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Volumn 24, Issue 12, 2019, Pages

Kaempferol: A key emphasis to its anticancer potential

(13)  Imran, Muhammad a   Salehi, Bahare b   Sharifi Rad, Javad c   Gondal, Tanweer Aslam d   Saeed, Farhan e   Imran, Ali e   Shahbaz, Muhammad f   Fokou, Patrick Valere Tsouh g   Arshad, Muhammad Umair e   Khan, Haroon h   Guerreiro, Susana G i,j,k   Martins, Natália i,j   Estevinho, Leticia M l  


Author keywords

Anticancer; Antioxidant; Apoptosis; Cell cycle arrest; Chemoprevention; Kaempferol; Metastasis; Pharmacodynamics; Pharmacokinetics; Reactive oxygen species

Indexed keywords

ANTINEOPLASTIC AGENT; ANTIOXIDANT; KAEMPFEROL; KAEMPFEROL DERIVATIVE;

EID: 85068472007     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules24122277     Document Type: Review
Times cited : (534)

References (125)
  • 1
    • 84939801121 scopus 로고    scopus 로고
    • Soy leaf extract containing kaempferol glycosides and pheophorbides improves glucose homeostasis by enhancing pancreatic β-cell function and suppressing hepatic lipid accumulation in db/db mice
    • Li, H.; Ji, H.-S.; Kang, J.-H.; Shin, D.-H.; Park, H.-Y.; Choi, M.-S.; Lee, C.-H.; Lee, I.-K.; Yun, B.-S.; Jeong, T.-S. Soy Leaf Extract Containing Kaempferol Glycosides and Pheophorbides Improves Glucose Homeostasis by Enhancing Pancreatic β-Cell Function and Suppressing Hepatic Lipid Accumulation in db/db Mice. J. Agric. Food. Chem. 2015, 63, 7198-7210. [CrossRef] [PubMed]
    • (2015) J. Agric. Food. Chem. , vol.63 , pp. 7198-7210
    • Li, H.1    Ji, H.-S.2    Kang, J.-H.3    Shin, D.-H.4    Park, H.-Y.5    Choi, M.-S.6    Lee, C.-H.7    Lee, I.-K.8    Yun, B.-S.9    Jeong, T.-S.10
  • 2
    • 0141738858 scopus 로고    scopus 로고
    • USDA database for the flavonoid content of selected foods, release 3.1
    • Nutrient Data Laboratory, B.H.N.R.C., ARS, USDA, Eds.; Beltsville Human Nutrition Research Center: Beltsville, MD, USA
    • Bhagwat, S.; Haytowitz, D.B.; Holden, J.M. USDA Database for the Flavonoid Content of Selected Foods, Release 3.1. In USDA Special Interest Databases on Flavonoids; Nutrient Data Laboratory, B.H.N.R.C., ARS, USDA, Eds.; Beltsville Human Nutrition Research Center: Beltsville, MD, USA, 2014.
    • (2014) USDA Special Interest Databases on Flavonoids
    • Bhagwat, S.1    Haytowitz, D.B.2    Holden, J.M.3
  • 6
    • 85026386160 scopus 로고    scopus 로고
    • One-pot synthesis of hyperoside by a three-enzyme cascade using a UDP-galactose regeneration system
    • Pei, J.; Chen, A.; Zhao, L.; Cao, F.; Ding, G.; Xiao, W. One-Pot Synthesis of Hyperoside by a Three-Enzyme Cascade Using a UDP-Galactose Regeneration System. J. Agric. Food. Chem. 2017, 65, 6042-6048. [CrossRef] [PubMed]
    • (2017) J. Agric. Food. Chem. , vol.65 , pp. 6042-6048
    • Pei, J.1    Chen, A.2    Zhao, L.3    Cao, F.4    Ding, G.5    Xiao, W.6
  • 7
    • 9744242794 scopus 로고    scopus 로고
    • Dietary flavonoids and cancer risk: Evidence from human population studies
    • Neuhouser, M.L. Dietary flavonoids and cancer risk: Evidence from human population studies. Nutr. Cancer 2004, 50, 1-7. [CrossRef] [PubMed]
    • (2004) Nutr. Cancer , vol.50 , pp. 1-7
    • Neuhouser, M.L.1
  • 8
    • 84862309686 scopus 로고    scopus 로고
    • Flavonoids, a ubiquitous dietary phenolic subclass, exert extensive in vitro anti-invasive and in vivo anti-metastatic activities
    • Weng, C.J.; Yen, G.C. Flavonoids, a ubiquitous dietary phenolic subclass, exert extensive in vitro anti-invasive and in vivo anti-metastatic activities. Cancer Metastasis Rev. 2012, 31, 323-351. [CrossRef]
    • (2012) Cancer Metastasis Rev , vol.31 , pp. 323-351
    • Weng, C.J.1    Yen, G.C.2
  • 9
    • 85016275207 scopus 로고    scopus 로고
    • Isolation of phytoconstituents and evaluation of anticancer and antioxidant potential of launaea mucronata (forssk.) muschl. SubSp
    • Elsharkawy, E.R. Isolation of phytoconstituents and evaluation of anticancer and antioxidant potential of launaea mucronata (forssk.) muschl. subsp. Pak. J. Pharm. Sci. 2017, 2017, 399-405.
    • (2017) Pak. J. Pharm. Sci. , vol.2017 , pp. 399-405
    • Elsharkawy, E.R.1
  • 10
    • 85006307723 scopus 로고    scopus 로고
    • Kaempferol, a flavonoid compound from gynura medica induced apoptosis and growth inhibition in mcf-7 breast cancer cell
    • Yi, X.; Zuo, J.; Tan, C.; Xian, S.; Luo, C.; Chen, S.; Yu, L.; Luo, Y. Kaempferol, a flavonoid compound from gynura medica induced apoptosis and growth inhibition in mcf-7 breast cancer cell. Afr. J. Tradit. AJTCAM 2016, 13, 210-215. [CrossRef]
    • (2016) Afr. J. Tradit. AJTCAM , vol.13 , pp. 210-215
    • Yi, X.1    Zuo, J.2    Tan, C.3    Xian, S.4    Luo, C.5    Chen, S.6    Yu, L.7    Luo, Y.8
  • 13
    • 62649152321 scopus 로고    scopus 로고
    • Kaempferol induces apoptosis in two different cell lines via Akt inactivation, Bax and SIRT3 activation, and mitochondrial dysfunction
    • Marfe, G.; Tafani, M.; Indelicato, M.; Sinibaldi-Salimei, P.; Reali, V.; Pucci, B.; Fini, M.; Russo, M.A. Kaempferol induces apoptosis in two different cell lines via Akt inactivation, Bax and SIRT3 activation, and mitochondrial dysfunction. J. Cell. Biochem. 2009, 106, 643-650. [CrossRef] [PubMed]
    • (2009) J. Cell. Biochem. , vol.106 , pp. 643-650
    • Marfe, G.1    Tafani, M.2    Indelicato, M.3    Sinibaldi-Salimei, P.4    Reali, V.5    Pucci, B.6    Fini, M.7    Russo, M.A.8
  • 14
    • 84975757970 scopus 로고    scopus 로고
    • Kaempferol activates G(2)-checkpoint of the cell cycle resulting in G(2)-arrest and mitochondria-dependent apoptosis in human acute leukemia Jurkat T cells
    • Kim, K.Y.; Jang, W.Y.; Lee, J.Y.; Jun, D.Y.; Ko, J.Y.; Yun, Y.H.; Kim, Y.H. Kaempferol Activates G(2)-Checkpoint of the Cell Cycle Resulting in G(2)-Arrest and Mitochondria-Dependent Apoptosis in Human Acute Leukemia Jurkat T Cells. J. Microbiol. Biotechnol. 2016, 26, 287-294. [CrossRef] [PubMed]
    • (2016) J. Microbiol. Biotechnol. , vol.26 , pp. 287-294
    • Kim, K.Y.1    Jang, W.Y.2    Lee, J.Y.3    Jun, D.Y.4    Ko, J.Y.5    Yun, Y.H.6    Kim, Y.H.7
  • 15
    • 85030455984 scopus 로고    scopus 로고
    • PGC1alpha induced by reactive oxygen species contributes to chemoresistance of ovarian cancer cells
    • Kim, B.; Jung, J.W.; Jung, J.; Han, Y.; Suh, D.H.; Kim, H.S.; Dhanasekaran, D.N.; Song, Y.S. PGC1alpha induced by reactive oxygen species contributes to chemoresistance of ovarian cancer cells. Oncotarget 2017, 8, 60299-60311. [CrossRef] [PubMed]
    • (2017) Oncotarget , vol.8 , pp. 60299-60311
    • Kim, B.1    Jung, J.W.2    Jung, J.3    Han, Y.4    Suh, D.H.5    Kim, H.S.6    Dhanasekaran, D.N.7    Song, Y.S.8
  • 16
    • 75249102388 scopus 로고    scopus 로고
    • Flavonol glycosides of sea buckthorn (Hippophae rhamnoides ssp. Sinensis) and lingonberry (Vaccinium vitis-idaea) are bioavailable in humans and monoglucuronidated for excretion
    • Lehtonen, H.-M.; Lehtinen, O.; Suomela, J.-P.; Viitanen, M.; Kallio, H. Flavonol glycosides of sea buckthorn (Hippophae rhamnoides ssp. sinensis) and lingonberry (Vaccinium vitis-idaea) are bioavailable in humans and monoglucuronidated for excretion. J. Agric. Food. Chem. 2009, 58, 620-627. [CrossRef] [PubMed]
    • (2009) J. Agric. Food. Chem. , vol.58 , pp. 620-627
    • Lehtonen, H.-M.1    Lehtinen, O.2    Suomela, J.-P.3    Viitanen, M.4    Kallio, H.5
  • 17
    • 0037910072 scopus 로고    scopus 로고
    • The splanchnic metabolism of flavonoids highly differed according to the nature of the compound
    • Crespy, V.; Morand, C.; Besson, C.; Cotelle, N.; Vezin, H.; Demigne, C.; Remesy, C. The splanchnic metabolism of flavonoids highly differed according to the nature of the compound. Am. J. Physiol. 2003, 284, G980-G988. [CrossRef] [PubMed]
    • (2003) Am. J. Physiol. , vol.284 , pp. G980-G988
    • Crespy, V.1    Morand, C.2    Besson, C.3    Cotelle, N.4    Vezin, H.5    Demigne, C.6    Remesy, C.7
  • 18
    • 75549086308 scopus 로고    scopus 로고
    • The relationship between fasting plasma concentrations of selected flavonoids and their ordinary dietary intake
    • Cao, J.; Zhang, Y.; Chen, W.; Zhao, X. The relationship between fasting plasma concentrations of selected flavonoids and their ordinary dietary intake. Br. J. Nutr. 2010, 103, 249-255. [CrossRef]
    • (2010) Br. J. Nutr. , vol.103 , pp. 249-255
    • Cao, J.1    Zhang, Y.2    Chen, W.3    Zhao, X.4
  • 19
    • 2142817076 scopus 로고    scopus 로고
    • Glucurono- And sulfo-conjugation of kaempferol in rat liver subcellular preparations and cultured hepatocytes
    • Yodogawa, S.; Arakawa, T.; Sugihara, N.; Furuno, K. Glucurono- and sulfo-conjugation of kaempferol in rat liver subcellular preparations and cultured hepatocytes. Biol. Pharm. Bull. 2003, 26, 1120-1124. [CrossRef]
    • (2003) Biol. Pharm. Bull. , vol.26 , pp. 1120-1124
