Effect of mdr1a p-glycoprotein gene disruption, gender, and substrate concentration on brain uptake of selected compounds

Pharmaceutical Research

Volumn 18, Issue 7, 2001, Pages 957-963

  Dagenais, C ^a   Zong, J ^a   Ducharme, J ^b,c   Pollack, G M ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b ASTRAZENECA   (United Kingdom)

^c UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

Blood brain barrier; mdr1a( ) mice; Morphine; P glycoprotein; Plasma protein binding; Quinidine; Verapamil

Indexed keywords

DEXVERAPAMIL; GLYCOPROTEIN P; LU 33925; MORPHINE; QUINIDINE; VERAPAMIL;

ADOLESCENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG CLEARANCE; DRUG TRANSPORT; DRUG UPTAKE; FEMALE; GENDER; GENE DISRUPTION; IC 50; ISOTOPE LABELING; MALE; MOUSE; NONHUMAN; PLASMA PROTEIN BINDING; PRIORITY JOURNAL;

EID: 0034874453     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1010984110732     Document Type: Article

References (30)

1. P-glycoprotein, a gatekeeper in the blood-brain barrier
2. Identification of a P-glycoprotein-deficient subpopulation in the CF-1 mouse strain using a restriction fragment length polymorphism
3. Brain perfusion systems for studies of drug uptake and metabolism in the central nervous system
4. Development of an in situ mouse brain perfusion model and its application to mdr1a P-glycoprotein-deficient mice
5. The effect of verapamil on the transport of peptides across the blood-brain barrier in rats: Kinetic evidence for an apically polarized efflux mechanism
6. Role of P-glycoprotein in the blood-brain transport of colchicine and vinblastine
7. Efflux transport of a new quinolone antibacterial agent, HSR-903, across the blood-brain barrier
8. Assessment of stereoselectivity of trimethylphenylalanine analogues of delta-opioid [D-Pen(2),D-Pen(5)]-enkephalin
9. The role of P-glycoprotein in blood-brain barrier transport of morphine: Transcortical microdialysis studies in mdr1a(-/-) and mdr1a(+/+) mice
10. Morphine antinociception is enhanced in mdr1a gene-deficient mice
11. P-Glycoprotein mediates the efflux of quinidine across the blood-brain barrier
12. Complete in vivo reversal of P-glycoprotein pump function in the blood-brain barrier visualized with positron emission tomography
13. 17β-Estradiol modulation of glucose transporter 1 expression in blood-brain barrier
14. Multidrug resistance gene expression is controlled by steroid hormones in the secretory epithelium of the uterus
15. Screening of multidrug resistance sensitive drugs by in situ brain perfusion in P-Glycoprotein-deficient mice
16. Nuclear statistics
17. Poor permeability of morphine 3-glucuronide and morphine 6-glucuronide through the blood-brain barrier in the rat
18. Increased plasma binding and decreased blood cell binding of quinidine in blood from anuric rats
19. Glucuronidation in vitro and in vivo. Comparison of intestinal and hepatic conjugation of morphine, naloxone, and buprenorphine
20. Intravenous verapamil kinetics in rats: Marked arteriovenous concentration difference and comparison with humans
21. Gender differences in regional cerebral blood flow
22. The P-glycoprotein efflux pump: How does it transport drugs?
23. Drug binding to P-glycoprotein is inhibited in normal tissues following SDZ-PSC 833 treatment
24. Interaction of structurally diverse pesticides with the human MDR1 gene product P-glycoprotein
25. The multidrug-resistance-reverser verapamil interferes with cellular P-glycoprotein-mediated pumping of daunorubicin as a non-competing substrate
26. Clinical studies with modulators of multidrug resistance
27. Sensitive and rapid bioassay for analysis of P-glycoprotein-inhibiting activity of chemosensitizers in patient serum
28. Modulation of P-glycoprotein activity by estramustine is limited by binding to plasma proteins
29. Availability of PSC833, a substrate and inhibitor of P-glycoproteins, in various concentrations of serum