demeule, M.; Regina, A.; Beliveau, R.; Castaigne, J.P. New Angiopepmodified doxorubicin (ANG1007) and etoposide (ANG1009) chemotherapeutics with increased brain penetration. J. Med. Chem., 2010, 53(7), 2814-2824.
    • (2010) J. Med. Chem. , vol.53 , Issue.7 , pp. 2814-2824
    • Che, C.1    Yang, G.2    Thiot, C.3    Lacoste, M.C.4    Currie, J.C.5    Demeule, M.6    Regina, A.7    Beliveau, R.8    Castaigne, J.P.9
  • 91
    • 70350200866 scopus 로고    scopus 로고
    • Gene delivery targeted to the brain using an Angiopep-conjugated polyethyleneglycol-modified polyamidoamine dendrimer
    • Ke, W.; Shao, K.; Huang, R.; Han, L.; Liu, Y.; Li, J.; Kuang, Y.; Ye, L.; Lou, J.; Jiang, C. Gene delivery targeted to the brain using an Angiopep-conjugated polyethyleneglycol-modified polyamidoamine dendrimer. Biomaterials, 2009, 30(36), 6976-6985.
    • (2009) Biomaterials , vol.30 , Issue.36 , pp. 6976-6985
    • Ke, W.1    Shao, K.2    Huang, R.3    Han, L.4    Liu, Y.5    Li, J.6    Kuang, Y.7    Ye, L.8    Lou, J.9    Jiang, C.10
  • 93
    • 33846565915 scopus 로고    scopus 로고
    • Nanoparticles--a historical perspective
    • Kreuter, J. Nanoparticles--a historical perspective. Int. J. Pharm., 2007, 331(1), 1-10.
    • (2007) Int. J. Pharm. , vol.331 , Issue.1 , pp. 1-10
    • Kreuter, J.1
  • 94
    • 33645863163 scopus 로고    scopus 로고
    • Biodistribution of polysorbate 80-coated doxorubicin-loaded [14C]-poly(butyl cyanoacrylate) nanoparticles after intravenous administration to glioblastoma-bearing rats
    • Ambruosi, A.; Khalansky, A.S.; Yamamoto, H.; Gelperina, S.E.; Begley, D.J.; Kreuter, J. Biodistribution of polysorbate 80-coated doxorubicin-loaded [14C]-poly(butyl cyanoacrylate) nanoparticles after intravenous administration to glioblastoma-bearing rats. J. Drug Target., 2006, 14(2), 97-105.
    • (2006) J. Drug Target. , vol.14 , Issue.2 , pp. 97-105
    • Ambruosi, A.1    Khalansky, A.S.2    Yamamoto, H.3    Gelperina, S.E.4    Begley, D.J.5    Kreuter, J.6
  • 97
    • 33847116764 scopus 로고    scopus 로고
    • Covalent attachment of apolipoprotein A-I and apolipoprotein B-100 to albumin nanoparticles enables drug transport into the brain
    • Kreuter, J.; Hekmatara, T.; Dreis, S.; Vogel, T.; Gelperina, S.; Langer, K. Covalent attachment of apolipoprotein A-I and apolipoprotein B-100 to albumin nanoparticles enables drug transport into the brain. J. Control. Release, 2007, 118(1), 54-58.
    • (2007) J. Control. Release , vol.118 , Issue.1 , pp. 54-58
    • Kreuter, J.1    Hekmatara, T.2    Dreis, S.3    Vogel, T.4    Gelperina, S.5    Langer, K.6
  • 100
    • 33344460518 scopus 로고    scopus 로고
    • Influence of particle size on transport of methotrexate across blood brain barrier by polysorbate 80-coated polybutylcyanoacrylate nanoparticles
    • Gao, K.; Jiang, X. Influence of particle size on transport of methotrexate across blood brain barrier by polysorbate 80-coated polybutylcyanoacrylate nanoparticles. Int. J. Pharm., 2006, 310 (1-2), 213-219.
