-
1
-
-
77649149667
-
-
Nature milestones in cancer. (2006) Nat. Rev. Cancer. 6:S8-9.
-
Nature milestones in cancer. (2006) Nat. Rev. Cancer. 6:S8-9.
-
-
-
-
2
-
-
84908007911
-
A new theory on cancerinducing mechanism
-
Nordling CO. (1953) A new theory on cancerinducing mechanism. Br. J. Cancer. 7:68-72.
-
(1953)
Br. J. Cancer
, vol.7
, pp. 68-72
-
-
Nordling, C.O.1
-
3
-
-
12944332175
-
A reconsideration of the somatic mutation theory of cancer in the light of some recent developments
-
Fardon JC. (1953) A reconsideration of the somatic mutation theory of cancer in the light of some recent developments. Science. 117:441-5.
-
(1953)
Science
, vol.117
, pp. 441-445
-
-
Fardon, J.C.1
-
4
-
-
84965187257
-
The age distribution of cancer and a multi-stage theory of carcinogenesis
-
Armitage P, Doll R. (1954) The age distribution of cancer and a multi-stage theory of carcinogenesis. Br. J. Cancer. 8:1-12.
-
(1954)
Br. J. Cancer
, vol.8
, pp. 1-12
-
-
Armitage, P.1
Doll, R.2
-
5
-
-
0017167185
-
The clonal evolution of tumor cell populations
-
Nowell PC. (1976) The clonal evolution of tumor cell populations. Science. 194:23-8.
-
(1976)
Science
, vol.194
, pp. 23-28
-
-
Nowell, P.C.1
-
6
-
-
0025312728
-
A genetic model for colorectal tumorigenesis
-
Fearon ER, Vogelstein B. (1990) A genetic model for colorectal tumorigenesis. Cell. 61:759-67.
-
(1990)
Cell
, vol.61
, pp. 759-767
-
-
Fearon, E.R.1
Vogelstein, B.2
-
7
-
-
0019960812
-
A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene
-
Reddy EP, Reynolds RK, Santos E, Barbacid M. (1982) A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene. Nature. 300:149-52.
-
(1982)
Nature
, vol.300
, pp. 149-152
-
-
Reddy, E.P.1
Reynolds, R.K.2
Santos, E.3
Barbacid, M.4
-
8
-
-
0020328955
-
Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene
-
Parada LF, Tabin CJ, Shih C, Weinberg RA. (1982) Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene. Nature. 297:474-8.
-
(1982)
Nature
, vol.297
, pp. 474-478
-
-
Parada, L.F.1
Tabin, C.J.2
Shih, C.3
Weinberg, R.A.4
-
9
-
-
0020046441
-
Isolation and preliminary characterization of a human transforming gene from T24 bladder carcinoma cells
-
Goldfarb M, Shimizu K, Perucho M, Wigler M. (1982) Isolation and preliminary characterization of a human transforming gene from T24 bladder carcinoma cells. Nature. 296:404-9.
-
(1982)
Nature
, vol.296
, pp. 404-409
-
-
Goldfarb, M.1
Shimizu, K.2
Perucho, M.3
Wigler, M.4
-
10
-
-
0023145547
-
The molecular genetics of cancer
-
Bishop JM. (1987) The molecular genetics of cancer. Science. 235:305-11.
-
(1987)
Science
, vol.235
, pp. 305-311
-
-
Bishop, J.M.1
-
11
-
-
0025021774
-
Identifying tumor suppressor genes in human colorectal cancer
-
Stanbridge EJ. (1990) Identifying tumor suppressor genes in human colorectal cancer. Science. 247:12-3.
-
(1990)
Science
, vol.247
, pp. 12-13
-
-
Stanbridge, E.J.1
-
13
-
-
0033592960
-
The onset and extent of genomic instability in sporadic colorectal tumor progression
-
Stoler DL, et al. (1999) The onset and extent of genomic instability in sporadic colorectal tumor progression. Proc. Natl. Acad. Sci. U. S. A. 96:15121-6.
-
(1999)
Proc. Natl. Acad. Sci. U. S. A
, vol.96
, pp. 15121-15126
-
-
Stoler, D.L.1
-
15
-
-
0028172057
-
Cancers beget mutations versus mutations beget cancers
-
Prehn RT. (1994) Cancers beget mutations versus mutations beget cancers. Cancer Res. 54:5296-300.
-
(1994)
Cancer Res
, vol.54
, pp. 5296-5300
-
-
Prehn, R.T.1
-
16
-
-
0347379799
-
Epigenetic theories of cancer initiation
-
Jaffe LF. (2003) Epigenetic theories of cancer initiation. Adv. Cancer Res. 90:209-30.
-
(2003)
Adv. Cancer Res
, vol.90
, pp. 209-230
-
-
Jaffe, L.F.1
-
17
-
-
0033564230
-
How aneuploidy affects metabolic control and causes cancer
-
Rasnick D, Duesberg PH. (1999) How aneuploidy affects metabolic control and causes cancer. Biochem. J. 340:621-30.
-
(1999)
Biochem. J
, vol.340
, pp. 621-630
-
-
Rasnick, D.1
Duesberg, P.H.2
-
18
-
-
9244263076
-
Aneuploidy and cancer
-
Rajagopalan H, Lengauer C. (2004) Aneuploidy and cancer. Nature. 432:338-41.
-
(2004)
Nature
, vol.432
, pp. 338-341
-
-
Rajagopalan, H.1
Lengauer, C.2
-
19
-
-
0034614637
-
The hallmarks of cancer
-
Hanahan D, Weinberg RA. (2000) The hallmarks of cancer. Cell. 100:57-70.
-
(2000)
Cell
, vol.100
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
20
-
-
0037079003
-
Rules for making human tumor cells
-
Hahn WC, Weinberg RA. (2002) Rules for making human tumor cells. N. Engl. J. Med. 347:1593-603.
-
(2002)
N. Engl. J. Med
, vol.347
, pp. 1593-1603
-
-
Hahn, W.C.1
Weinberg, R.A.2
-
21
-
-
4043181214
-
Cancer genes and the pathways they control
-
Vogelstein B, Kinzler KW. (2004) Cancer genes and the pathways they control. Nat. Med. 10:789-99.
-
(2004)
Nat. Med
, vol.10
, pp. 789-799
-
-
Vogelstein, B.1
Kinzler, K.W.2
-
23
-
-
41649114164
-
Enabling personalized cancer medicine through analysis of gene-expression patterns
-
van't Veer LJ, Bernards R. (2008) Enabling personalized cancer medicine through analysis of gene-expression patterns. Nature. 452:564-70.
-
(2008)
Nature
, vol.452
, pp. 564-570
-
-
van't Veer, L.J.1
Bernards, R.2
-
24
-
-
62249112106
-
Personalized cancer therapy gets closer
-
Hayden EC. (2009) Personalized cancer therapy gets closer. Nature. 458:131-2.
-
(2009)
Nature
, vol.458
, pp. 131-132
-
-
Hayden, E.C.1
-
25
-
-
64249135764
-
Novel agents on the horizon for cancer therapy
-
Ma WW, Adjei AA. (2009) Novel agents on the horizon for cancer therapy. CA Cancer J. Clin. 59:111-37.