    • Yodogawa, S.1    Arakawa, T.2    Sugihara, N.3    Furuno, K.4
  • 20
    • 70349972154 scopus 로고    scopus 로고
    • Metabolism, oral bioavailability and pharmacokinetics of chemopreventive kaempferol in rats
    • Barve, A.; Chen, C.; Hebbar, V.; Desiderio, J.; Saw, C.L.; Kong, A.N. Metabolism, oral bioavailability and pharmacokinetics of chemopreventive kaempferol in rats. Biopharm. Drug Dispos. 2009, 30, 356-365. [CrossRef]
    • (2009) Biopharm. Drug Dispos. , vol.30 , pp. 356-365
    • Barve, A.1    Chen, C.2    Hebbar, V.3    Desiderio, J.4    Saw, C.L.5    Kong, A.N.6
  • 21
    • 34250753380 scopus 로고    scopus 로고
    • Urinary excretion of kaempferol from common beans (Phaseolus vulgaris L.) in humans
    • Bonetti, A.; Marotti, I.; Dinelli, G. Urinary excretion of kaempferol from common beans (Phaseolus vulgaris L.) in humans. Int. J. Food Sci. Nutr. 2007, 58, 261-269. [CrossRef]
    • (2007) Int. J. Food Sci. Nutr. , vol.58 , pp. 261-269
    • Bonetti, A.1    Marotti, I.2    Dinelli, G.3
  • 22
    • 3142727692 scopus 로고    scopus 로고
    • Absorption of kaempferol from endive, a source of kaempferol-3-glucuronide, in humans
    • DuPont, M.S.; Day, A.J.; Bennett, R.N.; Mellon, F.A.; Kroon, P.A. Absorption of kaempferol from endive, a source of kaempferol-3-glucuronide, in humans. Eur. J. Clin. Nutr. 2004, 58, 947-954. [CrossRef] [PubMed]
    • (2004) Eur. J. Clin. Nutr. , vol.58 , pp. 947-954
    • DuPont1    Day, A.J.2    Bennett, R.N.3    Mellon, F.A.4    Kroon, P.A.5
  • 23
    • 0141625125 scopus 로고    scopus 로고
    • Disposition of quercetin and kaempferol in human following an oral administration of Ginkgo biloba extract tablets
    • Wang, F.M.; Yao, T.W.; Zeng, S. Disposition of quercetin and kaempferol in human following an oral administration of Ginkgo biloba extract tablets. Eur. J. Drug Metab. Pharmacokinet. 2003, 28, 173-177. [CrossRef] [PubMed]
    • (2003) Eur. J. Drug Metab. Pharmacokinet. , vol.28 , pp. 173-177
    • Wang, F.M.1    Yao, T.W.2    Zeng, S.3
  • 24
    • 41849099278 scopus 로고    scopus 로고
    • Deconjugation and degradation of flavonol glycosides by pig cecal microbiota characterized by Fluorescence in situ hybridization (FISH)
    • Hein, E.M.; Rose, K.; van't Slot, G.; Friedrich, A.W.; Humpf, H.U. Deconjugation and degradation of flavonol glycosides by pig cecal microbiota characterized by Fluorescence in situ hybridization (FISH). J. Agric. Food Chem. 2008, 56, 2281-2290. [CrossRef] [PubMed]
    • (2008) J. Agric. Food Chem. , vol.56 , pp. 2281-2290
    • Hein, E.M.1    Rose, K.2    Van't Slot, G.3    Friedrich, A.W.4    Humpf, H.U.5
  • 25
    • 31544433381 scopus 로고    scopus 로고
    • Use of the pig caecum model to mimic the human intestinal metabolism of hispidulin and related compounds
    • Labib, S.; Hummel, S.; Richling, E.; Humpf, H.U.; Schreier, P. Use of the pig caecum model to mimic the human intestinal metabolism of hispidulin and related compounds. Mol. Nutr. Food Res. 2006, 50, 78-86. [CrossRef] [PubMed]
    • (2006) Mol. Nutr. Food Res. , vol.50 , pp. 78-86
    • Labib, S.1    Hummel, S.2    Richling, E.3    Humpf, H.U.4    Schreier, P.5
  • 26
    • 34748829513 scopus 로고    scopus 로고
    • Effects of the flavonoids kaempferol and fisetin on thermotolerance, oxidative stress and FoxO transcription factor DAF-16 in the model organism Caenorhabditis elegans
    • Kampkotter, A.; Gombitang Nkwonkam, C.; Zurawski, R.F.; Timpel, C.; Chovolou, Y.; Watjen, W.; Kahl, R. Effects of the flavonoids kaempferol and fisetin on thermotolerance, oxidative stress and FoxO transcription factor DAF-16 in the model organism Caenorhabditis elegans. Arch. Toxicol. 2007, 81, 849-858. [CrossRef] [PubMed]
    • (2007) Arch. Toxicol. , vol.81 , pp. 849-858
    • Kampkotter, A.1    Gombitang Nkwonkam, C.2    Zurawski, R.F.3    Timpel, C.4    Chovolou, Y.5    Watjen, W.6    Kahl, R.7
  • 27
    • 67949104877 scopus 로고    scopus 로고
    • In vitro and in vivo antioxidant properties of different fractions of Moringa oleifera leaves
    • Verma, A.R.; Vijayakumar, M.; Mathela, C.S.; Rao, C.V. In vitro and in vivo antioxidant properties of different fractions of Moringa oleifera leaves. Food Chem. Toxicol. 2009, 47, 2196-2201. [CrossRef] [PubMed]
    • (2009) Food Chem. Toxicol. , vol.47 , pp. 2196-2201
    • Verma, A.R.1    Vijayakumar, M.2    Mathela, C.S.3    Rao, C.V.4
  • 28
    • 77649135478 scopus 로고    scopus 로고
    • A new view of carcinogenesis and an alternative approach to cancer therapy
    • López-Lázaro, M. A new view of carcinogenesis and an alternative approach to cancer therapy. Mol. Med. 2010, 16, 144-153. [CrossRef]
    • (2010) Mol. Med. , vol.16 , pp. 144-153
    • López-Lázaro, M.1
  • 32
    • 33846531384 scopus 로고    scopus 로고
    • Distinctive antioxidant and antiinflammatory effects of flavonols
    • Wang, L.; Tu, Y.C.; Lian, T.W.; Hung, J.T.; Yen, J.H.; Wu, M.J. Distinctive antioxidant and antiinflammatory effects of flavonols. J. Agric. Food Chem. 2006, 54, 9798-9804. [CrossRef] [PubMed]
    • (2006) J. Agric. Food Chem. , vol.54 , pp. 9798-9804
    • Wang, L.1    Tu, Y.C.2    Lian, T.W.3    Hung, J.T.4    Yen, J.H.5    Wu, M.J.6
  • 34
  • 35
    • 60249084758 scopus 로고    scopus 로고
    • Measurement of xanthine oxidase inhibition activity of phenolics and flavonoids with a modified cupric reducing antioxidant capacity (CUPRAC) method
    • Ozyurek, M.; Bektasoglu, B.; Guclu, K.; Apak, R. Measurement of xanthine oxidase inhibition activity of phenolics and flavonoids with a modified cupric reducing antioxidant capacity (CUPRAC) method. Anal. Chim. Acta 2009, 636, 42-50. [CrossRef] [PubMed]
    • (2009) Anal. Chim. Acta , vol.636 , pp. 42-50
    • Ozyurek, M.1    Bektasoglu, B.2    Guclu, K.3    Apak, R.4
  • 36
    • 33846965570 scopus 로고    scopus 로고
    • Chemical structure-dependent differential effects of flavonoids on the catalase activity as evaluated by a chemiluminescent method
    • Doronicheva, N.; Yasui, H.; Sakurai, H. Chemical structure-dependent differential effects of flavonoids on the catalase activity as evaluated by a chemiluminescent method. Biol. Pharm. Bull. 2007, 30, 213-217. [CrossRef]
    • (2007) Biol. Pharm. Bull. , vol.30 , pp. 213-217
    • Doronicheva, N.1    Yasui, H.2    Sakurai, H.3
  • 37
    • 67349218391 scopus 로고    scopus 로고
    • Regulation of heme oxygenase-1 expression and MAPK pathways in response to kaempferol and rhamnocitrin in PC12 cells
    • Hong, J.T.; Yen, J.H.; Wang, L.; Lo, Y.H.; Chen, Z.T.; Wu, M.J. Regulation of heme oxygenase-1 expression and MAPK pathways in response to kaempferol and rhamnocitrin in PC12 cells. Toxicol. Appl. Pharmacol. 2009, 237, 59-68. [CrossRef] [PubMed]
    • (2009) Toxicol. Appl. Pharmacol. , vol.237 , pp. 59-68
    • Hong, J.T.1    Yen, J.H.2    Wang, L.3    Lo, Y.H.4    Chen, Z.T.5    Wu, M.J.6
  • 38
    • 0036827673 scopus 로고    scopus 로고
    • Interactions of flavonoids with iron and copper ions: A mechanism for their antioxidant activity
    • Mira, L.; Fernandez, M.T.; Santos, M.; Rocha, R.; Florencio, M.H.; Jennings, K.R. Interactions of flavonoids with iron and copper ions: A mechanism for their antioxidant activity. Free Radic. Res. 2002, 36, 1199-1208. [CrossRef]
    • (2002) Free Radic. Res. , vol.36 , pp. 1199-1208
    • Mira, L.1    Fernandez, M.T.2    Santos, M.3    Rocha, R.4    Florencio, M.H.5    Jennings, K.R.6
  • 39
    • 39849109530 scopus 로고    scopus 로고
    • Complexation of flavonoids with iron: Structure and optical signatures
    • Ren, J.; Meng, S.; Lekka Ch, E.; Kaxiras, E. Complexation of flavonoids with iron: Structure and optical signatures. J. Phys. Chem. B 2008, 112, 1845-1850. [CrossRef]
    • (2008) J. Phys. Chem. B , vol.112 , pp. 1845-1850
    • Ren, J.1    Meng, S.2    Kaxiras, E.3    Lekka, Ch.4
  • 40
    • 84926523586 scopus 로고    scopus 로고
    • The chemopreventive effect of the dietary compound kaempferol on the MCF-7 human breast cancer cell line is dependent on inhibition of glucose cellular uptake
    • Azevedo, C.; Correia-Branco, A.; Araujo, J.R.; Guimaraes, J.T.; Keating, E.; Martel, F. The chemopreventive effect of the dietary compound kaempferol on the MCF-7 human breast cancer cell line is dependent on inhibition of glucose cellular uptake. Nutr. Cancer 2015, 67, 504-513. [CrossRef]
    • (2015) Nutr. Cancer , vol.67 , pp. 504-513
    • Azevedo, C.1    Correia-Branco, A.2    Araujo, J.R.3    Guimaraes, J.T.4    Keating, E.5    Martel, F.6
  • 41
    • 85051285309 scopus 로고    scopus 로고
    • Kaempferol suppresses proliferation and induces cell cycle arrest, apoptosis, and DNA damage in breast cancer cells
    • Zhu, L.; Xue, L. Kaempferol suppresses proliferation and induces cell cycle arrest, apoptosis, and DNA damage in breast cancer cells. Oncol. Res. 2018. [CrossRef]
    • (2018) Oncol. Res.
