메뉴 건너뛰기




Volumn 33, Issue 2, 2019, Pages 263-275

Chemo-preventive and therapeutic effect of the dietary flavonoid kaempferol: A comprehensive review

Author keywords

anticancer; antidiabetic; cardioprotective; kaempferol; mechanisms of action; oxidative stress

Indexed keywords

KAEMPFEROL; KAEMPFEROL DERIVATIVE;

EID: 85056118477     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.6227     Document Type: Review
Times cited : (260)

References (100)
  • 1
    • 84929630423 scopus 로고    scopus 로고
    • Small molecule kaempferol promotes insulin sensitivity and preserved pancreatic β-cell mass in middle-aged obese diabetic mice
    • Alkhalidy, H., Moore, W., Zhang, Y., McMillan, R., Wang, A., Ali, M., … Liu, D. (2015). Small molecule kaempferol promotes insulin sensitivity and preserved pancreatic β-cell mass in middle-aged obese diabetic mice. Journal of Diabetes Research, 2015.
    • (2015) Journal of Diabetes Research , vol.2015
    • Alkhalidy, H.1    Moore, W.2    Zhang, Y.3    McMillan, R.4    Wang, A.5    Ali, M.6    Liu, D.7
  • 2
    • 84940051411 scopus 로고    scopus 로고
    • Ameliorative effect of kaempferol, a flavonoid, on oxidative stress in streptozotocin-induced diabetic rats
    • Al-Numair, K. S., Chandramohan, G., Veeramani, C., & Alsaif, M. A. (2015). Ameliorative effect of kaempferol, a flavonoid, on oxidative stress in streptozotocin-induced diabetic rats. Redox Report, 20(5), 198–209.
    • (2015) Redox Report , vol.20 , Issue.5 , pp. 198-209
    • Al-Numair, K.S.1    Chandramohan, G.2    Veeramani, C.3    Alsaif, M.A.4
  • 3
    • 84943171588 scopus 로고    scopus 로고
    • Influence of kaempferol, a flavonoid compound, on membrane-bound ATPases in streptozotocin-induced diabetic rats
    • Al-Numair, K. S., Veeramani, C., Alsaif, M. A., & Chandramohan, G. (2015). Influence of kaempferol, a flavonoid compound, on membrane-bound ATPases in streptozotocin-induced diabetic rats. Pharmaceutical Biology, 53(9), 1372–1378.
    • (2015) Pharmaceutical Biology , vol.53 , Issue.9 , pp. 1372-1378
    • Al-Numair, K.S.1    Veeramani, C.2    Alsaif, M.A.3    Chandramohan, G.4
  • 5
    • 84926523586 scopus 로고    scopus 로고
    • The chemopreventive effect of the dietary compound kaempferol on the MCF-7 human breast cancer cell line is dependent on inhibition of glucose cellular uptake
    • Azevedo, C., Correia-Branco, A., Araújo, J. R., Guimarães, J. T., Keating, E., & Martel, F. (2015). The chemopreventive effect of the dietary compound kaempferol on the MCF-7 human breast cancer cell line is dependent on inhibition of glucose cellular uptake. Nutrition and Cancer, 67(3), 504–513.
    • (2015) Nutrition and Cancer , vol.67 , Issue.3 , pp. 504-513
    • Azevedo, C.1    Correia-Branco, A.2    Araújo, J.R.3    Guimarães, J.T.4    Keating, E.5    Martel, F.6
  • 8
    • 84894055126 scopus 로고    scopus 로고
    • Kaempferol induces cell cycle arrest in HT-29 human colon cancer cells
    • Cho, H. J., & Park, J. H. Y. (2013). Kaempferol induces cell cycle arrest in HT-29 human colon cancer cells. Journal of Cancer Prevention, 18(3), 257–263.
    • (2013) Journal of Cancer Prevention , vol.18 , Issue.3 , pp. 257-263
    • Cho, H.J.1    Park, J.H.Y.2
  • 9
    • 84934886613 scopus 로고    scopus 로고
    • Kaempferol inhibits thrombosis and platelet activation
    • Choi, J. H., Park, S. E., Kim, S. J., & Kim, S. (2015). Kaempferol inhibits thrombosis and platelet activation. Biochimie, 115, 177–186.
    • (2015) Biochimie , vol.115 , pp. 177-186
    • Choi, J.H.1    Park, S.E.2    Kim, S.J.3    Kim, S.4
  • 10
    • 84950286727 scopus 로고    scopus 로고
    • Galangin and kaempferol suppress phorbol-12-myristate-13-acetate-induced matrix metalloproteinase-9 expression in human fibrosarcoma HT-1080 cells
    • Choi, Y. J., Lee, Y. H., & Lee, S. T. (2015). Galangin and kaempferol suppress phorbol-12-myristate-13-acetate-induced matrix metalloproteinase-9 expression in human fibrosarcoma HT-1080 cells. Molecular Cell, 38(2), 151–155.
    • (2015) Molecular Cell , vol.38 , Issue.2 , pp. 151-155
    • Choi, Y.J.1    Lee, Y.H.2    Lee, S.T.3
  • 11
    • 84923628333 scopus 로고    scopus 로고
    • Inhibitory effects of kaempferol-3-O-rhamnoside on ovalbumin-induced lung inflammation in a mouse model of allergic asthma
    • Chung, M. J., Pandey, R. P., Choi, J. W., Sohng, J. K., Choi, D. J., & Park, Y. (2015). Inhibitory effects of kaempferol-3-O-rhamnoside on ovalbumin-induced lung inflammation in a mouse model of allergic asthma. International Immunopharmacology, 25(2), 302–310.
    • (2015) International Immunopharmacology , vol.25 , Issue.2 , pp. 302-310
    • Chung, M.J.1    Pandey, R.P.2    Choi, J.W.3    Sohng, J.K.4    Choi, D.J.5    Park, Y.6
  • 12
    • 84938992202 scopus 로고    scopus 로고
    • Kaempferol suppresses bladder cancer tumor growth by inhibiting cell proliferation and inducing apoptosis
    • Dang, Q., Song, W., Xu, D., Ma, Y., Li, F., Zeng, J., … Li, L. (2015). Kaempferol suppresses bladder cancer tumor growth by inhibiting cell proliferation and inducing apoptosis. Molecular Carcinogenesis, 54(9), 831–840.
    • (2015) Molecular Carcinogenesis , vol.54 , Issue.9 , pp. 831-840
    • Dang, Q.1    Song, W.2    Xu, D.3    Ma, Y.4    Li, F.5    Zeng, J.6    Li, L.7
  • 13
    • 85018637873 scopus 로고    scopus 로고
    • Correlation of binding efficacies of DNA to flavonoids and their induced cellular damage
    • Das, A., Majumder, D., & Saha, C. (2017). Correlation of binding efficacies of DNA to flavonoids and their induced cellular damage. Journal of Photochemistry and Photobiology B: Biology, 170, 256–262.