-
(2009)
CA Cancer J. Clin
, vol.59
, pp. 111-137
-
-
Ma, W.W.1
Adjei, A.A.2
-
26
-
-
0035810147
-
Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia
-
Druker BJ, et al. (2001) Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N. Engl. J. Med. 344:1031-7.
-
(2001)
N. Engl. J. Med
, vol.344
, pp. 1031-1037
-
-
Druker, B.J.1
-
28
-
-
34249676964
-
Chronic myeloid leukaemia as a model of disease evolution in human cancer
-
Melo JV, Barnes DJ. (2007) Chronic myeloid leukaemia as a model of disease evolution in human cancer. Nat. Rev. Cancer. 7:441-53.
-
(2007)
Nat. Rev. Cancer
, vol.7
, pp. 441-453
-
-
Melo, J.V.1
Barnes, D.J.2
-
29
-
-
67650874081
-
Cancer statistics, 2009
-
Jemal A, et al. (2009) Cancer statistics, 2009. CA Cancer J. Clin. 59:225-49.
-
(2009)
CA Cancer J. Clin
, vol.59
, pp. 225-249
-
-
Jemal, A.1
-
30
-
-
33749522888
-
American Cancer Society Guidelines on Nutrition and Physical Activity for cancer prevention: Reducing the risk of cancer with healthy food choices and physical activity
-
Kushi LH, et al. (2006) American Cancer Society Guidelines on Nutrition and Physical Activity for cancer prevention: reducing the risk of cancer with healthy food choices and physical activity. CA Cancer J. Clin. 56:254-81.
-
(2006)
CA Cancer J. Clin
, vol.56
, pp. 254-281
-
-
Kushi, L.H.1
-
31
-
-
32444434459
-
American Cancer Society guidelines for the early detection of cancer, 2006
-
Smith RA, Cokkinides V, Eyre HJ. (2006) American Cancer Society guidelines for the early detection of cancer, 2006. CA Cancer J. Clin. 56:11-25.
-
(2006)
CA Cancer J. Clin
, vol.56
, pp. 11-25
-
-
Smith, R.A.1
Cokkinides, V.2
Eyre, H.J.3
-
32
-
-
33744457297
-
HIF-1: Hypoxia-inducible factor or dysoxia-inducible factor?
-
Lopez-Lazaro M. (2006) HIF-1: Hypoxia-inducible factor or dysoxia-inducible factor? FASEB J. 20:828-32.
-
(2006)
FASEB J
, vol.20
, pp. 828-832
-
-
Lopez-Lazaro, M.1
-
33
-
-
33845609726
-
Does hypoxia really control tumor growth?
-
Lopez-Lazaro M. (2006) Does hypoxia really control tumor growth? Cell Oncol. 28:327-9.
-
(2006)
Cell Oncol
, vol.28
, pp. 327-329
-
-
Lopez-Lazaro, M.1
-
34
-
-
34247383169
-
Why do tumors metastasize?
-
Lopez-Lazaro M. (2007) Why do tumors metastasize? Cancer Biol. Ther. 6:141-4.
-
(2007)
Cancer Biol. Ther
, vol.6
, pp. 141-144
-
-
Lopez-Lazaro, M.1
-
35
-
-
33846987527
-
Excessive superoxide anion generation plays a key role in carcinogenesis
-
Lopez-Lazaro M. (2007) Excessive superoxide anion generation plays a key role in carcinogenesis. Int. J. Cancer. 120:1378-80.
-
(2007)
Int. J. Cancer
, vol.120
, pp. 1378-1380
-
-
Lopez-Lazaro, M.1
-
36
-
-
34248396033
-
Dual role of hydrogen peroxide in cancer: Possible relevance to cancer chemoprevention and therapy
-
Lopez-Lazaro M. (2007) Dual role of hydrogen peroxide in cancer: possible relevance to cancer chemoprevention and therapy. Cancer Lett. 252:1-8.
-
(2007)
Cancer Lett
, vol.252
, pp. 1-8
-
-
Lopez-Lazaro, M.1
-
37
-
-
43549121719
-
-
Lopez-Lazaro M. (2008) The Warburg effect: why and how do cancer cells activate glycolysis in the presence of oxygen? Anticancer Agents Med. Chem. 8:305-12.
-
Lopez-Lazaro M. (2008) The Warburg effect: why and how do cancer cells activate glycolysis in the presence of oxygen? Anticancer Agents Med. Chem. 8:305-12.
-
-
-
-
38
-
-
67651083751
-
-
Lopez-Lazaro M. (2009) Role of oxygen in cancer: looking beyond hypoxia. Anticancer Agents Med. Chem. 9:517-25.
-
Lopez-Lazaro M. (2009) Role of oxygen in cancer: looking beyond hypoxia. Anticancer Agents Med. Chem. 9:517-25.
-
-
-
-
39
-
-
60249083822
-
Hexokinase-2 bound to mitochondria: Cancer's stygian link to the "Warburg Effect" and a pivotal target for effective therapy
-
Mathupala SP, Ko YH, Pedersen PL. (2009) Hexokinase-2 bound to mitochondria: cancer's stygian link to the "Warburg Effect" and a pivotal target for effective therapy. Semin. Cancer Biol. 19:17-24.
-
(2009)
Semin. Cancer Biol
, vol.19
, pp. 17-24
-
-
Mathupala, S.P.1
Ko, Y.H.2
Pedersen, P.L.3
-
40
-
-
0033057367
-
An inducible gene product for 6-phosphofructo-2-kinase with an AUrich instability element: Role in tumor cell glycolysis and the Warburg effect
-
Chesney J, et al. (1999) An inducible gene product for 6-phosphofructo-2-kinase with an AUrich instability element: role in tumor cell glycolysis and the Warburg effect. Proc. Natl. Acad. Sci. U. S. A. 96:3047-52.
-
(1999)
Proc. Natl. Acad. Sci. U. S. A
, vol.96
, pp. 3047-3052
-
-
Chesney, J.1
-
41
-
-
40749163248
-
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
-
Christofk HR, et al. (2008) The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature. 452:230-3.
-
(2008)
Nature
, vol.452
, pp. 230-233
-
-
Christofk, H.R.1
-
42
-
-
8144228566
-
Why do cancers have high aerobic glycolysis?
-
Gatenby RA, Gillies RJ. (2004) Why do cancers have high aerobic glycolysis? Nat. Rev. Cancer. 4:891-9.
-
(2004)
Nat. Rev. Cancer
, vol.4
, pp. 891-899
-
-
Gatenby, R.A.1
Gillies, R.J.2
-
43
-
-
12444279265
-
On the origin of cancer cells
-
Warburg O. (1956) On the origin of cancer cells. Science. 123:309-14.
-
(1956)
Science
, vol.123
, pp. 309-314
-
-
Warburg, O.1
-
45
-
-
66249108601
-
Understanding the Warburg effect: The metabolic requirements of cell proliferation
-
Vander Heiden MG, Cantley LC, Thompson CB. (2009) Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science. 324:1029-33.