    • (2006) Int. J. Pharm. , vol.310 , Issue.1-2 , pp. 213-219
    • Gao, K.1    Jiang, X.2
  • 102
    • 0029935613 scopus 로고    scopus 로고
    • Reactive microglia specifically associated with amyloid plaques in Alzheimer's disease brain tissue express melanotransferrin
    • Jefferies, W.A.; Food, M.R.; Gabathuler, R.; Rothenberger, S.; Yamada, T.; Yasuhara, O.; McGeer, P.L. Reactive microglia specifically associated with amyloid plaques in Alzheimer's disease brain tissue express melanotransferrin. Brain Res., 1996, 712(1), 122-126.
    • (1996) Brain Res. , vol.712 , Issue.1 , pp. 122-126
    • Jefferies, W.A.1    Food, M.R.2    Gabathuler, R.3    Rothenberger, S.4    Yamada, T.5    Yasuhara, O.6    McGeer, P.L.7
  • 103
    • 67349093525 scopus 로고    scopus 로고
    • Clearance mechanisms of Alzheimer's amyloid-beta peptide: Implications for therapeutic design and diagnostic tests
    • Bates, K.A.; Verdile, G.; Li, Q.X.; Ames, D.; Hudson, P.; Masters, C.L.; Martins, R.N. Clearance mechanisms of Alzheimer's amyloid-beta peptide: implications for therapeutic design and diagnostic tests. Mol. Psychiatry., 2009, 14(5), 469-486.
    • (2009) Mol. Psychiatry. , vol.14 , Issue.5 , pp. 469-486
    • Bates, K.A.1    Verdile, G.2    Li, Q.X.3    Ames, D.4    Hudson, P.5    Masters, C.L.6    Martins, R.N.7
  • 104
    • 48949117577 scopus 로고    scopus 로고
    • The role of the cell surface LRP and soluble LRP in blood-brain barrier Abeta clearance in Alzheimer's disease
    • Deane, R.; Sagare, A.; Zlokovic, B.V. The role of the cell surface LRP and soluble LRP in blood-brain barrier Abeta clearance in Alzheimer's disease. Curr. Pharm. Des., 2008, 14(16), 1601-1605.
    • (2008) Curr. Pharm. Des. , vol.14 , Issue.16 , pp. 1601-1605
    • Deane, R.1    Sagare, A.2    Zlokovic, B.V.3
  • 105
    • 77951934845 scopus 로고    scopus 로고
    • Lack of brain-to-blood efflux transport activity of low-density lipoprotein receptor-related protein-1 (LRP-1) for amyloid-beta peptide(1-40) in mouse: Involvement of an LRP-1-independent pathway
    • Ito, S.; Ueno, T.; Ohtsuki, S.; Terasaki, T. Lack of brain-to-blood efflux transport activity of low-density lipoprotein receptor-related protein-1 (LRP-1) for amyloid-beta peptide(1-40) in mouse: involvement of an LRP-1-independent pathway. J. Neurochem., 2010, 113(5), 1356-1363.
    • (2010) J. Neurochem. , vol.113 , Issue.5 , pp. 1356-1363
    • Ito, S.1    Ueno, T.2    Ohtsuki, S.3    Terasaki, T.4
  • 107
    • 0031656728 scopus 로고    scopus 로고
    • Heparinbinding epidermal growth factor-like growth factor stimulates mitogenic signaling and is highly expressed in human malignant gliomas
    • Mishima, K.; Higashiyama, S.; Asai, A.; Yamaoka, K.; Nagashima, Y.; Taniguchi, N.; Kitanaka, C.; Kirino, T.; Kuchino, Y. Heparinbinding epidermal growth factor-like growth factor stimulates mitogenic signaling and is highly expressed in human malignant gliomas. Acta. Neuropathol., 1998, 96(4), 322-328.