    • (2017) Journal of Photochemistry and Photobiology B: Biology , vol.170 , pp. 256-262
    • Das, A.1    Majumder, D.2    Saha, C.3
  • 14
    • 85013477865 scopus 로고    scopus 로고
    • Kaempferol attenuates cardiac hypertrophy via regulation of ASK1/MAPK signaling pathway and oxidative stress
    • Feng, H., Cao, J., Zhang, G., & Wang, Y. (2017). Kaempferol attenuates cardiac hypertrophy via regulation of ASK1/MAPK signaling pathway and oxidative stress. Planta Medica, 83(10), 837–845.
    • (2017) Planta Medica , vol.83 , Issue.10 , pp. 837-845
    • Feng, H.1    Cao, J.2    Zhang, G.3    Wang, Y.4
  • 15
    • 77949275161 scopus 로고    scopus 로고
    • Kaempferol suppresses cisplatin-induced apoptosis via inductions of heme oxygenase-1 and glutamate-cysteine ligase catalytic subunit in HEI-OC1 cells
    • Gao, S. S., Choi, B.-M., Chen, X. Y., Zhu, R. Z., Kim, Y., So, H., … Kim, B. R. (2010). Kaempferol suppresses cisplatin-induced apoptosis via inductions of heme oxygenase-1 and glutamate-cysteine ligase catalytic subunit in HEI-OC1 cells. Pharmaceutical Research, 27(2), 235–245.
    • (2010) Pharmaceutical Research , vol.27 , Issue.2 , pp. 235-245
    • Gao, S.S.1    Choi, B.-M.2    Chen, X.Y.3    Zhu, R.Z.4    Kim, Y.5    So, H.6    Kim, B.R.7
  • 16
    • 84920258356 scopus 로고    scopus 로고
    • Antagonistic effects of black tea against gamma radiation-induced oxidative damage to normal lymphocytes in comparison with cancerous K562 cells
    • Ghosh, D., Dey, S. K., & Saha, C. (2014). Antagonistic effects of black tea against gamma radiation-induced oxidative damage to normal lymphocytes in comparison with cancerous K562 cells. Radiation and Environmental Biophysics, 53(4), 695–704.
    • (2014) Radiation and Environmental Biophysics , vol.53 , Issue.4 , pp. 695-704
    • Ghosh, D.1    Dey, S.K.2    Saha, C.3
  • 17
    • 85046096368 scopus 로고    scopus 로고
    • Dietary polyphenol intake and depression: Results from the Mediterranean healthy eating, lifestyle and aging (MEAL) study
    • Godos, J., Castellano, S., Ray, S., Grosso, G., & Galvano, F. (2018). Dietary polyphenol intake and depression: Results from the Mediterranean healthy eating, lifestyle and aging (MEAL) study. Molecules, 23(5).
    • (2018) Molecules , vol.23 , Issue.5
    • Godos, J.1    Castellano, S.2    Ray, S.3    Grosso, G.4    Galvano, F.5
  • 18
    • 84896881833 scopus 로고    scopus 로고
    • Inhibition of airway epithelial-to-mesenchymal transition and fibrosis by kaempferol in endotoxin-induced epithelial cells and ovalbumin-sensitized mice
    • Gong, J. H., Cho, I. H., Shin, D., Han, S. Y., Park, S.-H., & Kang, Y. H. (2014). Inhibition of airway epithelial-to-mesenchymal transition and fibrosis by kaempferol in endotoxin-induced epithelial cells and ovalbumin-sensitized mice. Laboratory Investigation, 94(3), 297–308.
    • (2014) Laboratory Investigation , vol.94 , Issue.3 , pp. 297-308
    • Gong, J.H.1    Cho, I.H.2    Shin, D.3    Han, S.Y.4    Park, S.-H.5    Kang, Y.H.6
  • 19
    • 84862907830 scopus 로고    scopus 로고
    • Kaempferol suppresses eosionphil infiltration and airway inflammation in airway epithelial cells and in mice with allergic asthma
    • Gong, J. H., Shin, D., Han, S. Y., Kim, J. L., & Kang, Y. H. (2012). Kaempferol suppresses eosionphil infiltration and airway inflammation in airway epithelial cells and in mice with allergic asthma. The Journal of Nutrition, 142(1), 47–56.
    • (2012) The Journal of Nutrition , vol.142 , Issue.1 , pp. 47-56
    • Gong, J.H.1    Shin, D.2    Han, S.Y.3    Kim, J.L.4    Kang, Y.H.5
  • 21
  • 22
    • 85019597768 scopus 로고    scopus 로고
    • Dietary flavonoid and lignan intake and mortality in prospective cohort studies: Systematic review and dose-response meta-analysis
    • Grosso, G., Micek, A., Godos, J., Pajak, A., Sciacca, S., Galvano, F., & Giovannucci, E. L. (2017). Dietary flavonoid and lignan intake and mortality in prospective cohort studies: Systematic review and dose-response meta-analysis. American Journal of Epidemiology, 185(12), 1304–1316.
    • (2017) American Journal of Epidemiology , vol.185 , Issue.12 , pp. 1304-1316
    • Grosso, G.1    Micek, A.2    Godos, J.3    Pajak, A.4    Sciacca, S.5    Galvano, F.6    Giovannucci, E.L.7
  • 23
    • 84934978743 scopus 로고    scopus 로고
    • Kaempferol protects cardiomyocytes against anoxia/reoxygenation injury via mitochondrial pathway mediated by SIRT1
    • Guo, Z., Liao, Z., Huang, L., Liu, D., Yin, D., & He, M. (2015). Kaempferol protects cardiomyocytes against anoxia/reoxygenation injury via mitochondrial pathway mediated by SIRT1. European Journal of Pharmacology, 761, 245–253.
    • (2015) European Journal of Pharmacology , vol.761 , pp. 245-253
    • Guo, Z.1    Liao, Z.2    Huang, L.3    Liu, D.4    Yin, D.5    He, M.6
  • 24
    • 84877672348 scopus 로고    scopus 로고
    • Osteogenic efficacy enhancement of kaempferol through an engineered layer-by-layer matrix: A study in ovariectomized rats
    • Gupta, G. K., Kumar, A., Khedgikar, V., Gautam, J., Nagar, G. K., Gupta, V., … Mishra, P. R. (2013). Osteogenic efficacy enhancement of kaempferol through an engineered layer-by-layer matrix: A study in ovariectomized rats. Nanomedicine, 8(5), 757–771.
    • (2013) Nanomedicine , vol.8 , Issue.5 , pp. 757-771
    • Gupta, G.K.1    Kumar, A.2    Khedgikar, V.3    Gautam, J.4    Nagar, G.K.5    Gupta, V.6    Mishra, P.R.7
  • 25
    • 84859535422 scopus 로고    scopus 로고
    • Effects of parsley (Petroselinum crispum) and its flavonol constituents, kaempferol and quercetin, on serum uric acid levels, biomarkers of oxidative stress and liver Xanthine oxidoreductase aactivity inOxonate-induced hyperuricemic rats
    • Haidari, F., Keshavarz, S. A., Shahi, M. M., Mahboob, S. A., & Rashidi, M. R. (2011). Effects of parsley (Petroselinum crispum) and its flavonol constituents, kaempferol and quercetin, on serum uric acid levels, biomarkers of oxidative stress and liver Xanthine oxidoreductase aactivity inOxonate-induced hyperuricemic rats. Iranian Journal of Pharmaceutical Research, 10(4), 811–819.