-
(2009)
Science
, vol.324
, pp. 1029-1033
-
-
Vander Heiden, M.G.1
Cantley, L.C.2
Thompson, C.B.3
-
46
-
-
10744221423
-
Alteration of the bioenergetic phenotype of mitochondria is a hallmark of breast, gastric, lung and oesophageal cancer
-
Isidoro A, et al. (2004) Alteration of the bioenergetic phenotype of mitochondria is a hallmark of breast, gastric, lung and oesophageal cancer. Biochem. J. 378:17-20.
-
(2004)
Biochem. J
, vol.378
, pp. 17-20
-
-
Isidoro, A.1
-
47
-
-
0042861598
-
Proteomic changes in renal cancer and co-ordinate demonstration of both the glycolytic and mitochondrial aspects of the Warburg effect
-
Unwin RD, et al. (2003) Proteomic changes in renal cancer and co-ordinate demonstration of both the glycolytic and mitochondrial aspects of the Warburg effect. Proteomics. 3:1620-32.
-
(2003)
Proteomics
, vol.3
, pp. 1620-1632
-
-
Unwin, R.D.1
-
48
-
-
33745149291
-
p53 regulates mitochondrial respiration
-
Matoba S, et al. (2006) p53 regulates mitochondrial respiration. Science. 312:1650-3.
-
(2006)
Science
, vol.312
, pp. 1650-1653
-
-
Matoba, S.1
-
49
-
-
0026021362
-
Production of large amounts of hydrogen peroxide by human tumor cells
-
Szatrowski TP, Nathan CF. (1991) Production of large amounts of hydrogen peroxide by human tumor cells. Cancer Res. 51:794-8.
-
(1991)
Cancer Res
, vol.51
, pp. 794-798
-
-
Szatrowski, T.P.1
Nathan, C.F.2
-
50
-
-
0028918334
-
Superoxide and hydrogen peroxide in relation to mammalian cell proliferation
-
Burdon RH. (1995) Superoxide and hydrogen peroxide in relation to mammalian cell proliferation. Free Radic. Biol. Med. 18:775-94.
-
(1995)
Free Radic. Biol. Med
, vol.18
, pp. 775-794
-
-
Burdon, R.H.1
-
51
-
-
0033856835
-
Comparison of hydrogen peroxide generation and the content of lipid peroxidation products in lung cancer tissue and pulmonary parenchyma
-
Zieba M, et al. (2000) Comparison of hydrogen peroxide generation and the content of lipid peroxidation products in lung cancer tissue and pulmonary parenchyma. Respir. Med. 94:800-5.
-
(2000)
Respir. Med
, vol.94
, pp. 800-805
-
-
Zieba, M.1
-
52
-
-
11844272091
-
Increased Nox1 and hydrogen peroxide in prostate cancer
-
Lim SD, et al. (2005) Increased Nox1 and hydrogen peroxide in prostate cancer. Prostate. 62:200-7.
-
(2005)
Prostate
, vol.62
, pp. 200-207
-
-
Lim, S.D.1
-
53
-
-
59849084800
-
Increased levels of superoxide and H2O2 mediate the differential susceptibility of cancer cells versus normal cells to glucose deprivation
-
Aykin-Burns N, Ahmad IM, Zhu Y, Oberley LW, Spitz DR. (2009) Increased levels of superoxide and H2O2 mediate the differential susceptibility of cancer cells versus normal cells to glucose deprivation. Biochem. J. 418:29-37.
-
(2009)
Biochem. J
, vol.418
, pp. 29-37
-
-
Aykin-Burns, N.1
Ahmad, I.M.2
Zhu, Y.3
Oberley, L.W.4
Spitz, D.R.5
-
54
-
-
0142166332
-
Targeting HIF-1 for cancer therapy
-
Semenza GL. (2003) Targeting HIF-1 for cancer therapy. Nat. Rev. Cancer. 3:721-32.
-
(2003)
Nat. Rev. Cancer
, vol.3
, pp. 721-732
-
-
Semenza, G.L.1
-
55
-
-
35048875691
-
Evaluation of HIF-1 inhibitors as anticancer agents
-
Semenza GL. (2007) Evaluation of HIF-1 inhibitors as anticancer agents. Drug Discov. Today. 12:853-9.
-
(2007)
Drug Discov. Today
, vol.12
, pp. 853-859
-
-
Semenza, G.L.1
-
56
-
-
33845984533
-
Hypoxia-inducible factor 1 as a possible target for cancer chemoprevention
-
Lopez-Lazaro M. (2006) Hypoxia-inducible factor 1 as a possible target for cancer chemoprevention. Cancer Epidemiol. Biomarkers Prev. 15:2332-5.
-
(2006)
Cancer Epidemiol. Biomarkers Prev
, vol.15
, pp. 2332-2335
-
-
Lopez-Lazaro, M.1
-
57
-
-
0034682786
-
Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: A mechanism of O2 sensing
-
Chandel NS, et al. (2000) Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing. J. Biol. Chem. 275:25130-8.
-
(2000)
J. Biol. Chem
, vol.275
, pp. 25130-25138
-
-
Chandel, N.S.1
-
58
-
-
0037189542
-
Hypoxiainducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis
-
Lu H, Forbes RA, Verma A. (2002) Hypoxiainducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis. J. Biol. Chem. 277:23111-5.
-
(2002)
J. Biol. Chem
, vol.277
, pp. 23111-23115
-
-
Lu, H.1
Forbes, R.A.2
Verma, A.3
-
59
-
-
0021964203
-
Prooxidant states and tumor promotion
-
Cerutti PA. (1985) Prooxidant states and tumor promotion. Science. 227:375-81.
-
(1985)
Science
, vol.227
, pp. 375-381
-
-
Cerutti, P.A.1
-
61
-
-
0029837398
-
Transformation in vitro of a nontumorigenic rat urothelial cell line by hydrogen peroxide
-
Okamoto M, Kawai K, Reznikoff CA, Oyasu R. (1996) Transformation in vitro of a nontumorigenic rat urothelial cell line by hydrogen peroxide. Cancer Res. 56:4649-53.
-
(1996)
Cancer Res
, vol.56
, pp. 4649-4653
-
-
Okamoto, M.1
Kawai, K.2
Reznikoff, C.A.3
Oyasu, R.4
-
62
-
-
0033517275
-
Cell transformation by the superoxide-generating oxidase Mox1
-
Suh YA, et al. (1999) Cell transformation by the superoxide-generating oxidase Mox1. Nature. 401:79-82.
-
(1999)
Nature
, vol.401
, pp. 79-82
-
-
Suh, Y.A.1
-
63
-
-
0035826733
-
Hydrogen peroxide mediates the cell growth and transformation caused by the mitogenic oxidase Nox1
-
Arnold RS, et al. (2001) Hydrogen peroxide mediates the cell growth and transformation caused by the mitogenic oxidase Nox1. Proc. Natl. Acad. Sci. U. S. A. 98:5550-5.
-
(2001)
Proc. Natl. Acad. Sci. U. S. A
, vol.98
, pp. 5550-5555
-
-
Arnold, R.S.1
-
64
-
-
0027405704
-
Increased manganese superoxide dismutase expression suppresses the malignant phenotype of human melanoma cells
-
Church SL, et al. (1993) Increased manganese superoxide dismutase expression suppresses the malignant phenotype of human melanoma cells. Proc. Natl. Acad. Sci. U. S. A. 90:3113-7.
