Delivery of therapeutic agents to the central nervous system: The problems and the possibilities

Pharmacology and Therapeutics

Volumn 104, Issue 1, 2004, Pages 29-45

  Begley, David J ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Blood brain barrier; Cerebral capillary endothelium; Choroid plexus; Circumventricular organs; CNS drug delivery; Drug targeting to the CNS

Indexed keywords

4,5 DIHYDRO 5 (4 PHENYL 1 PIPERAZINYLMETHYL) 2 OXAZOLAMINE; ABACAVIR; ACIVICIN; ARGININE DERIVATIVE; BACLOFEN; CARBOXYLIC ACID DERIVATIVE; CEFALEXIN; DEHYDROASCORBIC ACID; DIPHENHYDRAMINE; DIPHENYLPYRALINE; DOCOSAHEXAENOIC ACID; ELACRIDAR; FOSCARNET; GABAPENTIN; IMIPRAMINE; LEVODOPA; LIDOCAINE; MELPHALAN; MEPYRAMINE; METHYLDOPA; MEVINOLIN; NANOPARTICLE; PACLITAXEL DERIVATIVE; PEPTIDE DERIVATIVE; PROGESTERONE; PROPRANOLOL; RECOMBINANT HUMAN INSULIN; SIMVASTATIN; SULFONAMIDE; UNINDEXED DRUG; VALPROIC ACID; VALSPODAR; ZIDOVUDINE; ZOSUQUIDAR;

BLOOD BRAIN BARRIER; BLOOD CEREBROSPINAL FLUID BARRIER; CELL INTERACTION; CENTRAL NERVOUS SYSTEM; CHOROID PLEXUS; DRUG DELIVERY SYSTEM; DRUG TRANSPORT; HUMAN; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; REVIEW; TREATMENT FAILURE;

ANIMALS; BLOOD-BRAIN BARRIER; CENTRAL NERVOUS SYSTEM; CENTRAL NERVOUS SYSTEM AGENTS; CENTRAL NERVOUS SYSTEM DISEASES; DRUG DELIVERY SYSTEMS; GENE THERAPY; HUMANS; LIPOSOMES; NANOSTRUCTURES;

EID: 6944255523     PISSN: 01637258     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2004.08.001     Document Type: Review

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