    • (2011) Iranian Journal of Pharmaceutical Research , vol.10 , Issue.4 , pp. 811-819
    • Haidari, F.1    Keshavarz, S.A.2    Shahi, M.M.3    Mahboob, S.A.4    Rashidi, M.R.5
  • 28
    • 0036774226 scopus 로고    scopus 로고
    • Flavonoid antioxidants: Chemistry, metabolism and structure-activity relationships
    • Heim, K. E., Tagliaferro, A. R., & Bobilya, D. J. (2002). Flavonoid antioxidants: Chemistry, metabolism and structure-activity relationships. Journal of Nutritional Biochemistry, 13(10), 572–584.
    • (2002) Journal of Nutritional Biochemistry , vol.13 , Issue.10 , pp. 572-584
    • Heim, K.E.1    Tagliaferro, A.R.2    Bobilya, D.J.3
  • 30
    • 84876543464 scopus 로고    scopus 로고
    • Kaempferol induces autophagy through AMPK and AKT signaling molecules and causes G2/M arrest via downregulation of CDK1/cyclin B in SK-HEP-1 human hepatic cancer cells
    • Huang, W. W., Tsai, S. C., Peng, S. F., Lin, M. W., Chiang, J. H., Chiu, Y. J., … Yang, J. S. (2013). Kaempferol induces autophagy through AMPK and AKT signaling molecules and causes G2/M arrest via downregulation of CDK1/cyclin B in SK-HEP-1 human hepatic cancer cells. International Journal of Oncology, 42(6), 2069–2077.
    • (2013) International Journal of Oncology , vol.42 , Issue.6 , pp. 2069-2077
    • Huang, W.W.1    Tsai, S.C.2    Peng, S.F.3    Lin, M.W.4    Chiang, J.H.5    Chiu, Y.J.6    Yang, J.S.7
  • 31
    • 84895076421 scopus 로고    scopus 로고
    • Syk and Src are major pharmacological targets of a Cerbera manghas methanol extract with kaempferol-based anti-inflammatory activity
    • Jeong, H. Y., Sung, G. H., Kim, J. H., Yoon, J. Y., Yang, Y., Park, J. G., … Cho, J. Y. (2014). Syk and Src are major pharmacological targets of a Cerbera manghas methanol extract with kaempferol-based anti-inflammatory activity. Journal of Ethnopharmacology, 151(2), 960–969.
    • (2014) Journal of Ethnopharmacology , vol.151 , Issue.2 , pp. 960-969
    • Jeong, H.Y.1    Sung, G.H.2    Kim, J.H.3    Yoon, J.Y.4    Yang, Y.5    Park, J.G.6    Cho, J.Y.7
  • 32
    • 84963985160 scopus 로고    scopus 로고
    • Kaempferol suppresses transforming growth factor-β1–induced epithelial-to-mesenchymal transition and migration of A549 lung cancer cells by inhibiting Akt1-mediated phosphorylation of Smad3 at threonine-179
    • Jo, E., Park, S. J., Choi, Y. S., Jeon, W. K., & Kim, B. C. (2015). Kaempferol suppresses transforming growth factor-β1–induced epithelial-to-mesenchymal transition and migration of A549 lung cancer cells by inhibiting Akt1-mediated phosphorylation of Smad3 at threonine-179. Neoplasia, 17(7), 525–537.
    • (2015) Neoplasia , vol.17 , Issue.7 , pp. 525-537
    • Jo, E.1    Park, S.J.2    Choi, Y.S.3    Jeon, W.K.4    Kim, B.C.5
  • 33
    • 84897126996 scopus 로고    scopus 로고
    • A comparative evaluation of anticancer activities of flavonoids isolated from Mimosa pudica, Aloe vera and Phyllanthus niruri against human breast carcinoma cell line (MCF-7) using MTT assay
    • Jose, J., Sudhakaran, S., Kumar, S., Jayaraman, S., & Variyar, E. J. (2014). A comparative evaluation of anticancer activities of flavonoids isolated from Mimosa pudica, Aloe vera and Phyllanthus niruri against human breast carcinoma cell line (MCF-7) using MTT assay. International Journal of Pharmacy and Pharmaceutical Sciences, 6(2), 319–322.
    • (2014) International Journal of Pharmacy and Pharmaceutical Sciences , vol.6 , Issue.2 , pp. 319-322
    • Jose, J.1    Sudhakaran, S.2    Kumar, S.3    Jayaraman, S.4    Variyar, E.J.5
  • 34
    • 75749093933 scopus 로고    scopus 로고
    • Kaempferol and quercetin, components of Ginkgo biloba extract (EGb 761), induce caspase-3-dependent apoptosis in oral cavity cancer cells
    • Kang, J. W., Kim, J. H., Song, K., Kim, S. H., Yoon, J. H., & Kim, K. S. (2010). Kaempferol and quercetin, components of Ginkgo biloba extract (EGb 761), induce caspase-3-dependent apoptosis in oral cavity cancer cells. Phytotherapy Research, 24(1), 213–217.
    • (2010) Phytotherapy Research , vol.24 , Issue.1 , pp. 213-217
    • Kang, J.W.1    Kim, J.H.2    Song, K.3    Kim, S.H.4    Yoon, J.H.5    Kim, K.S.6
  • 35
    • 85014119232 scopus 로고    scopus 로고
    • Kaempferol increases apoptosis in human cervical cancer HeLa cells via PI3K/AKT and telomerase pathways
    • Kashafi, E., Moradzadeh, M., Mohamadkhani, A., & Erfanian, S. (2017). Kaempferol increases apoptosis in human cervical cancer HeLa cells via PI3K/AKT and telomerase pathways. Biomedicine and Pharmacotherapy, 89, 573–577.
    • (2017) Biomedicine and Pharmacotherapy , vol.89 , pp. 573-577
    • Kashafi, E.1    Moradzadeh, M.2    Mohamadkhani, A.3    Erfanian, S.4
  • 37
    • 84939267613 scopus 로고    scopus 로고
    • Kaempferol inhibits vascular smooth muscle cell migration by modulating BMP-mediated miR-21 expression
    • Kim, K., Kim, S., Moh, S. H., & Kang, H. (2015). Kaempferol inhibits vascular smooth muscle cell migration by modulating BMP-mediated miR-21 expression. Molecular and Cellular Biochemistry, 407(1-2), 143–149.
    • (2015) Molecular and Cellular Biochemistry , vol.407 , Issue.1-2 , pp. 143-149
    • Kim, K.1    Kim, S.2    Moh, S.H.3    Kang, H.4
  • 38
    • 84957798907 scopus 로고    scopus 로고
    • Treatment with kaempferol suppresses breast cancer cell growth caused by estrogen and triclosan in cellular and xenograft breast cancer models
    • Kim, S. H., Hwang, K. A., & Choi, K. C. (2016). Treatment with kaempferol suppresses breast cancer cell growth caused by estrogen and triclosan in cellular and xenograft breast cancer models. The Journal of Nutritional Biochemistry, 28, 70–82.
