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Volumn 10, Issue , 2017, Pages 4809-4819

Low dose of kaempferol suppresses the migration and invasion of triple-negative breast cancer cells by downregulating the activities of RhoA and Rac1

Author keywords

Invasion; Kaempferol; Migration; Rac1; RhoA; TNBC

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTROGEN RECEPTOR; KAEMPFEROL; MESSENGER RNA; PROGESTERONE RECEPTOR; PROTEIN CDC42; RAC1 PROTEIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; TRASTUZUMAB;

EID: 85031104881     PISSN: None     EISSN: 11786930     Source Type: Journal    
DOI: 10.2147/OTT.S140886     Document Type: Article
Times cited : (66)

References (31)
  • 1
    • 85015311802 scopus 로고    scopus 로고
    • New therapeutic strategies for triple-negative breast cancer
    • Szekely B, Silber AL, Pusztai L. New therapeutic strategies for triple-negative breast cancer. Oncology (Williston Park). 2017;31(2):130–137.
    • (2017) Oncology (Williston Park) , vol.31 , Issue.2 , pp. 130-137
    • Szekely, B.1    Silber, A.L.2    Pusztai, L.3
  • 2
    • 84957598268 scopus 로고    scopus 로고
    • Outcomes of triple-negative breast cancers (TNBC) compared with non-TNBC: Does the survival vary for all stages?
    • Agarwal G, Nanda G, Lal P, et al. Outcomes of triple-negative breast cancers (TNBC) compared with non-TNBC: does the survival vary for all stages? World J Surg. 2016;40(6):1362–1372.
    • (2016) World J Surg , vol.40 , Issue.6 , pp. 1362-1372
    • Agarwal, G.1    Nanda, G.2    Lal, P.3
  • 4
    • 85031106014 scopus 로고    scopus 로고
    • Bursts of chromosome changes drive TNBC. Cancer Discov. 2016;6(10):1075.
    • (2016) Cancer Discov , vol.6 , Issue.10 , pp. 1075
  • 5
    • 2542562423 scopus 로고
    • Synthesis of the monomethyl ethers of kae­mpferol, and the constitution of rhamnocitrin
    • Rao KV, Seshadri TR. Synthesis of the monomethyl ethers of kae­mpferol, and the constitution of rhamnocitrin. J Chem Soc. 1947:122–124.
    • (1947) J Chem Soc , pp. 122-124
    • Rao, K.V.1    Seshadri, T.R.2
  • 6
    • 84928529969 scopus 로고    scopus 로고
    • Antibacterial active compounds from hypericum ascyron L. Induce bacterial cell death through apoptosis pathway
    • Li XM, Luo XG, Si CL, et al. Antibacterial active compounds from hypericum ascyron L. induce bacterial cell death through apoptosis pathway. Eur J Med Chem. 2015;96:436–444.
    • (2015) Eur J Med Chem , vol.96 , pp. 436-444
    • Li, X.M.1    Luo, X.G.2    Si, C.L.3
  • 7
    • 84904806378 scopus 로고    scopus 로고
    • Characterization of phytochemicals and antioxidant activities of red radish brines during lactic acid fermentation
    • Jing P, Song LH, Shen SQ, Zhao SJ, Pang J, Qian BJ. Characterization of phytochemicals and antioxidant activities of red radish brines during lactic acid fermentation. Molecules. 2014;19(7):9675–9688.
    • (2014) Molecules , vol.19 , Issue.7 , pp. 9675-9688
    • Jing, P.1    Song, L.H.2    Shen, S.Q.3    Zhao, S.J.4    Pang, J.5    Qian, B.J.6
  • 8
    • 84964255463 scopus 로고    scopus 로고
    • Protective effect of kaempferol on LPS plus ATP-induced inflammatory response in cardiac fibroblasts
    • Tang XL, Liu JX, Dong W, et al. Protective effect of kaempferol on LPS plus ATP-induced inflammatory response in cardiac fibroblasts. Inflammation. 2015;38(1):94–101.
    • (2015) Inflammation , vol.38 , Issue.1 , pp. 94-101
    • Tang, X.L.1    Liu, J.X.2    Dong, W.3
  • 9
    • 85014119232 scopus 로고    scopus 로고
    • Kaempferol increases apoptosis in human cervical cancer HeLa cells via PI3K/AKT and telomerase pathways
    • Kashafi E, Moradzadeh M, Mohamadkhani A, Erfanian S. Kaempferol increases apoptosis in human cervical cancer HeLa cells via PI3K/AKT and telomerase pathways. Biomed Pharmacother. 2017;89:573–577.
