Augmentation of differentiation and gap junction function by kaempferol in partially differentiated colon cancer cells

Carcinogenesis

Volumn 26, Issue 3, 2005, Pages 665-671

  Nakamura, Yasushi ^a   Chang, Chia Cheng ^b   Mori, Toshio ^c   Sato, Kenji ^a   Ohtsuki, Kozo ^a   Upham, Brad L ^b   Trosko, James E ^b  

^a KYOTO PREFECTURAL UNIVERSITY   (Japan)

^b MICHIGAN STATE UNIVERSITY   (United States)

^c NARA MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CONNEXIN 43; KAEMPFEROL; MITOGEN ACTIVATED PROTEIN KINASE; STAT3 PROTEIN; ALKALINE PHOSPHATASE; DNA BINDING PROTEIN; KAEMPFEROL DERIVATIVE; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; PRIMER DNA; STAT3 PROTEIN, HUMAN; TRANSACTIVATOR PROTEIN; TYRPHOSTIN; TYRPHOSTIN AG-490;

ARTICLE; CELL COMMUNICATION; COLON CANCER; CONTROLLED STUDY; CYTOTOXICITY; DIFFERENTIATION; GAP JUNCTION; HUMAN; HUMAN CELL; PHOSPHORYLATION; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; CELL DIFFERENTIATION; CELL JUNCTION; CELL LINE; COLON TUMOR; DRUG EFFECT; ENZYMOLOGY; METABOLISM; NUCLEOTIDE SEQUENCE; PATHOLOGY;

ALKALINE PHOSPHATASE; BASE SEQUENCE; CELL DIFFERENTIATION; CELL LINE; COLONIC NEOPLASMS; CONNEXIN 43; DNA PRIMERS; DNA-BINDING PROTEINS; GAP JUNCTIONS; HUMANS; KAEMPFEROLS; STAT3 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS; TYRPHOSTINS;

EID: 16244375571     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/bgi003     Document Type: Article

References (30)