    • Zhu, L.1    Xue, L.2
  • 42
    • 85031104881 scopus 로고    scopus 로고
    • Low dose of kaempferol suppresses the migration and invasion of triple-negative breast cancer cells by downregulating the activities of RhoA and Rac1
    • Li, S.; Yan, T.; Deng, R.; Jiang, X.; Xiong, H.; Wang, Y.; Yu, Q.; Wang, X.; Chen, C.; Zhu, Y. Low dose of kaempferol suppresses the migration and invasion of triple-negative breast cancer cells by downregulating the activities of RhoA and Rac1. OncoTargets Ther. 2017, 10, 4809-4819. [CrossRef] [PubMed]
    • (2017) OncoTargets Ther , vol.10 , pp. 4809-4819
    • Li, S.1    Yan, T.2    Deng, R.3    Jiang, X.4    Xiong, H.5    Wang, Y.6    Yu, Q.7    Wang, X.8    Chen, C.9    Zhu, Y.10
  • 43
    • 85042367952 scopus 로고    scopus 로고
    • Kaempferol 7-O-beta-D-glucoside isolated from the leaves of Cudrania tricuspidata inhibits LPS-induced expression of pro-inflammatory mediators through inactivation of NF-kappaB, AP-1, and JAK-STAT in RAW 264.7 macrophages
    • Lee, S.B.; Shin, J.S.; Han, H.S.; Lee, H.H.; Park, J.C.; Lee, K.T. Kaempferol 7-O-beta-D-glucoside isolated from the leaves of Cudrania tricuspidata inhibits LPS-induced expression of pro-inflammatory mediators through inactivation of NF-kappaB, AP-1, and JAK-STAT in RAW 264.7 macrophages. Chem. Biol. Interact. 2018, 284, 101-111. [CrossRef] [PubMed]
    • (2018) Chem. Biol. Interact. , vol.284 , pp. 101-111
    • Lee, S.B.1    Shin, J.S.2    Han, H.S.3    Lee, H.H.4    Park, J.C.5    Lee, K.T.6
  • 44
    • 85047766311 scopus 로고    scopus 로고
    • Treatment with phytoestrogens reversed triclosan and bisphenol A-induced anti-apoptosis in breast cancer cells
    • Lee, G.A.; Choi, K.C.; Hwang, K.A. Treatment with Phytoestrogens Reversed Triclosan and Bisphenol A-Induced Anti-Apoptosis in Breast Cancer Cells. Biomol. Ther. 2018, 26, 503-511. [CrossRef] [PubMed]
    • (2018) Biomol. Ther. , vol.26 , pp. 503-511
    • Lee, G.A.1    Choi, K.C.2    Hwang, K.A.3
  • 45
    • 84857985828 scopus 로고    scopus 로고
    • Kaempferol-3-O-rhamnoside isolated from the leaves of Schima wallichii Korth. Inhibits MCF-7 breast cancer cell proliferation through activation of the caspase cascade pathway
    • Diantini, A.; Subarnas, A.; Lestari, K.; Halimah, E.; Susilawati, Y.; Supriyatna, S.; Julaeha, E.; Achmad, T.H.; Suradji, E.W.; Yamazaki, C.; et al. Kaempferol-3-O-rhamnoside isolated from the leaves of Schima wallichii Korth. inhibits MCF-7 breast cancer cell proliferation through activation of the caspase cascade pathway. Oncol. Lett. 2012, 3, 1069-1072. [CrossRef] [PubMed]
    • (2012) Oncol. Lett. , vol.3 , pp. 1069-1072
    • Diantini, A.1    Subarnas, A.2    Lestari, K.3    Halimah, E.4    Susilawati, Y.5    Supriyatna, S.6    Julaeha, E.7    Achmad, T.H.8    Suradji, E.W.9    Yamazaki, C.10
  • 46
    • 79951773740 scopus 로고    scopus 로고
    • Simultaneous determination of the flavonoids robinin and kaempferol in human breast cancer cells by liquid chromatography-tandem mass spectrometry
    • Tsiklauri, L.; An, G.; Ruszaj, D.M.; Alaniya, M.; Kemertelidze, E.; Morris, M.E. Simultaneous determination of the flavonoids robinin and kaempferol in human breast cancer cells by liquid chromatography-tandem mass spectrometry. J. Pharm. Biomed. Anal. 2011, 55, 109-113. [CrossRef] [PubMed]
    • (2011) J. Pharm. Biomed. Anal. , vol.55 , pp. 109-113
    • Tsiklauri, L.1    An, G.2    Ruszaj, D.M.3    Alaniya, M.4    Kemertelidze, E.5    Morris, M.E.6
  • 47
    • 84957798907 scopus 로고    scopus 로고
    • Treatment with kaempferol suppresses breast cancer cell growth caused by estrogen and triclosan in cellular and xenograft breast cancer models
    • Kim, S.H.; Hwang, K.A.; Choi, K.C. Treatment with kaempferol suppresses breast cancer cell growth caused by estrogen and triclosan in cellular and xenograft breast cancer models. J. Nutr. Biochem. 2016, 28, 70-82. [CrossRef] [PubMed]
    • (2016) J. Nutr. Biochem. , vol.28 , pp. 70-82
    • Kim, S.H.1    Hwang, K.A.2    Choi, K.C.3
  • 48
  • 49
    • 77952868913 scopus 로고    scopus 로고
    • Kaempferol induced the apoptosis via cell cycle arrest in human breast cancer MDA-MB-453 cells
    • Choi, E.J.; Ahn, W.S. Kaempferol induced the apoptosis via cell cycle arrest in human breast cancer MDA-MB-453 cells. Nutr. Res. Pract. 2008, 2, 322-325. [CrossRef]
    • (2008) Nutr. Res. Pract. , vol.2 , pp. 322-325
    • Choi, E.J.1    Ahn, W.S.2
  • 50
    • 33744922639 scopus 로고    scopus 로고
    • Biphasic effects of kaempferol on the estrogenicity in human breast cancer cells
    • Oh, S.M.; Kim, Y.P.; Chung, K.H. Biphasic effects of kaempferol on the estrogenicity in human breast cancer cells. Arch. Pharmacal Res. 2006, 29, 354-362. [CrossRef]
    • (2006) Arch. Pharmacal Res. , vol.29 , pp. 354-362
    • Oh, S.M.1    Kim, Y.P.2    Chung, K.H.3
  • 51
    • 85006928791 scopus 로고    scopus 로고
    • Kaempferol, a phytoestrogen, suppressed triclosan-induced epithelial-mesenchymal transition and metastatic-related behaviors of MCF-7 breast cancer cells
    • Lee, G.A.; Choi, K.C.; Hwang, K.A. Kaempferol, a phytoestrogen, suppressed triclosan-induced epithelial-mesenchymal transition and metastatic-related behaviors of MCF-7 breast cancer cells. Environ. Toxicol. Pharmacol. 2017, 49, 48-57. [CrossRef]
    • (2017) Environ. Toxicol. Pharmacol. , vol.49 , pp. 48-57
    • Lee, G.A.1    Choi, K.C.2    Hwang, K.A.3
  • 52
    • 84978143743 scopus 로고    scopus 로고
    • In vivo exposure of kaempferol is driven by phase II metabolic enzymes and efflux transporters
    • Zheng, L.; Zhu, L.; Zhao, M.; Shi, J.; Li, Y.; Yu, J.; Jiang, H.; Wu, J.; Tong, Y.; Liu, Y.; et al. In Vivo Exposure of Kaempferol Is Driven by Phase II Metabolic Enzymes and Efflux Transporters. AAPS 2016, 18, 1289-1299. [CrossRef] [PubMed]
    • (2016) AAPS , vol.18 , pp. 1289-1299
    • Zheng, L.1    Zhu, L.2    Zhao, M.3    Shi, J.4    Li, Y.5    Yu, J.6    Jiang, H.7    Wu, J.8    Tong, Y.9    Liu, Y.10
  • 53
    • 84921944403 scopus 로고    scopus 로고
    • Inhibitory effects of kaempferol on the invasion of human breast carcinoma cells by downregulating the expression and activity of matrix metalloproteinase-9
    • Li, C.; Zhao, Y.; Yang, D.; Yu, Y.; Guo, H.; Zhao, Z.; Zhang, B.; Yin, X. Inhibitory effects of kaempferol on the invasion of human breast carcinoma cells by downregulating the expression and activity of matrix metalloproteinase-9. Biochem. Cell Biol. 2015, 93, 16-27. [CrossRef] [PubMed]
    • (2015) Biochem. Cell Biol. , vol.93 , pp. 16-27
    • Li, C.1    Zhao, Y.2    Yang, D.3    Yu, Y.4    Guo, H.5    Zhao, Z.6    Zhang, B.7    Yin, X.8
  • 54
    • 47949120075 scopus 로고    scopus 로고
    • Sustained ERK activation is involved in the kaempferol-induced apoptosis of breast cancer cells and is more evident under 3-D culture condition
    • Kim, B.W.; Lee, E.R.; Min, H.M.; Jeong, H.S.; Ahn, J.Y.; Kim, J.H.; Choi, H.Y.; Choi, H.; Kim, E.Y.; Park, S.P.; et al. Sustained ERK activation is involved in the kaempferol-induced apoptosis of breast cancer cells and is more evident under 3-D culture condition. Cancer Boil. Ther. 2008, 7, 1080-1089. [CrossRef] [PubMed]
    • (2008) Cancer Boil. Ther. , vol.7 , pp. 1080-1089
