Genetically engineered brain drug delivery vectors: Cloning, expression and in vivo application of an anti-transferrin receptor single chain antibody-streptavidin fusion gene and protein

Protein Engineering

Volumn 12, Issue 9, 1999, Pages 787-796

  Li, Jean Yi ^a   Sugimura, Keijiro ^a,c   Boado, Ruben J ^a   Lee, Hwa Jeong ^a   Zhang, Crystal ^a   Duebel, Stefan ^b   Pardridge, William M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c SUNTORY LTD   (Japan)

Author keywords

Blood brain barrier; Drug delivery; Single chain antibody; Streptavidin

Indexed keywords

ANTIBODY CONJUGATE; BIOTIN; FLUORESCEIN; HYBRID PROTEIN; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; MACROGOL; MONOCLONAL ANTIBODY; STREPTAVIDIN; TRANSFERRIN RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOTINYLATION; BLOOD BRAIN BARRIER; BRAIN CAPILLARY; CELL INCLUSION; CELL TRANSPORT; CLONING; CONFOCAL MICROSCOPY; DRUG DELIVERY SYSTEM; DRUG RECEPTOR BINDING; EXPRESSION VECTOR; FEMALE; FLUORESCENCE MICROSCOPY; FUSION GENE; GENE EXPRESSION; GENE LOCUS; GENETIC ENGINEERING; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PURIFICATION; RAT;

ANIMALIA; BACTERIA (MICROORGANISMS); MURINAE;

EID: 0032824986     PISSN: 02692139     EISSN: None     Source Type: Journal    
DOI: 10.1093/protein/12.9.787     Document Type: Article

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