    • (2017) Biomed Pharmacother , vol.89 , pp. 573-577
    • Kashafi, E.1    Moradzadeh, M.2    Mohamadkhani, A.3    Erfanian, S.4
  • 10
    • 0141483543 scopus 로고    scopus 로고
    • Kaempferol-induced growth inhibition and apoptosis in A549 lung cancer cells is mediated by activation of MEK-MAPK
    • Nguyen TT, Tran E, Ong CK, et al. Kaempferol-induced growth inhibition and apoptosis in A549 lung cancer cells is mediated by activation of MEK-MAPK. J Cell Physiol. 2003;197(1):110–121.
    • (2003) J Cell Physiol , vol.197 , Issue.1 , pp. 110-121
    • Nguyen, T.T.1    Tran, E.2    Ong, C.K.3
  • 11
    • 84941979069 scopus 로고    scopus 로고
    • Radiosensitization of non-small cell lung cancer by kaempferol
    • Kuo WT, Tsai YC, Wu HC, et al. Radiosensitization of non-small cell lung cancer by kaempferol. Oncol Rep. 2015;34(5):2351–2356.
    • (2015) Oncol Rep , vol.34 , Issue.5 , pp. 2351-2356
    • Kuo, W.T.1    Tsai, Y.C.2    Wu, H.C.3
  • 12
    • 16244375571 scopus 로고    scopus 로고
    • Augmentation of differentiation and gap junction function by kaempferol in partially differentiated colon cancer cells
    • Nakamura Y, Chang CC, Mori T, et al. Augmentation of differentiation and gap junction function by kaempferol in partially differentiated colon cancer cells. Carcinogenesis. 2005;26(3):665–671.
    • (2005) Carcinogenesis , vol.26 , Issue.3 , pp. 665-671
    • Nakamura, Y.1    Chang, C.C.2    Mori, T.3
  • 13
    • 50149121804 scopus 로고    scopus 로고
    • Kaempferol sensitizes colon cancer cells to TRAIL-induced apoptosis
    • Yoshida T, Konishi M, Horinaka M, et al. Kaempferol sensitizes colon cancer cells to TRAIL-induced apoptosis. Biochem Biophys Res Commun. 2008;375(1):129–133.
    • (2008) Biochem Biophys Res Commun , vol.375 , Issue.1 , pp. 129-133
    • Yoshida, T.1    Konishi, M.2    Horinaka, M.3
  • 14
    • 77952868913 scopus 로고    scopus 로고
    • Kaempferol induced the apoptosis via cell cycle arrest in human breast cancer MDA-MB-453 cells
    • Choi EJ, Ahn WS. Kaempferol induced the apoptosis via cell cycle arrest in human breast cancer MDA-MB-453 cells. Nutr Res Pract. 2008;2(4):322–325.
    • (2008) Nutr Res Pract , vol.2 , Issue.4 , pp. 322-325
    • Choi, E.J.1    Ahn, W.S.2
  • 15
    • 84957798907 scopus 로고    scopus 로고
    • Treatment with kaempferol suppresses breast cancer cell growth caused by estrogen and triclosan in cellular and xenograft breast cancer models
    • Kim SH, Hwang KA, Choi KC. Treatment with kaempferol suppresses breast cancer cell growth caused by estrogen and triclosan in cellular and xenograft breast cancer models. J Nutr Biochem. 2016;28:70–82.
    • (2016) J Nutr Biochem , vol.28 , pp. 70-82
    • Kim, S.H.1    Hwang, K.A.2    Choi, K.C.3
  • 16
    • 84921944403 scopus 로고    scopus 로고
    • Inhibitory effects of kaempferol on the inva­sion of human breast carcinoma cells by downregulating the expression and activity of matrix metalloproteinase-9
    • Li C, Zhao Y, Yang D, et al. Inhibitory effects of kaempferol on the inva­sion of human breast carcinoma cells by downregulating the expression and activity of matrix metalloproteinase-9. Biochem Cell Biol. 2015;93(1):16–27.