-
(1993)
Proc. Natl. Acad. Sci. U. S. A
, vol.90
, pp. 3113-3117
-
-
Church, S.L.1
-
65
-
-
0027931870
-
Suppression of fibrosarcoma metastasis by elevated expression of manganese superoxide dismutase
-
Safford SE, Oberley TD, Urano M, St Clair DK. (1994) Suppression of fibrosarcoma metastasis by elevated expression of manganese superoxide dismutase. Cancer Res. 54:4261-5.
-
(1994)
Cancer Res
, vol.54
, pp. 4261-4265
-
-
Safford, S.E.1
Oberley, T.D.2
Urano, M.3
St Clair, D.K.4
-
66
-
-
0029886717
-
Manganese-containing superoxide dismutase overexpression causes phenotypic reversion in SV40-transformed human lung fibroblasts
-
Yan T, Oberley LW, Zhong W, St Clair DK. (1996) Manganese-containing superoxide dismutase overexpression causes phenotypic reversion in SV40-transformed human lung fibroblasts. Cancer Res. 56:2864-71.
-
(1996)
Cancer Res
, vol.56
, pp. 2864-2871
-
-
Yan, T.1
Oberley, L.W.2
Zhong, W.3
St Clair, D.K.4
-
67
-
-
0036170568
-
Overexpression of copper zinc superoxide dismutase suppresses human glioma cell growth
-
Zhang Y, Zhao W, Zhang HJ, Domann FE, Oberley LW. (2002) Overexpression of copper zinc superoxide dismutase suppresses human glioma cell growth. Cancer Res. 62:1205-12.
-
(2002)
Cancer Res
, vol.62
, pp. 1205-1212
-
-
Zhang, Y.1
Zhao, W.2
Zhang, H.J.3
Domann, F.E.4
Oberley, L.W.5
-
68
-
-
9344221090
-
Inhibition of metastatic tumor growth in mouse lung by repeated administration of polyethylene glycol-conjugated catalase: Quantitative analysis with firefly luciferaseexpressing melanoma cells
-
Hyoudou K, et al. (2004) Inhibition of metastatic tumor growth in mouse lung by repeated administration of polyethylene glycol-conjugated catalase: quantitative analysis with firefly luciferaseexpressing melanoma cells. Clin. Cancer Res. 10:7685-91.
-
(2004)
Clin. Cancer Res
, vol.10
, pp. 7685-7691
-
-
Hyoudou, K.1
-
69
-
-
17844383964
-
Perturbational profiling of a cell-line model of tumorigenesis by using metabolic measurements
-
Ramanathan A, Wang C, Schreiber SL. (2005) Perturbational profiling of a cell-line model of tumorigenesis by using metabolic measurements. Proc. Natl. Acad. Sci. U. S. A. 102:5992-7.
-
(2005)
Proc. Natl. Acad. Sci. U. S. A
, vol.102
, pp. 5992-5997
-
-
Ramanathan, A.1
Wang, C.2
Schreiber, S.L.3
-
70
-
-
43249112094
-
ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis
-
Ishikawa K, et al. (2008) ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis. Science. 320:661-4.
-
(2008)
Science
, vol.320
, pp. 661-664
-
-
Ishikawa, K.1
-
71
-
-
0030980641
-
Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts
-
Irani K, et al. (1997) Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts. Science. 275:1649-52.
-
(1997)
Science
, vol.275
, pp. 1649-1652
-
-
Irani, K.1
-
72
-
-
0036285034
-
c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: A mechanism for oncogene-induced genetic instability
-
Vafa O, et al. (2002) c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability. Mol. Cell. 9:1031-44.
-
(2002)
Mol. Cell
, vol.9
, pp. 1031-1044
-
-
Vafa, O.1
-
73
-
-
0034637599
-
The BCR/ABL tyrosine kinase induces production of reactive oxygen species in hematopoietic cells
-
Sattler M, et al. (2000) The BCR/ABL tyrosine kinase induces production of reactive oxygen species in hematopoietic cells. J. Biol. Chem. 275:24273-8.
-
(2000)
J. Biol. Chem
, vol.275
, pp. 24273-24278
-
-
Sattler, M.1
-
74
-
-
34250329446
-
Repression of sestrin family genes contributes to oncogenic Ras-induced reactive oxygen species up-regulation and genetic instability
-
Kopnin PB, Agapova LS, Kopnin BP, Chumakov PM. (2007) Repression of sestrin family genes contributes to oncogenic Ras-induced reactive oxygen species up-regulation and genetic instability. Cancer Res. 67:4671-8.
-
(2007)
Cancer Res
, vol.67
, pp. 4671-4678
-
-
Kopnin, P.B.1
Agapova, L.S.2
Kopnin, B.P.3
Chumakov, P.M.4
-
75
-
-
21544465580
-
Substantial DNA damage from submicromolar intracellular hydrogen peroxide detected in Hpx- mutants of Escherichia coli
-
Park S, You X, Imlay JA. (2005) Substantial DNA damage from submicromolar intracellular hydrogen peroxide detected in Hpx- mutants of Escherichia coli. Proc. Natl. Acad. Sci. U. S. A. 102:9317-22.
-
(2005)
Proc. Natl. Acad. Sci. U. S. A
, vol.102
, pp. 9317-9322
-
-
Park, S.1
You, X.2
Imlay, J.A.3
-
76
-
-
21844432918
-
Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability
-
Radisky DC, et al. (2005) Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability. Nature. 436:123-7.
-
(2005)
Nature
, vol.436
, pp. 123-127
-
-
Radisky, D.C.1
-
77
-
-
46249133363
-
Hydrogen peroxide mediates the radiation-induced mutator phenotype in mammalian cells
-
Dayal D, Martin SM, Limoli CL, Spitz DR. (2008) Hydrogen peroxide mediates the radiation-induced mutator phenotype in mammalian cells. Biochem. J. 413:185-91.
-
(2008)
Biochem. J
, vol.413
, pp. 185-191
-
-
Dayal, D.1
Martin, S.M.2
Limoli, C.L.3
Spitz, D.R.4
-
78
-
-
0034646080
-
Microsatellite instability induced by hydrogen peroxide in Escherichia coli
-
Jackson AL, Loeb LA. (2000) Microsatellite instability induced by hydrogen peroxide in Escherichia coli. Mutat. Res. 447:187-98.
-
(2000)
Mutat. Res
, vol.447
, pp. 187-198
-
-
Jackson, A.L.1
Loeb, L.A.2
-
79
-
-
0035025124
-
Mechanisms of carcinogenesis: Focus on oxidative stress and electron transfer
-
Kovacic P, Jacintho JD. (2001) Mechanisms of carcinogenesis: focus on oxidative stress and electron transfer. Curr. Med. Chem. 8:773-96.
-
(2001)
Curr. Med. Chem
, vol.8
, pp. 773-796
-
-
Kovacic, P.1
Jacintho, J.D.2
-
80
-
-
0032565569
-
Activation of procarcinogens by human cytochrome P450 enzymes
-
Guengerich FP, Shimada T. (1998) Activation of procarcinogens by human cytochrome P450 enzymes. Mutat. Res. 400:201-13.
