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Volumn 86, Issue , 2014, Pages 103-112

Kaempferol, a potential cytostatic and cure for inflammatory disorders

Author keywords

Apoptosis; Chemoprevention; Flavanoids; Inflammatory diseases; Kaempferol

Indexed keywords

KAEMPFEROL; PROTEIN P53; REACTIVE OXYGEN METABOLITE; SCAVENGER; STAT3 PROTEIN; ANTIINFLAMMATORY AGENT; ANTINEOPLASTIC AGENT; CYTOSTATIC AGENT; KAEMPFEROL DERIVATIVE; ANTIINFECTIVE AGENT; CYTOKINE; GLUTATHIONE; GLYCOSIDE; GLYCOSYLATED PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN;

EID: 84906492447     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.08.011     Document Type: Short Survey
Times cited : (226)

References (125)
  • 2
    • 0034736046 scopus 로고    scopus 로고
    • Advances in flavonoid research since 1992
    • J.B. Harborne, and C.A. Williams Advances in flavonoid research since 1992 Phytochemistry 55 2000 481 504
    • (2000) Phytochemistry , vol.55 , pp. 481-504
    • Harborne, J.B.1    Williams, C.A.2
  • 3
    • 47949120075 scopus 로고    scopus 로고
    • Sustained ERK activation is involved in the kaempferol-induced apoptosis of breast cancer cells and is more evident under 3-D culture condition
    • Bong-Woo Kim, Eung-Ryoung Lee, Hye-Min Min, Hyo-Soon Jeong, Jae-Yeon Ahn, Jung-Hyun Kim, Hye-Yeon Choi, Hana Choi, Eun Young Kim, Se Pill Park, and Ssang-Goo Cho Sustained ERK activation is involved in the kaempferol-induced apoptosis of breast cancer cells and is more evident under 3-D culture condition Cancer Biol. Ther. 7 2008 1080 1089
    • (2008) Cancer Biol. Ther. , vol.7 , pp. 1080-1089
    • Kim, B.-W.1    Lee, E.-R.2    Min, H.-M.3    Jeong, H.-S.4    Ahn, J.-Y.5    Kim, J.-H.6    Choi, H.-Y.7    Choi, H.8    Kim, E.Y.9    Park, S.P.10    Cho, S.-G.11
  • 4
    • 0031595885 scopus 로고    scopus 로고
    • Paclitaxel (Taxol®): A success story with valuable lessons for natural product drug discovery and development
    • DOI 10.1002/(SICI)1098-1128(199809)18:5<315::AID-MED3>3.0.CO;2-W
    • G.M. Cragg Paclitaxel (Taxol): a success story with valuable lessons for natural product drug discovery and development Med. Res. Rev. 18 1998 315 331 (Pubitemid 28419084)
    • (1998) Medicinal Research Reviews , vol.18 , Issue.5 , pp. 315-331
    • Cragg, G.M.1
  • 5
    • 84855810908 scopus 로고    scopus 로고
    • Thymoquinone: Potential cure for inflammatory disorders and cancer
    • Chern Chiuh Woo, Alan Prem Kumar, Gautam Sethi, and Kwong Huat Benny Tan Thymoquinone: potential cure for inflammatory disorders and cancer Biochem. Pharmacol. 83 2012 443 451
    • (2012) Biochem. Pharmacol. , vol.83 , pp. 443-451
    • Chiuh Woo, C.1    Prem Kumar, A.2    Sethi, G.3    Benny Tan, K.H.4
  • 6
    • 0034851475 scopus 로고    scopus 로고
    • Flavonoid (myricetin, quercetin, kaempferol, luteolin, and apigenin) content of edible tropical plants
    • K.H. Miean, and S. Mohamed Flavonoid (myricetin, quercetin, kaempferol, luteolin, and apigenin) content of edible tropical plants J. Agric. Food Chem. 49 2001 3106 3112 (Pubitemid 32826116)
    • (2001) Journal of Agricultural and Food Chemistry , vol.49 , Issue.6 , pp. 3106-3112
    • Koo Hui Miean1    Mohamed, S.2
  • 7
    • 0036400016 scopus 로고    scopus 로고
    • Dietary flavonoids: Bioavailability, metabolic effects, and safety
    • DOI 10.1146/annurev.nutr.22.111401.144957
    • J.A. Ross, and C.M. Kasum Dietary flavonoids: bioavailability, metabolic effects, and safety Annu. Rev. Nutr. 22 2002 19 34 (Pubitemid 35221452)
    • (2002) Annual Review of Nutrition , vol.22 , pp. 19-34
    • Ross, J.A.1    Kasum, C.M.2
  • 9
    • 0037467137 scopus 로고    scopus 로고
    • Radiolysis of kaempferol in water/methanol mixtures. Evaluation of antioxidant activity of kaempferol and products formed
    • A. Marfak, P. Trouillas, D.P. Allais, Y. Champavier, C.A. Calliste, and J.L. Duroux Radiolysis of kaempferol in water/methanol mixtures. Evaluation of antioxidant activity of kaempferol and products formed J. Agric. Food. Chem. 51 2003 1270 1277
    • (2003) J. Agric. Food. Chem. , vol.51 , pp. 1270-1277
    • Marfak, A.1    Trouillas, P.2    Allais, D.P.3    Champavier, Y.4    Calliste, C.A.5    Duroux, J.L.6
  • 10
    • 34547824635 scopus 로고    scopus 로고
    • Kaempferol induces apoptosis in human lung non-small carcinoma cells accompanied by an induction of antioxidant enzymes
    • DOI 10.1016/j.fct.2007.04.023, PII S0278691507001603
    • H.W. Leung, C.J. Lin, M.J. Hour, W.H. Yang, M.Y. Wang, and H.Z. Lee Kaempferol induces apoptosis in human lung non-small carcinoma cells accompanied by an induction of antioxidant enzymes Food Chem. Toxicol. 45 2007 2005 2013 (Pubitemid 47238216)
    • (2007) Food and Chemical Toxicology , vol.45 , Issue.10 , pp. 2005-2013
    • Leung, H.W.-C.1    Lin, C.-J.2    Hour, M.-J.3    Yang, W.-H.4    Wang, M.-Y.5    Lee, H.-Z.6
  • 11
    • 35148894128 scopus 로고    scopus 로고
    • Kaempferol induced inhibition of HL-60 cell growth results from a heterogeneous response, dominated by cell cycle alterations
    • DOI 10.1016/j.cbi.2007.07.002, PII S0009279707002311
    • C.S. Bestwick, L. Milne, and S.J. Duthie Kaempferol induced inhibition of HL-60 cell growth results from a heterogeneous response, dominated by cell cycle alterations Chem. Biol. Interact. 170 2007 76 85 (Pubitemid 47552417)
    • (2007) Chemico-Biological Interactions , vol.170 , Issue.2 , pp. 76-85
    • Bestwick, C.S.1    Milne, L.2    Duthie, S.J.3
  • 12
    • 0035874028 scopus 로고    scopus 로고
    • Effects of structurally related flavonoids on cell cycle progression of human melanoma cells: Regulation of cyclin-dependent kinases CDK2 and CDK1
    • DOI 10.1016/S0006-2952(01)00583-4, PII S0006295201005834
    • F. Casagrande, and J.M. Darbon Effects of structurally related flavonoids on cell cycle progression of human melanoma cells: regulation of cyclin-dependent kinases CDK2 and CDK1 Biochem. Pharmacol. 61 2001 1205 1215 (Pubitemid 32375112)
    • (2001) Biochemical Pharmacology , vol.61 , Issue.10 , pp. 1205-1215
    • Casagrande, F.1    Darbon, J.-M.2
  • 14
    • 18044383342 scopus 로고    scopus 로고
    • Dietary flavonoids as proteasome inhibitors and apoptosis inducers in human leukemia cells
    • DOI 10.1016/j.bcp.2005.02.022
    • D. Chen, K.G. Daniel, M.S. Chen, D.J. Kuhn, K.R. Landis-Piwowar, and Q.P. Dou Dietary flavonoids as proteasome inhibitors and apoptosis inducers in human leukemia cells Biochem. Pharmacol. 69 2005 1421 1432 (Pubitemid 40602442)
    • (2005) Biochemical Pharmacology , vol.69 , Issue.10 , pp. 1421-1432
    • Chen, D.1    Daniel, K.G.2    Chen, M.S.3    Kuhn, D.J.4    Landis-Piwowar, K.R.5    Dou, Q.P.6