    • (1998) Acta. Neuropathol. , vol.96 , Issue.4 , pp. 322-328
    • Mishima, K.1    Higashiyama, S.2    Asai, A.3    Yamaoka, K.4    Nagashima, Y.5    Taniguchi, N.6    Kitanaka, C.7    Kirino, T.8    Kuchino, Y.9
  • 108
    • 0033535831 scopus 로고    scopus 로고
    • Heparin-binding epidermal growth factor-like growth factor mRNA expression in neonatal rat brain with hypoxic/ischemic injury
    • Tanaka, N.; Sasahara, M.; Ohno, M.; Higashiyama, S.; Hayase, Y.; Shimada, M. Heparin-binding epidermal growth factor-like growth factor mRNA expression in neonatal rat brain with hypoxic/ischemic injury. Brain Res., 1999, 827(1-2), 130-138.
    • (1999) Brain Res. , vol.827 , Issue.1-2 , pp. 130-138
    • Tanaka, N.1    Sasahara, M.2    Ohno, M.3    Higashiyama, S.4    Hayase, Y.5    Shimada, M.6
  • 109
    • 0031561480 scopus 로고    scopus 로고
    • Heparin-binding EGF-like growth factor
    • Raab, G.; Klagsbrun, M. Heparin-binding EGF-like growth factor. Biochim. Biophys. Acta., 1997, 1333(3), F179-199.
    • (1997) Biochim. Biophys. Acta. , vol.1333 , Issue.3
    • Raab, G.1    Klagsbrun, M.2
  • 110
    • 49449113969 scopus 로고    scopus 로고
    • Design, synthesis and biological evaluation of glutathione peptidomimetics as components of anti-Parkinson prodrugs
    • More, S.S.; Vince, R. Design, synthesis and biological evaluation of glutathione peptidomimetics as components of anti-Parkinson prodrugs. J. Med. Chem., 2008, 51(15), 4581-4588.
    • (2008) J. Med. Chem. , vol.51 , Issue.15 , pp. 4581-4588
    • More, S.S.1    Vince, R.2
  • 111
    • 0025303448 scopus 로고
    • Evidence for carrier-mediated transport of glutathione across the blood-brain barrier in the rat
    • Kannan, R.; Kuhlenkamp, J.F.; Jeandidier, E.; Trinh, H.; Ookhtens, M.; Kaplowitz, N. Evidence for carrier-mediated transport of glutathione across the blood-brain barrier in the rat. J. Clin. Invest., 1990, 85(6), 2009-2013.
    • (1990) J. Clin. Invest. , vol.85 , Issue.6 , pp. 2009-2013
    • Kannan, R.1    Kuhlenkamp, J.F.2    Jeandidier, E.3    Trinh, H.4    Ookhtens, M.5    Kaplowitz, N.6
  • 112
    • 0033989175 scopus 로고    scopus 로고
    • GSH transport in human cerebrovascular endothelial cells and human astrocytes: Evidence for luminal localization of Na+-dependent GSH transport in HCEC
    • Kannan, R.; Chakrabarti, R.; Tang, D.; Kim, K.J.; Kaplowitz, N. GSH transport in human cerebrovascular endothelial cells and human astrocytes: evidence for luminal localization of Na+-dependent GSH transport in HCEC. Brain Res., 2000, 852(2), 374-382.
    • (2000) Brain Res. , vol.852 , Issue.2 , pp. 374-382
    • Kannan, R.1    Chakrabarti, R.2    Tang, D.3    Kim, K.J.4    Kaplowitz, N.5
  • 114
    • 66149130750 scopus 로고    scopus 로고
    • Differential receptor-mediated drug targeting to the diseased brain
    • Rip, J.; Schenk, G.J.; de Boer, A.G. Differential receptor-mediated drug targeting to the diseased brain. Expert Opin. Drug Deliv., 2009, 6(3), 227-237.
