Defining Neuropharmacokinetic Parameters in CNS Drug Discovery to Determine Cross-Species Pharmacologic Exposure-Response Relationships

Annual Reports in Medicinal Chemistry

Volumn 45, Issue C, 2010, Pages 55-70

  Shaffer, Christopher L ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 77957806870     PISSN: 00657743     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0065-7743(10)45004-6     Document Type: Book

References (49)

1. DiMasi J.A., Hansen R.W., Grabowski H.G. J. Health Econ. 2003, 22:151-185.
2. Caldwell J. J. Pharmaceut. Sci. 1996, 2:117-119.
3. Kola I., Landis J. Nat. Rev. Drug Discov. 2004, 3:711-715.
4. Tufts CSDD Impact Report 2005, 1-4. Tufts Center for the Study of Drug Development.
5. Pangalos M.N., Schechter L.E., Hurko O. Nature Rev. Drug Discov. 2007, 6:521-532.
6. Hitchcock S.A., Pennington L.D. J. Med. Chem. 2006, 49:7559-7583.
7. Wager T., Chandrasekaran R., Hou X., Troutman M., Verhoest P., Villalobos A., Will Y. ACS Chem. Neurosci. 2010, 1:420-434.
8. Wager T., Hou X., Verhoest P., Villalobos A. ACS Chem. Neurosci. 2010, 1:435-449.
9. Gabrielsson J., Green A.R. J. Pharmacol. Exp. Ther. 2009, 331:767-774.
10. Reichel A. Curr. Drug Metabol. 2006, 7:183-203.
11. Fagerholm U. Drug Discov. Today 2007, 12:1076-1082.
12. Summerfield S.G., Stevens A.J., Cutler L., Osuna M.d.C., Hammond B., Tang S-P., Hersey A., Spalding D.J., Jeffrey P. J. Pharmacol. Exp. Ther. 2006, 316:1282-1290.
13. Summerfield S.G., Read K., Begley D.J., Obradovic T., Hidalgo I.J., Coggon S., Lewis A.V., Porter R.A., Jeffrey P. J. Pharmacol. Exp. Ther. 2007, 322:205-213.
14. Summerfield S.G., Lucas A.J., Porter R.A., Jeffrey P., Gunn R.N., Read K.R., Stevens A.J., Metcalf A.C., Osuna M.C., Kilford P.J., Passchier J., Ruffo A.D. Xenobiotica 2008, 38:1518-1535.
15. Kalvass J.C., Maurer T.S., Pollack G.M. Drug Metab. Dispos. 2007, 35:660-666.
16. Becker S., Liu X. Drug Metab. Dispos. 2006, 34:855-861.
17. Liu X., Smith B.J., Chen C., Callegari E., Becker S.L., Chen X., Cianfrogna J., Doran A.C., Doran S.D., Gibbs J.P., Hosea N., Liu J., Nelson F.R., Szewc M.A., Van Deusen J. J. Pharmacol. Exp. Ther. 2005, 313:1254-1262.
18. Wan H., Rehngren M., Giordanetto F., Bergstrom F., Tunek A. J. Med. Chem. 2007, 50:4606-4615.
19. Doran A., Obach R.S., Smith B.J., Hosea N.A., Becker S., Callegari E., Chen C., Chen X., Choo E., Cianfrogna J., Cox L.M., Gibbs J.P., Gibbs M.A., Hatch H., Hop C.E.C.A., Kasman I.N., LaPerle J., Liu J., Liu X., Logman M., Maclin D., Nedza F.M., Nelson F., Olson E., Rahematpura S., Raunig D., Rogers S., Schmidt K., Spracklin D.K., Szewc M., Troutman M., Tseng E., Tu M., Van Deusen J.W., Venkatakrishnan K., Walens G., Wang E.Q., Wong D., Yasgar A.S., Zhang C. Drug Metab. Dispos. 2005, 33:165-174.
20. Fridén M., Winiwater S., Jerndal G., Bengtsson O., Wan H., Bredberg U., Hammarlund-Udenaes M., Antonsson M. J. Med. Chem. 2009, 52:6233-6243.
21. Hammarlund-Udenaes M., Fridén M., Syvänen S., Gupta A. Pharmaceut. Res. 2008, 25:1737-1750.
22. Liu X., Chen C. Curr. Opin. Drug Discov. Dev. 2005, 8:505-512.
23. Kalvass J.C., Maurer T.S. Biopharm. Drug Dispos. 2002, 23:327-338.
24. Lee G., Dallas S., Hong M., Bendayan R. Pharmacol. Rev. 2001, 53:569-596.