  • 16
    • 77952868913 scopus 로고    scopus 로고
    • Kaempferol induced the apoptosis via cell cycle arrest in human breast cancer MDA-MB-453 cells
    • Eun Jeong Choi, and Woong Shick Ahn Kaempferol induced the apoptosis via cell cycle arrest in human breast cancer MDA-MB-453 cells Nutr. Res. Prac. 2 2008 322 325
    • (2008) Nutr. Res. Prac. , vol.2 , pp. 322-325
    • Choi, E.J.1    Ahn, W.S.2
  • 19
    • 77950346282 scopus 로고    scopus 로고
    • Immunity, inflammation, and cancer
    • S.I. Grivennikov, F.R. Greten, and M. Karin Immunity, inflammation, and cancer Cell 140 2010 883 899
    • (2010) Cell , vol.140 , pp. 883-899
    • Grivennikov, S.I.1    Greten, F.R.2    Karin, M.3
  • 20
    • 36049033978 scopus 로고    scopus 로고
    • Blood micromolar concentrations of kaempferol afford protection against ischemia/reperfusion-induced damage in rat brain
    • DOI 10.1016/j.brainres.2007.08.087, PII S0006899307021336
    • C. Lopez-Sanchez, F.J. Martin-Romero, F. Sun, L. Luis, A.K. Samhan-Arias, V. Garcia-Martinez, and C. Gutierrez-Merino Blood micromolar concentrations of kaempferol afford protection against ischemia/reperfusion induced damage in rat brain Brain Res. 1182 2007 123 137 (Pubitemid 350086989)
    • (2007) Brain Research , vol.1182 , Issue.1 , pp. 123-137
    • Lopez-Sanchez, C.1    Martin-Romero, F.J.2    Sun, F.3    Luis, L.4    Samhan-Arias, A.K.5    Garcia-Martinez, V.6    Gutierrez-Merino, C.7
  • 21
    • 84891559401 scopus 로고    scopus 로고
    • Anti-oxidant activity and attenuation of bladder hyperactivity by the flavonoid compound kaempferol
    • Y.B. Huang, M.W. Lin, Y. Chao, C.T. Huang, Y.H. Tsai, and P.C. Wu Anti-oxidant activity and attenuation of bladder hyperactivity by the flavonoid compound kaempferol Int. J. Urol. 21 1 2014 94 98
    • (2014) Int. J. Urol. , vol.21 , Issue.1 , pp. 94-98
    • Huang, Y.B.1    Lin, M.W.2    Chao, Y.3    Huang, C.T.4    Tsai, Y.H.5    Wu, P.C.6
  • 22
    • 80054741464 scopus 로고    scopus 로고
    • Flavonol kaempferol improves chronic hyperglycemia-impaired pancreatic beta-cell viability and insulin secretory function
    • Y. Zhang, and D. Liu Flavonol kaempferol improves chronic hyperglycemia-impaired pancreatic beta-cell viability and insulin secretory function Eur. J. Pharmacol. 670 2011 325 332
    • (2011) Eur. J. Pharmacol. , vol.670 , pp. 325-332
    • Zhang, Y.1    Liu, D.2
  • 23
    • 80053143566 scopus 로고    scopus 로고
    • Anti-diabetic effects of a kaempferol glycoside-rich fraction from unripe soybean (Edamame, Glycine max L. Merrill. 'Jindai') leaves on KK-A(y) mice
    • Y. Zang, H. Sato, and K. Igarashi Anti-diabetic effects of a kaempferol glycoside-rich fraction from unripe soybean (Edamame, Glycine max L. Merrill. 'Jindai') leaves on KK-A(y) mice Biosci. Biotechnol. Biochem. 75 2011 1677 1684
    • (2011) Biosci. Biotechnol. Biochem. , vol.75 , pp. 1677-1684
    • Zang, Y.1    Sato, H.2    Igarashi, K.3
  • 24
    • 33846582444 scopus 로고    scopus 로고
    • The anti-inflammatory flavones quercetin and kaempferol cause inhibition of inducible nitric oxide synthase, cyclooxygenase-2 and reactive C-protein, and down-regulation of the nuclear factor kappaB pathway in Chang Liver cells
    • DOI 10.1016/j.ejphar.2006.11.014, PII S0014299906012659
    • V. Garcia-Mediavill, I. Crespo, P.S. Collado, A. Esteller, S. Sanchez-Campos, M.J. Tunon, and J. Gonzalez-Gallego The anti-inflammatory flavones quercetin and kaempferol cause inhibition of inducible nitric oxide synthase, cyclooxygenase-2 and reactive C-protein, and down-regulation of the nuclear factor kappaB pathway in Chang Liver cells Eur. J. Pharmacol. 557 2007 221 229 (Pubitemid 46186282)
    • (2007) European Journal of Pharmacology , vol.557 , Issue.2-3 , pp. 221-229
    • Garcia-Mediavilla, V.1    Crespo, I.2    Collado, P.S.3    Esteller, A.4    Sanchez-Campos, S.5    Tunon, M.J.6    Gonzalez-Gallego, J.7
  • 25
    • 0343390325 scopus 로고    scopus 로고
    • Hypoglycemic effect of Equisetum myriochaetum aerial parts on streptozotocin diabetic rats
    • A. Andrade Cetto, H. Wiedenfeld, M.C. Revilla, and I.A. Sergio Hypoglycemic effect of Equisetum myriochaetum aerial parts on streptozotocin diabetic rats J. Ethnopharmacol. 72 2000 129 133
    • (2000) J. Ethnopharmacol. , vol.72 , pp. 129-133
    • Andrade Cetto, A.1    Wiedenfeld, H.2    Revilla, M.C.3    Sergio, I.A.4
  • 26
    • 39649087113 scopus 로고    scopus 로고
    • Kaempferol and quercetin isolated from Euonymus alatus improve glucose uptake of 3T3-L1 cells without adipogenesis activity
    • X.K. Fang, J. Gao, and D.N. Zhu Kaempferol and quercetin isolated from Euonymus alatus improve glucose uptake of 3T3-L1 cells without adipogenesis activity Life Sci. 82 2008 615 622
    • (2008) Life Sci. , vol.82 , pp. 615-622
    • Fang, X.K.1    Gao, J.2    Zhu, D.N.3
  • 27
    • 84871333478 scopus 로고    scopus 로고
    • Protective effect and potential mechanism of Ginkgo biloba extract EGb 761 on STZ-induced Neuropathic Pain in rats
    • R. Taliyan, and P.L. Sharma Protective effect and potential mechanism of Ginkgo biloba extract EGb 761 on STZ-induced Neuropathic Pain in rats Phytother. Res. 26 2012 1823 1829
    • (2012) Phytother. Res. , vol.26 , pp. 1823-1829
    • Taliyan, R.1    Sharma, P.L.2
  • 28
    • 34249324133 scopus 로고    scopus 로고
    • Effects of Ginkgo biloba on prevention of development of experimental diabetic nephropathy in rats
    • DOI 10.1111/j.1745-7254.2007.00570.x
    • Q. Lu, X.X. Yin, J.Y. Wang, Y.Y. Gao, and Y.M. Pan Effects of Ginkgo biloba on prevention of development of experimental diabetic nephropathy in rats Acta Pharmacol. Sin. 28 6 2007 818 828 (Pubitemid 46817438)
    • (2007) Acta Pharmacologica Sinica , vol.28 , Issue.6 , pp. 818-828
    • Lu, Q.1    Yin, X.-X.2    Wang, J.-Y.3    Gao, Y.-Y.4    Pan, Y.-M.5
  • 29
    • 76649109274 scopus 로고    scopus 로고
    • Phaleria macrocarpa suppress nephropathy by increasing renal antioxidant enzyme activity in alloxan-induced diabetic rats
    • Asih Triastuti, Hee Juhn Park, and Jong Won Choi Phaleria macrocarpa suppress nephropathy by increasing renal antioxidant enzyme activity in alloxan-induced diabetic rats Nat. Prod. Sci. 15 2009 167 172
    • (2009) Nat. Prod. Sci. , vol.15 , pp. 167-172
    • Triastuti, A.1    Park, H.J.2    Choi, J.W.3
  • 30
    • 34547949432 scopus 로고    scopus 로고
    • The preliminary studies on antioxidation of three kinds of flavoniods from Litsea coreana
    • H. Ye, and J. Yu The preliminary studies on antioxidation of three kinds of flavoniods from Litsea coreana Zhong Yao Cai 27 2004 113 115