    • Kim, B.W.1    Lee, E.R.2    Min, H.M.3    Jeong, H.S.4    Ahn, J.Y.5    Kim, J.H.6    Choi, H.Y.7    Choi, H.8    Kim, E.Y.9    Park, S.P.10
  • 55
    • 67349190889 scopus 로고    scopus 로고
    • Kaempferol induces cell death through ERK and Akt-dependent down-regulation of XIAP and survivin in human glioma cells
    • Jeong, J.C.; Kim, M.S.; Kim, T.H.; Kim, Y.K. Kaempferol induces cell death through ERK and Akt-dependent down-regulation of XIAP and survivin in human glioma cells. Neurochem. Res. 2009, 34, 991-1001. [CrossRef] [PubMed]
    • (2009) Neurochem. Res. , vol.34 , pp. 991-1001
    • Jeong, J.C.1    Kim, M.S.2    Kim, T.H.3    Kim, Y.K.4
  • 56
    • 34748887195 scopus 로고    scopus 로고
    • Kaempferol induces apoptosis in glioblastoma cells through oxidative stress
    • Sharma, V.; Joseph, C.; Ghosh, S.; Agarwal, A.; Mishra, M.K.; Sen, E. Kaempferol induces apoptosis in glioblastoma cells through oxidative stress. Mol. Cancer Ther. 2007, 6, 2544-2553. [CrossRef]
    • (2007) Mol. Cancer Ther. , vol.6 , pp. 2544-2553
    • Sharma, V.1    Joseph, C.2    Ghosh, S.3    Agarwal, A.4    Mishra, M.K.5    Sen, E.6
  • 57
    • 85044720636 scopus 로고    scopus 로고
    • Kaempferol-loaded mucoadhesive nanoemulsion for intranasal administration reduces glioma growth in vitro
    • Colombo, M.; Figueiro, F.; de Fraga Dias, A.; Teixeira, H.F.; Battastini, A.M.O.; Koester, L.S. Kaempferol-loaded mucoadhesive nanoemulsion for intranasal administration reduces glioma growth in vitro. Int. J. Pharm. 2018, 543, 214-223. [CrossRef] [PubMed]
    • (2018) Int. J. Pharm. , vol.543 , pp. 214-223
    • Colombo, M.1    Figueiro, F.2    De Fraga Dias, A.3    Teixeira, H.F.4    Battastini, A.M.O.5    Koester, L.S.6
  • 58
    • 56249131797 scopus 로고    scopus 로고
    • The flavonoid kaempferol sensitizes human glioma cells to TRAIL-mediated apoptosis by proteasomal degradation of survivin
    • Siegelin, M.D.; Reuss, D.E.; Habel, A.; Herold-Mende, C.; von Deimling, A. The flavonoid kaempferol sensitizes human glioma cells to TRAIL-mediated apoptosis by proteasomal degradation of survivin. Mol. Cancer Ther. 2008, 7, 3566-3574. [CrossRef]
    • (2008) Mol. Cancer Ther. , vol.7 , pp. 3566-3574
    • Siegelin, M.D.1    Reuss, D.E.2    Habel, A.3    Herold-Mende, C.4    Von Deimling, A.5
  • 59
    • 85046007166 scopus 로고    scopus 로고
    • Selective cytotoxicity of luteolin and kaempferol on cancerous hepatocytes obtained from rat model of hepatocellular carcinoma: Involvement of ROS-mediated mitochondrial targeting
    • Seydi, E.; Salimi, A.; Rasekh, H.R.; Mohsenifar, Z.; Pourahmad, J. Selective Cytotoxicity of Luteolin and Kaempferol on Cancerous Hepatocytes Obtained from Rat Model of Hepatocellular Carcinoma: Involvement of ROS-Mediated Mitochondrial Targeting. Nutr. Cancer 2018, 70, 594-604. [CrossRef]
    • (2018) Nutr. Cancer , vol.70 , pp. 594-604
    • Seydi, E.1    Salimi, A.2    Rasekh, H.R.3    Mohsenifar, Z.4    Pourahmad, J.5
  • 60
    • 85057203897 scopus 로고    scopus 로고
    • Kaempferol inhibits proliferation, migration, and invasion of liver cancer HepG2 cells by down-regulation of microRNA-21
    • 2058738418814341
    • Zhu, G.; Liu, X.; Li, H.; Yan, Y.; Hong, X.; Lin, Z. Kaempferol inhibits proliferation, migration, and invasion of liver cancer HepG2 cells by down-regulation of microRNA-21. Int. J. Immunopathol. Pharmacol. 2018, 32, 2058738418814341. [CrossRef]
    • (2018) Int. J. Immunopathol. Pharmacol. , vol.32
    • Zhu, G.1    Liu, X.2    Li, H.3    Yan, Y.4    Hong, X.5    Lin, Z.6
  • 61
    • 77954818547 scopus 로고    scopus 로고
    • The dietary flavonoid kaempferol effectively inhibits HIF-1 activity and hepatoma cancer cell viability under hypoxic conditions
    • Mylonis, I.; Lakka, A.; Tsakalof, A.; Simos, G. The dietary flavonoid kaempferol effectively inhibits HIF-1 activity and hepatoma cancer cell viability under hypoxic conditions. Biochem. Biophys. Res. Commun. 2010, 398, 74-78. [CrossRef]
    • (2010) Biochem. Biophys. Res. Commun. , vol.398 , pp. 74-78
    • Mylonis, I.1    Lakka, A.2    Tsakalof, A.3    Simos, G.4
  • 62
    • 84876543464 scopus 로고    scopus 로고
    • Kaempferol induces autophagy through AMPK and AKT signaling molecules and causes G2/M arrest via downregulation of CDK1/cyclin B in SK-HEP-1 human hepatic cancer cells
    • Huang, W.W.; Tsai, S.C.; Peng, S.F.; Lin, M.W.; Chiang, J.H.; Chiu, Y.J.; Fushiya, S.; Tseng, M.T.; Yang, J.S. Kaempferol induces autophagy through AMPK and AKT signaling molecules and causes G2/M arrest via downregulation of CDK1/cyclin B in SK-HEP-1 human hepatic cancer cells. Int. J. Oncol. 2013, 42, 2069-2077. [CrossRef] [PubMed]
    • (2013) Int. J. Oncol. , vol.42 , pp. 2069-2077
    • Huang, W.W.1    Tsai, S.C.2    Peng, S.F.3    Lin, M.W.4    Chiang, J.H.5    Chiu, Y.J.6    Fushiya, S.7    Tseng, M.T.8    Yang, J.S.9
  • 63
    • 85031741003 scopus 로고    scopus 로고
    • 6-Hydroxy-3-O-methyl-kaempferol 6-O-glucopyranoside potentiates the anti-proliferative effect of interferon alpha/beta by promoting activation of the JAK/STAT signaling by inhibiting SOCS3 in hepatocellular carcinoma cells
    • Wonganan, O.; He, Y.J.; Shen, X.F.; Wongkrajang, K.; Suksamrarn, A.; Zhang, G.L.; Wang, F. 6-Hydroxy-3-O-methyl-kaempferol 6-O-glucopyranoside potentiates the anti-proliferative effect of interferon alpha/beta by promoting activation of the JAK/STAT signaling by inhibiting SOCS3 in hepatocellular carcinoma cells. Toxicol. Appl. Pharmacol. 2017, 336, 31-39. [CrossRef] [PubMed]
    • (2017) Toxicol. Appl. Pharmacol. , vol.336 , pp. 31-39
    • Wonganan, O.1    He, Y.J.2    Shen, X.F.3    Wongkrajang, K.4    Suksamrarn, A.5    Zhang, G.L.6    Wang, F.7
  • 65
    • 85053535745 scopus 로고    scopus 로고
    • Reactive oxygen species and p53 mediated activation of p38 and caspases is critically involved in kaempferol induced apoptosis in colorectal cancer cells
    • Choi, J.B.; Kim, J.H.; Lee, H.; Pak, J.N.; Shim, B.S.; Kim, S.H. Reactive Oxygen Species and p53 Mediated Activation of p38 and Caspases is Critically Involved in Kaempferol Induced Apoptosis in Colorectal Cancer Cells. J. Agric. Food Chem. 2018, 66, 9960-9967. [CrossRef]
    • (2018) J. Agric. Food Chem. , vol.66 , pp. 9960-9967
    • Choi, J.B.1    Kim, J.H.2    Lee, H.3    Pak, J.N.4    Shim, B.S.5    Kim, S.H.6
  • 66
    • 84894068756 scopus 로고    scopus 로고
    • Mechanisms underlying apoptosis-inducing effects of Kaempferol in HT-29 human colon cancer cells
    • Lee, H.S.; Cho, H.J.; Yu, R.; Lee, K.W.; Chun, H.S.; Park, J.H. Mechanisms underlying apoptosis-inducing effects of Kaempferol in HT-29 human colon cancer cells. Int. J. Mol. Sci. 2014, 15, 2722-2737. [CrossRef]
    • (2014) Int. J. Mol. Sci. , vol.15 , pp. 2722-2737
    • Lee, H.S.1    Cho, H.J.2    Yu, R.3    Lee, K.W.4    Chun, H.S.5    Park, J.H.6
  • 68
    • 84874641255 scopus 로고    scopus 로고
    • Antioxidant rich Morus alba leaf extract induces apoptosis in human colon and breast cancer cells by the downregulation of nitric oxide produced by inducible nitric oxide synthase
    • Deepa, M.; Sureshkumar, T.; Satheeshkumar, P.K.; Priya, S. Antioxidant rich Morus alba leaf extract induces apoptosis in human colon and breast cancer cells by the downregulation of nitric oxide produced by inducible nitric oxide synthase. Nutr. Cancer 2013, 65, 305-310. [CrossRef]
