Investigation of the high partition of YM992, a novel antidepressant, in rat brain - In vitro and in vivo evidence for the high binding in brain and the high permeability of the BBB

Biopharmaceutics and Drug Disposition

Volumn 23, Issue 9, 2002, Pages 351-360

  Mano, Yuji ^a   Higuchi, Saburo ^a   Kamimura, Hidetaka ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

Antidepressant drug; Binding in brain; Blood brain barrier transport; Brain microdialysis

Indexed keywords

2 [[(7 FLUORO 4 INDANYL)OXY]METHYL]MORPHOLINE; ALPHA (2,3 DIMETHOXYPHENYL) 1 [2 (4 FLUOROPHENYL)ETHYL] 4 PIPERIDINEMETHANOL; ANTIDEPRESSANT AGENT; CARBON 14; DIAZEPAM; IMIPRAMINE; MIDAZOLAM;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CALCULATION; CAROTID ARTERY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG BINDING; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG CEREBROSPINAL FLUID LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG MECHANISM; DRUG PENETRATION; DRUG RESEARCH; DRUG STRUCTURE; DRUG UPTAKE; EXTRACELLULAR FLUID; EXTRACTION; IN VITRO STUDY; IN VIVO STUDY; MALE; MICRODIALYSIS; NONHUMAN; RAT; STEADY STATE;

ANIMALS; ANTIDEPRESSIVE AGENTS; BLOOD-BRAIN BARRIER; BRAIN; CAROTID ARTERIES; EXTRACELLULAR SPACE; MALE; MOLECULAR STRUCTURE; MORPHOLINES; PERMEABILITY; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; TISSUE DISTRIBUTION;

EID: 12244305837     PISSN: 01422782     EISSN: None     Source Type: Journal    
DOI: 10.1002/bdd.328     Document Type: Article

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