Kaempferol increases apoptosis in human acute promyelocytic leukemia cells and inhibits multidrug resistance genes

Journal of Cellular Biochemistry

Volumn 119, Issue 2, 2018, Pages 2288-2297

  Moradzadeh, Maliheh ^a   Tabarraei, Alijan ^b   Sadeghnia, Hamid Reza ^a   Ghorbani, Ahmad ^c   Mohamadkhani, Ashraf ^d   Erfanian, Saiedeh ^e   Sahebkar, Amirhossein ^a,f  

^a MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b GOLESTAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^d TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^e JAHROM UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^f UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

APL; apoptosis; differentiation; kaempferol; MDR

Indexed keywords

ABC TRANSPORTER SUBFAMILY B; ABCB1 PROTEIN, HUMAN; KAEMPFEROL; KAEMPFEROL DERIVATIVE; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN; MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 1;

CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; DOWN REGULATION; DRUG EFFECT; GENE; GENE EXPRESSION REGULATION; GENETICS; HL-60 CELL LINE; HUMAN; PROMYELOCYTIC LEUKEMIA; TUMOR CELL LINE;

ATP BINDING CASSETTE TRANSPORTER, SUB-FAMILY B; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DOWN-REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, MDR; HL-60 CELLS; HUMANS; KAEMPFEROLS; LEUKEMIA, PROMYELOCYTIC, ACUTE; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS;

EID: 85031761709     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.26391     Document Type: Article

References (40)

