Kaempferol induced apoptosis via endoplasmic reticulum stress and mitochondria-dependent pathway in human osteosarcoma U-2 OS cells

Molecular Nutrition and Food Research

Volumn 54, Issue 11, 2010, Pages 1585-1595

  Huang, Wen Wen ^a   Chiu, Yu Jen ^b   Fan, Ming Jen ^c   Lu, Hsu Feng ^d,e   Yeh, Hsiu Feng ^a   Li, Kun Hong ^b   Chen, Po Yuan ^a   Chung, Jing Gung ^a,c   Yang, Jai Sing ^b  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

^c ASIA UNIVERSITY   (Taiwan)

^d FU JEN CATHOLIC UNIVERSITY   (Taiwan)

^e CHENG HSIN GENERAL HOSPITAL   (Taiwan)

Author keywords

Apoptosis; Endoplasmic reticulum stress; Kaempferol; Mitochondria dependent; U 2 OS

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE; KAEMPFEROL; KAEMPFEROL DERIVATIVE;

ANIMAL; APOPTOSIS; ARTICLE; BAGG ALBINO MOUSE; BONE TUMOR; CELL PROLIFERATION; CELL SURVIVAL; COMET ASSAY; DNA DAMAGE; DRUG ANTAGONISM; DRUG EFFECT; DRUG SCREENING; ENDOPLASMIC RETICULUM; HUMAN; METABOLISM; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; OSTEOSARCOMA; RANDOMIZATION; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ANIMALS; ANTICARCINOGENIC AGENTS; APOPTOSIS; BONE NEOPLASMS; CASPASES; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; COMET ASSAY; DNA DAMAGE; ENDOPLASMIC RETICULUM; HUMANS; KAEMPFEROLS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICE, INBRED BALB C; OSTEOSARCOMA; RANDOM ALLOCATION; SIGNAL TRANSDUCTION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

MUS;

EID: 78349236990     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.201000005     Document Type: Article

References (44)

