Measurement of unbound drug exposure in brain: Modeling of pH partitioning explains diverging results between the brain slice and brain homogenate methods

Drug Metabolism and Disposition

Volumn 39, Issue 3, 2011, Pages 353-362

  Fridén, Markus ^a,b   Bergström, Fredrik ^b   Wan, Hong ^b   Rehngren, Mikael ^b   Ahlin, Gustav ^a   Hammarlund Udenaes, Margareta ^a   Bredberg, Ulf ^b  

^a UPPSALA UNIVERSITY   (Sweden)

^b ASTRAZENECA R AND D   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ALPRAZOLAM; ALPRENOLOL; AMANTADINE; AMFEBUTAMONE; AMITRIPTYLINE; ATENOLOL; BACLOFEN; CIMETIDINE; CLONIDINE; CODEINE; DELAVIRDINE; DIAZEPAM; DICLOFENAC; DIPHENHYDRAMINE; ETHYL(PHENYL)MALONAMIDE; FLUORESCEIN; GABAPENTIN; LAMOTRIGINE; LATAMOXEF; LEVOFLOXACIN; LOPERAMIDE; METFORMIN; METHOTREXATE; METOPROLOL; MIDAZOLAM; MITOXANTRONE; MORPHINE; NADOLOL; NELFINAVIR; UNINDEXED DRUG;

ANIMAL TISSUE; ARTICLE; BRAIN CELL; BRAIN HOMOGENATE; BRAIN SLICE; CELL STRUCTURE; DRUG BINDING; DRUG BRAIN LEVEL; DRUG DISTRIBUTION; DRUG EXPOSURE; DRUG TRANSPORT; INTRACELLULAR SPACE; MATHEMATICAL MODEL; NONHUMAN; PH MEASUREMENT; PKA; PRIORITY JOURNAL; RAT;

ANIMALS; BIOLOGICAL TRANSPORT; BRAIN; DIALYSIS; HYDROGEN-ION CONCENTRATION; LYSOSOMES; MALE; MODELS, BIOLOGICAL; PHARMACEUTICAL PREPARATIONS; PHARMACOKINETICS; PHYSICOCHEMICAL PHENOMENA; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; TISSUE DISTRIBUTION;

EID: 79951865101     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.110.035998     Document Type: Article

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