    • (2004) Zhong Yao Cai , vol.27 , pp. 113-115
    • Ye, H.1    Yu, J.2
  • 32
    • 84883324461 scopus 로고    scopus 로고
    • Kaempferol inhibits IL-1β-induced proliferation of rheumatoid arthritis synovial fibroblasts and the production of COX-2, PGE2 and MMPs
    • H.Y. Yoon, E.G. Lee, H. Lee, I.J. Cho, Y.J. Choi, M.S. Sung, H.G. Yoo, and W.H. Yoo Kaempferol inhibits IL-1β-induced proliferation of rheumatoid arthritis synovial fibroblasts and the production of COX-2, PGE2 and MMPs Int. J. Mol. Med. 32 2013 971 977
    • (2013) Int. J. Mol. Med. , vol.32 , pp. 971-977
    • Yoon, H.Y.1    Lee, E.G.2    Lee, H.3    Cho, I.J.4    Choi, Y.J.5    Sung, M.S.6    Yoo, H.G.7    Yoo, W.H.8
  • 33
    • 60549096618 scopus 로고    scopus 로고
    • Effects of Egb 761 on bone mineral density, bone microstructure, and osteoblast function: Possible roles of quercetin and kaempferol
    • R. Trivedi, A. Kumar, V. Gupta, S. Kumar, G.K. Nagar, J.R. Romero, A.K. Dwivedi, and N. Chattopadhyay Effects of Egb 761 on bone mineral density, bone microstructure, and osteoblast function: possible roles of quercetin and kaempferol Mol. Cell Endocrinol. 302 2009 86 91
    • (2009) Mol. Cell Endocrinol. , vol.302 , pp. 86-91
    • Trivedi, R.1    Kumar, A.2    Gupta, V.3    Kumar, S.4    Nagar, G.K.5    Romero, J.R.6    Dwivedi, A.K.7    Chattopadhyay, N.8
  • 34
  • 35
    • 84878685744 scopus 로고    scopus 로고
    • Blockade of airway inflammation by kaempferol via disturbing Tyk-STAT signaling in airway epithelial cells and in asthmatic mice
    • J.H. Gong, D. Shin, S.Y. Han, S.H. Park, M.K. Kang, J.L. Kim, and Y.H. Kang Blockade of airway inflammation by kaempferol via disturbing Tyk-STAT signaling in airway epithelial cells and in asthmatic mice Evid. Based Complement. Altern. Med. 2013 1 13
    • (2013) Evid. Based Complement. Altern. Med. , pp. 1-13
    • Gong, J.H.1    Shin, D.2    Han, S.Y.3    Park, S.H.4    Kang, M.K.5    Kim, J.L.6    Kang, Y.H.7
  • 36
    • 84954358560 scopus 로고    scopus 로고
    • Anti-free radical activities of kaempferol isolated from Acacia nilotica (L.) Willd. Ex. Del
    • Rajbir Singh, Bikram Singh, Sukhpreet Singh, Neeraj Kumar, Subodh Kumar, and Saroj Arora Anti-free radical activities of kaempferol isolated from Acacia nilotica (L.) Willd. Ex. Del Toxicol. In Vitro 22 2008 1965 1970
    • (2008) Toxicol. in Vitro , vol.22 , pp. 1965-1970
    • Singh, R.1    Singh, B.2    Singh, S.3    Kumar, N.4    Kumar, S.5    Arora, S.6
  • 37
    • 78650771958 scopus 로고    scopus 로고
    • New model system for testing effects of flavonoids on doxorubicin-related formation of hydroxyl radicals
    • P. Soucek, E. Kondrova, J. Hermanek, P. Stopka, A. Boumendjel, Y.F. Ueng, and I. Gut New model system for testing effects of flavonoids on doxorubicin-related formation of hydroxyl radicals Anticancer Drugs 22 2011 176 184
    • (2011) Anticancer Drugs , vol.22 , pp. 176-184
    • Soucek, P.1    Kondrova, E.2    Hermanek, J.3    Stopka, P.4    Boumendjel, A.5    Ueng, Y.F.6    Gut, I.7
  • 38
    • 84906504519 scopus 로고    scopus 로고
    • Hepatoprotective role of kaempferol during alcohol- and ΔpUFA-induced oxidative stress
    • G. Shakya, S. Manjini, M. Hoda, and R. Rajagopalan Hepatoprotective role of kaempferol during alcohol- and ΔPUFA-induced oxidative stress J. Basic Clin. Physiol. Pharmacol. 24 2013 1 7
    • (2013) J. Basic Clin. Physiol. Pharmacol. , vol.24 , pp. 1-7
    • Shakya, G.1    Manjini, S.2    Hoda, M.3    Rajagopalan, R.4
  • 39
    • 40849085134 scopus 로고    scopus 로고
    • Differential effects of dietary flavonoids on reactive oxygen and nitrogen species generation and changes in antioxidant enzyme expression induced by proinflammatory cytokines in Chang Liver cells
    • G. Shakya, S. Manjini, M. Hoda, R. Rajagopalan, C. Irene, V. María, M. Garcia, A. Mar, G. Paquita, J.T. Maria, C. Sonia Sanchez, and G. Javier Gonzalez Differential effects of dietary flavonoids on reactive oxygen and nitrogen species generation and changes in antioxidant enzyme expression induced by proinflammatory cytokines in Chang Liver cells Food Chem. Toxicol. 46 2008 1555 2156
    • (2008) Food Chem. Toxicol. , vol.46 , pp. 1555-2156
    • Shakya, G.1    Manjini, S.2    Hoda, M.3    Rajagopalan, R.4    Irene, C.5    María, V.6    Garcia, M.7    Mar, A.8    Paquita, G.9    Maria, J.T.10    Sonia Sanchez, C.11    Javier Gonzalez, G.12
  • 40
    • 84856037087 scopus 로고    scopus 로고
    • Anti- Japanese-encephalitis-viral effects of kaempferol and daidzin and their RNA-binding characteristics
    • T. Zhang, Z. Wu, J. Du, Y. Hu, L. Liu, F. Yang, and Q. Jin Anti- Japanese-encephalitis-viral effects of kaempferol and daidzin and their RNA-binding characteristics PLoS One 7 2012 e30259
    • (2012) PLoS One , vol.7 , pp. 30259
    • Zhang, T.1    Wu, Z.2    Du, J.3    Hu, Y.4    Liu, L.5    Yang, F.6    Jin, Q.7
  • 41
    • 33845371073 scopus 로고    scopus 로고
    • Protective effect of the ethanol extract of the roots of Brassica rapa on cisplatin-induced nephrotoxicity in LLC-PK1 cells and rats
    • Y.H. Kim, Y.W. Kim, Y.J. Oh, N.I. Back, S.A. Chung, H.G. Chung, T.S. Jeong, M.S. Choi, and K.T. Lee Protective effect of the ethanol extract of the roots of Brassica rapa on cisplatin-induced nephrotoxicity in LLC-PK1 cells and rats Biol. Pharm. Bull. 2006 2436 2441
    • (2006) Biol. Pharm. Bull. , pp. 2436-2441
    • Kim, Y.H.1    Kim, Y.W.2    Oh, Y.J.3    Back, N.I.4    Chung, S.A.5    Chung, H.G.6    Jeong, T.S.7    Choi, M.S.8    Lee, K.T.9
  • 42
    • 0347927581 scopus 로고    scopus 로고
    • Protective effect of Pongamia pinnata flowers against cisplatin and gentamicin induced nephrotoxicity in rats
    • A. Shirwaikar, S. Malini, and S.C. Kumari Protective effect of Pongamia pinnata flowers against cisplatin and gentamicin induced nephrotoxicity in rats Indian J. Exp. Biol. 41 2003 58 62 (Pubitemid 36052889)
    • (2003) Indian Journal of Experimental Biology , vol.41 , Issue.1 , pp. 58-62
    • Shirwaikar, A.1    Malini, S.2    Kumari, S.C.3
  • 44
    • 33847698484 scopus 로고    scopus 로고
    • Phenolic-rich fraction from Rhus verniciflua Stokes (RVS) suppress inflammatory response via NF-κB and JNK pathway in lipopolysaccharide- induced RAW 264.7 macrophages
    • H.J. Chang, H.K. Ji, H.H. Myung, M.S. Ho, H.O. Seong, J.L. Pan, J.K. Gyung, M.K. Hyung, Y.U. Jae, and G.K. Seong Phenolic-rich fraction from Rhus verniciflua Stokes (RVS) suppress inflammatory response via NF-κB and JNK pathway in lipopolysaccharide-induced RAW 264.7 macrophages J. Ethnopharmacol. 110 2007 490 497
    • (2007) J. Ethnopharmacol. , vol.110 , pp. 490-497