    • (2016) The Journal of Nutritional Biochemistry , vol.28 , pp. 70-82
    • Kim, S.H.1    Hwang, K.A.2    Choi, K.C.3
  • 39
    • 84928242572 scopus 로고    scopus 로고
    • The dietary flavonoid Kaempferol mediates anti-inflammatory responses via the Src, Syk, IRAK1, and IRAK4 molecular targets
    • Kim, S. H., Park, J. G., Lee, J., Yang, W. S., Park, G. W., Kim, H. G., … Cho, J. Y. (2015). The dietary flavonoid Kaempferol mediates anti-inflammatory responses via the Src, Syk, IRAK1, and IRAK4 molecular targets. Mediators of Inflammation, 2015, Article ID 904142.
    • (2015) Mediators of Inflammation , vol.2015
    • Kim, S.H.1    Park, J.G.2    Lee, J.3    Yang, W.S.4    Park, G.W.5    Kim, H.G.6    Cho, J.Y.7
  • 41
    • 84880370306 scopus 로고    scopus 로고
    • Phenolic content, reducing power and membrane protective activities of Solanum xanthocarpum root extracts
    • Kumar, S., & Pandey, A. K. (2013). Phenolic content, reducing power and membrane protective activities of Solanum xanthocarpum root extracts. VEGETOS: An International Journal of Plant Research, 26(1), 301–307.
    • (2013) VEGETOS: An International Journal of Plant Research , vol.26 , Issue.1 , pp. 301-307
    • Kumar, S.1    Pandey, A.K.2
  • 43
    • 84962568892 scopus 로고    scopus 로고
    • Kaempferol induces ATM/p53-mediated death receptor and mitochondrial apoptosis in human umbilical vein endothelial cells
    • Lee, C. F., Yang, J. S., Tsai, F. J., Chiang, N. N., Lu, C. C., Huang, Y. S., … Chen, F. A. (2016). Kaempferol induces ATM/p53-mediated death receptor and mitochondrial apoptosis in human umbilical vein endothelial cells. International Journal of Oncology, 48(5), 2007–2014.
    • (2016) International Journal of Oncology , vol.48 , Issue.5 , pp. 2007-2014
    • Lee, C.F.1    Yang, J.S.2    Tsai, F.J.3    Chiang, N.N.4    Lu, C.C.5    Huang, Y.S.6    Chen, F.A.7
  • 44
    • 85006928791 scopus 로고    scopus 로고
    • Kaempferol, a phytoestrogen, suppressed triclosan-induced epithelial-mesenchymal transition and metastatic-related behaviors of MCF-7 breast cancer cells
    • Lee, G. A., Choi, K. C., & Hwang, K. A. (2017). Kaempferol, a phytoestrogen, suppressed triclosan-induced epithelial-mesenchymal transition and metastatic-related behaviors of MCF-7 breast cancer cells. Environomental Toxicology and Pharmacology, 49, 48–57.
    • (2017) Environomental Toxicology and Pharmacology , vol.49 , pp. 48-57
    • Lee, G.A.1    Choi, K.C.2    Hwang, K.A.3
  • 45
    • 84894068756 scopus 로고    scopus 로고
    • Mechanisms underlying apoptosis-inducing effects of Kaempferol in HT-29 human colon cancer cells
    • Lee, H. S., Cho, H. J., Yu, R., Lee, K. W., Chun, H. S., & Park, J. H. Y. (2014). Mechanisms underlying apoptosis-inducing effects of Kaempferol in HT-29 human colon cancer cells. International Journal of Molecular Sciences, 15(2), 2722–2737.
    • (2014) International Journal of Molecular Sciences , vol.15 , Issue.2 , pp. 2722-2737
    • Lee, H.S.1    Cho, H.J.2    Yu, R.3    Lee, K.W.4    Chun, H.S.5    Park, J.H.Y.6
  • 46
    • 84969903144 scopus 로고    scopus 로고
    • Kaempferol inhibits pancreatic cancer cell growth and migration through the blockade of EGFR-related pathway in vitro
    • Lee, J., & Kim, J. H. (2016). Kaempferol inhibits pancreatic cancer cell growth and migration through the blockade of EGFR-related pathway in vitro. PLoS One, 11(5), e0155264.
    • (2016) PLoS One , vol.11 , Issue.5
    • Lee, J.1    Kim, J.H.2
  • 47
    • 84904727195 scopus 로고    scopus 로고
    • Kaempferol inhibits IL-1β-stimulated, RANKL-mediated osteoclastogenesis via downregulation of MAPKs, c-Fos, and NFATc1
    • Lee, W. S., Lee, E. G., Sung, M. S., & Yoo, W. H. (2014). Kaempferol inhibits IL-1β-stimulated, RANKL-mediated osteoclastogenesis via downregulation of MAPKs, c-Fos, and NFATc1. Inflammation, 37, 1221–1230.
    • (2014) Inflammation , vol.37 , pp. 1221-1230
    • Lee, W.S.1    Lee, E.G.2    Sung, M.S.3    Yoo, W.H.4
  • 48
    • 84938781547 scopus 로고    scopus 로고
    • Kaempferol suppresses lipid accumulation by inhibiting early adipogenesis in 3T3-L1 cells and zebrafish
    • Lee, Y. J., Choi, H. S., Seo, M. J., Jeon, H. J., Kim, K. J., & Lee, B. Y. (2015). Kaempferol suppresses lipid accumulation by inhibiting early adipogenesis in 3T3-L1 cells and zebrafish. Food & Function, 6(8), 2824–2833.
    • (2015) Food & Function , vol.6 , Issue.8 , pp. 2824-2833
    • Lee, Y.J.1    Choi, H.S.2    Seo, M.J.3    Jeon, H.J.4    Kim, K.J.5    Lee, B.Y.6
  • 49
    • 77349084446 scopus 로고    scopus 로고
    • Kaempferol protects HIT-T15 pancreatic beta cells from 2-deoxy-D-ribose-induced oxidative damage
    • Lee, Y. J., Suh, K. S., Choi, M. C., Chon, S., Oh, S., Woo, J. T., … Kim, Y. S. (2010). Kaempferol protects HIT-T15 pancreatic beta cells from 2-deoxy-D-ribose-induced oxidative damage. Phytotherapy Research, 24(3), 419–423.
    • (2010) Phytotherapy Research , vol.24 , Issue.3 , pp. 419-423
    • Lee, Y.J.1    Suh, K.S.2    Choi, M.C.3    Chon, S.4    Oh, S.5    Woo, J.T.6    Kim, Y.S.7
  • 50
    • 80051512571 scopus 로고    scopus 로고
    • Neuroprotective effect of kaempferol against a 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-induced mouse model of Parkinson's disease
    • Li, S., & Pu, X. P. (2011). Neuroprotective effect of kaempferol against a 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-induced mouse model of Parkinson's disease. Biological and Pharmaceutical Bulletin, 34(8), 1291–1296.
    • (2011) Biological and Pharmaceutical Bulletin , vol.34 , Issue.8 , pp. 1291-1296
    • Li, S.1    Pu, X.P.2
  • 51
    • 84960379142 scopus 로고    scopus 로고
    • Protective effects of kaempferol against reactive oxygen species-induced hemolysis and its antiproliferative activity on human cancer cells
    • Liao, W., Chen, L., Ma, X., Jiao, R., Li, X., & Wang, Y. (2016). Protective effects of kaempferol against reactive oxygen species-induced hemolysis and its antiproliferative activity on human cancer cells. European Journal of Medicinal Chemistry, 114, 24–32.