-
(1998)
Mutat. Res
, vol.400
, pp. 201-213
-
-
Guengerich, F.P.1
Shimada, T.2
-
81
-
-
4444268690
-
Mechanisms that regulate production of reactive oxygen species by cytochrome P450
-
Zangar RC, Davydov DR, Verma S. (2004) Mechanisms that regulate production of reactive oxygen species by cytochrome P450. Toxicol. Appl. Pharmacol. 199:316-31.
-
(2004)
Toxicol. Appl. Pharmacol
, vol.199
, pp. 316-331
-
-
Zangar, R.C.1
Davydov, D.R.2
Verma, S.3
-
82
-
-
33644622570
-
HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption
-
Papandreou I, Cairns RA, Fontana L, Lim AL, Denko NC. (2006) HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption. Cell Metab. 3:187-97.
-
(2006)
Cell Metab
, vol.3
, pp. 187-197
-
-
Papandreou, I.1
Cairns, R.A.2
Fontana, L.3
Lim, A.L.4
Denko, N.C.5
-
83
-
-
35448961940
-
HIF-1 mediates the Warburg effect in clear cell renal carcinoma
-
Semenza GL. (2007) HIF-1 mediates the Warburg effect in clear cell renal carcinoma. J. Bioenerg. Biomembr. 39:231-4.
-
(2007)
J. Bioenerg. Biomembr
, vol.39
, pp. 231-234
-
-
Semenza, G.L.1
-
84
-
-
0033746761
-
Na+/H+ exchangerdependent intracellular alkalinization is an early event in malignant transformation and plays an essential role in the development of subsequent transformation-associated phenotypes
-
Reshkin SJ, et al. (2000) Na+/H+ exchangerdependent intracellular alkalinization is an early event in malignant transformation and plays an essential role in the development of subsequent transformation-associated phenotypes. FASEB J. 14:2185-97.
-
(2000)
FASEB J
, vol.14
, pp. 2185-2197
-
-
Reshkin, S.J.1
-
85
-
-
24944481656
-
The role of pH dynamics and the Na(+)/H(+) antiporter in the etiopathogenesis and treatment of cancer. Two faces of the same coin-one single nature
-
Harguindey S, Orive G, Luis PJ, Paradiso A, Reshkin SJ. (2005) The role of pH dynamics and the Na(+)/H(+) antiporter in the etiopathogenesis and treatment of cancer. Two faces of the same coin-one single nature. Biochim. Biophys. Acta. 1756:1-24.
-
(2005)
Biochim. Biophys. Acta
, vol.1756
, pp. 1-24
-
-
Harguindey, S.1
Orive, G.2
Luis, P.J.3
Paradiso, A.4
Reshkin, S.J.5
-
86
-
-
0022382209
-
Intracellular pH modulates the generation of superoxide radicals by human neutrophils
-
Simchowitz L. (1985) Intracellular pH modulates the generation of superoxide radicals by human neutrophils. J. Clin. Invest. 76:1079-89.
-
(1985)
J. Clin. Invest
, vol.76
, pp. 1079-1089
-
-
Simchowitz, L.1
-
87
-
-
33646517942
-
Accumulation of hydrogen peroxide is an early and crucial step for paclitaxel-induced cancer cell death both in vitro and in vivo
-
Alexandre J, et al. (2006) Accumulation of hydrogen peroxide is an early and crucial step for paclitaxel-induced cancer cell death both in vitro and in vivo. Int. J. Cancer 119:41-8.
-
(2006)
Int. J. Cancer
, vol.119
, pp. 41-48
-
-
Alexandre, J.1
-
88
-
-
33144488485
-
Improvement of the therapeutic index of anticancer drugs by the superoxide dismutase mimic mangafodipir
-
Alexandre J, et al. (2006) Improvement of the therapeutic index of anticancer drugs by the superoxide dismutase mimic mangafodipir. J. Natl. Cancer Inst. 98:236-44.
-
(2006)
J. Natl. Cancer Inst
, vol.98
, pp. 236-244
-
-
Alexandre, J.1
-
89
-
-
34248582844
-
Novel action of paclitaxel against cancer cells: Bystander effect mediated by reactive oxygen species
-
Alexandre J, Hu Y, Lu W, Pelicano H, Huang P. (2007) Novel action of paclitaxel against cancer cells: bystander effect mediated by reactive oxygen species. Cancer Res. 67:3512-7.
-
(2007)
Cancer Res
, vol.67
, pp. 3512-3517
-
-
Alexandre, J.1
Hu, Y.2
Lu, W.3
Pelicano, H.4
Huang, P.5
-
90
-
-
0033568238
-
Arsenic trioxide selectively induces acute promyelocytic leukemia cell apoptosis via a hydrogen peroxide-dependent pathway
-
Jing Y, Dai J, Chalmers-Redman RM, Tatton WG, Waxman S. (1999) Arsenic trioxide selectively induces acute promyelocytic leukemia cell apoptosis via a hydrogen peroxide-dependent pathway. Blood. 94:2102-11.
-
(1999)
Blood
, vol.94
, pp. 2102-2111
-
-
Jing, Y.1
Dai, J.2
Chalmers-Redman, R.M.3
Tatton, W.G.4
Waxman, S.5
-
91
-
-
12844275026
-
Mechanism of apoptosis induced by doxorubicin through the generation of hydrogen peroxide
-
Mizutani H, Tada-Oikawa S, Hiraku Y, Kojima M, Kawanishi S. (2005) Mechanism of apoptosis induced by doxorubicin through the generation of hydrogen peroxide. Life Sci. 76:1439-53.
-
(2005)
Life Sci
, vol.76
, pp. 1439-1453
-
-
Mizutani, H.1
Tada-Oikawa, S.2
Hiraku, Y.3
Kojima, M.4
Kawanishi, S.5
-
92
-
-
0028296066
-
Flow cytometric detection of hydrogen peroxide production induced by doxorubicin in cancer cells
-
Ubezio P, Civoli F. (1994) Flow cytometric detection of hydrogen peroxide production induced by doxorubicin in cancer cells. Free Radic. Biol. Med. 16:509-16.
-
(1994)
Free Radic. Biol. Med
, vol.16
, pp. 509-516
-
-
Ubezio, P.1
Civoli, F.2
-
93
-
-
0032906669
-
Involvement of hydrogen peroxide and hydroxyl radical in chemically induced apoptosis of HL-60 cells
-
Ikeda K, et al. (1999) Involvement of hydrogen peroxide and hydroxyl radical in chemically induced apoptosis of HL-60 cells. Biochem. Pharmacol. 57:1361-5.
-
(1999)
Biochem. Pharmacol
, vol.57
, pp. 1361-1365
-
-
Ikeda, K.1
-
94
-
-
34547670578
-
Tumortargeted induction of oxystress for cancer therapy
-
Fang J, Nakamura H, Iyer AK. (2007) Tumortargeted induction of oxystress for cancer therapy. J. Drug Target. 15:475-86.
