Kaempferol increases apoptosis in human cervical cancer HeLa cells via PI3K/AKT and telomerase pathways

Biomedicine and Pharmacotherapy

Volumn 89, Issue , 2017, Pages 573-577

  Kashafi, Elham ^a   Moradzadeh, Maliheh ^b   Mohamadkhani, Ashraf ^c   Erfanian, Saiedeh ^a  

^a JAHROM UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Apoptosis; Cervical cancer; Kaempferol; PI3K AKT signaling cascade; Telomerase

Indexed keywords

CASPASE 3; CASPASE 9; FLUOROURACIL; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; KAEMPFEROL; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; PROTEIN P21; TELOMERASE; TELOMERASE REVERSE TRANSCRIPTASE; ANTINEOPLASTIC AGENT; KAEMPFEROL DERIVATIVE; ONCOPROTEIN;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; FEMALE; GENE EXPRESSION; HELA CELL LINE; HUMAN; HUMAN CELL; IC50; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; UTERINE CERVIX CANCER; BIOSYNTHESIS; CELL SURVIVAL; DOSE RESPONSE; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; SIGNAL TRANSDUCTION;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HELA CELLS; HUMANS; KAEMPFEROLS; ONCOGENE PROTEIN V-AKT; PHOSPHATIDYLINOSITOL 3-KINASES; SIGNAL TRANSDUCTION; TELOMERASE;

EID: 85014119232     PISSN: 07533322     EISSN: 19506007     Source Type: Journal    
DOI: 10.1016/j.biopha.2017.02.061     Document Type: Article

References (33)

