Kaempferol sensitizes colon cancer cells to TRAIL-induced apoptosis

Biochemical and Biophysical Research Communications

Volumn 375, Issue 1, 2008, Pages 129-133

  Yoshida, Tatsushi ^a   Konishi, Masako ^a   Horinaka, Mano ^a   Yasuda, Takashi ^a   Goda, Ahmed E ^a,b   Taniguchi, Hiroya ^a   Yano, Kimihiro ^a   Wakada, Miki ^a   Sakai, Toshiyuki ^a  

^a KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^b Tanta University   (Egypt)

Author keywords

Apoptosis; Cancer; Caspase; Combination; DR5; Flavonoid; Kaempferol; TRAIL

Indexed keywords

KAEMPFEROL; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND RECEPTOR;

APOPTOSIS; ARTICLE; CANCER CELL; CELL CULTURE; COLON CANCER; CONTROLLED STUDY; DRUG EFFECT; HUMAN; HUMAN CELL; LIVER CELL; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; RECEPTOR BINDING; UPREGULATION;

APOPTOSIS; CASPASES; CELL LINE, TUMOR; COLONIC NEOPLASMS; HUMANS; KAEMPFEROLS; POLY(ADP-RIBOSE) POLYMERASES; RECEPTORS, TNF-RELATED APOPTOSIS-INDUCING LIGAND; RNA, SMALL INTERFERING; TNF-RELATED APOPTOSIS-INDUCING LIGAND; UP-REGULATION;

EID: 50149121804     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2008.07.131     Document Type: Article

References (20)

1. Park J.S., Rho H.S., Kim D.H., and Chang I.S. Enzymatic preparation of kaempferol from green tea seed and its antioxidant activity. J. Agric. Food Chem. 54 (2006) 2951-2956
2. Schubert W., Eriksson U., Edgar B., Cullberg G., and Hedner T. Flavonoids in grapefruit juice inhibit the in vitro hepatic metabolism of 17 beta-estradiol. Eur. J. Drug Metab. Pharmacokinet. 20 (1995) 219-224
3. Ahn M.R., Kumazawa S., Hamasaka T., Bang K.S., and Nakayama T. Antioxidant activity and constituents of propolis collected in various areas of Korea. J. Agric. Food Chem. 52 (2004) 7286-7292
4. Sharma V., Joseph C., Ghosh S., Agarwal A., Mishra M.K., and Sen E. Kaempferol induces apoptosis in glioblastoma cells through oxidative stress. Mol. Cancer Ther. 6 (2007) 2544-2553
5. Bestwick C.S., Milne L., and Duthie S.J. Kaempferol induced inhibition of HL-60 cell growth results from a heterogeneous response, dominated by cell cycle alterations. Chem. Biol. Interact. 170 (2007) 76-85
6. Leung H.W., Lin C.J., Hour M.J., Yang W.H., Wang M.Y., and Lee H.Z. Kaempferol induces apoptosis in human lung non-small carcinoma cells accompanied by an induction of antioxidant enzymes. Food Chem. Toxicol. 45 (2007) 2005-2013
7. Nadova S., Miadokova E., and Cipak L. Flavonoids potentiate the efficacy of cytarabine through modulation of drug-induced apoptosis. Neoplasma 54 (2007) 202-206
8. Walczak H., Miller R.E., Ariail K., Gliniak B., Griffith T.S., Kubin M., Chin W., Jones J., Woodward A., Le T., Smith C., Smolak P., Goodwin R.G., Rauch C.T., Schuh J.C., and Lynch D.H. Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo. Nat. Med. 5 (1999) 157-163
9. Ashkenazi A., Pai R.C., Fong S., Leung S., Lawrence D.A., Marsters S.A., Blackie C., Chang L., McMurtrey A.E., Hebert A., DeForge L., Koumenis I.L., Lewis D., Harris L., Bussiere J., Koeppen H., Shahrokh Z., and Schwall R.H. Safety and antitumor activity of recombinant soluble Apo2 ligand. J. Clin. Invest. 104 (1999) 155-162
10. Pan G., Ni J., Wei Y.-F., Yu G.-L., Gentz R., and Dixit V.M. An antagonist decoy receptor and a death domain-containing receptor for TRAIL. Science 277 (1997) 815-818
11. Sheridan J.P., Marsters S.A., Pitti R.M., Gurney A., Skubatch M., Baldwin D., Ramakrishnan L., Gray C.L., Baker K., Wood W.I., Goddard A.D., Godowski P., and Ashkenazi A. Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors. Science 277 (1997) 818-821
12. LeBlanc H.N., and Ashkenazi A. Apo2L/TRAIL and its death and decoy receptors. Cell Death Differ. 10 (2003) 66-75
13. Fesik S.W. Promoting apoptosis as a strategy for cancer drug discovery. Nat. Rev. Cancer 5 (2005) 876-885
14. Zhang L., and Fang B. Mechanisms of resistance to TRAIL-induced apoptosis in cancer. Cancer Gene Ther. 12 (2005) 228-237
15. Nakata S., Yoshida T., Horinaka M., Shiraishi T., Wakada M., and Sakai T. Histone deacetylase inhibitors up-regulate death receptor 5/TRAIL-R2 and sensitize apoptosis induced by TRAIL/APO2-L in human malignant tumor cells. Oncogene 23 (2004) 6261-6271
16. Horinaka M., Yoshida T., Shiraishi T., Nakata S., Wakada M., Nakanishi R., Nishino H., Matsui H., and Sakai T. Luteolin induces apoptosis via death receptor 5 upregulation in human malignant tumor cells. Oncogene 24 (2005) 7180-7189
17. Lazebnik Y.A., Kaufmann S.H., Desnoyers S., Poirier G.G., and Earnshaw W.C. Cleavage of poly(ADP-ribose)polymerase by a proteinase with properties like ICE. Nature 371 (1994) 346-347
18. LeBlanc H., Lawrence D., Varfolomeev E., Totpal K., Morlan J., Schow P., Fong S., Schwall R., Sinicropi D., and Ashkenazi A. Tumor-cell resistance to death receptor-induced apoptosis through mutational inactivation of the proapoptotic Bcl-2 homolog Bax. Nat. Med. 8 (2002) 274-281
19. Leung L.K., Po L.S., Lau T.Y., and Yuen Y.M. Effect of dietary flavonols on oestrogen receptor transactivation and cell death induction. Br. J. Nutr. 91 (2004) 831-839
20. Lawrence D., Shahrokh Z., Marsters S., Achilles K., Shih D., Mounho B., Hillan K., Totpal K., DeForge L., Schow P., Hooley J., Sherwood S., Pai R., Leung S., Khan L., Gliniak B., Bussiere J., Smith C.A., Strom S.S., Kelley S., Fox J.A., Thomas D., and Ashkenazi A. Differential hepatocyte toxicity of recombinant Apo2L/TRAIL versions. Nat. Med. 7 (2001) 383-385