-
(2007)
J. Drug Target
, vol.15
, pp. 475-486
-
-
Fang, J.1
Nakamura, H.2
Iyer, A.K.3
-
95
-
-
0032500543
-
Requirement of caspase-3(-like) proteasemediated hydrogen peroxide production for apoptosis induced by various anticancer drugs
-
Simizu S, Takada M, Umezawa K, Imoto M. (1998) Requirement of caspase-3(-like) proteasemediated hydrogen peroxide production for apoptosis induced by various anticancer drugs. J. Biol. Chem. 273:26900-7.
-
(1998)
J. Biol. Chem
, vol.273
, pp. 26900-26907
-
-
Simizu, S.1
Takada, M.2
Umezawa, K.3
Imoto, M.4
-
96
-
-
0031027794
-
Role of peroxide and superoxide anion during tumour cell apoptosis
-
Gorman A, McGowan A, Cotter TG. (1997) Role of peroxide and superoxide anion during tumour cell apoptosis. FEBS Lett. 404:27-33.
-
(1997)
FEBS Lett
, vol.404
, pp. 27-33
-
-
Gorman, A.1
McGowan, A.2
Cotter, T.G.3
-
97
-
-
0141706672
-
Reactive oxygen species generation and mitochondrial dysfunction in the apoptotic response to Bortezomib, a novel proteasome inhibitor, in human H460 non-small cell lung cancer cells
-
Ling YH, Liebes L, Zou Y, Perez-Soler R. (2003) Reactive oxygen species generation and mitochondrial dysfunction in the apoptotic response to Bortezomib, a novel proteasome inhibitor, in human H460 non-small cell lung cancer cells. J. Biol. Chem. 278:33714-23.
-
(2003)
J. Biol. Chem
, vol.278
, pp. 33714-33723
-
-
Ling, Y.H.1
Liebes, L.2
Zou, Y.3
Perez-Soler, R.4
-
98
-
-
30144442233
-
The proteasome inhibitor bortezomib induces apoptosis in mantlecell lymphoma through generation of ROS and Noxa activation independent of p53 status
-
Perez-Galan P, et al. (2006) The proteasome inhibitor bortezomib induces apoptosis in mantlecell lymphoma through generation of ROS and Noxa activation independent of p53 status. Blood. 107:257-64.
-
(2006)
Blood
, vol.107
, pp. 257-264
-
-
Perez-Galan, P.1
-
99
-
-
4143066896
-
The emerging role of reactive oxygen species in cancer therapy
-
Renschler MF. (2004) The emerging role of reactive oxygen species in cancer therapy. Eur. J. Cancer. 40:1934-40.
-
(2004)
Eur. J. Cancer
, vol.40
, pp. 1934-1940
-
-
Renschler, M.F.1
-
100
-
-
34548101114
-
-
Selective cell death of oncogenic Akt-transduced brain cancer cells by etoposide through reactive oxygen species mediated damage
-
Oh SY, et al. (2007) Selective cell death of oncogenic Akt-transduced brain cancer cells by etoposide through reactive oxygen species mediated damage. Mol. Cancer Ther. 6:2178-87.
-
(2007)
Mol. Cancer Ther
, vol.6
, pp. 2178-2187
-
-
Oh, S.Y.1
-
101
-
-
0001213485
-
Role of hydrogen peroxide and hydroxyl radical formation in the killing of Ehrlich tumor cells by anticancer quinones
-
Doroshow JH. (1986) Role of hydrogen peroxide and hydroxyl radical formation in the killing of Ehrlich tumor cells by anticancer quinones. Proc. Natl. Acad. Sci. U. S. A. 83:4514-8.
-
(1986)
Proc. Natl. Acad. Sci. U. S. A
, vol.83
, pp. 4514-4518
-
-
Doroshow, J.H.1
-
102
-
-
2942593991
-
ROS stress in cancer cells and therapeutic implications
-
Pelicano H, Carney D, Huang P. (2004) ROS stress in cancer cells and therapeutic implications. Drug Resist. Updat. 7:97-110.
-
(2004)
Drug Resist. Updat
, vol.7
, pp. 97-110
-
-
Pelicano, H.1
Carney, D.2
Huang, P.3
-
103
-
-
33847349283
-
Reactive oxygen species: A breath of life or death?
-
Fruehauf JP, Meyskens FL, Jr. (2007) Reactive oxygen species: a breath of life or death? Clin. Cancer Res. 13:789-94.
-
(2007)
Clin. Cancer Res
, vol.13
, pp. 789-794
-
-
Fruehauf, J.P.1
Meyskens Jr., F.L.2
-
104
-
-
33748165596
-
Reactive oxygen species in cancer cells: Live by the sword, die by the sword
-
Schumacker PT. (2006) Reactive oxygen species in cancer cells: live by the sword, die by the sword. Cancer Cell. 10:175-6.
-
(2006)
Cancer Cell
, vol.10
, pp. 175-176
-
-
Schumacker, P.T.1
-
105
-
-
70449107252
-
Redox-directed cancer therapeutics: Molecular mechanisms and opportunities
-
Wondrak GT. (2009) Redox-directed cancer therapeutics: molecular mechanisms and opportunities. Antioxid. Redox. Signal. 11:3013-69.
-
(2009)
Antioxid. Redox. Signal
, vol.11
, pp. 3013-3069
-
-
Wondrak, G.T.1
-
106
-
-
27744557065
-
Oxidative stress and apoptosis: A new treatment paradigm in cancer
-
Engel RH, Evens AM. (2006) Oxidative stress and apoptosis: a new treatment paradigm in cancer. Front. Biosci. 11:300-12.
-
(2006)
Front. Biosci
, vol.11
, pp. 300-312
-
-
Engel, R.H.1
Evens, A.M.2
-
107
-
-
0035808388
-
Intracellular acidification triggered by mitochondrial-derived hydrogen peroxide is an effector mechanism for drug-induced apoptosis in tumor cells
-
Hirpara JL, Clement MV, Pervaiz S. (2001) Intracellular acidification triggered by mitochondrial-derived hydrogen peroxide is an effector mechanism for drug-induced apoptosis in tumor cells. J. Biol. Chem. 276:514-21.
-
(2001)
J. Biol. Chem
, vol.276
, pp. 514-521
-
-
Hirpara, J.L.1
Clement, M.V.2
Pervaiz, S.3
-
108
-
-
26444521256
-
Pharmacologic ascorbic acid concentrations selectively kill cancer cells: Action as a pro-drug to deliver hydrogen peroxide to tissues
-
Chen Q, et al. (2005) Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a pro-drug to deliver hydrogen peroxide to tissues. Proc. Natl. Acad. Sci. U. S. A. 102:13604-9.
-
(2005)
Proc. Natl. Acad. Sci. U. S. A
, vol.102
, pp. 13604-13609
-
-
Chen, Q.1
-
109
-
-
3543084996
-
Effective treatment of advanced solid tumors by the combination of arsenic trioxide and L-buthionine-sulfoximine
-
Maeda H, et al. (2004) Effective treatment of advanced solid tumors by the combination of arsenic trioxide and L-buthionine-sulfoximine. Cell Death. Differ. 11:737-46.