    • (2016) European Journal of Medicinal Chemistry , vol.114 , pp. 24-32
    • Liao, W.1    Chen, L.2    Ma, X.3    Jiao, R.4    Li, X.5    Wang, Y.6
  • 52
    • 84948568042 scopus 로고    scopus 로고
    • Kaempferol enhances the suppressive function of Treg cells by inhibiting FOXP3 phosphorylation
    • Lin, F., Luo, X., Tsun, A., Li, Z., Li, D., & Li, B. (2015). Kaempferol enhances the suppressive function of Treg cells by inhibiting FOXP3 phosphorylation. International Immunopharmacology, 28(2), 859–865.
    • (2015) International Immunopharmacology , vol.28 , Issue.2 , pp. 859-865
    • Lin, F.1    Luo, X.2    Tsun, A.3    Li, Z.4    Li, D.5    Li, B.6
  • 53
    • 84892492922 scopus 로고    scopus 로고
    • Dietary flavonoids intake and risk of type 2 diabetes: A meta-analysis of prospective cohort studies
    • Liu, Y. J., Zhan, J., Liu, X. L., Wang, Y., Ji, J., & He, Q. Q. (2014). Dietary flavonoids intake and risk of type 2 diabetes: A meta-analysis of prospective cohort studies. Clinical Nutrition, 33(1), 59–63.
    • (2014) Clinical Nutrition , vol.33 , Issue.1 , pp. 59-63
    • Liu, Y.J.1    Zhan, J.2    Liu, X.L.3    Wang, Y.4    Ji, J.5    He, Q.Q.6
  • 55
    • 84938840930 scopus 로고    scopus 로고
    • Kaempferol alleviates insulin resistance via hepatic IKK/NF-κB signal in type 2 diabetic rats
    • Luo, C., Yang, H., Tang, C., Yao, G., Kong, L., He, H., & Zhou, Y. (2015). Kaempferol alleviates insulin resistance via hepatic IKK/NF-κB signal in type 2 diabetic rats. International Immunopharmacology, 28(1), 744–750.
    • (2015) International Immunopharmacology , vol.28 , Issue.1 , pp. 744-750
    • Luo, C.1    Yang, H.2    Tang, C.3    Yao, G.4    Kong, L.5    He, H.6    Zhou, Y.7
  • 56
    • 19744367536 scopus 로고    scopus 로고
    • Antimicrobial activities and phytochemical profiles of endemic medicinal plants of Mauritius
    • Mahomoodally, M. F., Gurib-Fakim, A., & Subratty, A. H. (2005). Antimicrobial activities and phytochemical profiles of endemic medicinal plants of Mauritius. Pharmaceutical Biology, 43(3), 237–242.
    • (2005) Pharmaceutical Biology , vol.43 , Issue.3 , pp. 237-242
    • Mahomoodally, M.F.1    Gurib-Fakim, A.2    Subratty, A.H.3
  • 58
    • 30644456411 scopus 로고    scopus 로고
    • Dietary flavonoids: Effects on xenobiotic and carcinogen metabolism
    • Moon, Y. J., Wang, X., & Morris, M. E. (2006). Dietary flavonoids: Effects on xenobiotic and carcinogen metabolism. Toxicology In Vitro, 20, 187–210.
    • (2006) Toxicology In Vitro , vol.20 , pp. 187-210
    • Moon, Y.J.1    Wang, X.2    Morris, M.E.3
  • 59
    • 85024107841 scopus 로고    scopus 로고
    • Kaempferol impedes IL-32-induced monocyte-macrophage differentiation
    • Nam, S.-Y., Jeong, H.-J., & Kim, H.-M. (2017). Kaempferol impedes IL-32-induced monocyte-macrophage differentiation. Chemico-Biological Interactions, 274, 107–115.
    • (2017) Chemico-Biological Interactions , vol.274 , pp. 107-115
    • Nam, S.-Y.1    Jeong, H.-J.2    Kim, H.-M.3
  • 60
    • 84904263428 scopus 로고    scopus 로고
    • Inhibition of catalase by tea catechins in free and cellular state: A biophysical approach
    • Pal, S., Dey, S. K., & Saha, C. (2014). Inhibition of catalase by tea catechins in free and cellular state: A biophysical approach. PLoS One, 9(7), e102460.
    • (2014) PLoS One , vol.9 , Issue.7
    • Pal, S.1    Dey, S.K.2    Saha, C.3
  • 61
    • 84963900805 scopus 로고    scopus 로고
    • Kaempferol inhibits endoplasmic reticulum stress-associated mucus hypersecretion in airway epithelial cells and ovalbumin-sensitized mice
    • Park, S. H., Gong, J. H., Choi, Y. J., Kang, M. K., Kim, Y. H., & Kang, Y. H. (2015). Kaempferol inhibits endoplasmic reticulum stress-associated mucus hypersecretion in airway epithelial cells and ovalbumin-sensitized mice. PLoS One, 10(11), 143526.
    • (2015) PLoS One , vol.10 , Issue.11
    • Park, S.H.1    Gong, J.H.2    Choi, Y.J.3    Kang, M.K.4    Kim, Y.H.5    Kang, Y.H.6
  • 62
    • 84866026226 scopus 로고    scopus 로고
    • Negative regulation of adipogenesis by kaempferol, a component of Rhizoma Polygonati falcatum in 3T3-L1 cells
    • Park, U. H., Jeong, J. C., Jang, J. S., Sung, M. R., Youn, H., Lee, S. J., … Um, S. J. (2012). Negative regulation of adipogenesis by kaempferol, a component of Rhizoma Polygonati falcatum in 3T3-L1 cells. Biological and Pharmaceutical Bulletin, 35(9), 1525–1533.
    • (2012) Biological and Pharmaceutical Bulletin , vol.35 , Issue.9 , pp. 1525-1533
    • Park, U.H.1    Jeong, J.C.2    Jang, J.S.3    Sung, M.R.4    Youn, H.5    Lee, S.J.6    Um, S.J.7
  • 63
    • 84930224913 scopus 로고    scopus 로고
    • Inhibitory kinetics and mechanism of kaempferol on α-glucosidase
    • Peng, X., Zhang, G., Liao, Y., & Gong, D. (2016). Inhibitory kinetics and mechanism of kaempferol on α-glucosidase. Food Chemistry, 190, 207–215.
    • (2016) Food Chemistry , vol.190 , pp. 207-215
    • Peng, X.1    Zhang, G.2    Liao, Y.3    Gong, D.4
  • 64
    • 84906962954 scopus 로고    scopus 로고
    • Cytoprotective effect of kaempferol on paraquat-exposed BEAS-2B cells via modulating expression of MUC5AC
    • Podder, B., Song, K. S., Song, H. Y., & Kim, Y. S. (2014). Cytoprotective effect of kaempferol on paraquat-exposed BEAS-2B cells via modulating expression of MUC5AC. Biological and Pharmaceutical Bulletin, 37(9), 1486–1494.