1. Hollman, P. C., Katan, M. B., Dietary flavonoids: intake, health effects and bioavailability. Food Chem. Toxicol. 1999, 37, 937-942.
2. Guo, Q., Zhao, L., You, Q., Yang, Y. et al., Anti-hepatitis B virus activity of wogonin in vitro and in vivo. Antiviral Res. 2007, 74, 16-24.
3. Cardenas, M., Marder, M., Blank, V. C., Roguin, L. P., Antitumor activity of some natural flavonoids and synthetic derivatives on various human and murine cancer cell lines. Bioorg. Med. Chem. 2006, 14, 2966-2971.
4. Burda, S., Oleszek, W., Antioxidant and antiradical activities of flavonoids. J. Agric. Food. Chem. 2001, 49, 2774-2779.
5. Gonzalez-Gallego, J., Sanchez-Campos, S., Tunon, M. J., Anti-inflammatory properties of dietary flavonoids. Nutr. Hosp. 2007, 22, 287-293.
6. Yao, P., Nussler, A., Liu, L., Hao, L. et al., Quercetin protects human hepatocytes from ethanol-derived oxidative stress by inducing heme oxygenase-1 via the MAPK/Nrf2 pathways. J. Hepatol. 2007, 47, 253-261.
7. Tijburg, L. B., Mattern, T., Folts, J. D., Weisgerber, U. M., Katan, M. B., Tea flavonoids and cardiovascular disease: a review. Crit. Rev. Food. Sci. Nutr. 1997, 37, 771-785.
8. Park, J. S., Rho, H. S., Kim, D. H., Chang, I. S., Enzymatic preparation of kaempferol from green tea seed and its antioxidant activity. J. Agric. Food. Chem. 2006, 54, 2951-2956.
9. Leung, H. W., Lin, C. J., Hour, M. J., Yang, W. H. et al., Kaempferol induces apoptosis in human lung non-small carcinoma cells accompanied by an induction of antioxidant enzymes. Food Chem. Toxicol. 2007, 45, 2005-2013.
10. Marfe, G., Tafani, M., Indelicato, M., Sinibaldi-Salimei, P. et al., Kaempferol induces apoptosis in two different cell lines via Akt inactivation, Bax and SIRT3 activation, and mitochondrial dysfunction. J. Cell. Biochem. 2009, 106, 643-650.
11. Zhang, Q., Zhao, X. H., Wang, Z. J., Flavones and flavonols exert cytotoxic effects on a human oesophageal adenocarcinoma cell line (OE33) by causing G2/M arrest and inducing apoptosis. Food Chem. Toxicol. 2008, 46, 2042-2053.
12. De Leo, M., Braca, A., Sanogo, R., Cardile, V. et al., Antiproliferative activity of Pteleopsis suberosa leaf extract and its flavonoid components in human prostate carcinoma cells. Planta. Med. 2006, 72, 604-610.
13. Kim, K. S., Rhee, K. H., Yoon, J. H., Lee, J. G. et al., Ginkgo biloba extract (EGb 761) induces apoptosis by the activation of caspase-3 in oral cavity cancer cells. Oral Oncol. 2005, 41, 383-389.
14. Mutoh, M., Takahashi, M., Fukuda, K., Matsushima-Hibiya, Y. et al., Suppression of cyclooxygenase-2 promoter-dependent transcriptional activity in colon cancer cells by chemopreventive agents with a resorcin-type structure. Carcinogenesis 2000, 21, 959-963.
15. Arndt, C. A., Crist, W. M., Common musculoskeletal tumors of childhood and adolescence. N. Engl. J. Med. 1999, 341, 342-352.
16. Bielack, S., Carrle, D., Jost, L., Osteosarcoma: ESMO clinical recommendations for diagnosis, treatment and follow-up. Ann. Oncol. 2008, 19, ii94-ii96.
17. Siegel, H. J., Pressey, J. G., Current concepts on the surgical and medical management of osteosarcoma. Expert Rev. Anticancer Ther. 2008, 8, 1257-1269.
18. Duan, Z., Choy, E., Harmon, D., Yang, C. et al., Insulin-like growth factor-I receptor tyrosine kinase inhibitor cyclolignan picropodophyllin inhibits proliferation and induces apoptosis in multidrug resistant osteosarcoma cell lines. Mol. Cancer. Ther. 2009, 8, 2122-2130.
19. Degterev, A., Boyce, M., Yuan, J., A decade of caspases. Oncogene 2003, 22, 8543-8567.
20. Lockshin, R. A., Zakeri, Z., Cell death in health and disease. J. Cell Mol. Med. 2007, 11, 1214-1224.
21. Moran, J. M., Gonzalez-Polo, R. A., Ortiz-Ortiz, M. A., Niso-Santano, M. et al., Identification of genes associated with paraquat-induced toxicity in SH-SY5Y cells by PCR array focused on apoptotic pathways. J. Toxicol. Environ. Health A 2008, 71, 1457-1467.
22. Hsu, S. C., Yang, J. S., Kuo, C. L., Lo, C. et al., Novel quinolone CHM-1 induces apoptosis and inhibits metastasis in a human osterogenic sarcoma cell line. J. Orthop. Res. 2009, 27, 1637-1644.
23. Lin, S. S., Huang, H. P., Yang, J. S., Wu, J. Y. et al., DNA damage and endoplasmic reticulum stress mediated curcumin-induced cell cycle arrest and apoptosis in human lung carcinoma A-549 cells through the activation caspases cascade- and mitochondrial-dependent pathway. Cancer Lett. 2008, 272, 77-90.