    • (2015) Biochem Cell Biol , vol.93 , Issue.1 , pp. 16-27
    • Li, C.1    Zhao, Y.2    Yang, D.3
  • 17
    • 85006928791 scopus 로고    scopus 로고
    • Kaempferol, a phytoestrogen, sup­pressed triclosan-induced epithelial-mesenchymal transition and metastatic-related behaviors of MCF-7 breast cancer cells
    • Lee GA, Choi KC, Hwang KA. Kaempferol, a phytoestrogen, sup­pressed triclosan-induced epithelial-mesenchymal transition and metastatic-related behaviors of MCF-7 breast cancer cells. Environ Toxicol Pharmacol. 2017;49:48–57.
    • (2017) Environ Toxicol Pharmacol , vol.49 , pp. 48-57
    • Lee, G.A.1    Choi, K.C.2    Hwang, K.A.3
  • 18
    • 85016954870 scopus 로고    scopus 로고
    • Tumor suppressor role of miR-3622b-5p in ERBB2-positive cancer
    • Lu M, Wang T, He M, et al. Tumor suppressor role of miR-3622b-5p in ERBB2-positive cancer. Oncotarget. 2017;8(14):23008–23019.
    • (2017) Oncotarget , vol.8 , Issue.14 , pp. 23008-23019
    • Lu, M.1    Wang, T.2    He, M.3
  • 19
    • 84861395028 scopus 로고    scopus 로고
    • Dvl2-dependent activation of Daam1 and RhoA regulates Wnt5a-induced breast cancer cell migration
    • Zhu Y, Tian Y, Du J, et al. Dvl2-dependent activation of Daam1 and RhoA regulates Wnt5a-induced breast cancer cell migration. PLoS One. 2012;7(5):e37823.
    • (2012) Plos One , vol.7 , Issue.5
    • Zhu, Y.1    Tian, Y.2    Du, J.3
  • 20
    • 84874980245 scopus 로고    scopus 로고
    • Rab35 is required for Wnt5a/Dvl2-induced Rac1 activation and cell migration in MCF-7 breast cancer cells
    • Zhu Y, Shen T, Liu J, et al. Rab35 is required for Wnt5a/Dvl2-induced Rac1 activation and cell migration in MCF-7 breast cancer cells. Cell Signal. 2013;25(5):1075–1085.
    • (2013) Cell Signal , vol.25 , Issue.5 , pp. 1075-1085
    • Zhu, Y.1    Shen, T.2    Liu, J.3
  • 21
    • 84870351089 scopus 로고    scopus 로고
    • PI3K/Akt-dependent phosphorylation of GSK3beta and activation of RhoA regulate Wnt5a-induced gastric cancer cell migration
    • Liu J, Zhang Y, Xu R, et al. PI3K/Akt-dependent phosphorylation of GSK3beta and activation of RhoA regulate Wnt5a-induced gastric cancer cell migration. Cell Signal. 2013;25(2):447–456.
    • (2013) Cell Signal , vol.25 , Issue.2 , pp. 447-456
    • Liu, J.1    Zhang, Y.2    Xu, R.3
  • 22
    • 85009952085 scopus 로고    scopus 로고
    • MiR 1296–5p inhibits the migration and invasion of gastric cancer cells by repressing ERBB2 expression
    • Shan X, Wen W, Zhu D, et al. miR 1296–5p inhibits the migration and invasion of gastric cancer cells by repressing ERBB2 expression. PLoS One. 2017;12(1): e0170298.
    • (2017) Plos One , vol.12 , Issue.1
    • Shan, X.1    Wen, W.2    Zhu, D.3
  • 23
    • 84990928906 scopus 로고    scopus 로고
    • Nab-paclitaxel for the treatment of triple-negative breast cancer: Rationale, clinical data and future perspectives
    • Schettini F, Giuliano M, De Placido S, Arpino G. Nab-paclitaxel for the treatment of triple-negative breast cancer: rationale, clinical data and future perspectives. Cancer Treat Rev. 2016;50:129–141.
    • (2016) Cancer Treat Rev , vol.50 , pp. 129-141
    • Schettini, F.1    Giuliano, M.2    De Placido, S.3    Arpino, G.4
  • 24
    • 47949120075 scopus 로고    scopus 로고
    • Sustained ERK activation is involved in the kaempferol-induced apoptosis of breast cancer cells and is more evident under 3-D culture condition
    • Kim BW, Lee ER, Min HM, et al. Sustained ERK activation is involved in the kaempferol-induced apoptosis of breast cancer cells and is more evident under 3-D culture condition. Cancer Biol Ther. 2008;7(7):1080–1089.