    • (2013) Nutr. Cancer , vol.65 , pp. 305-310
    • Deepa, M.1    Sureshkumar, T.2    Satheeshkumar, P.K.3    Priya, S.4
  • 69
    • 78951490151 scopus 로고    scopus 로고
    • Effect of kaempferol on lipid peroxidation and antioxidant status in 1,2-dimethyl hydrazine induced colorectal carcinoma in rats
    • Nirmala, P.; Ramanathan, M. Effect of kaempferol on lipid peroxidation and antioxidant status in 1,2-dimethyl hydrazine induced colorectal carcinoma in rats. Eur. J. Pharmacol. 2011, 654, 75-79. [CrossRef]
    • (2011) Eur. J. Pharmacol. , vol.654 , pp. 75-79
    • Nirmala, P.1    Ramanathan, M.2
  • 70
    • 57649192456 scopus 로고    scopus 로고
    • Kaempferol induces apoptosis in human HCT116 colon cancer cells via the Ataxia-Telangiectasia Mutated-p53 pathway with the involvement of p53 Upregulated Modulator of Apoptosis
    • Li, W.; Du, B.; Wang, T.; Wang, S.; Zhang, J. Kaempferol induces apoptosis in human HCT116 colon cancer cells via the Ataxia-Telangiectasia Mutated-p53 pathway with the involvement of p53 Upregulated Modulator of Apoptosis. Chem. Biol. Interact. 2009, 177, 121-127. [CrossRef]
    • (2009) Chem. Biol. Interact. , vol.177 , pp. 121-127
    • Li, W.1    Du, B.2    Wang, T.3    Wang, S.4    Zhang, J.5
  • 71
    • 16244375571 scopus 로고    scopus 로고
    • Augmentation of differentiation and gap junction function by kaempferol in partially differentiated colon cancer cells
    • Nakamura, Y.; Chang, C.C.; Mori, T.; Sato, K.; Ohtsuki, K.; Upham, B.L.; Trosko, J.E. Augmentation of differentiation and gap junction function by kaempferol in partially differentiated colon cancer cells. Carcinogenesis 2005, 26, 665-671. [CrossRef]
    • (2005) Carcinogenesis , vol.26 , pp. 665-671
    • Nakamura, Y.1    Chang, C.C.2    Mori, T.3    Sato, K.4    Ohtsuki, K.5    Upham, B.L.6    Trosko, J.E.7
  • 73
    • 43549102633 scopus 로고    scopus 로고
    • Kaempferol and quercetin stimulate granulocyte-macrophage colony-stimulating factor secretion in human prostate cancer cells
    • Bandyopadhyay, S.; Romero, J.R.; Chattopadhyay, N. Kaempferol and quercetin stimulate granulocyte-macrophage colony-stimulating factor secretion in human prostate cancer cells. Mol. Cell. Endocrinol. 2008, 287, 57-64. [CrossRef] [PubMed]
    • (2008) Mol. Cell. Endocrinol. , vol.287 , pp. 57-64
    • Bandyopadhyay, S.1    Romero, J.R.2    Chattopadhyay, N.3
  • 74
    • 85049860330 scopus 로고    scopus 로고
    • A novel flavonoid composition targets androgen receptor signaling and inhibits prostate cancer growth in preclinical models
    • Mamouni, K.; Zhang, S.; Li, X.; Chen, Y.; Yang, Y.; Kim, J.; Bartlett, M.G.; Coleman, I.M.; Nelson, P.S.; Kucuk, O.; et al. A novel flavonoid composition targets androgen receptor signaling and inhibits prostate cancer growth in preclinical models. Neoplasia 2018, 20, 789-799. [CrossRef] [PubMed]
    • (2018) Neoplasia , vol.20 , pp. 789-799
    • Mamouni, K.1    Zhang, S.2    Li, X.3    Chen, Y.4    Yang, Y.5    Kim, J.6    Bartlett, M.G.7    Coleman, I.M.8    Nelson, P.S.9    Kucuk, O.10
  • 75
    • 45049088538 scopus 로고    scopus 로고
    • Ginkgo biloba extract kaempferol inhibits cell proliferation and induces apoptosis in pancreatic cancer cells
    • Zhang, Y.; Chen, A.Y.; Li, M.; Chen, C.; Yao, Q. Ginkgo biloba extract kaempferol inhibits cell proliferation and induces apoptosis in pancreatic cancer cells. J. Surg. Res. 2008, 148, 17-23. [CrossRef] [PubMed]
    • (2008) J. Surg. Res. , vol.148 , pp. 17-23
    • Zhang, Y.1    Chen, A.Y.2    Li, M.3    Chen, C.4    Yao, Q.5
  • 76
    • 84969903144 scopus 로고    scopus 로고
    • Kaempferol inhibits pancreatic cancer cell growth and migration through the blockade of EGFR-related pathway in vitro
    • Lee, J.; Kim, J.H. Kaempferol Inhibits Pancreatic Cancer Cell Growth and Migration through the Blockade of EGFR-Related Pathway In Vitro. PLoS ONE 2016, 11, e0155264. [CrossRef] [PubMed]
    • (2016) PLoS ONE , vol.11
    • Lee, J.1    Kim, J.H.2
  • 77
    • 84948568042 scopus 로고    scopus 로고
    • Kaempferol enhances the suppressive function of Treg cells by inhibiting FOXP3 phosphorylation
    • Lin, F.; Luo, X.; Tsun, A.; Li, Z.; Li, D.; Li, B. Kaempferol enhances the suppressive function of Treg cells by inhibiting FOXP3 phosphorylation. Int. Immunopharmacol. 2015, 28, 859-865. [CrossRef]
    • (2015) Int. Immunopharmacol. , vol.28 , pp. 859-865
    • Lin, F.1    Luo, X.2    Tsun, A.3    Li, Z.4    Li, D.5    Li, B.6
  • 79
  • 80
    • 84928391008 scopus 로고    scopus 로고
    • Kaempferol induces DNA damage and inhibits DNA repair associated protein expressions in human promyelocytic leukemia HL-60 cells
    • Wu, L.Y.; Lu, H.F.; Chou, Y.C.; Shih, Y.L.; Bau, D.T.; Chen, J.C.; Hsu, S.C.; Chung, J.G. Kaempferol induces DNA damage and inhibits DNA repair associated protein expressions in human promyelocytic leukemia HL-60 cells. Am. J. Chin. Med. 2015, 43, 365-382. [CrossRef]
    • (2015) Am. J. Chin. Med. , vol.43 , pp. 365-382
    • Wu, L.Y.1    Lu, H.F.2    Chou, Y.C.3    Shih, Y.L.4    Bau, D.T.5    Chen, J.C.6    Hsu, S.C.7    Chung, J.G.8
  • 81
    • 35148894128 scopus 로고    scopus 로고
    • Kaempferol induced inhibition of HL-60 cell growth results from a heterogeneous response, dominated by cell cycle alterations
    • Bestwick, C.S.; Milne, L.; Duthie, S.J. Kaempferol induced inhibition of HL-60 cell growth results from a heterogeneous response, dominated by cell cycle alterations. Chem. Biol. Interact. 2007, 170, 76-85. [CrossRef]
    • (2007) Chem. Biol. Interact. , vol.170 , pp. 76-85
    • Bestwick, C.S.1    Milne, L.2    Duthie, S.J.3
  • 82
    • 20444371369 scopus 로고    scopus 로고
    • The effect of short-term kaempferol exposure on reactive oxygen levels and integrity of human (HL-60) leukaemic cells
    • Bestwick, C.S.; Milne, L.; Pirie, L.; Duthie, S.J. The effect of short-term kaempferol exposure on reactive oxygen levels and integrity of human (HL-60) leukaemic cells. BBA 2005, 1740, 340-349. [CrossRef] [PubMed]
    • (2005) BBA , vol.1740 , pp. 340-349
    • Bestwick, C.S.1    Milne, L.2    Pirie, L.3    Duthie, S.J.4
  • 83
    • 14644438576 scopus 로고    scopus 로고
    • Structurally related flavonoids with antioxidative properties differentially affect cell cycle progression and apoptosis of human acute leukemia cells
    • Rusak, G.; Gutzeit, H.O.; Müller, J.L. Structurally related flavonoids with antioxidative properties differentially affect cell cycle progression and apoptosis of human acute leukemia cells. Nutr. Res. 2005, 25, 143-155. [CrossRef]
    • (2005) Nutr. Res. , vol.25 , pp. 143-155
    • Rusak, G.1    Gutzeit, H.O.2    Müller, J.L.3
  • 84
    • 0035874028 scopus 로고    scopus 로고
    • Effects of structurally related flavonoids on cell cycle progression of human melanoma cells: Regulation of cyclin-dependent kinases CDK2 and CDK1
    • Casagrande, F.; Darbon, J.M. Effects of structurally related flavonoids on cell cycle progression of human melanoma cells: Regulation of cyclin-dependent kinases CDK2 and CDK1. Biochem. Pharmacol. 2001, 61, 1205-1215. [CrossRef]
    • (2001) Biochem. Pharmacol. , vol.61 , pp. 1205-1215