    • Chang, H.J.1    Ji, H.K.2    Myung, H.H.3    Ho, M.S.4    Seong, H.O.5    Pan, J.L.6    Gyung, J.K.7    Hyung, M.K.8    Jae, Y.U.9    Seong, G.K.10
  • 45
    • 84879371343 scopus 로고    scopus 로고
    • Dietary flavonoids as therapeutics for preterm birth: Luteolin and kaempferol suppress inflammation in human gestational tissues in vitro
    • C. Wall, R. Lim, M. Poljak, and M. Lappas Dietary flavonoids as therapeutics for preterm birth: luteolin and kaempferol suppress inflammation in human gestational tissues in vitro Oxid. Med. Cell. Longev. 2013 1 11
    • (2013) Oxid. Med. Cell. Longev. , pp. 1-11
    • Wall, C.1    Lim, R.2    Poljak, M.3    Lappas, M.4
  • 46
    • 79952701698 scopus 로고    scopus 로고
    • Euonymus alatus extract attenuates LPS-induced NF-κB activation via IKKβ inhibition in RAW 264.7 cells
    • B.K. Oh, J. Mun, H.W. Seo, S.Y. Ryu, Y.S. Kim, B.H. Lee, and K.S. Oh Euonymus alatus extract attenuates LPS-induced NF-κB activation via IKKβ inhibition in RAW 264.7 cells J. Ethnopharmacol. 134 2 2011 288 293
    • (2011) J. Ethnopharmacol. , vol.134 , Issue.2 , pp. 288-293
    • Oh, B.K.1    Mun, J.2    Seo, H.W.3    Ryu, S.Y.4    Kim, Y.S.5    Lee, B.H.6    Oh, K.S.7
  • 47
    • 79953208248 scopus 로고    scopus 로고
    • STAT3 signaling: Anticancer strategies and challenges
    • P.A. Johnston, and J.R. Grandis STAT3 signaling: anticancer strategies and challenges Mol. Interv. 11 2011 18 26
    • (2011) Mol. Interv. , vol.11 , pp. 18-26
    • Johnston, P.A.1    Grandis, J.R.2
  • 48
    • 0036782706 scopus 로고    scopus 로고
    • Transcription factors as targets for cancer therapy
    • J.E. Darnell Transcription factors as targets for cancer therapy Nat. Rev. Cancer 2 2002 740 749
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 740-749
    • Darnell, J.E.1
  • 49
    • 79954459349 scopus 로고    scopus 로고
    • γ-Tocotrienol is a novel inhibitor of constitutive and inducible STAT3 signalling pathway in human hepatocellular carcinoma: Potential role as an antiproliferative, pro-apoptotic and chemosensitizing agent
    • P. Rajendran, F. Li, K.A. Manu, M.K. Shanmugam, S.Y. Loo, A.P. Kumar, and G. Sethi γ-Tocotrienol is a novel inhibitor of constitutive and inducible STAT3 signalling pathway in human hepatocellular carcinoma: potential role as an antiproliferative, pro-apoptotic and chemosensitizing agent Br. J. Pharmacol. 63 2011 283 298
    • (2011) Br. J. Pharmacol. , vol.63 , pp. 283-298
    • Rajendran, P.1    Li, F.2    Manu, K.A.3    Shanmugam, M.K.4    Loo, S.Y.5    Kumar, A.P.6    Sethi, G.7
  • 51
    • 77956325713 scopus 로고    scopus 로고
    • Thymoquinone inhibits proliferation, induces apoptosis and chemosensitizes human multiple myeloma cells through suppression of signal transducer and activator of transcription 3 activation pathway
    • F. Li, P. Rajendran, and G. Sethi Thymoquinone inhibits proliferation, induces apoptosis and chemosensitizes human multiple myeloma cells through suppression of signal transducer and activator of transcription 3 activation pathway Br. J. Pharmacol. 161 2010 541 554
    • (2010) Br. J. Pharmacol. , vol.161 , pp. 541-554
    • Li, F.1    Rajendran, P.2    Sethi, G.3
  • 52
    • 56249131797 scopus 로고    scopus 로고
    • The flavonoid kaempferol sensitizes human glioma cells to TRAIL-mediated apoptosis by proteasomal degradation of survivin
    • M.D. Siegelin, D.E. Reuss, A. Habel, C. Herold-Mende, and A. von Deimling The flavonoid kaempferol sensitizes human glioma cells to TRAIL-mediated apoptosis by proteasomal degradation of survivin Mol. Cancer Ther. 7 2008 3566 3574
    • (2008) Mol. Cancer Ther. , vol.7 , pp. 3566-3574
    • Siegelin, M.D.1    Reuss, D.E.2    Habel, A.3    Herold-Mende, C.4    Von Deimling, A.5
  • 53
    • 34948888880 scopus 로고    scopus 로고
    • Dietary flavones and flavonoles are inhibitors of poly(ADP-ribose) polymerase-1 in pulmonary epithelial cells
    • G. Liesbeth, J.J.M. Harald, B. Karen, F.M.W. Emiel, B. Aalt, and J.H. Geja Dietary flavones and flavonoles are inhibitors of poly(ADP-ribose) polymerase-1 in pulmonary epithelial cells J. Nutr. 137 2007 2190 2195
    • (2007) J. Nutr. , vol.137 , pp. 2190-2195
    • Liesbeth, G.1    Harald, J.J.M.2    Karen, B.3    Emiel, F.M.W.4    Aalt, B.5    Geja, J.H.6
  • 54
    • 51349098155 scopus 로고    scopus 로고
    • Cytokines as a key component of cancer related inflammation
    • G. Germano, P. Allavena, and A. Mantovani Cytokines as a key component of cancer related inflammation Cytokine 43 2008 374 379
    • (2008) Cytokine , vol.43 , pp. 374-379
    • Germano, G.1    Allavena, P.2    Mantovani, A.3
  • 55
    • 84876125385 scopus 로고    scopus 로고
    • Kaempferol inhibits P. Intermedia lipopolysaccharide-induced production of nitric oxide through translational regulation in murine macrophages: Critical role of heme oxygenase-1-mediated ROS reduction
    • I.S. Choi, E.Y. Choi, J.Y. Jin, H.R. Park, J.I. Choi, and S.J. Kim Kaempferol inhibits P. intermedia lipopolysaccharide-induced production of nitric oxide through translational regulation in murine macrophages: critical role of heme oxygenase-1-mediated ROS reduction J. Periodontol. 84 2013 545 555
    • (2013) J. Periodontol. , vol.84 , pp. 545-555
    • Choi, I.S.1    Choi, E.Y.2    Jin, J.Y.3    Park, H.R.4    Choi, J.I.5    Kim, S.J.6
  • 56
    • 84862777526 scopus 로고    scopus 로고
    • Inhibitory effects of kaempferol-3-O-sophoroside on HMGB1-mediated proinflammatory responses
    • T.H. Kim, S.K. Ku, and J.S. Bae Inhibitory effects of kaempferol-3-O-sophoroside on HMGB1-mediated proinflammatory responses Food Chem. Toxicol. 50 2012 1118 1123
    • (2012) Food Chem. Toxicol. , vol.50 , pp. 1118-1123
    • Kim, T.H.1    Ku, S.K.2    Bae, J.S.3
  • 57
    • 0035467993 scopus 로고    scopus 로고
    • Global cancer statistics in the year 2000
    • D.M. Parkin Global cancer statistics in the year 2000 Lancet Oncol. 2 2000 533 543
    • (2000) Lancet Oncol. , vol.2 , pp. 533-543
    • Parkin, D.M.1
  • 58
    • 84874002570 scopus 로고    scopus 로고
    • A review of the dietary flavonoid, kaempferol on human health and cancer chemoprevention
    • Y.C. Allen, and C.C. Yi A review of the dietary flavonoid, kaempferol on human health and cancer chemoprevention Food Chem. 138 2013 2099 2107
    • (2013) Food Chem. , vol.138 , pp. 2099-2107
    • Allen, Y.C.1    Yi, C.C.2
  • 59
    • 79952037796 scopus 로고    scopus 로고
    • Single and concerted effects of benzo[a]pyrene and flavonoids on the AhR and Nrf2-pathway in the human colon carcinoma cell line Caco-2
    • J. Niestroy, A. Barbara, K. Herbst, S. Rode, M. van Liempt, and P.H. Roos Single and concerted effects of benzo[a]pyrene and flavonoids on the AhR and Nrf2-pathway in the human colon carcinoma cell line Caco-2 Toxicol. In Vitro 25 2011 671 683