1. [1] Fitzmaurice, C., Allen, C., Barber, R.M., Barregard, L., Bhutta, Z.A., Brenner, H., Dicker, D.J., Chimed-Orchir, O., Dandona, R., Dandona, L., Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life-years for 32 cancer groups, 1990 to 2015: a systematic analysis for the global burden of disease study. JAMA Oncol., 2016.
2. [2] Waggoner, S.E., Cervical cancer. Lancet Oncol. 361 (2003), 2217–2225.
3. [3] Haverkos, H., Rohrer, M., Pickworth, W., The cause of invasive cervical cancer could be multifactorial. Biomed. Pharmacother. 54 (2000), 54–59.
4. [4] Surh, Y.-J., Cancer chemoprevention with dietary phytochemicals. Nat. Rev. Cancer 3 (2003), 768–780.
5. [5] Teiten, M.-H., Gaascht, F., Dicato, M., Diederich, M., Anticancer bioactivity of compounds from medicinal plants used in European medieval traditions. Biochem. Pharmacol. 86 (2013), 1239–1247.
6. [6] Shu, L., Cheung, K.-L., Khor, T.O., Chen, C., Kong, A.-N., Phytochemicals: cancer chemoprevention and suppression of tumor onset and metastasis. Cancer Metastasis Rev. 29 (2010), 483–502.
7. [7] Saklani, A., Kutty, S.K., Plant-derived compounds in clinical trials. Drug Discov. Today. 13 (2008), 161–171.
8. [8] Li, H., Yang, L., Zhang, Y., Gao, Z., Kaempferol inhibits fibroblast collagen synthesis, proliferation and activation in hypertrophic scar via targeting TGF-β receptor type I. Biomed. Pharmacother. 83 (2016), 967–974.
9. [9] Chen, A.Y., Chen, Y.C., A review of the dietary flavonoid, kaempferol on human health and cancer chemoprevention. Food Chem. 138 (2013), 2099–2107.
10. [10] Kim, S.-H., Choi, K.-C., Anti-cancer effect and underlying mechanism (s) of kaempferol, a phytoestrogen, on the regulation of apoptosis in diverse cancer cell models. Toxicol. Res. 29 (2013), 229–234.
11. [11] Hosseini, A., Shafiee-Nick, R., Mousavi, S.H., Combination of Nigella sativa with Glycyrrhiza glabra and Zingiber officinale augments their protective effects on doxorubicin-induced toxicity in h9c2 cells. Iran J. Basic Med. Sci., 17, 2014, 993.
12. [12] Pfaffl, M.W., Relative quantification. Real-time PCR 63 (2006), 63–82.
13. [13] Swarnalatha, S., Puratchikody, A., Cytokines mediated immunomodulatory properties of Kaempferol-5-O-β-D-glucopyranoside from methanol extract of aerial parts of Indigofera aspalathoides Vahl ex DC. Int. J. Res. Pharm. Sci. 5 (2014), 73–78.
14. [14] Barve, A., Chen, C., Hebbar, V., Desiderio, J., Saw, C.L.L., Kong, A.N., Metabolism, oral bioavailability and pharmacokinetics of chemopreventive kaempferol in rats. Biopharm. Drug Dispos. 30 (2009), 356–365.
15. [15] Zhang, Y., Chen, A.Y., Li, M., Chen, C., Yao, Q., Ginkgo biloba extract kaempferol inhibits cell proliferation and induces apoptosis in pancreatic cancer cells. J. Surg. Res. 148 (2008), 17–23.
16. [16] Lee, J., Kim, J.H., Kaempferol inhibits pancreatic cancer cell growth and migration through the blockade of EGFR-related pathway in vitro. PLoS One, 11, 2016, e0155264.
17. [17] Tu, L.Y., Bai, H.H., Cai, J.Y., Deng, S.P., The mechanism of kaempferol induced apoptosis and inhibited proliferation in human cervical cancer SiHa cell: from macro to nano. Scanning, 2016.
18. [18] Alonso-Castro, A.J., Ortiz-Sánchez, E., García-Regalado, A., Ruiz, G., Núñez-Martínez, J.M., González-Sánchez, I., Quintanar-Jurado, V., Morales-Sánchez, E., Dominguez, F., López-Toledo, G., Kaempferitrin induces apoptosis via intrinsic pathway in HeLa cells and exerts antitumor effects. J. Ethnopharmacol. 145 (2013), 476–489.
19. [19] Xu, W., Liu, J., Li, C., Wu, H.-Z., Liu, Y.-W., Kaempferol-7-O-β-d-glucoside (KG) isolated from Smilax china L. rhizome induces G 2/M phase arrest and apoptosis on HeLa cells in a p53-independent manner. Cancer Lett. 264 (2008), 229–240.
20. [20] Luo, H., Daddysman, M.K., Rankin, G.O., Jiang, B.H., Chen, Y.C., Kaempferol enhances cisplatin's effect on ovarian cancer cells through promoting apoptosis caused by down regulation of cMyc. Cancer Cell Int., 10, 2010, 16.
21. [21] Luo, H., Rankin, G.O., Li, Z., DePriest, L., Chen, Y.C., Kaempferol induces apoptosis in ovarian cancer cells through activating p53 in the intrinsic pathway. Food Chem. 128 (2011), 513–519.
22. [22] Lee, H.S., Cho, H.J., Kwon, G.T., Park, J.H., Kaempferol downregulates insulin-like growth factor-I receptor and ErbB3 signaling in HT-29 human colon cancer cells. J. Cancer Prev. 19 (2014), 161–169.
23. [23] Lee, H.S., Cho, H.J., Yu, R., Lee, K.W., Chun, H.S., Park, J.H., Mechanisms underlying apoptosis-inducing effects of Kaempferol in HT-29 human colon cancer cells. Int. J. Mol. Sci. 15 (2014), 2722–2737.
24. [24] Yoshida, T., Konishi, M., Horinaka, M., Yasuda, T., Goda, A.E., Taniguchi, H., Yano, K., Wakada, M., Sakai, T., Kaempferol sensitizes colon cancer cells to TRAIL-induced apoptosis. Biochem. Biophys. Res. Commun. 375 (2008), 129–133.
25. [25] Diantini, A., Subarnas, A., Lestari, K., Halimah, E., Susilawati, Y., Julaeha, Supriyatna E., Achmad, T.H., Suradji, E.W., Yamazaki, C., Kobayashi, K., Koyama, H., Abdulah, R., Kaempferol-3-O-rhamnoside isolated from the leaves of Schima wallichii Korth. inhibits MCF-7 breast cancer cell proliferation through activation of the caspase cascade pathway. Oncol. Lett. 3 (2012), 1069–1072.
26. [26] Choi, E.J., Ahn, W.S., Kaempferol induced the apoptosis via cell cycle arrest in human breast cancer MDA-MB-453 cells. Nutr. Res. Pract. 2 (2008), 322–325.
27. [27] Halimah, E., Diantini, A., Destiani, D.P., Pradipta, I.S., Sastramihardja, H.S., Lestari, K., Subarnas, A., Abdulah, R., Koyama, H., Induction of caspase cascade pathway by kaempferol-3-O-rhamnoside in LNCaP prostate cancer cell lines. Biomed. Rep. 3 (2015), 115–117.
28. [28] Kumar, A.D., Bevara, G.B., Kaja, L.K., Badana, A.K., Malla, R.R., Protective effect of 3-O-methyl quercetin and kaempferol from Semecarpus anacardium against H2O2 induced cytotoxicity in lung and liver cells. BMC Complement. Altern. Med., 16, 2016, 376.
29. [29] Leung, H.W.-C., Lin, C.-J., Hour, M.-J., Yang, W.-H., Wang, M.-Y., Lee, H.-Z., Kaempferol induces apoptosis in human lung non-small carcinoma cells accompanied by an induction of antioxidant enzymes. Food Chem. Toxicol. 45 (2007), 2005–2013.
30. [30] Nguyen, T., Tran, E., Ong, C., Lee, S., Do, P., Huynh, T., Nguyen, T., Lee, J., Tan, Y., Ong, C., Kaempferol-induced growth inhibition and apoptosis in A549 lung cancer cells is mediated by activation of MEK-MAPK. J. Cell Physiol. 197 (2003), 110–121.
31. [31] Xie, F., Su, M., Qiu, W., Zhang, M., Guo, Z., Su, B., Liu, J., Li, X., Zhou, L., Kaempferol promotes apoptosis in human bladder cancer cells by inducing the tumor suppressor, PTEN. Int. J. Mol. Sci. 14 (2013), 21215–21226.
32. [32] Song, W., Dang, Q., Xu, D., Chen, Y., Zhu, G., Wu, K., Zeng, J., Long, Q., Wang, X., He, D., Kaempferol induces cell cycle arrest and apoptosis in renal cell carcinoma through EGFR/p38 signaling. Oncol. Rep. 31 (2014), 1350–1356.
33. [33] Bestwick, C.S., Milne, L., Duthie, S.J., Kaempferol induced inhibition of HL-60 cell growth results from a heterogeneous response, dominated by cell cycle alterations. Chem. Biol. Interact. 170 (2007), 76–85.