    • (2014) Biological and Pharmaceutical Bulletin , vol.37 , Issue.9 , pp. 1486-1494
    • Podder, B.1    Song, K.S.2    Song, H.Y.3    Kim, Y.S.4
  • 65
    • 1542345740 scopus 로고    scopus 로고
    • Stimulatory effect of naturally occurring flavonols quercetin and kaempferol on alkaline phosphatase activity in MG-63 human osteoblasts through ERK and estrogen receptor pathway
    • Prouillet, C., Mazière, J. C., Maziere, C., Wattel, A., Brazier, M., & Kamel, S. (2004). Stimulatory effect of naturally occurring flavonols quercetin and kaempferol on alkaline phosphatase activity in MG-63 human osteoblasts through ERK and estrogen receptor pathway. Biochemical Pharmacology, 67(7), 1307–1313.
    • (2004) Biochemical Pharmacology , vol.67 , Issue.7 , pp. 1307-1313
    • Prouillet, C.1    Mazière, J.C.2    Maziere, C.3    Wattel, A.4    Brazier, M.5    Kamel, S.6
  • 66
    • 84960131606 scopus 로고    scopus 로고
    • Kaempferol inhibits the growth and metastasis of cholangiocarcinoma in vitro and in vivo
    • Qin, Y., Cui, W., Yang, X., & Tong, B. (2016). Kaempferol inhibits the growth and metastasis of cholangiocarcinoma in vitro and in vivo. Acta Biochimica et Biophysica Sinica, 48(3), 238–245.
    • (2016) Acta Biochimica et Biophysica Sinica , vol.48 , Issue.3 , pp. 238-245
    • Qin, Y.1    Cui, W.2    Yang, X.3    Tong, B.4
  • 67
    • 85015659742 scopus 로고    scopus 로고
    • Kaempferol modulates DNA methylation and downregulates DNMT3B in bladder cancer
    • Qiu, W., Lin, J., Zhu, Y., Zeng, L., Su, M., & Tian, Y. (2017). Kaempferol modulates DNA methylation and downregulates DNMT3B in bladder cancer. Cellular Physiology and Biochemistry, 41(4), 1325–1335.
    • (2017) Cellular Physiology and Biochemistry , vol.41 , Issue.4 , pp. 1325-1335
    • Qiu, W.1    Lin, J.2    Zhu, Y.3    Zeng, L.4    Su, M.5    Tian, Y.6
  • 69
    • 0033179287 scopus 로고    scopus 로고
    • Phytoestrogen kaempferol (3,4′,5,7-tetrahydroxyflavone) protects PC12 and T47D cells from β-amyloid–induced toxicity
    • Roth, A., Schaffner, W., & Hertel, C. (1999). Phytoestrogen kaempferol (3,4′,5,7-tetrahydroxyflavone) protects PC12 and T47D cells from β-amyloid–induced toxicity. Journal of Neuroscience Research, 57(3), 399–404.
    • (1999) Journal of Neuroscience Research , vol.57 , Issue.3 , pp. 399-404
    • Roth, A.1    Schaffner, W.2    Hertel, C.3
  • 70
    • 84907359336 scopus 로고    scopus 로고
    • The berry constituents quercetin, kaempferol, and pterostilbene synergistically attenuate reactive oxygen species: Involvement of the Nrf2-ARE signaling pathway
    • Saw, C. L. L., Guo, Y., Yang, A. Y., Paredes-Gonzalez, X., Ramirez, C., Pung, D., & Kong, A. N. (2014). The berry constituents quercetin, kaempferol, and pterostilbene synergistically attenuate reactive oxygen species: Involvement of the Nrf2-ARE signaling pathway. Food and Chemical Toxicology, 72, 303–311.
    • (2014) Food and Chemical Toxicology , vol.72 , pp. 303-311
    • Saw, C.L.L.1    Guo, Y.2    Yang, A.Y.3    Paredes-Gonzalez, X.4    Ramirez, C.5    Pung, D.6    Kong, A.N.7
  • 71
    • 0033863355 scopus 로고    scopus 로고
    • Dietary intake and bioavailability of polyphenols
    • Scalbert, A., & Williamson, G. (2000). Dietary intake and bioavailability of polyphenols. The Journal of Nutrition, 130, 2073S–2085S.
    • (2000) The Journal of Nutrition , vol.130 , pp. 2073S-2085S
    • Scalbert, A.1    Williamson, G.2
  • 73
    • 84871365338 scopus 로고    scopus 로고
    • Keampferol-3-O-rhamnoside abrogates amyloid beta toxicity by modulating monomers and remodeling oligomers and fibrils to non-toxic aggregates
    • Sharoar, M. G., Thapa, A., Shahnawaz, M., Ramasamy, V. S., Woo, E. R., Shin, S. Y., & Park, I. S. (2012). Keampferol-3-O-rhamnoside abrogates amyloid beta toxicity by modulating monomers and remodeling oligomers and fibrils to non-toxic aggregates. Journal of Biomedical Science, 19(1), 104.
    • (2012) Journal of Biomedical Science , vol.19 , Issue.1 , pp. 104
    • Sharoar, M.G.1    Thapa, A.2    Shahnawaz, M.3    Ramasamy, V.S.4    Woo, E.R.5    Shin, S.Y.6    Park, I.S.7
  • 74
    • 84949989450 scopus 로고    scopus 로고
    • Dietary compound Kaempferol inhibits airway thickening induced by allergic reaction in a bovine serum albumin-induced model of asthma
    • Shin, D., Park, S. H., Choi, Y. J., Kim, Y. H., Antika, L. D., Habibah, N. U., … Kang, Y. H. (2015). Dietary compound Kaempferol inhibits airway thickening induced by allergic reaction in a bovine serum albumin-induced model of asthma. International Journal of Molecular Sciences, 16(12), 29980–29995.
    • (2015) International Journal of Molecular Sciences , vol.16 , Issue.12 , pp. 29980-29995
    • Shin, D.1    Park, S.H.2    Choi, Y.J.3    Kim, Y.H.4    Antika, L.D.5    Habibah, N.U.6    Kang, Y.H.7
  • 75
    • 84919427485 scopus 로고    scopus 로고
    • Kaempferol inhibits gastric cancer tumor growth: An in vitro and in vivo study
    • Song, H., Bao, J., Wei, Y., Chen, Y., Mao, X., Li, J., … Xue, Y. (2015). Kaempferol inhibits gastric cancer tumor growth: An in vitro and in vivo study. Oncology Reports, 33(2), 868–874.
    • (2015) Oncology Reports , vol.33 , Issue.2 , pp. 868-874
    • Song, H.1    Bao, J.2    Wei, Y.3    Chen, Y.4    Mao, X.5    Li, J.6    Xue, Y.7
  • 76
    • 84896691526 scopus 로고    scopus 로고
    • Kaempferol induces cell cycle arrest and apoptosis in renal cell carcinoma through EGFR/p38 signaling
    • Song, W., Dang, Q., Xu, D., Chen, Y., Zhu, G., Wu, K., … Li, L. (2014). Kaempferol induces cell cycle arrest and apoptosis in renal cell carcinoma through EGFR/p38 signaling. Oncology Reports, 31(3), 1350–1356.