    • (2011) Toxicol. in Vitro , vol.25 , pp. 671-683
    • Niestroy, J.1    Barbara, A.2    Herbst, K.3    Rode, S.4    Van Liempt, M.5    Roos, P.H.6
  • 60
    • 67650073265 scopus 로고    scopus 로고
    • Cell cycle kinases as therapeutic targets for cancer
    • S. Lapenna, and A. Giordano Cell cycle kinases as therapeutic targets for cancer Nat. Rev. Drug Discov. 8 2009 547 566
    • (2009) Nat. Rev. Drug Discov. , vol.8 , pp. 547-566
    • Lapenna, S.1    Giordano, A.2
  • 62
    • 34748887195 scopus 로고    scopus 로고
    • Kaempferol induces apoptosis in glioblastoma cells through oxidative stress
    • DOI 10.1158/1535-7163.MCT-06-0788
    • V. Sharma, C. Joseph, S. Ghosh, A. Agarwal, M.K. Mishra, and E. Sen Kaempferol induces apoptosis in glioblastoma cells through oxidative stress Mol. Cancer Ther. 6 9 2007 2544 2553 (Pubitemid 47480420)
    • (2007) Molecular Cancer Therapeutics , vol.6 , Issue.9 , pp. 2544-2553
    • Sharma, V.1    Joseph, C.2    Ghosh, S.3    Agarwal, A.4    Mishra, M.K.5    Sen, E.6
  • 63
    • 77953070882 scopus 로고    scopus 로고
    • Effects of kaempferol on the mechanisms of drug resistance in the human glioblastoma cell line T98G
    • A. Nakatsuma, T. Fukami, T. Suzuki, T. Furuishi, K. Tomono, and S. Hidaka Effects of kaempferol on the mechanisms of drug resistance in the human glioblastoma cell line T98G Pharmazie 65 2010 379 383
    • (2010) Pharmazie , vol.65 , pp. 379-383
    • Nakatsuma, A.1    Fukami, T.2    Suzuki, T.3    Furuishi, T.4    Tomono, K.5    Hidaka, S.6
  • 65
    • 68349110545 scopus 로고    scopus 로고
    • Inhibition of MMP-3 activity and invasion of the MDA-MB-231 human invasive breast carcinoma cell line by bioflavonoids
    • K. Phromnoi, S. Yodkeeree, S. Anuchapreeda, and P. Limtrakul Inhibition of MMP-3 activity and invasion of the MDA-MB-231 human invasive breast carcinoma cell line by bioflavonoids Acta Pharmacol. Sin. 30 2009 1169 1176
    • (2009) Acta Pharmacol. Sin. , vol.30 , pp. 1169-1176
    • Phromnoi, K.1    Yodkeeree, S.2    Anuchapreeda, S.3    Limtrakul, P.4
  • 66
    • 80054040531 scopus 로고    scopus 로고
    • Apoptosis-inducing effect of quercetin and kaempferol on human HL-60 cells and its mechanism
    • H.J. Ren, H.J. Hao, Y.J. Shi, X.M. Meng, and Y.Q. Han Apoptosis-inducing effect of quercetin and kaempferol on human HL-60 cells and its mechanism Zhongguo Shi Yan Xue Ye Xue Za Zhi 18 2010 629 633
    • (2010) Zhongguo Shi Yan Xue Ye Xue Za Zhi , vol.18 , pp. 629-633
    • Ren, H.J.1    Hao, H.J.2    Shi, Y.J.3    Meng, X.M.4    Han, Y.Q.5
  • 67
    • 20444371369 scopus 로고    scopus 로고
    • The effect of short-term kaempferol exposure on reactive oxygen levels and integrity of human (HL-60) leukaemic cells
    • S.B. Charles, M. Lesleye, P. Lynn, and J.D. Susan The effect of short-term kaempferol exposure on reactive oxygen levels and integrity of human (HL-60) leukaemic cells Biochim. Biophys. Acta (BBA) - Mol. Basis Dis. 1740 2005 340 349
    • (2005) Biochim. Biophys. Acta (BBA) - Mol. Basis Dis. , vol.1740 , pp. 340-349
    • Charles, S.B.1    Lesleye, M.2    Lynn, P.3    Susan, J.D.4
  • 68
    • 24744456125 scopus 로고    scopus 로고
    • Kaempferol, a Tea flavonol, effect on Interleukin-2 signal transduction of human T cell leukemia
    • A. Kazumi, M. Sawako, and M.M. Mari Kaempferol, a Tea flavonol, effect on Interleukin-2 signal transduction of human T cell leukemia JARQ 39 2005 175 179
    • (2005) JARQ , vol.39 , pp. 175-179
    • Kazumi, A.1    Sawako, M.2    Mari, M.M.3
  • 69
    • 57649192456 scopus 로고    scopus 로고
    • Kaempferol induces apoptosis in human HCT116 colon cancer cells via the Ataxia-Telangiectasia Mutated-p53 pathway with the involvement of p53 Upregulated Modulator of Apoptosis
    • W. Li, B. Du, T. Wang, S. Wang, and J. Zhang Kaempferol induces apoptosis in human HCT116 colon cancer cells via the Ataxia-Telangiectasia Mutated-p53 pathway with the involvement of p53 Upregulated Modulator of Apoptosis Chem. Biol. Interact. 177 2009 121 127
    • (2009) Chem. Biol. Interact. , vol.177 , pp. 121-127
    • Li, W.1    Du, B.2    Wang, T.3    Wang, S.4    Zhang, J.5
  • 71
    • 35748973566 scopus 로고    scopus 로고
    • Kaempferol inhibits IL-4-Induced STAT6 activation by specifically targeting JAK31
    • R.C. Jose, P.G. Moises, D.R. Maria, and Z. Jose Kaempferol inhibits IL-4-Induced STAT6 activation by specifically targeting JAK31 J. Immunol. 179 2007 3881 4388
    • (2007) J. Immunol. , vol.179 , pp. 3881-4388
    • Jose, R.C.1    Moises, P.G.2    Maria, D.R.3    Jose, Z.4
  • 72
    • 45049088538 scopus 로고    scopus 로고
    • Ginkgo biloba extract kaempferol inhibits cell proliferation and induces apoptosis in pancreatic cancer cells
    • Y. Zhang, A.Y. Chen, M. Li, C. Chen, and Q. Yao Ginkgo biloba extract kaempferol inhibits cell proliferation and induces apoptosis in pancreatic cancer cells J. Surg. Res. 148 2008 17 23
    • (2008) J. Surg. Res. , vol.148 , pp. 17-23
    • Zhang, Y.1    Chen, A.Y.2    Li, M.3    Chen, C.4    Yao, Q.5
  • 73
    • 84879657942 scopus 로고    scopus 로고
    • Kaempferol suppresses cell metastasis via inhibition of the ERK-p38-JNK and AP-1 signaling pathways in U-2 OS human osteosarcoma cells
    • H.J. Chen, C.M. Lin, C.Y. Lee, N.C. Shih, S.F. Peng, M.T. Suzuki, S. Amagaya, W.W. Huang, and J.S. Yang Kaempferol suppresses cell metastasis via inhibition of the ERK-p38-JNK and AP-1 signaling pathways in U-2 OS human osteosarcoma cells Oncol. Rep. 30 2013 925 932
    • (2013) Oncol. Rep. , vol.30 , pp. 925-932
    • Chen, H.J.1    Lin, C.M.2    Lee, C.Y.3    Shih, N.C.4    Peng, S.F.5    Suzuki, M.T.6    Amagaya, S.7    Huang, W.W.8    Yang, J.S.9
  • 74
    • 78349236990 scopus 로고    scopus 로고
    • Kaempferol induced apoptosis via endoplasmic reticulum stress and mitochondria-dependent pathway in human osteosarcoma U-2 OS cells
    • W.W. Huang, Y.J. Chiu, M.J. Fan, H.F. Lu, H.F. Yeh, K.H. Li, P.Y. Chen, J.G. Chung, and J.S. Yang Kaempferol induced apoptosis via endoplasmic reticulum stress and mitochondria-dependent pathway in human osteosarcoma U-2 OS cells Mol. Nutr. Food Res. 54 2010 1585 1595
    • (2010) Mol. Nutr. Food Res. , vol.54 , pp. 1585-1595
    • Huang, W.W.1    Chiu, Y.J.2    Fan, M.J.3    Lu, H.F.4    Yeh, H.F.5    Li, K.H.6    Chen, P.Y.7    Chung, J.G.8    Yang, J.S.9
  • 75
    • 43549102633 scopus 로고    scopus 로고
    • Kaempferol and quercetin stimulate granulocyte-macrophage colony-stimulating factor secretion in human prostate cancer cells