    • Casagrande, F.1    Darbon, J.M.2
  • 85
    • 2042519322 scopus 로고    scopus 로고
    • Isolation from Eucalyptus occidentalis and identification of a new kaempferol derivative that induces apoptosis in human myeloid leukemia cells
    • Benyahia, S.; Benayache, S.; Benayache, F.; Quintana, J.; Lopez, M.; Leon, F.; Hernandez, J.C.; Estevez, F.; Bermejo, J. Isolation from Eucalyptus occidentalis and identification of a new kaempferol derivative that induces apoptosis in human myeloid leukemia cells. J. Nat. Prod. 2004, 67, 527-531. [CrossRef] [PubMed]
    • (2004) J. Nat. Prod. , vol.67 , pp. 527-531
    • Benyahia, S.1    Benayache, S.2    Benayache, F.3    Quintana, J.4    Lopez, M.5    Leon, F.6    Hernandez, J.C.7    Estevez, F.8    Bermejo, J.9
  • 86
    • 18044383342 scopus 로고    scopus 로고
    • Dietary flavonoids as proteasome inhibitors and apoptosis inducers in human leukemia cells
    • Chen, D.; Daniel, K.G.; Chen, M.S.; Kuhn, D.J.; Landis-Piwowar, K.R.; Dou, Q.P. Dietary flavonoids as proteasome inhibitors and apoptosis inducers in human leukemia cells. Biochem. Pharmacol. 2005, 69, 1421-1432. [CrossRef] [PubMed]
    • (2005) Biochem. Pharmacol. , vol.69 , pp. 1421-1432
    • Chen, D.1    Daniel, K.G.2    Chen, M.S.3    Kuhn, D.J.4    Landis-Piwowar, K.R.5    Dou, Q.P.6
  • 87
    • 70349696220 scopus 로고    scopus 로고
    • Structures of new flavonoids and benzofuran-type stilbene and degranulation inhibitors of rat basophilic leukemia cells from the Brazilian herbal medicine Cissus sicyoides
    • Xu, F.; Matsuda, H.; Hata, H.; Sugawara, K.; Nakamura, S.; Yoshikawa, M. Structures of new flavonoids and benzofuran-type stilbene and degranulation inhibitors of rat basophilic leukemia cells from the Brazilian herbal medicine Cissus sicyoides. Chem. Pharm. Bull. 2009, 57, 1089-1095. [CrossRef] [PubMed]
    • (2009) Chem. Pharm. Bull. , vol.57 , pp. 1089-1095
    • Xu, F.1    Matsuda, H.2    Hata, H.3    Sugawara, K.4    Nakamura, S.5    Yoshikawa, M.6
  • 89
    • 84963985160 scopus 로고    scopus 로고
    • Kaempferol Suppresses Transforming Growth Factor-beta1-Induced Epithelial-to-Mesenchymal Transition and Migration of A549 Lung Cancer Cells by Inhibiting Akt1-Mediated Phosphorylation of Smad3 at Threonine-179
    • Jo, E.; Park, S.J.; Choi, Y.S.; Jeon, W.K.; Kim, B.C. Kaempferol Suppresses Transforming Growth Factor-beta1-Induced Epithelial-to-Mesenchymal Transition and Migration of A549 Lung Cancer Cells by Inhibiting Akt1-Mediated Phosphorylation of Smad3 at Threonine-179. Neoplasia 2015, 17, 525-537. [CrossRef] [PubMed]
    • (2015) Neoplasia , vol.17 , pp. 525-537
    • Jo, E.1    Park, S.J.2    Choi, Y.S.3    Jeon, W.K.4    Kim, B.C.5
  • 90
    • 85020900618 scopus 로고    scopus 로고
    • Kaempherol and luteolin decrease claudin-2 expression mediated by inhibition of STAT3 in lung adenocarcinoma A549 cells
    • Sonoki, H.; Tanimae, A.; Endo, S.; Matsunaga, T.; Furuta, T.; Ichihara, K.; Ikari, A. Kaempherol and Luteolin Decrease Claudin-2 Expression Mediated by Inhibition of STAT3 in Lung Adenocarcinoma A549 Cells. Nutrients 2017, 9, 597. [CrossRef] [PubMed]
    • (2017) Nutrients , vol.9 , pp. 597
    • Sonoki, H.1    Tanimae, A.2    Endo, S.3    Matsunaga, T.4    Furuta, T.5    Ichihara, K.6    Ikari, A.7
  • 91
    • 85040967192 scopus 로고    scopus 로고
    • Effects of quercetin, kaempferol, and exogenous glutathione on phospho- And total-Akt in 3T3-L1 preadipocytes
    • Boadi, W.Y.; Lo, A. Effects of Quercetin, Kaempferol, and Exogenous Glutathione on Phospho- and Total-AKT in 3T3-L1 Preadipocytes. J. Diet. Suppl. 2018, 15, 814-826. [CrossRef]
    • (2018) J. Diet. Suppl. , vol.15 , pp. 814-826
    • Boadi, W.Y.1    Lo, A.2
  • 92
    • 85053806630 scopus 로고    scopus 로고
    • Kaempferol suppresses proliferation but increases apoptosis and autophagy by up-regulating microRNA-340 in human lung cancer cells
    • Han, X.; Liu, C.F.; Gao, N.; Zhao, J.; Xu, J. Kaempferol suppresses proliferation but increases apoptosis and autophagy by up-regulating microRNA-340 in human lung cancer cells. Biomed. Pharmacother. 2018, 108, 809-816. [CrossRef] [PubMed]
    • (2018) Biomed. Pharmacother. , vol.108 , pp. 809-816
    • Han, X.1    Liu, C.F.2    Gao, N.3    Zhao, J.4    Xu, J.5
  • 93
    • 0141483543 scopus 로고    scopus 로고
    • Kaempferol-induced growth inhibition and apoptosis in A549 lung cancer cells is mediated by activation of MEK-MAPK
    • Nguyen, T.T.; Tran, E.; Ong, C.K.; Lee, S.K.; Do, P.T.; Huynh, T.T.; Nguyen, T.H.; Lee, J.J.; Tan, Y.; Ong, C.S.; et al. Kaempferol-induced growth inhibition and apoptosis in A549 lung cancer cells is mediated by activation of MEK-MAPK. J. Cell. Physiol. 2003, 197, 110-121. [CrossRef] [PubMed]
    • (2003) J. Cell. Physiol. , vol.197 , pp. 110-121
    • Nguyen, T.T.1    Tran, E.2    Ong, C.K.3    Lee, S.K.4    Do, P.T.5    Huynh, T.T.6    Nguyen, T.H.7    Lee, J.J.8    Tan, Y.9    Ong, C.S.10
  • 94
    • 84960131606 scopus 로고    scopus 로고
    • Kaempferol inhibits the growth and metastasis of cholangiocarcinoma in vitro and in vivo
    • Qin, Y.; Cui, W.; Yang, X.; Tong, B. Kaempferol inhibits the growth and metastasis of cholangiocarcinoma in vitro and in vivo. Acta Biochim. Biophy. Sin. 2016, 48, 238-245. [CrossRef] [PubMed]
    • (2016) Acta Biochim. Biophy. Sin. , vol.48 , pp. 238-245
    • Qin, Y.1    Cui, W.2    Yang, X.3    Tong, B.4
  • 95
    • 34547824635 scopus 로고    scopus 로고
    • Kaempferol induces apoptosis in human lung non-small carcinoma cells accompanied by an induction of antioxidant enzymes
    • Leung, H.W.; Lin, C.J.; Hour, M.J.; Yang, W.H.; Wang, M.Y.; Lee, H.Z. Kaempferol induces apoptosis in human lung non-small carcinoma cells accompanied by an induction of antioxidant enzymes. Food Chem. Toxicol. 2007, 45, 2005-2013. [CrossRef] [PubMed]
    • (2007) Food Chem. Toxicol. , vol.45 , pp. 2005-2013
    • Leung, H.W.1    Lin, C.J.2    Hour, M.J.3    Yang, W.H.4    Wang, M.Y.5    Lee, H.Z.6
  • 96
    • 84941979069 scopus 로고    scopus 로고
    • Radiosensitization of non-small cell lung cancer by kaempferol
    • Kuo, W.T.; Tsai, Y.C.; Wu, H.C.; Ho, Y.J.; Chen, Y.S.; Yao, C.H.; Yao, C.H. Radiosensitization of non-small cell lung cancer by kaempferol. Oncol. Rep. 2015, 34, 2351-2356. [CrossRef] [PubMed]
    • (2015) Oncol. Rep. , vol.34 , pp. 2351-2356
    • Kuo, W.T.1    Tsai, Y.C.2    Wu, H.C.3    Ho, Y.J.4    Chen, Y.S.5    Yao, C.H.6    Yao, C.H.7
  • 97
    • 85028569782 scopus 로고    scopus 로고
    • Kaempferol inhibits the invasion and migration of renal cancer cells through the downregulation of Akt and FAK pathways
    • Hung, T.-W.; Chen, P.-N.; Wu, H.-C.; Wu, S.-W.; Tsai, P.-Y.; Hsieh, Y.-S.; Chang, H.-R. Kaempferol Inhibits the Invasion and Migration of Renal Cancer Cells through the Downregulation of AKT and FAK Pathways. Int. J. Med. Sci. 2017, 14, 984-993. [CrossRef] [PubMed]
    • (2017) Int. J. Med. Sci. , vol.14 , pp. 984-993
    • Hung, T.-W.1    Chen, P.-N.2    Wu, H.-C.3    Wu, S.-W.4    Tsai, P.-Y.5    Hsieh, Y.-S.6    Chang, H.-R.7
  • 98
    • 79951923564 scopus 로고    scopus 로고
    • The bioflavonoid kaempferol is an Abcg2 substrate and inhibits Abcg2-mediated quercetin efflux