    • (2014) Oncology Reports , vol.31 , Issue.3 , pp. 1350-1356
    • Song, W.1    Dang, Q.2    Xu, D.3    Chen, Y.4    Zhu, G.5    Wu, K.6    Li, L.7
  • 77
    • 84964894091 scopus 로고    scopus 로고
    • Kaempferol attenuates myocardial ischemic injury via inhibition of MAPK signaling pathway in experimental model of myocardial ischemia-reperfusion injury
    • 7580731
    • Suchal, K., Malik, S., Gamad, N., Malhotra, R. K., Goyal, S. N., Chaudhary, U., … Arya, D. S. (2016). Kaempferol attenuates myocardial ischemic injury via inhibition of MAPK signaling pathway in experimental model of myocardial ischemia-reperfusion injury. Oxidative Medicine and Cellular Longevity, 2016. 7580731
    • (2016) Oxidative Medicine and Cellular Longevity , vol.2016
    • Suchal, K.1    Malik, S.2    Gamad, N.3    Malhotra, R.K.4    Goyal, S.N.5    Chaudhary, U.6    Arya, D.S.7
  • 78
    • 84982263748 scopus 로고    scopus 로고
    • Kampeferol protects against oxidative stress and apoptotic damage in experimental model of isoproterenol-induced cardiac toxicity in rats
    • Suchal, K., Malik, S., Gamad, N., Malhotra, R. K., Goyal, S. N., Bhatia, J., & Arya, D. S. (2016a). Kampeferol protects against oxidative stress and apoptotic damage in experimental model of isoproterenol-induced cardiac toxicity in rats. Phytomedicine, 23(12), 1401–1408.
    • (2016) Phytomedicine , vol.23 , Issue.12 , pp. 1401-1408
    • Suchal, K.1    Malik, S.2    Gamad, N.3    Malhotra, R.K.4    Goyal, S.N.5    Bhatia, J.6    Arya, D.S.7
  • 81
    • 84964255463 scopus 로고    scopus 로고
    • Protective effect of kaempferol on LPS plus ATP-induced inflammatory response in cardiac fibroblasts
    • Tang, X. l., Liu, J. X., Dong, W., Li, P., Li, L., Hou, J. C., … Ren, J. G. (2015). Protective effect of kaempferol on LPS plus ATP-induced inflammatory response in cardiac fibroblasts. Inflammation, 38(1), 94–101.
    • (2015) Inflammation , vol.38 , Issue.1 , pp. 94-101
    • Tang, X.L.1    Liu, J.X.2    Dong, W.3    Li, P.4    Li, L.5    Hou, J.C.6    Ren, J.G.7
  • 82
    • 60549096618 scopus 로고    scopus 로고
    • Effects of Egb 761 on bone mineral density, bone microstructure, and osteoblast function: Possible roles of quercetin and kaempferol
    • Trivedi, R., Kumar, A., Gupta, V., Kumar, S., Nagar, G. K., Romero, J. R., … Chattopadhyay, N. (2009). Effects of Egb 761 on bone mineral density, bone microstructure, and osteoblast function: Possible roles of quercetin and kaempferol. Molecular and Cellular Endocrinology, 302(1), 86–91.
    • (2009) Molecular and Cellular Endocrinology , vol.302 , Issue.1 , pp. 86-91
    • Trivedi, R.1    Kumar, A.2    Gupta, V.3    Kumar, S.4    Nagar, G.K.5    Romero, J.R.6    Chattopadhyay, N.7
  • 84
    • 84975757505 scopus 로고    scopus 로고
    • The mechanism of kaempferol induced apoptosis and inhibited proliferation in human cervical cancer SiHa cell: From macro to nano
    • Tu, L. Y., Bai, H. H., Cai, J. Y., & Deng, S. P. (2016). The mechanism of kaempferol induced apoptosis and inhibited proliferation in human cervical cancer SiHa cell: From macro to nano. Scanning, 38(6), 644–653.
    • (2016) Scanning , vol.38 , Issue.6 , pp. 644-653
    • Tu, L.Y.1    Bai, H.H.2    Cai, J.Y.3    Deng, S.P.4
  • 85
    • 85017137771 scopus 로고    scopus 로고
    • Cytoprotective effect of kaempferol against palmitic acid-induced pancreatic β-cell death through modulation of autophagy via AMPK/mTOR signaling pathway
    • Varshney, R., Gupta, S., & Roy, P. (2017). Cytoprotective effect of kaempferol against palmitic acid-induced pancreatic β-cell death through modulation of autophagy via AMPK/mTOR signaling pathway. Molecular and Cellular Endocrinology, 448, 1–20.
    • (2017) Molecular and Cellular Endocrinology , vol.448 , pp. 1-20
    • Varshney, R.1    Gupta, S.2    Roy, P.3
  • 86
    • 61449216050 scopus 로고    scopus 로고
    • Dietary intake of selected flavonols, flavones, and flavonoid-rich foods and risk of cancer in middle-aged and older women
    • Wang, L., Lee, I. M., Zhang, S. M., Blumberg, J. B., Buring, J. E., & Sesso, H. D. (2009). Dietary intake of selected flavonols, flavones, and flavonoid-rich foods and risk of cancer in middle-aged and older women. The American Journal of Clinical Nutrition, 89(3), 905–912.
    • (2009) The American Journal of Clinical Nutrition , vol.89 , Issue.3 , pp. 905-912
    • Wang, L.1    Lee, I.M.2    Zhang, S.M.3    Blumberg, J.B.4    Buring, J.E.5    Sesso, H.D.6
  • 89
    • 84961289132 scopus 로고    scopus 로고
    • Kaempferol suppresses collagen-induced platelet activation by inhibiting NADPH oxidase and protecting SHP-2 from oxidative inactivation
    • Wang, S. B., Jang, J. Y., Chae, Y. H., Min, J. H., Baek, J. Y., Kim, M., … Chang, T. S. (2015). Kaempferol suppresses collagen-induced platelet activation by inhibiting NADPH oxidase and protecting SHP-2 from oxidative inactivation. Free Radical Biology & Medicine, 83, 41–53.
    • (2015) Free Radical Biology & Medicine , vol.83 , pp. 41-53
    • Wang, S.B.1    Jang, J.Y.2    Chae, Y.H.3    Min, J.H.4    Baek, J.Y.5    Kim, M.6    Chang, T.S.7
  • 90
    • 84928391008 scopus 로고    scopus 로고
    • Kaempferol induces DNA damage and inhibits DNA repair associated protein expressions in human promyelocytic leukemia HL-60 cells
    • Wu, L. Y., Lu, H. F., Chou, Y. C., Shih, Y. L., Bau, D. T., Chen, J. C., … Chung, J. G. (2015). Kaempferol induces DNA damage and inhibits DNA repair associated protein expressions in human promyelocytic leukemia HL-60 cells. The American Journal of Chinese Medicine, 43, 365–382.