    • (2009) Expert Opin. Drug Deliv. , vol.6 , Issue.3 , pp. 227-237
    • Rip, J.1    Schenk, G.J.2    de Boer, A.G.3
  • 115
    • 23844507575 scopus 로고    scopus 로고
    • Glycyl-L-glutamine disposition in rat choroid plexus epithelial cells in primary culture: Role of PEPT2
    • Hu, Y.; Ocheltree, S.M.; Xiang, J.; Keep, R.F.; Smith, D.E. Glycyl-L-glutamine disposition in rat choroid plexus epithelial cells in primary culture: role of PEPT2. Pharm. Res., 2005, 22(8), 1281-1286.
    • (2005) Pharm. Res. , vol.22 , Issue.8 , pp. 1281-1286
    • Hu, Y.1    Ocheltree, S.M.2    Xiang, J.3    Keep, R.F.4    Smith, D.E.5
  • 116
    • 0034858814 scopus 로고    scopus 로고
    • PEPT2-mediated uptake of neuropeptides in rat choroid plexus
    • Teuscher, N.S.; Keep, R.F.; Smith, D.E. PEPT2-mediated uptake of neuropeptides in rat choroid plexus. Pharm. Res., 2001, 18(6), 807-813.
    • (2001) Pharm. Res. , vol.18 , Issue.6 , pp. 807-813
    • Teuscher, N.S.1    Keep, R.F.2    Smith, D.E.3
  • 119
    • 13944272576 scopus 로고    scopus 로고
    • The role of insulin receptor signaling in the brain
    • Plum, L.; Schubert, M.; Bruning, J.C. The role of insulin receptor signaling in the brain. Trends Endocrinol. Metab., 2005, 16(2), 59-65.
    • (2005) Trends Endocrinol. Metab. , vol.16 , Issue.2 , pp. 59-65
    • Plum, L.1    Schubert, M.2    Bruning, J.C.3
  • 120
    • 0346727326 scopus 로고    scopus 로고
    • LRP: A bright beacon at the blood-brain barrier
    • Herz, J. LRP: a bright beacon at the blood-brain barrier. J. Clin. Invest., 2003, 112(10), 1483-1485.
    • (2003) J. Clin. Invest. , vol.112 , Issue.10 , pp. 1483-1485
    • Herz, J.1
  • 121
    • 0036889760 scopus 로고    scopus 로고
    • Targeted drug delivery via the transferrin receptor-mediated endocytosis pathway
    • Qian, Z.M.; Li, H.; Sun, H.; Ho, K. Targeted drug delivery via the transferrin receptor-mediated endocytosis pathway. Pharmacol. Rev., 2002, 54(4), 561-587.
    • (2002) Pharmacol. Rev. , vol.54 , Issue.4 , pp. 561-587
    • Qian, Z.M.1    Li, H.2    Sun, H.3    Ho, K.4
  • 122
    • 0033961913 scopus 로고    scopus 로고
    • Transferrin and transferrin receptor function in brain barrier systems
    • Moos, T.; Morgan, E.H. Transferrin and transferrin receptor function in brain barrier systems. Cell. Mol. Neurobiol., 2000, 20(1), 77-95.
    • (2000) Cell. Mol. Neurobiol. , vol.20 , Issue.1 , pp. 77-95
    • Moos, T.1    Morgan, E.H.2
  • 123
    • 8344282653 scopus 로고    scopus 로고
    • Targeting antitransferrin receptor antibody (OX26) and OX26-conjugated liposomes to brain capillary endothelial cells using in situ perfusion
    • Gosk, S.; Vermehren, C.; Storm, G.; Moos, T. Targeting antitransferrin receptor antibody (OX26) and OX26-conjugated liposomes to brain capillary endothelial cells using in situ perfusion. J. Cereb. Blood Flow Metab., 2004, 24(11), 1193-1204.