    • An, G.; Gallegos, J.; Morris, M.E. The bioflavonoid kaempferol is an Abcg2 substrate and inhibits Abcg2-mediated quercetin efflux. Drug Metab. Dispos. 2011, 39, 426-432. [CrossRef]
    • (2011) Drug Metab. Dispos. , vol.39 , pp. 426-432
    • An, G.1    Gallegos, J.2    Morris, M.E.3
  • 99
    • 84896691526 scopus 로고    scopus 로고
    • Kaempferol induces cell cycle arrest and apoptosis in renal cell carcinoma through EGFR/p38 signaling
    • Song, W.; Dang, Q.; Xu, D.; Chen, Y.; Zhu, G.; Wu, K.; Zeng, J.; Long, Q.; Wang, X.; He, D.; et al. Kaempferol induces cell cycle arrest and apoptosis in renal cell carcinoma through EGFR/p38 signaling. Oncol. Rep. 2014, 31, 1350-1356. [CrossRef]
    • (2014) Oncol. Rep. , vol.31 , pp. 1350-1356
    • Song, W.1    Dang, Q.2    Xu, D.3    Chen, Y.4    Zhu, G.5    Wu, K.6    Zeng, J.7    Long, Q.8    Wang, X.9    He, D.10
  • 100
    • 85054732267 scopus 로고    scopus 로고
    • Kaempferol attenuates ROS-induced hemolysis and the molecular mechanism of its induction of apoptosis on bladder cancer
    • Wu, P.; Meng, X.; Zheng, H.; Zeng, Q.; Chen, T.; Wang, W.; Zhang, X.; Su, J. Kaempferol Attenuates ROS-Induced Hemolysis and the Molecular Mechanism of Its Induction of Apoptosis on Bladder Cancer. Molecules 2018, 23, 2592. [CrossRef]
    • (2018) Molecules , vol.23 , pp. 2592
    • Wu, P.1    Meng, X.2    Zheng, H.3    Zeng, Q.4    Chen, T.5    Wang, W.6    Zhang, X.7    Su, J.8
  • 101
    • 84938992202 scopus 로고    scopus 로고
    • Kaempferol suppresses bladder cancer tumor growth by inhibiting cell proliferation and inducing apoptosis
    • Dang, Q.; Song, W.; Xu, D.; Ma, Y.; Li, F.; Zeng, J.; Zhu, G.; Wang, X.; Chang, L.S.; He, D.; et al. Kaempferol suppresses bladder cancer tumor growth by inhibiting cell proliferation and inducing apoptosis. Mol. Carcinog. 2015, 54, 831-840. [CrossRef]
    • (2015) Mol. Carcinog. , vol.54 , pp. 831-840
    • Dang, Q.1    Song, W.2    Xu, D.3    Ma, Y.4    Li, F.5    Zeng, J.6    Zhu, G.7    Wang, X.8    Chang, L.S.9    He, D.10
  • 102
    • 0033500023 scopus 로고    scopus 로고
    • High intake of specific carotenoids and flavonoids does not reduce the risk of bladder cancer
    • Garcia, R.; Gonzalez, C.A.; Agudo, A.; Riboli, E. High intake of specific carotenoids and flavonoids does not reduce the risk of bladder cancer. Nutr. Cancer 1999, 35, 212-214. [CrossRef] [PubMed]
    • (1999) Nutr. Cancer , vol.35 , pp. 212-214
    • Garcia, R.1    Gonzalez, C.A.2    Agudo, A.3    Riboli, E.4
  • 103
    • 84886508466 scopus 로고    scopus 로고
    • Kaempferol promotes apoptosis in human bladder cancer cells by inducing the tumor suppressor
    • Xie, F.; Su, M.; Qiu, W.; Zhang, M.; Guo, Z.; Su, B.; Liu, J.; Li, X.; Zhou, L. Kaempferol promotes apoptosis in human bladder cancer cells by inducing the tumor suppressor, PTEN. Int. J. Mol. Sci. 2013, 14, 21215-21226. [CrossRef] [PubMed]
    • (2013) PTEN. Int. J. Mol. Sci. , vol.14 , pp. 21215-21226
    • Xie, F.1    Su, M.2    Qiu, W.3    Zhang, M.4    Guo, Z.5    Su, B.6    Liu, J.7    Li, X.8    Zhou, L.9
  • 104
    • 84896690124 scopus 로고    scopus 로고
    • Kaempferol reduces matrix metalloproteinase-2 expression by down-regulating ERK1/2 and the activator protein-1 signaling pathways in oral cancer cells
    • Lin, C.W.; Chen, P.N.; Chen, M.K.; Yang, W.E.; Tang, C.H.; Yang, S.F.; Hsieh, Y.S. Kaempferol reduces matrix metalloproteinase-2 expression by down-regulating ERK1/2 and the activator protein-1 signaling pathways in oral cancer cells. PLoS ONE 2013, 8, e80883. [CrossRef] [PubMed]
    • (2013) PLoS ONE , vol.8
    • Lin, C.W.1    Chen, P.N.2    Chen, M.K.3    Yang, W.E.4    Tang, C.H.5    Yang, S.F.6    Hsieh, Y.S.7
  • 106
    • 84877141820 scopus 로고    scopus 로고
    • Kaempferol-induced apoptosis of human esophageal squamous carcinoma Eca-109 cells and the mechanism
    • Li, R.J.; Mei, J.Z.; Liu, G.J. [Kaempferol-induced apoptosis of human esophageal squamous carcinoma Eca-109 cells and the mechanism]. J. South Med. Univ. 2011, 31, 1440-1442.
    • (2011) J. South Med. Univ. , vol.31 , pp. 1440-1442
    • Li, R.J.1    Mei, J.Z.2    Liu, G.J.3
  • 107
    • 84983613474 scopus 로고    scopus 로고
    • Kaempferol inhibits cell proliferation and glycolysis in esophagus squamous cell carcinoma via targeting EGFR signaling pathway
    • Yao, S.; Wang, X.; Li, C.; Zhao, T.; Jin, H.; Fang, W. Kaempferol inhibits cell proliferation and glycolysis in esophagus squamous cell carcinoma via targeting EGFR signaling pathway. Tumour Boil. 2016, 37, 10247-10256. [CrossRef] [PubMed]
    • (2016) Tumour Boil , vol.37 , pp. 10247-10256
    • Yao, S.1    Wang, X.2    Li, C.3    Zhao, T.4    Jin, H.5    Fang, W.6
  • 108
    • 75749093933 scopus 로고    scopus 로고
    • Kaempferol and quercetin, components of Ginkgo biloba extract (EGb 761), induce caspase-3-dependent apoptosis in oral cavity cancer cells
    • Kang, J.W.; Kim, J.H.; Song, K.; Kim, S.H.; Yoon, J.H.; Kim, K.S. Kaempferol and quercetin, components of Ginkgo biloba extract (EGb 761), induce caspase-3-dependent apoptosis in oral cavity cancer cells. Phytother. Res. 2010, 24 (Suppl. 1), S77-S82. [CrossRef]
    • (2010) Phytother. Res. , vol.24 , pp. S77-S82
    • Kang, J.W.1    Kim, J.H.2    Song, K.3    Kim, S.H.4    Yoon, J.H.5    Kim, K.S.6
  • 109
    • 78349236990 scopus 로고    scopus 로고
    • Kaempferol induced apoptosis via endoplasmic reticulum stress and mitochondria-dependent pathway in human osteosarcoma U-2 OS cells
    • Huang, W.W.; Chiu, Y.J.; Fan, M.J.; Lu, H.F.; Yeh, H.F.; Li, K.H.; Chen, P.Y.; Chung, J.G.; Yang, J.S. Kaempferol induced apoptosis via endoplasmic reticulum stress and mitochondria-dependent pathway in human osteosarcoma U-2 OS cells. Mol. Nutr. Food Res. 2010, 54, 1585-1595. [CrossRef]
    • (2010) Mol. Nutr. Food Res. , vol.54 , pp. 1585-1595
    • Huang, W.W.1    Chiu, Y.J.2    Fan, M.J.3    Lu, H.F.4    Yeh, H.F.5    Li, K.H.6    Chen, P.Y.7    Chung, J.G.8    Yang, J.S.9
  • 110
    • 84879657942 scopus 로고    scopus 로고
    • Kaempferol suppresses cell metastasis via inhibition of the ERK-p38-JNK and AP-1 signaling pathways in U-2 OS human osteosarcoma cells
    • Chen, H.J.; Lin, C.M.; Lee, C.Y.; Shih, N.C.; Peng, S.F.; Tsuzuki, M.; Amagaya, S.; Huang, W.W.; Yang, J.S. Kaempferol suppresses cell metastasis via inhibition of the ERK-p38-JNK and AP-1 signaling pathways in U-2 OS human osteosarcoma cells. Oncol. Rep. 2013, 30, 925-932. [CrossRef]
    • (2013) Oncol. Rep. , vol.30 , pp. 925-932
    • Chen, H.J.1    Lin, C.M.2    Lee, C.Y.3    Shih, N.C.4    Peng, S.F.5    Tsuzuki, M.6    Amagaya, S.7    Huang, W.W.8    Yang, J.S.9
  • 111
    • 85014119232 scopus 로고    scopus 로고
    • Kaempferol increases apoptosis in human cervical cancer HeLa cells via PI3K/AKT and telomerase pathways
    • Kashafi, E.; Moradzadeh, M.; Mohamadkhani, A.; Erfanian, S. Kaempferol increases apoptosis in human cervical cancer HeLa cells via PI3K/AKT and telomerase pathways. Biomed. Pharmacother. 2017, 89, 573-577. [CrossRef]
    • (2017) Biomed. Pharmacother. , vol.89 , pp. 573-577
    • Kashafi, E.1    Moradzadeh, M.2    Mohamadkhani, A.3    Erfanian, S.4
  • 112
    • 84960379142 scopus 로고    scopus 로고