    • (2015) The American Journal of Chinese Medicine , vol.43 , pp. 365-382
    • Wu, L.Y.1    Lu, H.F.2    Chou, Y.C.3    Shih, Y.L.4    Bau, D.T.5    Chen, J.C.6    Chung, J.G.7
  • 91
    • 84961789510 scopus 로고    scopus 로고
    • Kaempferol inhibits the production of ROS to modulate OPN–αvβ3 integrin pathway in HUVECs
    • Xiao, H. B., Lu, X. Y., Liu, Z. K., & Luo, Z. F. (2016). Kaempferol inhibits the production of ROS to modulate OPN–αvβ3 integrin pathway in HUVECs. Journal of Physiology and Biochemistry, 72(2), 303–313.
    • (2016) Journal of Physiology and Biochemistry , vol.72 , Issue.2 , pp. 303-313
    • Xiao, H.B.1    Lu, X.Y.2    Liu, Z.K.3    Luo, Z.F.4
  • 92
    • 85014734224 scopus 로고    scopus 로고
    • Kaempferol inhibited VEGF and PGF expression and in vitro angiogenesis of HRECs under diabetic-like environment
    • Xu, X., Zhao, C., Peng, Q., Xie, P., & Liu, Q. (2017). Kaempferol inhibited VEGF and PGF expression and in vitro angiogenesis of HRECs under diabetic-like environment. Brazilian Journal of Medical and Biological Research, 50(3), e5396.
    • (2017) Brazilian Journal of Medical and Biological Research , vol.50 , Issue.3
    • Xu, X.1    Zhao, C.2    Peng, Q.3    Xie, P.4    Liu, Q.5
  • 93
    • 84930221780 scopus 로고    scopus 로고
    • Kaempferol enhances endothelium-dependent relaxation in the porcine coronary artery through activation of large-conductance Ca(2+) -activated K(+) channels
    • Xu, Y. C., Leung, S. W., Leung, G. P., & Man, R. Y. (2015). Kaempferol enhances endothelium-dependent relaxation in the porcine coronary artery through activation of large-conductance Ca(2+) -activated K(+) channels. British Journal of Pharmacology, 172(12), 3003–3014.
    • (2015) British Journal of Pharmacology , vol.172 , Issue.12 , pp. 3003-3014
    • Xu, Y.C.1    Leung, S.W.2    Leung, G.P.3    Man, R.Y.4
  • 94
    • 84903286886 scopus 로고    scopus 로고
    • Kaempferol attenuates the glutamate-induced oxidative stress in mouse-derived hippocampal neuronal HT22 cells
    • Yang, E. J., Kim, G. S., Jun, M., & Song, K. S. (2014). Kaempferol attenuates the glutamate-induced oxidative stress in mouse-derived hippocampal neuronal HT22 cells. Food & Function, 5(7), 1395–1402.
    • (2014) Food & Function , vol.5 , Issue.7 , pp. 1395-1402
    • Yang, E.J.1    Kim, G.S.2    Jun, M.3    Song, K.S.4
  • 95
    • 84907287826 scopus 로고    scopus 로고
    • Kaempferol targets RSK2 and MSK1 to suppress UV radiation-induced skin cancer
    • Yao, K., Chen, H., Liu, K., Langfald, A., Yang, G., Zhang, Y., … Dong, Z. (2014). Kaempferol targets RSK2 and MSK1 to suppress UV radiation-induced skin cancer. Cancer Prevention Research, 7(9), 958–967.
    • (2014) Cancer Prevention Research , vol.7 , Issue.9 , pp. 958-967
    • Yao, K.1    Chen, H.2    Liu, K.3    Langfald, A.4    Yang, G.5    Zhang, Y.6    Dong, Z.7
  • 96
    • 84925395796 scopus 로고    scopus 로고
    • The anti-obesity and anti-diabetic effects of kaempferol glycosides from unripe soybean leaves in high-fat-diet mice
    • Zang, Y., Zhang, L., Igarashi, K., & Yu, C. (2015). The anti-obesity and anti-diabetic effects of kaempferol glycosides from unripe soybean leaves in high-fat-diet mice. Food & Function, 6(3), 834–841.
    • (2015) Food & Function , vol.6 , Issue.3 , pp. 834-841
    • Zang, Y.1    Zhang, L.2    Igarashi, K.3    Yu, C.4
  • 97
    • 84875069606 scopus 로고    scopus 로고
    • Small molecule kaempferol modulates PDX-1 protein expression and subsequently promotes pancreatic β-cell survival and function via CREB
    • Zhang, Y., Zhen, W., Maechler, P., & Liu, D. (2013). Small molecule kaempferol modulates PDX-1 protein expression and subsequently promotes pancreatic β-cell survival and function via CREB. J Nutr Biochem, 24(4), 638–646.
    • (2013) J Nutr Biochem , vol.24 , Issue.4 , pp. 638-646
    • Zhang, Y.1    Zhen, W.2    Maechler, P.3    Liu, D.4
  • 98
    • 85014253794 scopus 로고    scopus 로고
    • Kaempferol ameliorates H9N2 swine influenza virus-induced acute lung injury by inactivation of TLR4/MyD88-mediated NF-κB and MAPK signaling pathways
    • Zhang, R., Ai, X., Duan, Y., Xue, M., He, W., Wang, C., … Liu, H. (2017). Kaempferol ameliorates H9N2 swine influenza virus-induced acute lung injury by inactivation of TLR4/MyD88-mediated NF-κB and MAPK signaling pathways. Biomedicine & Pharmacotherapy, 89, 660–672.
    • (2017) Biomedicine & Pharmacotherapy , vol.89 , pp. 660-672
    • Zhang, R.1    Ai, X.2    Duan, Y.3    Xue, M.4    He, W.5    Wang, C.6    Liu, H.7
  • 99
    • 84938635678 scopus 로고    scopus 로고
    • Protective effects of kaempferol against myocardial ischemia/reperfusion injury in isolated rat heart via antioxidant activity and inhibition of glycogen synthase kinase-3
    • Zhou, M., Ren, H., Han, J., Wang, W., Zheng, Q., & Wang, D. (2015). Protective effects of kaempferol against myocardial ischemia/reperfusion injury in isolated rat heart via antioxidant activity and inhibition of glycogen synthase kinase-3. Oxidative Medicine and Cellular Longevity, 2015.
    • (2015) Oxidative Medicine and Cellular Longevity , vol.2015
    • Zhou, M.1    Ren, H.2    Han, J.3    Wang, W.4    Zheng, Q.5    Wang, D.6
  • 100
    • 85007477141 scopus 로고    scopus 로고
    • Kaempferol slows intervertebral disc degeneration by modifying LPS-induced osteogenesis/adipogenesis imbalance and inflammation response in BMSCs
    • Zhu, J., Tang, H., Zhang, Z., Zhang, Y., Qiu, C., Zhang, L., … Li, F. (2017). Kaempferol slows intervertebral disc degeneration by modifying LPS-induced osteogenesis/adipogenesis imbalance and inflammation response in BMSCs. International Immunopharmacology, 43, 236–242.
    • (2017) International Immunopharmacology , vol.43 , pp. 236-242
    • Zhu, J.1    Tang, H.2    Zhang, Z.3    Zhang, Y.4    Qiu, C.5    Zhang, L.6    Li, F.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.