    • B. Sanghamitr, R.R. Jose, and C. Naibedy Kaempferol and quercetin stimulate granulocyte-macrophage colony-stimulating factor secretion in human prostate cancer cells Mol. Cell Endocrinol. 287 2008 57 64
    • (2008) Mol. Cell Endocrinol. , vol.287 , pp. 57-64
    • Sanghamitr, B.1    Jose, R.R.2    Naibedy, C.3
  • 76
    • 33747053913 scopus 로고    scopus 로고
    • Cyanidin attenuates PGE2 production and cyclooxygenase-2 expression in LNCaP human prostate cancer cells
    • M.E. Ana Cecilia, and A.W. Bruce Cyanidin attenuates PGE2 production and cyclooxygenase-2 expression in LNCaP human prostate cancer cells J. Nutr. Biochem. 17 2006 589 596
    • (2006) J. Nutr. Biochem. , vol.17 , pp. 589-596
    • Ana Cecilia, M.E.1    Bruce, A.W.2
  • 77
    • 29144495965 scopus 로고    scopus 로고
    • Blueberry flavonoids inhibit matrix metalloproteinase activity in DU145 human prostate cancer cells
    • D.M. Michael, L.M. Shawna, I.S. Marva, T.G.P. Katherine, and A.R.H. Robert Blueberry flavonoids inhibit matrix metalloproteinase activity in DU145 human prostate cancer cells Biochem Cell Biol. 83 2005 637 643
    • (2005) Biochem Cell Biol. , vol.83 , pp. 637-643
    • Michael, D.M.1    Shawna, L.M.2    Marva, I.S.3    Katherine, T.G.P.4    Robert, A.R.H.5
  • 78
    • 0036152763 scopus 로고    scopus 로고
    • Hepatoprotective principles from the flowers of Tilia argentea (Linden): Structure requirements of tiliroside and mechanisms of action
    • M. Hisashi, N. Kiyofumi, S. Hiroshi, and Y. Masayuki Hepatoprotective principles from the flowers of Tilia argentea (Linden): structure requirements of tiliroside and mechanisms of action Bioorg Med. Chem. 10 2002 707 712
    • (2002) Bioorg Med. Chem. , vol.10 , pp. 707-712
    • Hisashi, M.1    Kiyofumi, N.2    Hiroshi, S.3    Masayuki, Y.4
  • 80
    • 42749084654 scopus 로고    scopus 로고
    • Kaempferol-7-O-beta-D-glucoside (KG) isolated from Smilax china L. Rhizome induces G2/M phase arrest and apoptosis on HeLa cells in a p53-independent manner
    • W. Xu, J. Liu, C. Li, H.Z. Wu, and Y.W. Liu Kaempferol-7-O-beta-D- glucoside (KG) isolated from Smilax china L. rhizome induces G2/M phase arrest and apoptosis on HeLa cells in a p53-independent manner Cancer Lett. 264 2008 229 240
    • (2008) Cancer Lett. , vol.264 , pp. 229-240
    • Xu, W.1    Liu, J.2    Li, C.3    Wu, H.Z.4    Liu, Y.W.5
  • 81
    • 84865759701 scopus 로고    scopus 로고
    • Gynura procumbens modulates the microtubules integrity and enhances distinct mechanism on doxorubicin and 5-fl urouracil-induced breast cancer cell death
    • N.A. Nurulita, E. Meiyanto, M.E. Sugiyanto, and M. Kawaichi Gynura procumbens modulates the microtubules integrity and enhances distinct mechanism on doxorubicin and 5-fl urouracil-induced breast cancer cell death Orient. Pharm. Exp. Med. 12 2012 205 218
    • (2012) Orient. Pharm. Exp. Med. , vol.12 , pp. 205-218
    • Nurulita, N.A.1    Meiyanto, E.2    Sugiyanto, M.E.3    Kawaichi, M.4
  • 82
    • 67649382925 scopus 로고    scopus 로고
    • Cytotoxicity of flavones and flavonols to a human esophageal squamous cell carcinoma cell line (KYSE-510) by induction of G2/M arrest and apoptosis
    • Q. Zhang, X.H. Zhao, and Z.J. Wang Cytotoxicity of flavones and flavonols to a human esophageal squamous cell carcinoma cell line (KYSE-510) by induction of G2/M arrest and apoptosis Toxicol. In Vitro 23 2009 797 807
    • (2009) Toxicol. in Vitro , vol.23 , pp. 797-807
    • Zhang, Q.1    Zhao, X.H.2    Wang, Z.J.3
  • 83
    • 47249086549 scopus 로고    scopus 로고
    • Selective anticancer strategies via intervention of the death pathways relevant to cell transformation
    • DOI 10.1038/cdd.2008.48, PII CDD200848
    • Q.X. Li, D.H. Yu, G. Liu, N. Ke, J. McKelvy, and F. Wong-Staal Selective anticancer strategies via intervention of the death pathways relevant to cell transformation Cell Death Differ. 15 2008 1197 1210 (Pubitemid 351984750)
    • (2008) Cell Death and Differentiation , vol.15 , Issue.8 , pp. 1197-1210
    • Li, Q.-X.1    Yu, D.H.2    Liu, G.3    Ke, N.4    McKelvy, J.5    Wong-Staal, F.6
  • 84
    • 62649152321 scopus 로고    scopus 로고
    • Kaempferol induces apoptosis in two different cell lines via Akt inactivation, Bax and SIRT3 activation, and mitochondrial dysfunction
    • G. Marfe, M. Tafani, M. Indelicato, P. Sinibaldi-Salimei, V. Reali, B. Pucci, M. Fini, and M.A. Russo Kaempferol induces apoptosis in two different cell lines via Akt inactivation, Bax and SIRT3 activation, and mitochondrial dysfunction J. Cell Biochem. 106 2009 643 650
    • (2009) J. Cell Biochem. , vol.106 , pp. 643-650
    • Marfe, G.1    Tafani, M.2    Indelicato, M.3    Sinibaldi-Salimei, P.4    Reali, V.5    Pucci, B.6    Fini, M.7    Russo, M.A.8
  • 85
    • 34347361698 scopus 로고    scopus 로고
    • Fisetin, an inhibitor of cyclin-dependent kinase 6, down-regulates nuclear factor-κB-regulated cell proliferation, antiapoptotic and metastatic gene products through the suppression of TAK-1 and receptor-interacting protein-regulated IκBα kinase activation
    • DOI 10.1124/mol.107.034512
    • B. Sung, M.K. Pandey, and B.B. Aggarwal Fisetin, an inhibitor of cyclin-dependent kinase 6, down-regulates nuclear factor-kappaB-regulated cell proliferation, antiapoptotic and metastatic gene products through the suppression of TAK-1 and receptor-interacting protein-regulated IkappaBalpha kinase activation Mol. Pharmacol. 71 2007 1703 1714 (Pubitemid 47010923)
    • (2007) Molecular Pharmacology , vol.71 , Issue.6 , pp. 1703-1714
    • Sung, B.1    Pandey, M.K.2    Aggarwal, B.B.3
  • 87
    • 77951944654 scopus 로고    scopus 로고
    • Kaempferol enhances cisplatin's effect on ovarian cancer cells through promoting apoptosis caused by down regulation of cMyc
    • H. Luo, M.K. Daddysman, G.O. Rankin, B.H. Jiang, and Y.C. Chen Kaempferol enhances cisplatin's effect on ovarian cancer cells through promoting apoptosis caused by down regulation of cMyc Cancer Cell Int. 10 2010 1 9
    • (2010) Cancer Cell Int. , vol.10 , pp. 1-9
    • Luo, H.1    Daddysman, M.K.2    Rankin, G.O.3    Jiang, B.H.4    Chen, Y.C.5
  • 88
    • 16244371036 scopus 로고    scopus 로고
    • Inhibition of P-glycoprotein function and expression by kaempferol and quercetin
    • P. Limtrakul, O. Khantamat, and K. Pintha Inhibition of P-glycoprotein function and expression by kaempferol and quercetin J. Chemother. 17 2005 86 95 (Pubitemid 40463763)
    • (2005) Journal of Chemotherapy , vol.17 , Issue.1 , pp. 86-95
    • Limtrakul, P.1    Khantamat, O.2    Pintha, K.3
  • 89
    • 78951490151 scopus 로고    scopus 로고
    • Effect of kaempferol on lipid peroxidation and antioxidant status in 1,2-dimethyl hydrazine induced colorectal carcinoma in rats
