Kaempferol 7-O-β-D-glucoside isolated from the leaves of Cudrania tricuspidata inhibits LPS-induced expression of pro-inflammatory mediators through inactivation of NF-κB, AP-1, and JAK-STAT in RAW 264.7 macrophages

Chemico-Biological Interactions

Volumn 284, Issue , 2018, Pages 101-111

  Lee, Seung Bin ^a   Shin, Ji Sun ^a   Han, Hee Soo ^a   Lee, Hwi Ho ^a   Park, Jong Cheol ^b   Lee, Kyung Tae ^a  

^a Kyung Hee University   (South Korea)

^b Sunchon National University   (South Korea)

Author keywords

AP 1; JAK STAT; Kaempferol 7 O D glucoside; NF B; RAW 264.7 macrophages

Indexed keywords

CYCLOOXYGENASE 2; I KAPPA B KINASE ALPHA; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; JANUS KINASE; JANUS KINASE 1; JANUS KINASE 2; KAEMPFEROL; KAEMPFEROL 7 O BETA DEXTRO GLUCOSIDE; LIPOPOLYSACCHARIDE; MESSENGER RNA; NITRIC OXIDE; PROSTAGLANDIN E2; PROTEIN C FOS; STAT PROTEIN; STAT1 PROTEIN; STAT3 PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; AUTACOID; KAEMPFEROL DERIVATIVE;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BONE MARROW DERIVED MACROPHAGE; CELL NUCLEUS; CONTROLLED STUDY; CUDRANIA TRICUSPIDATA; DOWN REGULATION; DRUG ISOLATION; DRUG STRUCTURE; ENZYME DEGRADATION; ENZYME PHOSPHORYLATION; JAK-STAT SIGNALING; MORACEAE; MOUSE; NONHUMAN; PLANT LEAF; PROTEIN EXPRESSION; RAW 264.7 CELL LINE; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL SURVIVAL; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; GENETICS; ISOLATION AND PURIFICATION; MACROPHAGE; METABOLISM; SIGNAL TRANSDUCTION;

ANIMALS; CELL SURVIVAL; CYCLOOXYGENASE 2; DOWN-REGULATION; INFLAMMATION MEDIATORS; INTERLEUKIN-1BETA; JANUS KINASES; KAEMPFEROLS; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MORACEAE; NF-KAPPA B; NITRIC OXIDE SYNTHASE TYPE II; PLANT LEAVES; RAW 264.7 CELLS; SIGNAL TRANSDUCTION; STAT TRANSCRIPTION FACTORS; TRANSCRIPTION FACTOR AP-1; TUMOR NECROSIS FACTOR-ALPHA;

EID: 85042367952     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2018.02.022     Document Type: Article

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