-
(2004)
Cell Death. Differ
, vol.11
, pp. 737-746
-
-
Maeda, H.1
-
110
-
-
0038531029
-
2-Methoxyestradiol induces apoptosis in Ewing sarcoma cells through mitochondrial hydrogen peroxide production
-
Djavaheri-Mergny M, Wietzerbin J, Besancon F. (2003) 2-Methoxyestradiol induces apoptosis in Ewing sarcoma cells through mitochondrial hydrogen peroxide production. Oncogene. 22:2558-67.
-
(2003)
Oncogene
, vol.22
, pp. 2558-2567
-
-
Djavaheri-Mergny, M.1
Wietzerbin, J.2
Besancon, F.3
-
111
-
-
12544256565
-
Inhibition of glycolysis in cancer cells: A novel strategy to overcome drug resistance associated with mitochondrial respiratory defect and hypoxia
-
Xu RH, et al. (2005) Inhibition of glycolysis in cancer cells: a novel strategy to overcome drug resistance associated with mitochondrial respiratory defect and hypoxia. Cancer Res. 65:613-21.
-
(2005)
Cancer Res
, vol.65
, pp. 613-621
-
-
Xu, R.H.1
-
113
-
-
34547754022
-
Digitoxin as an anticancer agent with selectivity for cancer cells: Possible mechanisms involved
-
Lopez-Lazaro M. (2007) Digitoxin as an anticancer agent with selectivity for cancer cells: possible mechanisms involved. Expert. Opin. Ther. Targets. 11:1043-53.
-
(2007)
Expert. Opin. Ther. Targets
, vol.11
, pp. 1043-1053
-
-
Lopez-Lazaro, M.1
-
114
-
-
34447094919
-
Glycolysis in cancer: A potential target for therapy
-
Gatenby RA, Gillies RJ. (2007) Glycolysis in cancer: a potential target for therapy. Int. J. Biochem. Cell Biol. 39:1358-66.
-
(2007)
Int. J. Biochem. Cell Biol
, vol.39
, pp. 1358-1366
-
-
Gatenby, R.A.1
Gillies, R.J.2
-
115
-
-
33846002728
-
A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth
-
Bonnet S, et al. (2007) A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth. Cancer Cell. 11:37-51.
-
(2007)
Cancer Cell
, vol.11
, pp. 37-51
-
-
Bonnet, S.1
-
116
-
-
0018573622
-
Vascular smooth muscle: Aerobic glycolysis linked to sodium and potassium transport processes
-
Paul RJ, Bauer M, Pease W. (1979) Vascular smooth muscle: aerobic glycolysis linked to sodium and potassium transport processes. Science. 206:1414-6.
-
(1979)
Science
, vol.206
, pp. 1414-1416
-
-
Paul, R.J.1
Bauer, M.2
Pease, W.3
-
117
-
-
0029849945
-
Linkage of aerobic glycolysis to sodium-potassium transport in rat skeletal muscle: Implications for increased muscle lactate production in sepsis
-
James JH, et al. (1996) Linkage of aerobic glycolysis to sodium-potassium transport in rat skeletal muscle: implications for increased muscle lactate production in sepsis. J. Clin. Invest. 98:2388-97.
-
(1996)
J. Clin. Invest
, vol.98
, pp. 2388-2397
-
-
James, J.H.1
-
118
-
-
29044433675
-
Digitoxin inhibits the growth of cancer cell lines at concentrations commonly found in cardiac patients
-
Lopez-Lazaro M, et al. (2005) Digitoxin inhibits the growth of cancer cell lines at concentrations commonly found in cardiac patients. J. Nat. Prod. 68:1642-5.
-
(2005)
J. Nat. Prod
, vol.68
, pp. 1642-1645
-
-
Lopez-Lazaro, M.1
-
119
-
-
67650921941
-
Proton transport inhibitors as potentially selective anticancer drugs
-
Harguindey S, Arranz JL, Wahl ML, Orive G, Reshkin SJ. (2009) Proton transport inhibitors as potentially selective anticancer drugs. Anticancer Res. 29:2127-36.
-
(2009)
Anticancer Res
, vol.29
, pp. 2127-2136
-
-
Harguindey, S.1
Arranz, J.L.2
Wahl, M.L.3
Orive, G.4
Reshkin, S.J.5
-
121
-
-
0028106016
-
Glutathione-associated enzymes in anticancer drug resistance
-
Tew KD. (1994) Glutathione-associated enzymes in anticancer drug resistance. Cancer Res. 54:4313-20.
-
(1994)
Cancer Res
, vol.54
, pp. 4313-4320
-
-
Tew, K.D.1
-
122
-
-
33645804599
-
Role of the glutathione metabolic pathway in lung cancer treatment and prognosis: A review
-
Yang P, Ebbert JO, Sun Z, Weinshilboum RM. (2006) Role of the glutathione metabolic pathway in lung cancer treatment and prognosis: a review. J. Clin. Oncol. 24:1761-9.
-
(2006)
J. Clin. Oncol
, vol.24
, pp. 1761-1769
-
-
Yang, P.1
Ebbert, J.O.2
Sun, Z.3
Weinshilboum, R.M.4
-
123
-
-
0031939392
-
Glutathione-related mechanisms in cellular resistance to anticancer drugs
-
Zhang K, Mack P, Wong KP. (1998) Glutathione-related mechanisms in cellular resistance to anticancer drugs. Int. J. Oncol. 12:871-82.
-
(1998)
Int. J. Oncol
, vol.12
, pp. 871-882
-
-
Zhang, K.1
Mack, P.2
Wong, K.P.3
-
125
-
-
0037827160
-
Increased expression of mitochondrial peroxiredoxin-3 (thioredoxin peroxidase-2) protects cancer cells against hypoxia and drug-induced hydrogen peroxide-dependent apoptosis
-
Nonn L, Berggren M, Powis G. (2003) Increased expression of mitochondrial peroxiredoxin-3 (thioredoxin peroxidase-2) protects cancer cells against hypoxia and drug-induced hydrogen peroxide-dependent apoptosis. Mol. Cancer Res. 1:682-9.
-
(2003)
Mol. Cancer Res
, vol.1
, pp. 682-689
-
-
Nonn, L.1
Berggren, M.2
Powis, G.3
-
126
-
-
0033796101
-
The role of the redox protein thioredoxin in cell growth and cancer
-
Powis G, Mustacich D, Coon A. (2000) The role of the redox protein thioredoxin in cell growth and cancer. Free Radic. Biol. Med. 29:312-22.
-
(2000)
Free Radic. Biol. Med
, vol.29
, pp. 312-322
-
-
Powis, G.1
Mustacich, D.2
Coon, A.3
-
127
-
-
0037163688
-
Evaluation of 2-deoxy-D-glucose as a chemotherapeutic agent: Mechanism of cell death
-
Aft RL, Zhang FW, Gius D. (2002) Evaluation of 2-deoxy-D-glucose as a chemotherapeutic agent: mechanism of cell death. Br. J. Cancer. 87:805-12.
-
(2002)
Br. J. Cancer
, vol.87
, pp. 805-812
-
-
Aft, R.L.1
Zhang, F.W.2
Gius, D.3
-
128
-
-
1642494855
-
2-deoxy-D-glucose increases the efficacy of adriamycin and paclitaxel in human osteosarcoma and non-small cell lung cancers in vivo
-
Maschek G, et al. (2004) 2-deoxy-D-glucose increases the efficacy of adriamycin and paclitaxel in human osteosarcoma and non-small cell lung cancers in vivo. Cancer Res. 64:31-4.