    • P. Nirmala, and M. Ramanathan Effect of kaempferol on lipid peroxidation and antioxidant status in 1,2-dimethyl hydrazine induced colorectal carcinoma in rats Eur. J. Pharmacol. 654 2011 75 79
    • (2011) Eur. J. Pharmacol. , vol.654 , pp. 75-79
    • Nirmala, P.1    Ramanathan, M.2
  • 90
    • 70349972154 scopus 로고    scopus 로고
    • Metabolism, oral bioavailability and pharmacokinetics of chemopreventive kaempferol in rats
    • A. Barve, C. Chen, V. Hebbar, J. Desiderio, C.L. Saw, and A.N. Kong Metabolism, oral bioavailability and pharmacokinetics of chemopreventive kaempferol in rats Biopharm. Drug Dispos. 30 2009 356 365
    • (2009) Biopharm. Drug Dispos. , vol.30 , pp. 356-365
    • Barve, A.1    Chen, C.2    Hebbar, V.3    Desiderio, J.4    Saw, C.L.5    Kong, A.N.6
  • 91
    • 70449643130 scopus 로고    scopus 로고
    • Kaempferol inhibits angiogenesis and VEGF expression through both HIF dependent and independent pathways in human ovarian cancer cells
    • H. Luo, G.O. Rankin, L. Liu, M.K. Daddysman, B.H. Jiang, and Y.C. Chen Kaempferol inhibits angiogenesis and VEGF expression through both HIF dependent and independent pathways in human ovarian cancer cells Nutr. Cancer 61 2009 554 563
    • (2009) Nutr. Cancer , vol.61 , pp. 554-563
    • Luo, H.1    Rankin, G.O.2    Liu, L.3    Daddysman, M.K.4    Jiang, B.H.5    Chen, Y.C.6
  • 93
    • 33646520821 scopus 로고    scopus 로고
    • Lipopolysaccharide plus 12-o-tetradecanoylphorbol 13-acetate induction of migration and invasion of glioma cells in vitro and in vivo: Differential inhibitory effects of flavonoids
    • S.C. Shen, C.W. Lin, H.M. Lee, L.L. Chien, and Y.C. Chen Lipopolysaccharide plus 12-o-tetradecanoylphorbol 13-acetate induction of migration and invasion of glioma cells in vitro and in vivo: differential inhibitory effects of flavonoids Neuroscience 140 2 2006 30 477 489
    • (2006) Neuroscience , vol.140 , Issue.2 , pp. 477-489
    • Shen, S.C.1    Lin, C.W.2    Lee, H.M.3    Chien, L.L.4    Chen, Y.C.5
  • 96
    • 67349150108 scopus 로고    scopus 로고
    • Signaling pathways of kaempferol-3-neohesperidoside in glycogen synthesis in rat soleus muscle
    • L.H. Cazarolli, P. Folador, M.G. Pizzolatti, and F.R. Mena Barreto Silva Signaling pathways of kaempferol-3-neohesperidoside in glycogen synthesis in rat soleus muscle Biochimie 91 2009 843 849
    • (2009) Biochimie , vol.91 , pp. 843-849
    • Cazarolli, L.H.1    Folador, P.2    Pizzolatti, M.G.3    Mena Barreto Silva, F.R.4
  • 99
    • 0036000264 scopus 로고    scopus 로고
    • Hypoglycemic effect of Equisetum myriochaetum aerial parts on type 2 diabetic patients
    • DOI 10.1016/S0378-8741(02)00053-3, PII S0378874102000533
    • M.C. Revilla, A. Andrade-Cetto, S. Islas, and H. Wiedenfeld Hypoglycemic effect of Equisetum myriochaetum aerial parts on type 2 diabetic patients J. Ethnopharmacol. 81 2002 117 120 (Pubitemid 34518476)
    • (2002) Journal of Ethnopharmacology , vol.81 , Issue.1 , pp. 117-120
    • Revilla, Ma.C.1    Andrade-Cetto, A.2    Islas, S.3    Wiedenfeld, H.4
  • 101
    • 28844473846 scopus 로고    scopus 로고
    • Radical medicine: Treating ageing to cure disease
    • DOI 10.1038/nrm1763
    • T. Finkel Radical medicine: treating ageing to cure disease Nat. Rev. Mol. Cell Biol. 6 2005 971 976 (Pubitemid 41778716)
    • (2005) Nature Reviews Molecular Cell Biology , vol.6 , Issue.12 , pp. 971-976
    • Finkel, T.1
  • 102
    • 2942596005 scopus 로고    scopus 로고
    • Kaempferol blocks oxidative stress in cerebellar granule cells and reveals a key role for reactive oxygen species production at the plasma membrane in the commitment to apoptosis
    • DOI 10.1016/j.freeradbiomed.2004.04.002, PII S0891584904003053
    • A.K. Samhan-Arias, F.J. Martin-Romero, and C. Gutierrez-Merino Kaempferol blocks oxidative stress in cerebellar granule cells and reveals a key role for reactive oxygen species production at the plasma membrane in the commitment to apoptosis Free Radic. Biol. Med. 37 2004 48 61 (Pubitemid 38746650)
    • (2004) Free Radical Biology and Medicine , vol.37 , Issue.1 , pp. 48-61
    • Samhan-Arias, A.K.1    Martin-Romero, F.J.2    Gutierrez-Merino, C.3
  • 105
    • 0021989459 scopus 로고
    • Inhibition of mast cell histamine release by flavonoids and biflavonoids
    • M. Amellal, C. Bronner, F. Briancon, M. Haag, R. Anton, and Y. Landry Inhibition of mast cell histamine release by flavonoids and biflavonoids Planta Med. 51 1985 16 20 (Pubitemid 15146406)
    • (1985) Planta Medica , vol.NO. 1 , pp. 16-20
    • Amellal, M.1    Bronner, C.2    Briancon, F.3
  • 107
    • 67651094097 scopus 로고    scopus 로고
    • Inhibitory effects of flavonoids isolated from Fragaria ananassa Duch on IgE-mediated degranulation in rat basophilic leukemia RBL-2H3
    • T. Itoh, M. Ninomiya, M. Yasuda, K. Koshikawa, Y. Deyashiki, Y. Nozawa, Y. Akao, and M. Koketsu Inhibitory effects of flavonoids isolated from Fragaria ananassa Duch on IgE-mediated degranulation in rat basophilic leukemia RBL-2H3 Bioorg. Med. Chem. 17 2009 5374 5379
    • (2009) Bioorg. Med. Chem. , vol.17 , pp. 5374-5379
    • Itoh, T.1    Ninomiya, M.2    Yasuda, M.3    Koshikawa, K.4    Deyashiki, Y.5    Nozawa, Y.6    Akao, Y.7    Koketsu, M.8
  • 108
    • 77956926249 scopus 로고    scopus 로고
    • Quercetin and kaempferol suppress immunoglobulin E-mediated allergic inflammation in RBL-2H3 and Caco-2 cells
    • E.J. Lee, G.E. Ji, and M.K. Sung Quercetin and kaempferol suppress immunoglobulin E-mediated allergic inflammation in RBL-2H3 and Caco-2 cells Inflamm. Res. 59 2009 847 854
    • (2009) Inflamm. Res. , vol.59 , pp. 847-854
    • Lee, E.J.1    Ji, G.E.2    Sung, M.K.3
  • 110
    • 0027402672 scopus 로고
    • The analgesic activity of Hedyosmum bonplandianum: Flavonoid glycosides
    • DOI 10.1055/s-2006-959597
    • L.C. Cardenas, J. Rodriguez, M.C. Villaverde, R. Riguera, R. Cadena, and J.A. Otero The analgesic activity of Hedyosmum bonplandianum: flavonoid glycosides Planta Med. 59 1993 26 27 (Pubitemid 23055641)
    • (1993) Planta Medica , vol.59 , Issue.1 , pp. 26-27
    • Cardenas, L.C.1    Rodriguez, J.2    Villaverde, M.C.3    Riguera, R.4    Cadena, R.5    Otero, J.A.6
  • 111
    • 38049098241 scopus 로고    scopus 로고
    • Antinociceptive properties of extracts and two flavonoids isolated from leaves of Danae racemosa
    • N. Maleki-Dizaji, F. Fathiazad, and A. Garjani Antinociceptive properties of extracts and two flavonoids isolated from leaves of Danae racemosa Arch. Pharm. Res. 30 2007 1536 1542
    • (2007) Arch. Pharm. Res. , vol.30 , pp. 1536-1542