    • Protective effects of kaempferol against reactive oxygen species-induced hemolysis and its antiproliferative activity on human cancer cells
    • Liao, W.; Chen, L.; Ma, X.; Jiao, R.; Li, X.; Wang, Y. Protective effects of kaempferol against reactive oxygen species-induced hemolysis and its antiproliferative activity on human cancer cells. Eur. J. Med. Chem. 2016, 114, 24-32. [CrossRef] [PubMed]
    • (2016) Eur. J. Med. Chem. , vol.114 , pp. 24-32
    • Liao, W.1    Chen, L.2    Ma, X.3    Jiao, R.4    Li, X.5    Wang, Y.6
  • 113
    • 16244371036 scopus 로고    scopus 로고
    • Inhibition of P-glycoprotein function and expression by kaempferol and quercetin
    • Limtrakul, P.; Khantamat, O.; Pintha, K. Inhibition of P-glycoprotein function and expression by kaempferol and quercetin. J. Chemother. 2005, 17, 86-95. [CrossRef] [PubMed]
    • (2005) J. Chemother. , vol.17 , pp. 86-95
    • Limtrakul, P.1    Khantamat, O.2    Pintha, K.3
  • 114
    • 84975757505 scopus 로고    scopus 로고
    • The mechanism of kaempferol induced apoptosis and inhibited proliferation in human cervical cancer SiHa cell: From macro to nano
    • Tu, L.Y.; Bai, H.H.; Cai, J.Y.; Deng, S.P. The mechanism of kaempferol induced apoptosis and inhibited proliferation in human cervical cancer SiHa cell: From macro to nano. Scanning 2016, 38, 644-653. [CrossRef] [PubMed]
    • (2016) Scanning , vol.38 , pp. 644-653
    • Tu, L.Y.1    Bai, H.H.2    Cai, J.Y.3    Deng, S.P.4
  • 115
    • 42749084654 scopus 로고    scopus 로고
    • Kaempferol-7-O-beta-D-glucoside (KG) isolated from Smilax China L. Rhizome induces G2/M phase arrest and apoptosis on HeLa cells in a p53-independent manner
    • Xu, W.; Liu, J.; Li, C.; Wu, H.Z.; Liu, Y.W. Kaempferol-7-O-beta-D-glucoside (KG) isolated from Smilax china L. rhizome induces G2/M phase arrest and apoptosis on HeLa cells in a p53-independent manner. Cancer Lett. 2008, 264, 229-240. [CrossRef] [PubMed]
    • (2008) Cancer Lett , vol.264 , pp. 229-240
    • Xu, W.1    Liu, J.2    Li, C.3    Wu, H.Z.4    Liu, Y.W.5
  • 116
    • 84919427485 scopus 로고    scopus 로고
    • Kaempferol inhibits gastric cancer tumor growth: An in vitro and in vivo study
    • Song, H.; Bao, J.; Wei, Y.; Chen, Y.; Mao, X.; Li, J.; Yang, Z.; Xue, Y. Kaempferol inhibits gastric cancer tumor growth: An in vitro and in vivo study. Oncol. Rep. 2015, 33, 868-874. [CrossRef]
    • (2015) Oncol. Rep. , vol.33 , pp. 868-874
    • Song, H.1    Bao, J.2    Wei, Y.3    Chen, Y.4    Mao, X.5    Li, J.6    Yang, Z.7    Xue, Y.8
  • 117
    • 85052717563 scopus 로고    scopus 로고
    • Kaempferol induces autophagic cell death via IRE1-JNK-CHOP pathway and inhibition of G9a in gastric cancer cells
    • Kim, T.W.; Lee, S.Y.; Kim, M.; Cheon, C.; Ko, S.G. Kaempferol induces autophagic cell death via IRE1-JNK-CHOP pathway and inhibition of G9a in gastric cancer cells. Cell Death Dis. 2018, 9, 875. [CrossRef]
    • (2018) Cell Death Dis , vol.9 , pp. 875
    • Kim, T.W.1    Lee, S.Y.2    Kim, M.3    Cheon, C.4    Ko, S.G.5
  • 118
    • 70449643130 scopus 로고    scopus 로고
    • Kaempferol inhibits angiogenesis and VEGF expression through both HIF dependent and independent pathways in human ovarian cancer cells
    • Luo, H.; Rankin, G.O.; Liu, L.; Daddysman, M.K.; Jiang, B.H.; Chen, Y.C. Kaempferol inhibits angiogenesis and VEGF expression through both HIF dependent and independent pathways in human ovarian cancer cells. Nutr. Cancer 2009, 61, 554-563. [CrossRef]
    • (2009) Nutr. Cancer , vol.61 , pp. 554-563
    • Luo, H.1    Rankin, G.O.2    Liu, L.3    Daddysman, M.K.4    Jiang, B.H.5    Chen, Y.C.6
  • 119
    • 85046634267 scopus 로고    scopus 로고
    • Kaempferol induces G2/M cell cycle arrest via checkpoint kinase 2 and promotes apoptosis via death receptors in human ovarian carcinoma A2780/CP70 cells
    • Gao, Y.; Yin, J.; Rankin, G.O.; Chen, Y.C. Kaempferol Induces G2/M Cell Cycle Arrest via Checkpoint Kinase 2 and Promotes Apoptosis via Death Receptors in Human Ovarian Carcinoma A2780/CP70 Cells. Molecules 2018, 23, 1095. [CrossRef]
    • (2018) Molecules , vol.23 , pp. 1095
    • Gao, Y.1    Yin, J.2    Rankin, G.O.3    Chen, Y.C.4
  • 120
    • 80052263870 scopus 로고    scopus 로고
    • Kaempferol inhibits VEGF expression and in vitro angiogenesis through a novel ERK-NFκB-cMyc-p21 pathway
    • Luo, H.; Rankin, G.O.; Juliano, N.; Jiang, B.-H.; Chen, Y.C. Kaempferol inhibits VEGF expression and in vitro angiogenesis through a novel ERK-NFκB-cMyc-p21 pathway. Food Chem. 2012, 130, 321-328. [CrossRef]
    • (2012) Food Chem , vol.130 , pp. 321-328
    • Luo, H.1    Rankin, G.O.2    Juliano, N.3    Jiang, B.-H.4    Chen, Y.C.5
  • 121
    • 85032455969 scopus 로고    scopus 로고
    • Kaempferol sensitizes human ovarian cancer cells-ovcar-3 and SKOV-3 to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis via JNK/ERK-CHOP pathway and up-regulation of death receptors 4 and 5
    • Zhao, Y.; Tian, B.; Wang, Y.; Ding, H. Kaempferol Sensitizes Human Ovarian Cancer Cells-OVCAR-3 and SKOV-3 to Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)-Induced Apoptosis via JNK/ERK-CHOP Pathway and Up-Regulation of Death Receptors 4 and 5. Med. Sci. Monit. 2017, 23, 5096-5105. [CrossRef]
    • (2017) Med. Sci. Monit. , vol.23 , pp. 5096-5105
    • Zhao, Y.1    Tian, B.2    Wang, Y.3    Ding, H.4
  • 122
    • 79955598035 scopus 로고    scopus 로고
    • Kaempferol induces apoptosis in ovarian cancer cells through activating p53 in the intrinsic pathway
    • Luo, H.; Rankin, G.O.; Li, Z.; Depriest, L.; Chen, Y.C. Kaempferol induces apoptosis in ovarian cancer cells through activating p53 in the intrinsic pathway. Food Chem. 2011, 128, 513-519. [CrossRef] [PubMed]
    • (2011) Food Chem , vol.128 , pp. 513-519
    • Luo, H.1    Rankin, G.O.2    Li, Z.3    Depriest, L.4    Chen, Y.C.5
  • 123
    • 77951944654 scopus 로고    scopus 로고
    • Kaempferol enhances cisplatin's effect on ovarian cancer cells through promoting apoptosis caused by down regulation of cMyc
    • Luo, H.; Daddysman, M.K.; Rankin, G.O.; Jiang, B.H.; Chen, Y.C. Kaempferol enhances cisplatin's effect on ovarian cancer cells through promoting apoptosis caused by down regulation of cMyc. Cancer Cell Int. 2010, 10, 16. [CrossRef] [PubMed]
    • (2010) Cancer Cell Int , vol.10 , pp. 16
    • Luo, H.1    Daddysman, M.K.2    Rankin, G.O.3    Jiang, B.H.4    Chen, Y.C.5
  • 124
    • 85015659742 scopus 로고    scopus 로고
    • Kaempferol modulates DNA methylation and downregulates DNMT3B in bladder cancer
    • Qiu, W.; Lin, J.; Zhu, Y.; Zhang, J.; Zeng, L.; Su, M.; Tian, Y. Kaempferol Modulates DNA Methylation and Downregulates DNMT3B in Bladder Cancer. Cell. Physiol. Biochem. 2017, 41, 1325-1335. [CrossRef] [PubMed]
    • (2017) Cell. Physiol. Biochem. , vol.41 , pp. 1325-1335
    • Qiu, W.1    Lin, J.2    Zhu, Y.3    Zhang, J.4    Zeng, L.5    Su, M.6    Tian, Y.7
  • 125
    • 84894055126 scopus 로고    scopus 로고
    • Kaempferol induces cell cycle arrest in HT-29 human colon cancer cells
    • Cho, H.J.; Park, J.H. Kaempferol Induces Cell Cycle Arrest in HT-29 Human Colon Cancer Cells. J. Cancer Prev. 2013, 18, 257-263. [CrossRef] [PubMed]
    • (2013) J. Cancer Prev. , vol.18 , pp. 257-263
    • Cho, H.J.1    Park, J.H.2


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