1. Adams J, Nassiri M. Acute promyelocytic leukemia: a review and discussion of variant translocations. Arch Pathol Lab Med. 2015; 139:1308–1313.
2. Pitha-Rowe I, Petty W, Kitareewan S, Dmitrovsky E. Retinoid target genes in acute promyelocytic leukemia. Leukemia. 2003; 17:1723–1730.
3. Cardinale L, Asteggiano F, Moretti F, et al. Pathophysiology, clinical features and radiological findings of differentiation syndrome/all-trans-retinoic acid syndrome. World J Radiol. 2014; 6:583–588.
4. Hosseini A, Ghorbani A. Cancer therapy with phytochemicals: evidence from clinical studies. Avicenna J Phytomed. 2015; 5:84.
5. Shahabipour F, Caraglia M, Majeed M, Derosa G, Maffioli P, Sahebkar A. Naturally occurring anti-cancer agents targeting EZH2. Cancer Lett. 2017; 400:325–335.
6. Moradzadeh M, Sadeghnia HR, Tabarraei A, Sahebkar A. Anti-tumor effects of crocetin and related molecular targets. J Cell Physiol. 2017. E-pub ahead of print. https://doi.org/10.1002/jcp.25953
7. Shu L, Cheung K-L, Khor TO, Chen C, Kong A-N. Phytochemicals: cancer chemoprevention and suppression of tumor onset and metastasis. Cancer Metastasis Rev. 2010; 29:483–502.
8. Karthick T, Tandon P. Computational approaches to find the active binding sites of biological targets against busulfan. J Mol Model. 2016; 22:142.
9. Li H, Yang L, Zhang Y, Gao Z. Kaempferol inhibits fibroblast collagen synthesis, proliferation and activation in hypertrophic scar via targeting TGF-β receptor type I. Biomed Pharmacother. 2016; 83:967–974.
10. Chen AY, Chen YC. A review of the dietary flavonoid, kaempferol on human health and cancer chemoprevention. Food Chem. 2013; 138:2099–2107.
11. Kim S-H, Choi K-C. Anti-cancer effect and underlying mechanism (s) of kaempferol, a phytoestrogen, on the regulation of apoptosis in diverse cancer cell models. Toxicol Res. 2013; 29:229.
12. Cassatella M, Cappelli R, Della Bianca V, Grzeskowiak M, Dusi S, Berton G. Interferon-gamma activates human neutrophil oxygen metabolism and exocytosis. Immunology. 1988; 63:499.
13. Mashkani B, Tanipour MH, Saadatmandzadeh M, Ashman LK, Griffith R. FMS-like tyrosine kinase 3 (FLT3) inhibitors: Molecular docking and experimental studies. Eur J Pharmacol. 2016; 776:156–166.
14. Rangarajan P, Subramaniam D, Paul S, et al. Crocetinic acid inhibits hedgehog signaling to inhibit pancreatic cancer stem cells. Oncotarget. 2015; 6:27661.
15. Gupta K, Stefan T, Ignatz-Hoover J, et al. GSK-3 inhibition sensitizes acute myeloid leukemia cells to 1, 25D-mediated differentiation. Cancer Res. 2016; 76:2743–2753.
16. Pfaffl MW. Relative quantification. Real-time PCR. 2006; 63:63–82.
17. Moradzadeh M, Hosseini A, Erfanian S, Rezaei H. Epigallocatechin-3-gallate promotes apoptosis in human breast cancer T47D cells through down-regulation of PI3 K/AKT and Telomerase. Pharmacol Rep. 2017; 69:924–928.
18. Luo H, Daddysman MK, Rankin GO, Jiang B-H, Chen YC. Kaempferol enhances cisplatin's effect on ovarian cancer cells through promoting apoptosis caused by down regulation of cMyc. Cancer Cell Int. 2010; 10:16.
19. Luo H, Rankin GO, Li Z, DePriest L, Chen YC. Kaempferol induces apoptosis in ovarian cancer cells through activating p53 in the intrinsic pathway. Food Chem. 2011; 128:513–519.
20. Alonso-Castro AJ, Ortiz-Sánchez E, García-Regalado A, et al. Kaempferitrin induces apoptosis via intrinsic pathway in HeLa cells and exerts antitumor effects. J Ethnopharmacol. 2013; 145:476–489.
21. Xu W, Liu J, Li C, Wu H-Z, Liu Y-W. Kaempferol-7-O-β-d-glucoside (KG) isolated from Smilax china L. rhizome induces G 2/M phase arrest and apoptosis on HeLa cells in a p53-independent manner. Cancer Lett. 2008; 264:229–240.
22. Tu LY, Bai HH, Cai JY, Deng SP. The mechanism of kaempferol induced apoptosis and inhibited proliferation in human cervical cancer SiHa cell: from macro to nano. Scanning. 2016; 38:644–653.
23. Santos BL, Oliveira MN, Coelho PL, et al. Flavonoids suppress human glioblastoma cell growth by inhibiting cell metabolism, migration, and by regulating extracellular matrix proteins and metalloproteinases expression. Chem Biol Interact. 2015; 242:123–138.
24. Takahashi T, Kobori M, Shinmoto H, Tsushida T. Structure-activity relationships of flavonoids and the induction of granulocytic-or monocytic-differentiation in HL60 human myeloid leukemia cells. Biosci Biotechnol Biochem. 1998; 62:2199–2204.
25. Bestwick CS, Milne L, Duthie SJ. Kaempferol induced inhibition of HL-60 cell growth results from a heterogeneous response, dominated by cell cycle alterations. Chem Biol Interact. 2007; 170:76–85.
26. Kang HJ, Youn Y-K, Hong M-K, Kim LS. Antiproliferation and redifferentiation in thyroid cancer cell lines by polyphenol phytochemicals. J Korean Med Sci. 2011; 26:893–899.
27. Ouyang L, Shi Z, Zhao S, et al. Programmed cell death pathways in cancer: a review of apoptosis, autophagy and programmed necrosis. Cell Prolif. 2012; 45:487–498.
28. Kashafi E, Moradzadeh M, Mohamadkhani A, Erfanian S. Kaempferol increases apoptosis in human cervical cancer HeLa cells via PI3K/AKT and telomerase pathways. Biomed Pharmacother. 2017; 89:573–577.
29. Petrie K, Zelent A, Waxman S. Differentiation therapy of acute myeloid leukemia: past, present and future. Curr Opin Hematol. 2009; 16:84–91.
30. Minucci S, Nervi C, Coco FL, Pelicci PG. Histone deacetylases: a common molecular target for differentiation treatment of acute myeloid leukemias? Oncogene. 2001; 20:3110.
31. Pallis M, Turzanski J, Higashi Y, Russell N. P-glycoprotein in acute myeloid leukaemia: therapeutic implications of its association with both a multidrug-resistant and an apoptosis-resistant phenotype. Leuk Lymphoma. 2002; 43:1221–1228.
32. Shaffer BC, Gillet J-P, Patel C, Baer MR, Bates SE, Gottesman MM. Drug resistance: still a daunting challenge to the successful treatment of AML. Drug Resist Updat. 2012; 15:62–69.
33. Kitagawa S, Nabekura T, Takahashi T, et al. Structure-activity relationships of the inhibitory effects of flavonoids on P-glycoprotein-mediated transport in KB-C2 cells. Biol Pharm Bull. 2005; 28:2274–2278.
34. Chung SY, Jang DS, Han AR, et al. Modulation of P-glycoprotein-mediated resistance by kaempferol derivatives isolated from Zingiber zerumbet. Phytother Res. 2007; 21:565–569.
35. Kuete V, Ango PY, Yeboah SO, et al. Cytotoxicity of four Aframomum species (A. arundinaceum, A. alboviolaceum, A. kayserianum and A. polyanthum) towards multi-factorial drug resistant cancer cell lines. BMC Complement Altern Med. 2014; 14:340.
36. Limtrakul P, Khantamat O, Pintha K. Inhibition of P-glycoprotein function and expression by kaempferol and quercetin. J Chemother. 2005; 17:86–95.
37. Nakamura Y, Chang C-C, Mori T, et al. Augmentation of differentiation and gap junction function by kaempferol in partially differentiated colon cancer cells. Carcinogenesis. 2005; 26:665–671.
38. Pal D, Mitra AK. MDR-and CYP3A4-mediated drug-herbal interactions. Life Sci. 2006; 78:2131–2145.
39. To KK, Yu L, Liu S, Fu J, Cho CH. Constitutive AhR activation leads to concomitant ABCG2-mediated multidrug resistance in cisplatin-resistant esophageal carcinoma cells. Mol Carcinog. 2012; 51:449–464.
40. Gyemant N, Tanaka M, Antus S, et al. In vitro search for synergy between flavonoids and epirubicin on multidrug-resistant cancer cells. In Vivo. 2005; 19:367–374.