-
(2004)
Cancer Res
, vol.64
, pp. 31-34
-
-
Maschek, G.1
-
129
-
-
38149063508
-
2-deoxy-D-glucose causes cytotoxicity, oxidative stress, and radiosensitization in pancreatic cancer
-
Coleman MC, et al. (2008) 2-deoxy-D-glucose causes cytotoxicity, oxidative stress, and radiosensitization in pancreatic cancer. Free Radic. Biol. Med. 44:322-31.
-
(2008)
Free Radic. Biol. Med
, vol.44
, pp. 322-331
-
-
Coleman, M.C.1
-
130
-
-
0038407274
-
2-Deoxy-D-glucose-induced cytotoxicity and radiosensitization in tumor cells is mediated via disruptions in thiol metabolism
-
Lin X, et al. (2003) 2-Deoxy-D-glucose-induced cytotoxicity and radiosensitization in tumor cells is mediated via disruptions in thiol metabolism. Cancer Res. 63:3413-7.
-
(2003)
Cancer Res
, vol.63
, pp. 3413-3417
-
-
Lin, X.1
-
131
-
-
34248142302
-
2-Deoxy-D-glucose combined with cisplatin enhances cytotoxicity via metabolic oxidative stress in human head and neck cancer cells
-
Simons AL, Ahmad IM, Mattson DM, Dornfeld KJ, Spitz DR. (2007) 2-Deoxy-D-glucose combined with cisplatin enhances cytotoxicity via metabolic oxidative stress in human head and neck cancer cells. Cancer Res. 67:3364-70.
-
(2007)
Cancer Res
, vol.67
, pp. 3364-3370
-
-
Simons, A.L.1
Ahmad, I.M.2
Mattson, D.M.3
Dornfeld, K.J.4
Spitz, D.R.5
-
132
-
-
44949149074
-
Potentiation of chemotherapeutic drugs by energy metabolism inhibitors 2-deoxyglucose and etomoxir
-
Hernlund E, et al. (2008) Potentiation of chemotherapeutic drugs by energy metabolism inhibitors 2-deoxyglucose and etomoxir. Int. J. Cancer. 123:476-83.
-
(2008)
Int. J. Cancer
, vol.123
, pp. 476-483
-
-
Hernlund, E.1
-
133
-
-
0034038708
-
Glucose deprivation-induced oxidative stress in human tumor cells: A fundamental defect in metabolism?
-
Spitz DR, Sim JE, Ridnour LA, Galoforo SS, Lee YJ. (2000) Glucose deprivation-induced oxidative stress in human tumor cells: a fundamental defect in metabolism? Ann. N. Y. Acad. Sci. 899:349-62.
-
(2000)
Ann. N. Y. Acad. Sci
, vol.899
, pp. 349-362
-
-
Spitz, D.R.1
Sim, J.E.2
Ridnour, L.A.3
Galoforo, S.S.4
Lee, Y.J.5
-
134
-
-
20044361991
-
Mitochondrial O2*- and H2O2 mediate glucose deprivation-induced stress in human cancer cells
-
Ahmad IM, et al. (2005) Mitochondrial O2*- and H2O2 mediate glucose deprivation-induced stress in human cancer cells. J. Biol. Chem. 280:4254-63.
-
(2005)
J. Biol. Chem
, vol.280
, pp. 4254-4263
-
-
Ahmad, I.M.1
-
135
-
-
33744828248
-
Glucose withdrawal induces oxidative stress followed by apoptosis in glioblastoma cells but not in normal human astrocytes
-
Jelluma N, et al. (2006) Glucose withdrawal induces oxidative stress followed by apoptosis in glioblastoma cells but not in normal human astrocytes. Mol. Cancer Res. 4:319-30.
-
(2006)
Mol. Cancer Res
, vol.4
, pp. 319-330
-
-
Jelluma, N.1
-
136
-
-
0028850950
-
alpha-Ketoacids scavenge H2O2 in vitro and in vivo and reduce menadione-induced DNA injury and cytotoxicity
-
Nath KA, et al. (1995) alpha-Ketoacids scavenge H2O2 in vitro and in vivo and reduce menadione-induced DNA injury and cytotoxicity. Am. J. Physiol. 268:C227-36.
-
(1995)
Am. J. Physiol
, vol.268
-
-
Nath, K.A.1
-
137
-
-
0034036570
-
Pyruvate secreted by human lymphoid cell lines protects cells from hydrogen peroxide mediated cell death
-
Miwa H, Fujii J, Kanno H, Taniguchi N, Aozasa K. (2000) Pyruvate secreted by human lymphoid cell lines protects cells from hydrogen peroxide mediated cell death. Free Radic. Res. 33:45-56.
-
(2000)
Free Radic. Res
, vol.33
, pp. 45-56
-
-
Miwa, H.1
Fujii, J.2
Kanno, H.3
Taniguchi, N.4
Aozasa, K.5
-
139
-
-
0026326943
-
Hydrogen peroxide-induced renal injury. A protective role for pyruvate in vitro and in vivo
-
Salahudeen AK, Clark EC, Nath KA. (1991) Hydrogen peroxide-induced renal injury. A protective role for pyruvate in vitro and in vivo. J. Clin. Invest. 88:1886-93.
-
(1991)
J. Clin. Invest
, vol.88
, pp. 1886-1893
-
-
Salahudeen, A.K.1
Clark, E.C.2
Nath, K.A.3
-
140
-
-
0026598058
-
Sensitivity to chemical oxidants and radiation in CHO cell lines deficient in oxidative pentose cycle activity
-
Tuttle SW, Varnes ME, Mitchell JB, Biaglow JE. (1992) Sensitivity to chemical oxidants and radiation in CHO cell lines deficient in oxidative pentose cycle activity. Int. J. Radiat. Oncol. Biol. Phys. 22:671-5.
-
(1992)
Int. J. Radiat. Oncol. Biol. Phys
, vol.22
, pp. 671-675
-
-
Tuttle, S.W.1
Varnes, M.E.2
Mitchell, J.B.3
Biaglow, J.E.4
-
141
-
-
0027933692
-
The role of glucose in cellular defences against cytotoxicity of hydrogen peroxide in Chinese hamster ovary cells
-
Averill-Bates DA, Przybytkowski E. (1994) The role of glucose in cellular defences against cytotoxicity of hydrogen peroxide in Chinese hamster ovary cells. Arch. Biochem. Biophys. 312:52-8.
-
(1994)
Arch. Biochem. Biophys
, vol.312
, pp. 52-58
-
-
Averill-Bates, D.A.1
Przybytkowski, E.2
-
142
-
-
14944385553
-
Global cancer statistics, 2002
-
Parkin DM, Bray F, Ferlay J, Pisani P. (2005) Global cancer statistics, 2002. CA Cancer J. Clin. 55:74-108.
-
(2005)
CA Cancer J. Clin
, vol.55
, pp. 74-108
-
-
Parkin, D.M.1
Bray, F.2
Ferlay, J.3
Pisani, P.4
|