1. Upham, B.L. and Wagner, J.G. (2001) Toxicological highlight: toxicant-induced oxidative stress in cancer. Toxicol. Sci., 64, 1-3.
2. Trosko, J.E. and Ruch, R.J. (1998) Cell-cell communication in carcinogenesis. Front. Biosci., 3, 208-236.
3. Rummel, A.M., Trosko, J.E., Wilson, M.R. and Upham, B.L. (1999) Polycyclic aromatic hydrocarbons with bay-like regions inhibited gap junctional intercellular communication and stimulated MAPK activity. Toxicol. Sci., 49, 232-240.
4. Trosko, J.E., Chang, C.-C., Upham, B.L. and Wilson, M. (1998) Epigenetic toxicology as toxicant-induced changes in intracellular signalling leading to altered gap junctional intercellular communication. Toxicol. Lett., 102/ 103, 71-78.
5. Goodenough, D.A., Goliger, J.A. and Paul, D.L. (1996) Connexins, connexons and intercellular communication. Annu. Rev. Biochem., 65, 475-502.
6. Kumar, N.M. and Gilula, N.B. (1996) The gap junction communication channel. Cell, 84, 381-388.
7. Yamasaki, H., Omori, Y., Krutovskikh, V., Zhu, W., Mironov, N., Yamakage, K. and Mesnil, M. (1999) Connexins in tumour suppression and cancer therapy. Novartis Found. Symp., 219, 241-254.
8. de-Feijter-Rupp, H.L., Hayashi, T., Kalimi, G.H., Edwards, P., Redpath, J.L., Chang, C.-C., Stanbridge, E.J. and Trosko, J.E. (1998) Restored gap junctional communication in non-tumorigenic HeLa-normal human fibroblast hybrids. Carcinogenesis, 19, 747-754.
9. Huang, R.P., Fan, Y., Hossain, M.Z., Peng, A., Zeng, Z.L. and Boynton, A.L. (1998) Reversion of the neoplastic phenotype of human glioblastoma cells by connexin43 (cx43). Cancer Res., 58, 5089-5096.
10. Hirschi, K.K., Xu, C.E., Tsukamoto, T. and Sager, R. (1996) Gap junction genes Cx26 and Cx43 individually suppress the cancer phenotype of human mammary carcinoma cells and restore differentiation potential. Cell Growth Differ., 7, 861-870.
11. Rose, B., Mehta, P.P. and Loewenstein, W.R. (1993) Gap-junction protein gene suppresses tumorigenicity. Carcinogenesis, 14, 1073-1075.
12. Mesnil, M., Krutovskikh, V., Piccoli, C., Elfgang, C., Traub, O., Willecke, K. and Yamasaki, H. (1995) Negative growth control of HeLa cells by connexin genes: connexin species specificity. Cancer Res., 55, 629-639.
13. Naus, C.C., Elisevich, K., Zhu, D., Belliveau, D.J. and Del-Maestro, R.F. (1992) In vivo growth of C6 glioma cells transfected with connexin43 cDNA. Cancer Res., 52, 4208-4213.
14. Zhang, L.X., Cooney, R.V. and Bertram, J.S. (1991) Carotenoids enhance gap junctional communication and inhibit lipid peroxidation in C3H/10T1/ 2 cells: relationship to their cancer chemopreventive action. Carcinogenesis, 12, 2109-2114.
15. Na, H.K., Wilson, M.R., Kang, K.S., Chang, C.-C., Grunberger, D. and Trosko, J.E. (2000) Restoration of gap junctionnal intercellular communication by caffeic acid phenylethyl ester (CAPE) in a ras-transformed rat liver epithelial cell line. Cancer Lett., 157, 31-38.
16. Chaumontet, C., Bex, V., Gaillard-Sanchez, I., Seillan-Heberden, C., Suschetet, M. and Martel, P. (1994) Apigenin and tangeretin enhance gap junctional intercellular communication in rat liver epithelial cells. Carcinogenesis, 15, 2325-2330.
17. Chaumontet, C., Droumaguet, C., Bex, V., Heberden, C., Gaillard-Sanchez, I. and Martel, P. (1997) Flavonoids (apigenin, tangeretin) counteract tumor promoter-induced inhibition of intercellular communication of rat liver epithelial cells. Cancer Lett., 114, 207-210.
18. Huard, C., Druesne, N., Guyonnet, D., Thomas, M., Pagniez, A., Le Bon, A.M., Martel, P. and Chaumontet, C. (2004) Diallyl disulfide (DADS) enhances gap-junctional intercellular communication by both direct and indirect mechanisms in rat liver cells. Carcinogenesis, 25, 91-98.
19. Ozawa, Y., Nakao, K., Shimazaki, T., Takeda, J., Akira, S., Ishihara, K., Hirano, T., Oguchi, Y. and Okano, H. (2004) Downregulation of Stat3 activation is required for presumptive rod photoreceptor cells to differentiate in the postnatal retina. Mol. Cell. Neurosci., 26, 258-270.
20. Muthian, G. and Bright, J.J. (2004) Quercetin, a flavonoid phytoestrogen, ameliorates experimental allergic encephalomyelitis by blocking IL-12 signaling through JAK-STAT pathway in T lymphocyte. J. Clin. Immunol., 24, 542-552.
21. Palmer, J., Hertzog, P.J. and Hammacher, A. (2004) Differential expression and effects of gp130 cytokines and receptors in prostate cancer cells. Int. J. Biochem. Cell Biol., 36, 2258-2269.
22. Bromberg, J. (2002) Stat proteins and oncogenesis. Clin. Invest., 109, 1139-1142.
23. Trosko, J.E., Chang, C.-C., Wilson, M.R., Upham, B.L., Hayashi, T. and Wade, M. (2000) Gap junctions and the regulation of cellular function of stem cells during development and differentiation. Methods, 20, 245-264.
24. Laemmli, U.K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature, 227, 680-685.
25. Upham, B.L., Kang, K.S., Cho, H.Y. and Trosko, J.E. (1997) Hydrogen peroxide inhibits gap junctional intercellular communication in glutathione sufficient but not glutathione deficient cells. Carcinogenesis, 18, 37-42.
26. Schroder, C.P. and Maurer, H.R. (2002) Tributyrin-induced differentiation promotes apoptosis of LS 174T colon cancer cells in vitro. Int. J. Oncol., 20, 195-200.
27. Levy, D.E. and Darnell, J.E. Jr (2002) Stats: transcriptional control and biological impact. Nature Rev. Mol. Cell Biol., 3, 651-662.
28. Laird, D.W. (1996) The life cycle of a connexin: gap junction formation, removal and degradation. J. Bioenerg. Biomembr., 28, 311-318.
29. Laing, J.G., Tadros, P.N., Westphale, E.M. and Beyer, E.C. (1997) Degradation of connexin43 gap junctions involves both the proteasome and the lysosome. Exp. Cell Res., 236, 482-492.
30. Trosko, J.E. and Ruch, R.J. (2002) Gap junctions as targets for cancer chemoprevention and chemotherapy. Curr. Drug Targets, 3, 465-482.