    • (2004) J. Cereb. Blood Flow Metab. , vol.24 , Issue.11 , pp. 1193-1204
    • Gosk, S.1    Vermehren, C.2    Storm, G.3    Moos, T.4
  • 125
    • 0020694727 scopus 로고
    • Antibody responses to Haemophilus influenzae type b and diphtheria toxin induced by conjugates of oligosaccharides of the type b capsule with the nontoxic protein CRM197
    • Anderson, P. Antibody responses to Haemophilus influenzae type b and diphtheria toxin induced by conjugates of oligosaccharides of the type b capsule with the nontoxic protein CRM197. Infect. Immun., 1983, 39(1), 233-238.
    • (1983) Infect. Immun. , vol.39 , Issue.1 , pp. 233-238
    • Anderson, P.1
  • 126
    • 49749097982 scopus 로고    scopus 로고
    • Impact of antioxidant supplementation on chemotherapeutic toxicity: A systematic review of the evidence from randomized controlled trials
    • Block, K.I.; Koch, A.C.; Mead, M.N.; Tothy, P.K.; Newman, R.A.; Gyllenhaal, C. Impact of antioxidant supplementation on chemotherapeutic toxicity: a systematic review of the evidence from randomized controlled trials. Int. J. Cancer., 2008, 123(6), 1227-1239.
    • (2008) Int. J. Cancer. , vol.123 , Issue.6 , pp. 1227-1239
    • Block, K.I.1    Koch, A.C.2    Mead, M.N.3    Tothy, P.K.4    Newman, R.A.5    Gyllenhaal, C.6
  • 127
    • 77949375780 scopus 로고    scopus 로고
    • Biopharmaceutical drug targeting to the brain
    • Pardridge, W.M. Biopharmaceutical drug targeting to the brain. J. Drug Target, 2010, 18(3), 157-167.
    • (2010) J. Drug Target , vol.18 , Issue.3 , pp. 157-167
    • Pardridge, W.M.1
  • 130
    • 67349179610 scopus 로고    scopus 로고
    • Nanoparticle-based targeted drug delivery
    • Singh, R.; Lillard, J.W.; Jr. Nanoparticle-based targeted drug delivery. Exp. Mol. Pathol., 2009, 86(3), 215-223.
    • (2009) Exp. Mol. Pathol. , vol.86 , Issue.3 , pp. 215-223
    • Singh, R.1    Lillard Jr., J.W.2
  • 132
    • 0026774346 scopus 로고
    • Sterically stabilized liposomes
    • Woodle, M.C.; Lasic, D.D. Sterically stabilized liposomes. Biochim. Biophys. Acta, 1992, 1113(2), 171-199.
    • (1992) Biochim. Biophys. Acta , vol.1113 , Issue.2 , pp. 171-199
    • Woodle, M.C.1    Lasic, D.D.2
  • 133
    • 64649103437 scopus 로고    scopus 로고
    • IgGparaoxonase-1 fusion protein for targeted drug delivery across the human blood-brain barrier
    • Boado, R.J.; Zhang, Y.; Wang, Y.; Pardridge, W.M. IgGparaoxonase-1 fusion protein for targeted drug delivery across the human blood-brain barrier. Mol. Pharm., 2008, 5(6), 1037-1043.
    • (2008) Mol. Pharm. , vol.5 , Issue.6 , pp. 1037-1043
    • Boado, R.J.1    Zhang, Y.2    Wang, Y.3    Pardridge, W.M.4
  • 134
    • 0038046761 scopus 로고    scopus 로고
    • Transgenic mice expressing the diphtheria toxin receptor are sensitive to the toxin
    • Cha, J.H.; Chang, M.Y.; Richardson, J.A.; Eidels, L. Transgenic mice expressing the diphtheria toxin receptor are sensitive to the toxin. Mol. Microbiol., 2003, 49(1), 235-240.
    • (2003) Mol. Microbiol. , vol.49 , Issue.1 , pp. 235-240
    • Cha, J.H.1    Chang, M.Y.2    Richardson, J.A.3    Eidels, L.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.