24. Ho, Y. T., Yang, J. S., Li, T. C., Lin, J. J. et al., Berberine suppresses in vitro migration and invasion of human SCC-4 tongue squamous cancer cells through the inhibitions of FAK, IKK, NF-kappaB, u-PA and MMP-2 and -9. Cancer Lett. 2009, 279, 155-162.
25. Chou, L. C., Yang, J. S., Huang, L. J., Wu, H. C. et al., The synthesized 2-(2-fluorophenyl)-6, 7-methylenedioxyquinolin-4-one (CHM-1) promoted G2/M arrest through inhibition of CDK1 and induced apoptosis through the mitochondrial-dependent pathway in CT-26 murine colorectal adenocarcinoma cells. J. Gastroenterol 2009, 44, 1055-1063.
26. Yang, J. S., Chen, G. W., Hsia, T. C., Ho, H. C. et al., Diallyl disulfide induces apoptosis in human colon cancer cell line (COLO 205) through the induction of reactive oxygen species, endoplasmic reticulum stress, caspases casade and mitochondrial-dependent pathways. Food Chem. Toxicol. 2009, 47, 171-179.
27. Chung, J. G., Yang, J. S., Huang, L. J., Lee, F. Y. et al., Proteomic approach to studying the cytotoxicity of YC-1 on U937 leukemia cells and antileukemia activity in orthotopic model of leukemia mice. Proteomics 2007, 7, 3305-3317.
28. Lee, M. J., Kee, K. H., Suh, C. H., Lim, S. C., Oh, S. H., Capsaicin-induced apoptosis is regulated by endoplasmic reticulum stress- and calpain-mediated mitochondrial cell death pathways. Toxicology 2009, 264, 205-214.
29. Wen, Y. F., Yang, J. S., Kuo, S. C., Hwang, C. S. et al., Investigation of anti-leukemia molecular mechanism of ITR-284, a carboxamide analog, in leukemia cells and its effects in WEHI-3 leukemia mice. Biochem. Pharmacol. 2010, 79, 389-398.
30. Koch, T. C., Briviba, K., Watzl, B., Fahndrich, C. et al., Prevention of colon carcinogenesis by apple juice in vivo: impact of juice constituents and obesity. Mol. Nutr. Food Res. 2009, 53, 1289-1302.
31. Danial, N. N., Korsmeyer, S. J., Cell death: critical control points. Cell 2004, 116, 205-219.
32. Chen, J. Q., Brown, T. R., Yager, J. D., Mechanisms of hormone carcinogenesis: evolution of views, role of mitochondria. Adv. Exp. Med. Biol. 2008, 630, 1-18.
33. Kang, J. W., Kim, J. H., Song, K., Kim, S. H. et al., Kaempferol and quercetin, components of Ginkgo biloba extract (EGb 761), induce caspase-3-dependent apoptosis in oral cavity cancer cells. Phytother. Res. 2010, 148, S77-82.
34. Zhang, Y., Chen, A. Y., Li, M., Chen, C., Yao, Q., Ginkgo biloba extract kaempferol inhibits cell proliferation and induces apoptosis in pancreatic cancer cells. J. Surg. Res. 2008, 148, 17-23.
35. Li, N., Liu, J. H., Zhang, J., Yu, B. Y., Comparative evaluation of cytotoxicity and antioxidative activity of 20 flavonoids. J. Agric. Food Chem. 2008, 56, 3876-3883.
36. Soares, V. C., Varanda, E. A., Raddi, M. S., In vitro basal and metabolism-mediated cytotoxicity of flavonoids. Food Chem. Toxicol. 2006, 44, 835-838.
37. Ziegler, D. S., Kung, A. L., Therapeutic targeting of apoptosis pathways in cancer. Curr. Opin. Oncol. 2008, 20, 97-103.
38. Nieto-Miguel, T., Fonteriz, R. I., Vay, L., Gajate, C. et al., Endoplasmic reticulum stress in the proapoptotic action of edelfosine in solid tumor cells. Cancer Res. 2007, 67, 10368-10378.
39. Hitomi, J., Katayama, T., Eguchi, Y., Kudo, T. et al., Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Abeta-induced cell death. J. Cell Biol. 2004, 165, 347-356.
40. Rao, R. V., Ellerby, H. M., Bredesen, D. E., Coupling endoplasmic reticulum stress to the cell death program. Cell Death Differ. 2004, 11, 372-380.
41. Chen, Y. C., Shen, S. C., Chow, J. M., Ko, C. H., Tseng, S. W., Flavone inhibition of tumor growth via apoptosis in vitro and in vivo. Int. J. Oncol. 2004, 25, 661-670.
42. Shen, S. C., Lin, C. W., Lee, H. M., Chien, L. L., Chen, Y. C., Lipopolysaccharide plus 12-o-tetradecanoylphorbol 13-acetate induction of migration and invasion of glioma cells in vitro and in vivo: Differential inhibitory effects of flavonoids. Neuroscience 2006, 140, 477-489.
43. Gates, M. A., Tworoger, S. S., Hecht, J. L., De Vivo, I. et al., A prospective study of dietary flavonoid intake and incidence of epithelial ovarian cancer. Int. J. Cancer 2007, 121, 2225-2232.
44. Simons, C. C., Hughes, L. A., Arts, I. C., Goldbohm, R. A. et al., Dietary flavonol, flavone and catechin intake and risk of colorectal cancer in the Netherlands Cohort Study. Int. J. Cancer 2009, 125, 2945-2952.