25. Shen D.D., Artru A.A., Adkison K.K. Adv. Drug Deliv. Rev. 2004, 56:1825-1857.
26. de Lange E.C.M., Danhof M. Clin. Pharmacokinet. 2002, 41:691-703.
27. Tillement J.-P., Urien S., Chaumet-Riffaud P., Riant P., Bree F., Morin D., Albengres E., Barre J. Fundam. Clin. Pharmacol. 1988, 2:223-238.
28. Liu X., Chen C., Smith B.J. J. Pharmacol. Exp. Ther. 2008, 325:349-356.
29. Wilkinson G.R. Goodman and Gilman's The Pharmacological Basis of Therapeutics 2001, 3-29. McGraw-Hill, New York. 10th Edition. J.G. Hardman, L.E. Limbird, A.G. Gilman (Eds.).
30. Wolfe M.S. Chem. Rev. 2009, 109:1599-1612.
31. Fridén M., Gupta A., Antonsson M., Bredberg U., Hammarlund-Udenaes M. Drug Metab. Dispos. 2007, 35:1711-1719.
32. de Lange E.C.M., Danhof M., de Boer A.G., Breimer D.D. Brain Res. 1994, 666:1-8.
33. Liu X., Smith B.J., Chen C., Callegari E., Becker S.L., Chen X., Cianfrogna J., Doran A.C., Doran S.D., Gibbs J.P., Hosea N., Liu J., Nelson F.R., Szewc M.A., Van Deusen J. Drug Metab. Dispos. 2006, 34:1443-1447.
34. Venkatakrishnan K., Tseng E., Nelson F.R., Rollema H., French J.L., Kaplan I.V., Horner W.E., Gibbs M.A. Drug Metab. Dispos. 2007, 35:1341-1349.
35. Maurer T.S., DeBartolo D.B., Tess D.A., Scott D.O. Drug Metab. Dispos. 2005, 33:175-181.
36. Kalvass J.C., Olson E.R., Cassidy M.P., Selley D.E., Pollack G.M. J. Pharmacol. Exp. Ther. 2007, 323:346-355.
37. Shaffer C.L. Drug Metabol. Rev. 2008, 40:14.
38. Watson J., Wright S., Lucas A., Clarke K.L., Viggers J., Cheetham S., Jeffrey P., Porter R., Read K.D. Drug Metab. Dispos. 2009, 37:753-760.
39. Liu X., Van Natta K., Yeo H., Vilenski O., Weller P.E., Worboys P.D., Monshouwer M. Drug Metab. Dispos. 2009, 37:787-793.
40. Liu X., Vilenski O., Kwan J., Apparsundaram S., Weikert R. Drug Metab. Dispos. 2009, 37:1548-1556.
41. Osgood S.M., Becker S.L., Gorczyca R., Buchholz L.M., Rollema H., Shaffer C.L. 57th ASMS Conference on Mass Spectrometry and Allied Topics 2009, 146.
42. Shaffer C.L., Scialis R.J., Lotarski S., Bryce D.K., Liu J., Majchrzak M.J., Christoffersen C., Hoffmann W.E., Campbell B., Hurst R.S., McLean S., Ganong A.H., Hajos M., Seymour P.A., Menniti F.S., Schmidt C.J. 883.17, Society for Neuroscience 2009, Chicago, IL.
43. Holford N.H.G., Sheiner L.B. Clin. Pharmacokinet. 1981, 6:429-453.
44. Boström E., Simonsson U.S.H., Hammarlund-Udenaes M. Drug Metab. Dispos. 2006, 34:1624-1631.
45. Shaffer C.L. ACS ProSpectives Conference Series: Discovery and Selection of Successful Drug Candidates with special emphasis on Structure-based Drug Design 2009.
46. Syvänen S., Lindhe Ö., Palner M., Kornum B.R., Rahman O., Långström B., Knudsen G.M., Hammarlund-Udenaes M. Drug Metab. Dispos. 2009, 37:635-643.
47. Hurst R.S., Mather R.J, Ward K.M, Shrikhande A., Johnson D.E., Tingley F.D., Tritto T., Kozak R., Ellerbrock B., Osgood S.M., Shaffer C.L., Rogers B.N., Arora G., Coe J.W., Deninno S.L., Lowe J.A., Nguyen T., Sakurada I., Zhang L. 228.10, Society for Neuroscience 2009, Chicago, IL.
48. Grimwood S., Hartig P.R. Pharmacol. Therapeut. 2009, 122:281-301.
49. Taylor P., Insel P.A. Principles of Drug Action: The Basis of Pharmacology 1990, 1-102. Churchill Livingstone, New York. 3rd Edition. W.B. Pratt, P. Taylor (Eds.).