    • Maleki-Dizaji, N.1    Fathiazad, F.2    Garjani, A.3
  • 112
    • 13444270324 scopus 로고    scopus 로고
    • Identification of the first specific inhibitor of p90 ribosomal S6 kinase (RSK) reveals an unexpected role for RSK in cancer cell proliferation
    • J.A. Smith, C.E. Poteet-Smith, Y. Xu, T.M. Errington, S.M. Hecht, and D.A. Lannigan Identification of the first specific inhibitor of p90 ribosomal S6 kinase (RSK) reveals an unexpected role for RSK in cancer cell proliferation Cancer Res. 65 2005 1027 1034 (Pubitemid 40216465)
    • (2005) Cancer Research , vol.65 , Issue.3 , pp. 1027-1034
    • Smith, J.A.1    Poteet-Smith, C.E.2    Xu, Y.3    Errington, T.M.4    Hecht, S.M.5    Lannigan, D.A.6
  • 113
    • 17144376084 scopus 로고    scopus 로고
    • The serine/threonine protein kinase, p90 ribosomal S6 kinase, is an important regulator of prostate cancer cell proliferation
    • D.E. Clark, T.M. Errington, J.A. Smith, H.F. Frierson, M.J. Weber, and D.A. Lannigan The serine/threonine protein kinase, p90 ribosomal S6 kinase, is an important regulator of prostate cancer cell proliferation Cancer Res. 65 2005 3108 3116 (Pubitemid 40524591)
    • (2005) Cancer Research , vol.65 , Issue.8 , pp. 3108-3116
    • Clark, D.E.1    Errington, T.M.2    Smith, J.A.3    Frierson Jr., H.F.4    Weber, M.J.5    Lannigan, D.A.6
  • 114
    • 34548548518 scopus 로고    scopus 로고
    • Ribosomal S6 kinase 2 is a key regulator in tumor promoter-induced cell transformation
    • DOI 10.1158/0008-5472.CAN-06-4668
    • Y.Y. Cho, K. Yao, H.G. Kim, B.S. Kang, D. Zheng, A.M. Bode, and Z. Dong Ribosomal S6 kinase 2 is a key regulator in tumor promoter induced cell transformation Cancer Res. 67 2007 8104 8112 (Pubitemid 47395145)
    • (2007) Cancer Research , vol.67 , Issue.17 , pp. 8104-8112
    • Cho, Y.-Y.1    Yao, K.2    Kim, H.-G.3    Bong, S.K.4    Zheng, D.5    Bode, A.M.6    Dong, Z.7
  • 116
    • 33750921265 scopus 로고    scopus 로고
    • De novo asymmetric syntheses of SL0101 and its analogues via a palladium-catalyzed glycosylation
    • DOI 10.1021/ol062076r
    • M. Shan, and G.A. O'Doherty De novo asymmetric syntheses of SL0101 and its analogues via a palladium-catalyzed glycosylation Org. Lett. 8 22 2006, 26 5149 5152 (Pubitemid 44728900)
    • (2006) Organic Letters , vol.8 , Issue.22 , pp. 5149-5152
    • Shan, M.1    O'Doherty, G.A.2
  • 117
    • 77954126464 scopus 로고    scopus 로고
    • Synthesis of SL0101 carbasugar analogues: Carbasugars via Pd-catalyzed cyclitolization and post-cyclitolization transformations
    • M. Shan, and G.A. O'Doherty Synthesis of SL0101 carbasugar analogues: carbasugars via Pd-catalyzed cyclitolization and post-cyclitolization transformations Org. Lett. 12 13 2010 2 2986 2989
    • (2010) Org. Lett. , vol.12 , Issue.13 , pp. 2986-2989
    • Shan, M.1    O'Doherty, G.A.2
  • 119
    • 24144496829 scopus 로고    scopus 로고
    • Phytoestrogens induce differential estrogen receptor alpha- or beta-mediated responses in transfected breast cancer cells
    • D.M. Harris, E. Besselink, S.M. Henning, V.L. Go, and D. Heber Phytoestrogens induce differential estrogen receptor alpha- or Betamediated responses in transfected breast cancer cells Exp. Biol. Med. 230 2005 558 568 (Pubitemid 41233155)
    • (2005) Experimental Biology and Medicine , vol.230 , Issue.8 , pp. 558-568
    • Harris, D.M.1    Besselink, E.2    Henning, S.M.3    Go, V.L.W.4    Heber, D.5
  • 120
    • 33744922639 scopus 로고    scopus 로고
    • Biphasic effects of kaempferol on the estrogenicity in human breast cancer cells
    • S.M. Oh, Y.P. Kim, and K.H. Chung Biphasic effects of kaempferol on the estrogenicity in human breast cancer cells Arch. Pharm. Res. 29 2006 354 362
    • (2006) Arch. Pharm. Res. , vol.29 , pp. 354-362
    • Oh, S.M.1    Kim, Y.P.2    Chung, K.H.3
  • 121
    • 65449172057 scopus 로고    scopus 로고
    • Phytoestrogens induce differential estrogen receptor beta-mediated responses in transfected MG-63 cells
    • X. Tang, X. Zhu, S. Liu, R.C. Nicholson, and X. Ni Phytoestrogens induce differential estrogen receptor beta-mediated responses in transfected MG-63 cells Endocrine 34 2008 29 35
    • (2008) Endocrine , vol.34 , pp. 29-35
    • Tang, X.1    Zhu, X.2    Liu, S.3    Nicholson, R.C.4    Ni, X.5
  • 122
    • 59849083230 scopus 로고    scopus 로고
    • Kaempferol is an estrogen-related receptor alpha and gamma inverse agonist
    • J. Wang, F. Fang, Z. Huang, Y. Wang, and C. Wong Kaempferol is an estrogen-related receptor alpha and gamma inverse agonist FEBS Lett. 583 4 2009 643 647
    • (2009) FEBS Lett. , vol.583 , Issue.4 , pp. 643-647
    • Wang, J.1    Fang, F.2    Huang, Z.3    Wang, Y.4    Wong, C.5
  • 123
    • 16244375571 scopus 로고    scopus 로고
    • Augmentation of differentiation and gap junction function by kaempferol in partially differentiated colon cancer cells
    • DOI 10.1093/carcin/bgi003
    • Y. Nakamura, C.C. Chang, T. Mori, K. Sato, K. Ohtsuki, B.L. Upham, and J.E. Trosko Augmentation of differentiation and gap junction function by kaempferol in partially differentiated colon cancer cells Carcinogen 26 2005 665 671 (Pubitemid 41214158)
    • (2005) Carcinogenesis , vol.26 , Issue.3 , pp. 665-671
    • Nakamura, Y.1    Chang, C.-C.2    Mori, T.3    Sato, K.4    Ohtsuki, K.5    Upham, B.L.6    Trosko, J.E.7
  • 124
    • 77949275161 scopus 로고    scopus 로고
    • Kaempferol suppresses cisplatin-induced apoptosis via inductions of heme oxygenase-1 and glutamate-cysteine ligase catalytic subunit in HEI-OC1 cells
    • S.S. Gao, B.M. Choi, X.Y. Chen, R.Z. Zhu, Y. Kim, H. So, R. Park, M. Sung, and B.R. Kim Kaempferol suppresses cisplatin-induced apoptosis via inductions of heme oxygenase-1 and glutamate-cysteine ligase catalytic subunit in HEI-OC1 cells Pharm. Res. 27 2010 235 245
    • (2010) Pharm. Res. , vol.27 , pp. 235-245
    • Gao, S.S.1    Choi, B.M.2    Chen, X.Y.3    Zhu, R.Z.4    Kim, Y.5    So, H.6    Park, R.7    Sung, M.8    Kim, B.R.9
  • 125
    • 44949209644 scopus 로고    scopus 로고
    • Effects of oral kaempferol on the pharmacokinetics of tamoxifen and one of its metabolites, 4-hydroxytamoxifen, after oral administration of tamoxifen to rats
    • DOI 10.1002/bdd.593
    • Y. Piao, S.C. Shin, and J.S. Choi Effects of oral kaempferol on the pharmacokinetics of tamoxifen and one of its metabolites, 4-hydroxytamoxifen, after oral administration of tamoxifen to rats Biopharm. Drug Dispos. 29 4 2008 245 249 (Pubitemid 351802847)
    • (2008) Biopharmaceutics and Drug Disposition , vol.29 , Issue.4 , pp. 245-249
    • Piao, Y.1    Shin, S.-C.2    Choi, J.-S.3


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