Improved measurement of drug exposure in the brain using drug-specific correction for residual blood

Journal of Cerebral Blood Flow and Metabolism

Volumn 30, Issue 1, 2010, Pages 150-161

  Fridén, Markus ^a,b   Ljungqvist, Helena ^c   Middleton, Brian ^d   Bredberg, Ulf ^b   Hammarlund Udenaes, Margareta ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b ASTRAZENECA R AND D   (Sweden)

^c UNIVERSITY OF GOTHENBURG   (Sweden)

^d ASTRAZENECA   (United Kingdom)

Author keywords

BBB (blood brain barrier); Brain distribution (of neuroactive substances); CBV (cerebral blood volume)

Indexed keywords

ALBUMIN I 125; ALBUMIN I 131; CARBON 14; DEXTRAN; DEXTRAN C 14; DEXTRAN H 3; ERYTHROCYTE CR 51; ERYTHROCYTE FE 55; ERYTHROCYTE TC 99M; INDOMETACIN; INULIN; INULIN H 3; IRON 55; LATAMOXEF; LOPERAMIDE; TRITIUM; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG EXPOSURE; ERYTHROCYTE; MALE; NONHUMAN; PLASMA; PRIORITY JOURNAL; RAT; STATISTICAL ANALYSIS;

ANIMALS; ANTI-BACTERIAL AGENTS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIDIARRHEALS; BLOOD-BRAIN BARRIER; BRAIN; CENTRAL NERVOUS SYSTEM; CEREBROVASCULAR CIRCULATION; CHROMATOGRAPHY, LIQUID; ERYTHROCYTE VOLUME; HEMATOCRIT; INDOMETHACIN; LOPERAMIDE; MALE; MASS SPECTROMETRY; MOXALACTAM; PHARMACEUTICAL PREPARATIONS; PHARMACOKINETICS; PLASMA; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS;

EID: 73949148635     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1038/jcbfm.2009.200     Document Type: Article

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