    • (2008) Cancer Biol Ther , vol.7 , Issue.7 , pp. 1080-1089
    • Kim, B.W.1    Lee, E.R.2    Min, H.M.3
  • 25
    • 84857985828 scopus 로고    scopus 로고
    • Kaempferol-3-O-rhamnoside isolated from the leaves of schima wallichii Korth. Inhibits MCF-7 breast cancer cell proliferation through activation of the caspase cascade pathway
    • Diantini A, Subarnas A, Lestari K, et al. Kaempferol-3-O-rhamnoside isolated from the leaves of schima wallichii Korth. inhibits MCF-7 breast cancer cell proliferation through activation of the caspase cascade pathway. Oncol Lett. 2012;3(5):1069–1072.
    • (2012) Oncol Lett , vol.3 , Issue.5 , pp. 1069-1072
    • Diantini, A.1    Subarnas, A.2    Lestari, K.3
  • 26
    • 84925481938 scopus 로고    scopus 로고
    • HER2-directed therapy: Current treatment options for HER2-positive breast cancer
    • Ahmed S, Sami A, Xiang J. HER2-directed therapy: current treatment options for HER2-positive breast cancer. Breast Cancer. 2015;22(2):101–116.
    • (2015) Breast Cancer , vol.22 , Issue.2 , pp. 101-116
    • Ahmed, S.1    Sami, A.2    Xiang, J.3
  • 27
    • 84930203898 scopus 로고    scopus 로고
    • Kaempferol and inflammation: From chemistry to medicine
    • Devi KP, Malar DS, Nabavi SF, et al. Kaempferol and inflammation: from chemistry to medicine. Pharmacol Res. 2015;99:1–10.
    • (2015) Pharmacol Res , vol.99 , pp. 1-10
    • Devi, K.P.1    Malar, D.S.2    Nabavi, S.F.3
  • 28
    • 16244371036 scopus 로고    scopus 로고
    • Inhibition of P-glycoprotein func­tion and expression by kaempferol and quercetin
    • Limtrakul P, Khantamat O, Pintha K. Inhibition of P-glycoprotein func­tion and expression by kaempferol and quercetin. J Chemother. 2005;17(1):86–95.
    • (2005) J Chemother , vol.17 , Issue.1 , pp. 86-95
    • Limtrakul, P.1    Khantamat, O.2    Pintha, K.3
  • 29
    • 34748887195 scopus 로고    scopus 로고
    • Kaemp­ferol induces apoptosis in glioblastoma cells through oxidative stress
    • Sharma V, Joseph C, Ghosh S, Agarwal A, Mishra MK, Sen E. Kaemp­ferol induces apoptosis in glioblastoma cells through oxidative stress. Mol Cancer Ther. 2007;6(9):2544–2553.
    • (2007) Mol Cancer Ther , vol.6 , Issue.9 , pp. 2544-2553
    • Sharma, V.1    Joseph, C.2    Ghosh, S.3    Agarwal, A.4    Mishra, M.K.5    Sen, E.6
  • 30
    • 84960131606 scopus 로고    scopus 로고
    • Kaempferol inhibits the growth and metastasis of cholangiocarcinoma in vitro and in vivo
    • Qin Y, Cui W, Yang X, Tong B. Kaempferol inhibits the growth and metastasis of cholangiocarcinoma in vitro and in vivo. Acta Biochim Biophys Sin (Shanghai). 2016;48(3):238–245.
    • (2016) Acta Biochim Biophys Sin (Shanghai) , vol.48 , Issue.3 , pp. 238-245
    • Qin, Y.1    Cui, W.2    Yang, X.3    Tong, B.4
  • 31
    • 84919427485 scopus 로고    scopus 로고
    • Kaempferol inhibits gastric cancer tumor growth: An in vitro and in vivo study
    • Song H, Bao J, Wei Y, et al. Kaempferol inhibits gastric cancer tumor growth: an in vitro and in vivo study. Oncol Rep. 2015;33(2):868–874.
    • (2015) Oncol Rep , vol.33 , Issue.2 , pp. 868-874
    • Song, H.1    Bao, J.2    Wei, Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.